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Effects of renal denervation on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats

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Chinese Journal of Traumatology 2018年第5期21卷 293-300页

作者： Xiao-Na cai Chao-Yi Wang yuan cai Fang Peng Department of Cardiology Shaoxing People's Hospital Shaoxing 312000 Zhejiang China Department of Cardiology. TianTai People's Hospital. Taizhou. 317200 Zhejiang China Department ofPharrnacy. Wenzhou People's Hospital Wenzhou 325000 Zhejiang China

Purpose： Renal denervation （RD） has been demonstrated to be an effective approach to reduce blood pressure for those with resistant hypertension. Yet, we aimed to explore the effect and possible mech- anism of RD on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats. Methods： A total of 48 male spontaneously hypertensive rats were randomized to three groups： study group, sham-operation group and control group. RD was achieved by cutting off renal nerves and swabbing phenol on it. Ten weeks after RD, 8 rats in each group were sacrificed to collect the kidney and heart tissues. The remaining rats were subjected to an operation to induce hemorrhagic shock which would lead to 40% loss of total blood volume, and observed for 120 min. The serum concentration of norepinephrine was measured before and three weeks after RD. Results： The blood-pressure and norepinephrine levels were reduced significantly after RD （p 〈 0.05）, Systolic blood pressure and diastolic blood pressure of the surgerygroup were higher than those in the sham and control groups at 15, 30 and 45 min after hemorrhagic shock （p 〈 0.05）, while no significant difference was observed at 60, 90 and 120 min （p 〉 0.05）. Additionally, the beta-1 adrenergic receptor （β1 -AR） in the study group was significantly higher than those in the other two groups （p 〈 0.05） after hemorrhagic shock. Conclusion： This study demonstrated that RD could to some extent improve blood-pressure response to hemorrhagic shock in an established model of severe hemorrhagic shock in spontaneously hypertensive rats. The mechanism might be associated with uo-regulation of β1-AR.

关键词： Renal denervation Hemorrhage Beta-1 adrenergic receptor Spontaneously hypertensive rats

营养干预措施对温州市初中学校食堂午餐供应及剩菜剩饭率的影响

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现代预防医学 2024年第4期51卷 625-629+704页

作者：蔡圆圆刘倩倩温丹丹夏子淇高四海陈民和温州市疾病预防控制中心营养与食品卫生所

目的评价营养干预措施对温州市学生午餐各类食物、能量和营养素供应量及剩菜剩饭率的干预效果。方法 2021—2022年在温州市13个县(市、区)各随机抽取一所初中，在干预前后分别对学校进行连续一周采用称重法和记账法对食堂各类食物的供... 详细信息

目的评价营养干预措施对温州市学生午餐各类食物、能量和营养素供应量及剩菜剩饭率的干预效果。方法 2021—2022年在温州市13个县(市、区)各随机抽取一所初中，在干预前后分别对学校进行连续一周采用称重法和记账法对食堂各类食物的供应量和每日就餐人数进行调查，对剩菜、剩饭进行分类称重。干预措施包括营养供餐支持、营养健康教育。结果参照《学生餐营养指南》、《中国居民膳食营养素参考摄入量(2013版)》进行评价。结果干预后，温州市初中学校食堂食物供应方面达到推荐量80.00%的食物有谷薯类、鱼虾类，低于推荐量80.00%的食物有蔬菜类、水果类、蛋类、奶类，高于推荐量120.00%的食物有禽畜肉类、植物油、盐，其中水果类、鱼虾类的供应量得到明显改善(t=2.342,P=0.029;t=-1.914,P=0.070)。营养素供应方面达到推荐量60.00%的营养素有能量、钙、维生素B1、维生素B2的供应量及碳水化合物供能比，低于推荐量60.00%的营养素有维生素A、膳食纤维，蛋白质、锌、铁、维生素C的供应量及脂肪供能比均高于推荐量，其中锌、维生素A、维生素C供应量及脂肪供能比得到明显改善(t=2.280,P=0.0340;t=-3.261,P=0.004;U=-2.638,P=0.008;t=-2.173,P=0.041)。主食、素菜剩菜剩饭率下降明显(χ2=4.828,P=0.028;χ2=15.813,P<0.001)。结论以学校为基础采取营养供餐支持、开展营养健康教育干预办法，能在一定程度上改善学校食堂午餐食物、能量和营养素供应状况，降低学生剩饭、剩菜率。

关键词：营养干预学校午餐食物供应

Effect of kaolin on tensile strength and humidity resistance of a water-soluble potassium carbonate sand core

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China Foundry 2016年第1期13卷 15-21页

作者： Long Zhang Li-na Zhang yuan-cai Li School of Metallurgical Engineering Anhui University of Technology School of Material Science and Engineering Huazhong University of Science and Technology

