检索结果-南通市图书馆

Is surgical axillary staging necessary in women with T1 breast cancer who are treated with breast-conserving therapy?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2019年第1期39卷 233-244页

作者： Jin Wang Hailin Tang Xing Li cailu song Zhenchong Xiong Xi Wang Xiaoming Xie Jun Tang Department of Breast Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterNo.651 Dongfeng East RoadYuexiu DistrictGuangzhou 510060GuangdongP.R.China

Background:In the post-Z0011 trial era,the need to perform surgical axillary staging for early-stage breast cancer patients,who are treated with breast-conserving therapy(BCT),is being *** conducted a retrospective cohort study using the Surveillance,Epidemiology,and End Results(SEER)database to evaluate the safety of waiving surgical axillary staging in patients with T1 breast cancer treated with ***:A total of 166,615 eligible patients diagnosed between 2000 and 2012 were divided into staging(sentinel lymph node biopsy or axillary lymph node dissection)and non-staging(no lymph node examined or only needle aspiration biopsy of lymph nodes)*** score matching(PSM)was performed to balance disparities between the two *** analysis with the Cox proportional hazards model was used to assess factors related to breast cancer-specific survival(BCSS).Results:Although the tumor size at time of presentation was decreasing over years,the rate of surgical axillary stag-ing increased from 93.3%to 96.9%.The 5-year BCSS rates of the whole cohort(before PSM)and matched cohort(after PSM)were 98.0%and 97.5%.Within the matched cohort,the BCSS was significantly longer in the staging group than in the non-staging group(P0.05).Race,marital status,hormone receptors,and chemotherapy were not associated with the favorable impact of surgical axillary staging on BCSS(P>0.05).Conclusion:Although surgical axillary staging remains important for T1 breast cancer patients treated with BCT,it might be unnecessary for patients with old age,small tumor,grade I disease,or favorable histological types.

关键词： Surgical axillary staging T1 breast cancer Breast-conserving therapy Surveillance Epidemiology and End Results

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui cailu song Jinhui Zhang Hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第6期32卷 1129-1139页

作者： JUNZHE YI BINBIN LI XIAOMIN YIN LINGRUI LIU cailu song YING ZHAO MANBO CAI HAILIN TANG DONG CHEN NING LYU State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Medical Oncology The Third People’s Hospital of YongzhouYongzhou425000China Department of Radiotherapy The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421001China Center of Hepato-Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain *** sought to unveil the expression profile and biological role of circMYBL2 in *** microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of *** experiments were conducted to evaluate the biological function of circMYBL2 in HCC ***,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and ***2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell *** expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting ***,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging *** findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.

关键词： Circular RNAs circMYBL2 miR-1205 E2F1 Hepatocellular carcinoma

保乳治疗的T1期乳腺癌患者是否可以免除外科腋窝分期?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2019年第11期38卷 499-511页

作者： Jin Wang Hailin Tang Xing Li cailu song Zhenchong Xiong Xi Wang Xiaoming Xie Jun Tang 乳腺科华南肿瘤学国家重点实验室肿瘤医学协同创新中心中山大学肿瘤防治中心广东广州510060

背景与目的在后"Z0011"时代,外科腋窝分期在保乳治疗(breast-conserving therapy,BCT)的早期乳腺癌患者中的重要性逐渐受到质疑。我们使用监测、流行病学和最终结果(Sur veillance,Epidemiology,andEndResults,SEER)数据库进行了一项回... 详细信息

背景与目的在后"Z0011"时代,外科腋窝分期在保乳治疗(breast-conserving therapy,BCT)的早期乳腺癌患者中的重要性逐渐受到质疑。我们使用监测、流行病学和最终结果(Sur veillance,Epidemiology,andEndResults,SEER)数据库进行了一项回顾性队列研究,评估保乳治疗的T1期乳腺癌患者免除外科腋窝分期的安全性。方法166,615例T1期乳腺癌患者于2000–2012年期间实施了保乳治疗(保乳手术+放疗),根据外科腋窝分期情况被分为两组:分期组(前哨淋巴结活检术或腋窝淋巴结清扫术)和未分期组(无淋巴结手术或仅行淋巴结针吸活检)。倾向评分匹配(propensity score matching,PSM)用于减少组间偏差和混杂变量的影响。多因素Cox比例风险模型用于分析乳腺癌特异性生存(breast cancer-specific survival,BCSS)的预后因素。结果虽然肿瘤大小随时间推移呈缩小趋势,但外科腋窝分期的比例从93.3%增加到96.9%。所有患者(PSM之前)和配对患者(PSM之后)的5年BCSS率分别为98.0%和97.5%。配对后分期组患者的BCSS明显优于未分期组(P0.05)。种族、婚姻状况、激素受体、化疗与外科腋窝分期对BCSS的有利影响无关(P>0.05)。结论虽然外科腋窝分期对于T1期保乳治疗的患者仍然至关重要,然而对于老年、小肿瘤、Grade I级或预后良好组织型的患者,外科腋窝分期可能不是必要操作。

关键词：外科腋窝分期 T1乳腺癌保乳治疗监测、流行病学和最终结果

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song Jiang Congwen Zhu Ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Constraints on holographic QCD phase transitions from PTA observations

