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预应力锚杆柔性支护法力学行为影响的数值模拟研究

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岩土工程学报 2014年第S2期36卷 146-153页

作者：涂兵雄贾金青俞缙蔡燕燕刘士雨华侨大学岩土工程研究所福建厦门361021 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024 重庆交通大学水利水运工程教育部重点实验室重庆400074

在岩质深基坑及超深基坑中,预应力锚杆柔性支护法具有造价低,工期短,施工简便,安全性高等诸多优点,经济效益和社会效益十分显著。结合大连胜利广场深基坑工程,采用FLAC软件进行数值模拟分析,重点研究了不同锚杆预应力对基坑力学行为的... 详细信息

在岩质深基坑及超深基坑中,预应力锚杆柔性支护法具有造价低,工期短,施工简便,安全性高等诸多优点,经济效益和社会效益十分显著。结合大连胜利广场深基坑工程,采用FLAC软件进行数值模拟分析,重点研究了不同锚杆预应力对基坑力学行为的影响。结果表明:锚杆的预应力较小时,预应力越大,基坑侧壁的水平变形和地表的竖向沉降越小;预应力较大时,预应力的继续增加已不能进一步降低水平变形和减小竖向沉降;锚杆的预应力能有效减小岩土体内的最大剪切应变增量,在一定程度上延缓基坑剪切滑移破坏的发生;锚杆预应力存在一个合理的界限值。本文关于应力锚杆柔性支护法的设计方案及数值模拟研究结果对该技术的推广和应用提供了很好的借鉴作用。

关键词：预应力锚杆深基坑数值模拟力学行为

Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 339-347页

作者： Jue Wang Jing Jia yan Sun Chong-Bing Ma Yu-Zhu Chen An-Guo Liu Xing-Ke yan College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730101Gansu ProvinceChina Department of Ophthalmology Lanzhou Purui Ophthalmology HospitalLanzhou 730050Gansu ProvinceChina

AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)technology based on clinical ***:Eighty children with anisometropic monocular amblyopia were randomly divided into two groups:control(40 cases,1 case of shedding)and acupuncture(40 cases,1 case of shedding)*** control group was treated with glasses,red flash,grating,and visual stimulations,with each procedure conducted for 5min per *** on routine treatment,the acupuncture group underwent acupuncture of“regulating qi and unblocking meridians to bright eyes”,Jingming(BL1),Cuanzhu(BL2),Guangming(GB37),Fengchi(GB20)acupoints were taken on both sides,with the needle kept for 30min each *** groups were treated once every other day,three times per week,for a total of *** the treatment,the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were *** the same time,nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rsfMRI before and after *** differences in the brain regions between the two groups were compared and analyzed with ***:Chi-square test showed a notable difference in the total efficiency rate between the acupuncture(94.87%)and control groups(79.49%).Regarding the P100 wave latency and amplitude,the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control ***,the VMHC values of the bilateral temporal lobe,superior temporal gyrus,and middle temporal gyrus were notably increased in the acupuncture group after ***:Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic ***

关键词： resting functional magnetic resonance imaging voxel-mirror homotopy connection anisometropic amblyopia acupuncture

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一种新型电子变压器的研制

厦门大学学报（自然科学版） 2005年第B6期44卷 302-306页

作者：王晗闫彩艳游龙翔厦门大学机电工程系福建厦门361005

根据常用电子变压器的电磁兼容性和安全方面的新要求,对其基本线路进行改进设计和分析.在输入端加入了滤波网络和输入保护电路,并加入了实用的输出保护电路,既实现了220V输入、12V/60W输出的功能,又大大提高了电子变压器的性能,达到了IE... 详细信息

根据常用电子变压器的电磁兼容性和安全方面的新要求,对其基本线路进行改进设计和分析.在输入端加入了滤波网络和输入保护电路,并加入了实用的输出保护电路,既实现了220V输入、12V/60W输出的功能,又大大提高了电子变压器的性能,达到了IEC制定的技术标准.通过理论和实验分析,证明了该设计的优点,给出了元件参考参数.本电路设计具有实用性,适用于工业化生产.