Water soluble cores(WSCs) have been widely applied in manufacture of complex metal components with hollow configurations or internal channels. However, the WSCs without any additons have low tensile strength and low humidity resistance. The purpose of this study is to prepare a water-soluble potassium carbonate sand core with addition of kaolin by the hot-temping method. The effects of kaolin on tensile strength, humidity resistance, fracture mechanism, as well as the gas evolution and collapsibility of WSCs were investigated. Results show that both the crystal morphology and the fracture mechanism of the inorganic salt are changed under the participation of kaolin, contributing to the increase of the tensile strength and the humidity resistance of the core. With the addition of 3wt.% kaolin, the tensile strength could be increased by a factor of 2, reached 1.50 MPa and the hygroscopic rate could be decreased by 14%, achieved 0.559%(after stored for 8 h), respectively. As the addition amount of kaolin increases from 0wt.% to 3wt.%, the main fracture mechanism changes from a adhesive to a cohesive fracture mechanism. The water-soluble potassium carbonate core obtained has the low gas evolution and excellent collapsibility, which makes it suitable for casting low melting metal with complex cavities and crooked channels.

关键词： water-soluble core kaolin tensile strength humidity resistance strengthening mechanism

基于STFT与改进ConvNeXt配电网故障区段定位方法研究

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电工电气 2024年第7期 16-26,52页

作者：邓思敬吴浩邓力川蔡源四川轻化工大学自动化与信息工程学院四川宜宾644000 人工智能四川省重点实验室四川宜宾644000

在目前的配电线路智能故障诊断研究方法中,存在着难以充分提取故障特征、抗噪声干扰能力弱、抗高阻能力差等问题。提出了一种基于短时傅里叶变换(STFT)并引入迁移学习的改进ConvNeXt配电网故障区段定位方法。该方法通过采集配电网各馈... 详细信息

在目前的配电线路智能故障诊断研究方法中,存在着难以充分提取故障特征、抗噪声干扰能力弱、抗高阻能力差等问题。提出了一种基于短时傅里叶变换(STFT)并引入迁移学习的改进ConvNeXt配电网故障区段定位方法。该方法通过采集配电网各馈线两端的零序电流,计算出各馈线两端的零序电流幅值差,然后将各段的零序电流幅值差拼接成一个组合信号,用STFT处理组合信号,得到时频图,并将得到的时频图分为训练集和测试集。仿真结果表明,基于STFT并改进的ConvNeXt配电网故障区段定位方法在不同的故障距离、不同的接地电阻和不同的初始故障角度下都能有效地实现故障区段的选择,并且该方法具有较强的抗高阻能力以及较强的抗噪声干扰能力,在部分数据丢失的情况下仍能准确进行区段定位。

关键词：配电网暂态零序电流区段定位短时傅里叶变换 ConvNeXt模型

Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia： systematic review of randomized controlled trials

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Asian Journal of Andrology 2013年第4期15卷 471-482,I0007页

作者： Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-yuan cai Vivian Taam Wong Kun-yuan cai Eric Zie Zhang-Jin Zhang The University of Hong Kong School of Chinese Medicine Hong Kong 852 China The University of Hong Kong Tung Wah Hospital Hong Kong China and 3Hospital Authority Chinese Medicine Section Hong Kong China

Chinese herbal medicine is commonly used as a treatment for benign prostatic hyperplasia （BPH）, but its efficacy and safety remain to be examined. To compare the efficacy and adverse events of Chinese herbal medicine alone or used adjuvantly with Western medications for BPH. Two independent reviewers searched the major electronic databases for randomized controlled trials comparing Chinese herbal medicine, either in single or adjuvant use with Western medication, with placebo or Western medication. Relevant journals and grey literature were also hand-searched. The outcome measures included changes in urological symptoms, urodynamic measures, prostate volume and adverse events. The frequency of commonly used herbs was also identified. Out of 13 922 identified citations of publications, 31 studies were included. Eleven studies with a Jadad score i〉 3 were selected for meta-analysis. Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume. The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication. The evidence is too weak to support the efficacy of Chinese herbal medicine for BPH due to the poor methodological quality and small number of trials included. The commonly used herbs identified here should provide insights for future clinical practice and research. Larger randomized controlled trials of better quality are needed to truly evaluate the efficacy of Chinese herbal medicine.