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

circ0000799经miR-1287-5p/GPX4轴调控铁死亡促进三阴乳腺癌脑转移

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中南医学科学杂志 2024年第1期52卷 6-11页

作者：刘庆宋彩露刘凌蕊许嫒淇莫运仙中山大学肿瘤防治中心广东广州510060

目的探索circ0000799经miR-1287-5p/GPX4轴对铁死亡促进三阴乳腺癌脑转移的影响机制。方法检测circ0000799在乳腺癌细胞系及乳腺癌组织中的表达。沉默亲代三阴乳腺癌细胞MDA-MB-231和子代脑转移细胞MDA-MB-231-BM中circ0000799的表达。... 详细信息

目的探索circ0000799经miR-1287-5p/GPX4轴对铁死亡促进三阴乳腺癌脑转移的影响机制。方法检测circ0000799在乳腺癌细胞系及乳腺癌组织中的表达。沉默亲代三阴乳腺癌细胞MDA-MB-231和子代脑转移细胞MDA-MB-231-BM中circ0000799的表达。比较各组细胞生长、侵袭能力、脑转移结节数目。使用双荧光素酶报告基因实验验证circ0000799、miR-1287-5p、GPX4调控关系。检测circ0000799对铁死亡相关蛋白谷胱甘肽过氧化酶4(GPX4)表达和总谷胱甘肽/氧化型谷胱甘肽比的影响。结果与人正常乳腺上皮细胞(MCF-10A)或癌旁组织比较,circ0000799在三阴乳腺癌细胞系及乳腺癌组织中上调,且在子代三阴乳腺癌细胞系及脑转移灶中上调最为显著(P<0.05)。与sh-circCTR组比较,sh-circ0000799组细胞生长、侵袭能力降低(P<0.05)。sh-circCTR组、sh-circ0000799组、sh-circ0000799+RSL3组脑转移结节数量依次降低(P<0.05)。双荧光素酶报告基因实验显示,circ0000799可与miR-1287-5p相互作用,miR-1287-5p可与GPX4相互作用。与sh-circCTR组比较,sh-circ0000799组miR-1287-5表达增加,总谷胱甘肽/氧化型谷胱甘肽比和GPX4表达降低(P<0.05)。与miR-CTR组比较,miR-1287-5p组GPX4 mRNA表达降低(P<0.05)。结论circ0000799在三阴乳腺癌中高表达且可能通过miR-1287-5p/GPX4轴促进三阴乳腺癌脑转移。

关键词：三阴乳腺癌脑转移 circ0000799 铁死亡 miR-1287-5p/GPX4

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

circSLCO1B3在三阴乳腺癌脑转移中的作用及其调控机制

在线全文

学校读者我要写书评

暂无评论

老年医学研究 2023年第5期4卷 31-37页

作者：张颖宋彩露刘凌蕊唐海林赖洁兰中山大学肿瘤防治中心广东广州510060

目的探讨circSLCO1B3在三阴乳腺癌(TNBC)脑转移中的作用及其可能的调控机制。方法采用qRT-PCR实验检测circSLCO1B3在乳腺癌细胞系中的表达。采用过表达质粒上调TNBC子代脑转移细胞231Br中circSLCO1B3的表达,设为circSLCOB3-OE组(转染对... 详细信息

目的探讨circSLCO1B3在三阴乳腺癌(TNBC)脑转移中的作用及其可能的调控机制。方法采用qRT-PCR实验检测circSLCO1B3在乳腺癌细胞系中的表达。采用过表达质粒上调TNBC子代脑转移细胞231Br中circSLCO1B3的表达,设为circSLCOB3-OE组(转染对照质粒的为circCTR-OE组),采用Transwell侵袭实验检测circSLCO1B3对231Br细胞侵袭能力的影响。经小鼠左心室注射231Br细胞,构建体内脑转移模型,检测circSLCO1B3对TNBC脑转移能力的影响。通过CircInteractome及TargetScan在线软件分别预测与circSLCO1B3结合的miRNA及miRNA下游靶基因,并使用双荧光素酶报告基因和qRT-PCR、Western blotting实验验证其调控关系。结果相对正常乳腺上皮细胞,circSLCO1B3在TNBC细胞系中均显著下调,且在TNBC子代脑转移细胞231Br中下调最为显著(P<0.05)。与circCTR-OE组比较,circSLCOB3-OE组231Br细胞的侵袭能力、脑转移结节数目均显著降低(P均<0.05)。与细胞核比较,circSLCO1B3在细胞质中的相对含量高(P<0.05)。与野生型circSLCO1B3+miR-NC共转染组相比,野生型circSLCO1B3+miR-155组的相对荧光酶活性显著降低(P<0.05);与circCTR-OE组相比,circSLCO1B3-OE组miR-155的相对表达量显著降低(P<0.05)。与野生型PTEN+miR-NC共转染组相比,野生型PTEN+miR-155组的相对荧光酶活性显著降低(P<0.05)。与转染miR-NC相比,转染miR-155细胞PTEN mRNA的相对表达量显著降低(P<0.05)。与circCTR-OE组比较,circSLCOB3-OE组PTEN mRNA的相对表达量及PTEN蛋白表达显著增加,而与circSLCOB3-OE组比较,circSLCOB3-OE+miR-155组PTEN的表达则显著降低(P均<0.05)。结论circSLCO1B3通过吸附miR-155,上调PTEN蛋白的表达,进而抑制TNBC脑转移。

关键词：三阴乳腺癌脑转移 circSLCO1B3 miR-155 PTEN