关键词：电子变压器研制输入保护电路电磁兼容性工业化生产滤波网络改进设计实验分析技术标准电路设计输入端 IEC 实用性输出

Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

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Traditional Medicine Research 2024年第6期9卷 42-54页

作者： Jing-yan yang Xiao-Xing Li Juan Chen yan-Jun Liu Yue-Hong Wu Ning-Yu Luo cai-Xia yang yang Li Si-Jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as *** HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was ***,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

Most Tibetan weedy barleys originated via recombination between Btr1 and Btr2 in domesticated barley

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Plant Communications 2024年第5期5卷 163-175页

作者： Guangqi Gao Luxi yan Yu cai Yu Guo Congcong Jiang Qiang He Sarah Tasnim Zongyun Feng Jun Liu Jing Zhang Takao Komatsuda Martin Mascher Ping yang State Key Laboratory of Crop Gene Resources and Breeding/Key Laboratory of Grain Crop Genetic Resources Evaluation and Utilization(MARA)/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China College of Agronomy Sichuan Agricultural UniversityChengdu 611130China Leibniz Institute of Plant Genetics and Crop Plant Research 06466 SeelandGermany Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100China

Tibetan weedy barleys reside at the edges of qingke(hulless barley)fields in Tibet(Xizang).The spikes of these weedy barleys contain or lack a brittle rachis,with either two-or six-rowed spikes and either hulled or hulless grains at *** the brittle rachis trait of Tibetan weedy barleys is similar to that of wild barley(Hordeum vulgare *** Thell.),these plants share genetic similarity with domesticated *** origin of Tibetan weedy barleys continues to be ***,we show that most Tibetan weedy barleys originated from cross-pollinated hybridization of domesticated barleys,followed by hybrid self-pollination and recombination between Non-brittle rachis 1(btr1)and 2(btr2).We discovered the specific genetic ancestry of these weedy barleys in South Asian *** weedy barleys exhibit lower genetic diversity than wild and Chinese landraces/cultivars and share a close relationship with qingke,genetically differing from typical eastern and western barley *** classified Tibetan weedy barleys into two groups,brittle rachis(BR)and non-brittle rachis(NBR);these traits align with the haplotypes of the btr1 and btr2 *** wild barleys carry haplotype combinations of Btr1 and Btr2,each showing lower proportions in a population,the recombinant haplotype BTR2H8+BTR1H24 is predominant in the BR *** block analysis based on whole-genome sequencing revealed two recombination breakpoints,which are present in 80.6%and 16.8%of BR acces-sions according to marker-assisted *** events between wild and domesticated barley were rarely *** support the notion that Tibetan weedy barleys originated via recom-bination between Btr1 and Btr2 in domesticated barley.

关键词： Tibetan weedy barley agriocrithon de-domestication out-pollination recombination brittle rachis

Tiliroside protects against diabetic nephropathy in streptozotocininduced diabetes rats by attenuating oxidative stress and inflammation

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World Journal of Diabetes 2024年第11期15卷 2220-2236页

作者： yan Shang cai-Yun yan Hui Li Na Liu Hui-Feng Zhang Department of Nephrology Shanxi Bethune HospitalShanxi Academy of Medical SciencesThird Hospital of Shanxi Medical UniversityTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Diabetic nephropathy(DN),affecting half of diabetic patients and contributing significantly to end-stage kidney disease,poses a substantial medical challenge requiring dialysis or *** nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent *** To investigate Tiliroside's(Til)protective effect against diabetic nephropathy(DN)in rats under diabetic *** Five groups of six rats each were included in this study:Rats treated with DMSO by intraperitoneal injection as controls,those treated with STZ by intraperitoneal injection,those treated with STZ+Til(25 mg/kg body weight[bwt])or Til(50 mg/kg bwt),and those treated with anti-diabetic medication glibenclamide(600μg/kg bwt).Biochemical markers,fasting blood glucose,food intake,kidney weight,antioxidant enzymes,inflammatory and fibrotic markers,and renal injury were monitored in different *** docking analysis was performed to identify the interactions between Til and its targeted *** Til significantly reduced biochemical markers,fasting blood glucose,food intake,and kidney weight and elevated antioxidant enzymes in diabetic *** also mitigated inflammatory and fibrotic markers,lessened renal injury,and displayed inhibitory potential against crucial markers associated with DN as demonstrated by molecular docking *** These findings suggest Til's potential as a therapeutic agent for DN treatment,highlighting its promise for future drug development.