关键词： benign prostatic hyperplasia (BPH) meta-analysis review traditional Chinese medicine

ZL205A合金侧盖壳体铸造工艺研究与产品试制

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铸造 2024年第6期73卷 865-871页

作者：马文龙杨力杨小冬徐远财罗辉樊自田唐锦球江麓机电集团有限公司湖南湘潭411100 华中科技大学材料成形与模具技术全国重点实验室湖北武汉430000

模拟分析了重力铸造与低压铸造方法下ZL205A合金侧盖壳体铸件的充型、凝固过程及缺陷特征,进行了侧盖壳体铸件试制及性能对比。采用重力铸造时,模拟显示铸件充型速度快,紊流、混流现象严重,凝固速率慢且过程混乱,孔隙率高;样件表面及内... 详细信息

模拟分析了重力铸造与低压铸造方法下ZL205A合金侧盖壳体铸件的充型、凝固过程及缺陷特征,进行了侧盖壳体铸件试制及性能对比。采用重力铸造时,模拟显示铸件充型速度快,紊流、混流现象严重,凝固速率慢且过程混乱,孔隙率高;样件表面及内部缩松、偏析等缺陷严重,基体组织及晶界中微观缩松与成分偏析交织显现。取样部位平均抗拉强度与伸长率为A区:400 MPa,3.1%,B区:444 MPa,3.4%,铸件为不合格品。采用低压铸造时,模拟显示铸件充型平稳,凝固速率快且自上而下顺序凝固,孔隙率低,样件探伤合格,组织均匀致密且微观缩松和偏析占比显著降低。取样部位平均抗拉强度与伸长率为A区:478 MPa,4.7%,B区:484 MPa,4.9%,铸件合格且性能优异。验证了低压铸造工艺对ZL205A合金侧盖壳体铸件的适应性与优势。

关键词： ZL205A 铸造侧盖壳体组织结构力学性能

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Suppression of the Drift Field in the p-Type Quasineutral Region of a Semiconductor p-n Junction

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Chinese Physics Letters 2012年第9期29卷 151-154页

作者： cai Xue-yuan YANG Jian-Hong WEI Ying Institute of Microelectronics School of Physical Science and TechnologyLanzhou UniversityLanzhou 730000

An improved analytical model of the drift field suppressed by the Dember field due to ambipolar diffusion in the p-type quasineutral region(p-QNR)of a forward silicon p–n junction at low injection levels is presented with a good fit to the numerical simulation *** ambipolar transport of both carriers,the diode current in the p-QNR is found to consist of a minority-electron diffusion-current component and majority-hole drift-and diffusion-current components,and the Dember field plays a dominant role in balancing all the components mentioned above to keep the current *** analytical model is beneficial to completely understand ambipolar current transport mechanisms in semiconductor p–n junction devices.

关键词： neutral diffusion transport

指纹图谱结合化学模式识别及网络药理学的石菖蒲质量标志物预测分析

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中国新药杂志 2024年第11期33卷 1174-1184页

作者：李鹏辉孙瑜冯小龙陶新如龚年春蔡媛彭艳梅湖南省中医药研究院长沙410006

目的:指纹图谱结合化学模式识别技术及网络药理学,分析预测不同产地野生石菖蒲(Acorus tatarinowii Schott)中潜在的差异质量标志物(quality marker,Q-marker)。方法:采用HPLC法建立石菖蒲药材指纹图谱,确认共有峰并进行指认,通过主成... 详细信息

目的:指纹图谱结合化学模式识别技术及网络药理学,分析预测不同产地野生石菖蒲(Acorus tatarinowii Schott)中潜在的差异质量标志物(quality marker,Q-marker)。方法:采用HPLC法建立石菖蒲药材指纹图谱,确认共有峰并进行指认,通过主成分分析(principal component analysis,PCA)及正交偏最小二乘-判别分析(orthogonal partial least square-discriminant analysis,OPLS-DA),筛选引起产地差异的主要特征化学成分;再运用网络药理学构建“活性成分-靶点-通路网络”图,预测Q-marker。结果:建立了4个产地18批石菖蒲药材指纹图谱,共有峰的选择显示不同产地石菖蒲药材的内在质量存在明显差异,PCA和OPLS-DA显示同一产地石菖蒲药材各自聚为一类,指认的3号峰(β-细辛醚)是引起产地差异的主要特征化学成分。网络药理学筛选出6个潜在Q-marker,结合Q-marker五要素原则,进一步明确β-细辛醚可作为石菖蒲的潜在Q-marker。结论:预测了β-细辛醚可作为不同产地石菖蒲药材的差异Q-marker,为石菖蒲质控指标的选择提供思路和参考依据。

关键词：石菖蒲指纹图谱化学模式识别网络药理学差异质量标志物 β-细辛醚

A Cooperative Approach for the Extraction of Protein Motifs

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Chinese Chemical Letters 2006年第5期17卷 707-710页

作者： Chao CHEN yuan Xin TIAN Xiao Yong ZOU Pei Xiang cai Jin yuan MO School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275

By integrating the concept of cooperative approach, an extension of the fast annealing coevolutionary algorithm is presented in this paper. It outperformed the original algorithm in the domain of function optimization, especially in terms of convergence rate. It was also applied to a real optimization problem, protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database.

关键词： Cooperative approach global optimization protein motifs extraction.