关键词： Tiliroside Diabetic nephropathy Antioxidant Diabetes mellitus Oxidative stress Inflammation

Ambient electrosynthesis of urea from carbon dioxide and nitrate over Mo_(2)C nanosheet

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Chinese Chemical Letters 2024年第8期35卷 319-323页

作者： Yue Zhang Xiaoya Fan Xun He Tingyu yan Yongchao Yao Dongdong Zheng Jingxiang Zhao Qinghai cai Qian Liu Luming Li Wei Chu Shengjun Sun Xuping Sun College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJi’nan 250014China

Electrocatalytic synthesis of urea through C-N bond formation,converting carbon dioxide(CO_(2))and ni-trate(NO_(3)^(-)),presents a promising,less energy-intensive alternative to industrial urea production *** this communication,we report the application of Mo_(2)C nanosheets-decorated carbon sheets(Mo_(2)C/C)as a highly efficient electrocatalyst for facilitating C-N coupling in ambient urea *** CO_(2)-saturated 0.2 mol/L Na_(2)SO_(4)solution containing 0.05 mol/L NO_(3)^(-),the Mo_(2)C/C catalyst achieves an impres-sive urea yield of 579.13μg h^(-1)mg^(-1)with high Faradaic efficiency of 44.80%at-0.5 V versus the reversible hydrogen *** theoretical calculations reveal that the multiple Mo active sites enhance the formation of^(∗)CO and^(∗)NH_(2)intermediates and facilitate their C-N *** research propels the use of Mo_(2)C-based electrodes in electrocatalysis and accentuates the capabilities of binary metal-based catalysts in C-N coupling reactions.

关键词： Mo_(2)C Multiple active sites C-N coupling Electrocatalysis Urea synthesis Density functional theory calculation

Application of Time-Tracking Platform in the Reperfusion Treatment of Patients with Acute Ischemic Stroke in Primary Hospitals

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Journal of Biosciences and Medicines 2024年第7期12卷 230-238页

作者： Yaojie cai yan Chen Feng Fu Yuping He Department of Neurology Zhuji Peoples Hospital of Zhejiang Province Shaoxing China

Objective To explore the application effect of time tracking platform in improving the reperfusion treatment of patients with acute ischemic stroke in primary hospitals. Methods and Results Patients with acute ischemic stroke who carried out emergency intravenous thrombolysis and arterial thrombectomy in our hospital in 2021, 2022 and 2023 were selected. The time tracking mode was implemented, and the patients were recorded at each time node of the hospital and the whole-process digital management was conducted. Compared the mean DNT (Door to Needle Time) of intravenous thrombolysis in emergency stroke patients in 2021, 2022 and 2023, the total number of hospital cases within 4.5 h of onset, the total number of thrombolysis cases within 4.5 h of onset, the number of intravenous thrombolysis in 60 minutes of acute ischemic stroke, and the number of thrombolysis cases. The results show that from 2021 to 2023 our emergency stroke patients with intravenous thrombolysis average DNT shortened year by year, to the hospital within 4.5 h after the onset of the difference is statistically significant (all P < 0.05) conclusion through the application of stroke time tracking platform, is beneficial to shorten the treatment time of each link, can effectively reduce the hospital time delay, improve the rate of thrombolysis, improve the reperfusion of stroke centers in primary hospitals.

关键词： Time-Tracking Platform Acute Ischemic Stroke Thrombolysis Thrombectomy

Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer

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World Journal of Gastroenterology 2024年第24期30卷 3076-3085页

作者： Ling-Xiao Jin Yu-Peng Fang Chen-Mei Xia Teng-Wei cai Qian-Qian Li Yu-Yin Wang Hai-Fan yan Xia Chen Department of Gastroenterology Wenling Hospital of Wenzhou Medical University(The First People’s Hospital of Wenling)Wenling 317500Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is closely associated with gastrointestinal *** preliminary studies have indicated that *** infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer(GU)or duodenal ulcer(DU).AIM To investigate the contributions of *** infection and the mucosal microbiome to the pathogenesis and progression of ulcerative *** Patients with *** infection and either GU or DU,and healthy individuals without *** infection were *** or duodenal mucosal samples was obtained and subjected to metagenomic *** compositions of the microbial communities and their metabolic functions in the mucosal tissues were *** Compared with that in the healthy individuals,the gastric mucosal microbiota in the ***-positive patients with GU was dominated by ***,with signi-ficantly reduced *** intergroup differential functions,which were enriched in the ***-positive GU patients,were all derived from ***,particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones.A significant enrichment of the uibE gene was detected in the synthesis *** was no significant difference in microbial diversity between the ***-positive DU patients and healthy *** *** infection significantly alters the gastric microbiota structure,diversity,and biological functions,which may be important contributing factors for GU.

关键词： Helicobacter pylori Gastric ulcer Duodenal ulcer Metagenomic sequencing Transfer RNA queuosine-modification Menaquinones