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Neural Regeneration research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang gao Fundamental research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

REAL-TIME MOTION PLANNING METHOD BASED ON NEURAL NETWORKS FOR MULTIPLE MOBILE robotS

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Chinese Journal of Mechanical Engineering 2001年第1期14卷 1-4页

作者： Zhan Qiang Zhang Qixian robot research institute,Beijing University of Aeronautics and Astronautics Wang Shuguo Harbin institute of Technology 北京航空航天大学机器人研究所北京哈尔滨工业大学黑龙江哈尔滨

The motion planning of multiple mobile robots undertaking individual tasks in the same environment is studied A motion planning method based on neural networks is proposed By storing fuzzy rules in neural networks the method can fully make use of the association ability and high processing speed of neural networks to make robots avoid collisions with other objects in real time Compared with rules method,the method can not only avoid building a large and complex rules base but also make robots avoid collisions and conflicts at higher speed and with higher intelligence

关键词： Multiple mobile robots Motion planning Fuzzy rules Neural networks

LAMELLAR MICROSTRUCTURE IN DUPLEX Ti-Al-V INTERMETALLIC COMPOUND

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Acta Metallurgica Sinica(English Letters) 1992年第4期5卷 282-285页

作者： gao Ying ZHU Jing cai Qigong Central Iron and Steel research institute,Ministry of Metallurgical Industry,Beijing,China Central Iron and Steel research Inst Beijing China

The morphology and crystallographic orientation of(α_2+γ)lamellar structure in duplex Ti-47.5Al-2.5V intermetallic compound have been studied by means of TEM, microdiffraction as well as 180° and non-180° rotation twinning analysis.A possible atomic model of the interface was ***,approach was made to a mechanism on complex nucleation of α_2+γ two phases along α-Ti interface,and growth of α_2/γ/γ_1/α_2 or α_2/γ/α_2/γ as fundamental structural unit.

关键词： TiAl intermetallic compound lamellar structure rotation twinning analysis interface

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Review and Comprehensive Analysis of Composition and Origin of High Acidity Crude Oils

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China Petroleum Processing & Petrochemical Technology 2011年第1期13卷 6-15页

作者： cai Xinheng Tian Songbai (research institute of Petroleum Processing,SINOPEC,Beijing 100083,China) SINOPEC Res Inst Petr Proc Beijing 100083 Peoples R China

High acidity crude oils have an advantage over normal oils in terms of their price,but can cause corrosion and refinery *** are the so-called opportunity crudes and likely to be important reserved resources in the 21st *** on high acidity crude oils are becoming more and more *** on the existing research achievements,this article has given an overview of the chemical composition and acid distribution of high acidity oils,and also analyzed their origin types and potential influence factors.

关键词： high acidity oils total acid number acid composition origin influence factors

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical research Center for Geriatric Diseases BeijingChina institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Design and Dynamic Model of a Frog-inspired Swimming robot Powered by Pneumatic Muscles

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1123-1132页

作者： Ji-Zhuang Fan Wei Zhang Peng-Cheng Kong he-gao cai Gang-Feng Liu State Key Laboratory of robotics and System Harbin Institute of Technology

Pneumatic muscles with similar characteristics to biological muscles have been widely used in robots, and thus are promising drivers for frog inspired robots. How- ever, the application and nonlinearity of the pneumatic system limit the advance. On the basis of the swimming mechanism of the frog, a frog-inspired robot based on pneumatic muscles is developed. To realize the indepen- dent tasks by the robot, a pneumatic system with internal chambers, micro air pump, and valves is implemented. The micro pump is used to maintain the pressure difference between the source and exhaust chambers. The pneumatic muscles are controlled by high-speed switch valves which can reduce the robot cost, volume, and mass. A dynamic model of the pneumatic system is established for the sim- ulation to estimate the system, including the chamber, muscle, and pneumatic circuit models. The robot design is verified by the robot swimming experiments and the dynamic model is verified through the experiments and simulations of the pneumatic system. The simulation results are compared to analyze the functions of the source pressure, internal volume of the muscle, and circuit flow rate which is proved the main factor that limits the response of muscle pressure. The proposed research provides the application of the pneumatic muscles in the frog inspired robot and the pneumatic model to study muscle controller.

关键词： Frog-inspired robot Pneumatic muscle High-speed switch valve Pneumatic model

Gravitational correlation, black hole entropy,and information conservation

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Science China(Physics,Mechanics & Astronomy) 2017年第4期60卷 1-9页

作者： DongShan he QingYu cai College of Physics & Electronic Engineering Xianyang Normal University State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of Sciences

When two objects have gravitational interaction between them, they are no longer independent of each other. In fact, there exists gravitational correlation between these two objects. Inspired by Verlinde's paper, we first calculate the entropy change of a system when gravity does positive work on this system. Based on the concept of gravitational correlation entropy, we prove that the entropy of a Schwarzschild black hole originates from the gravitational correlations between the interior matters of the black hole. By analyzing the gravitational correlation entropies in the process of Hawking radiation in a general context, we prove that the reduced entropy of a black hole is exactly carried away by the radiation and the gravitational correlations between these radiating particles, and the entropy or information is conserved at all times during Hawking radiation. Finally, we attempt to give a unified description of the non-extensive black-hole entropy and the extensive entropy of ordinary matter.

关键词： black hole information gravitational correlation entropy

Leader-following adaptive consensus of multiple uncertain rigid spacecraft systems

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Science China(Information Sciences) 2016年第1期59卷 6-18页

作者： he cai Jie HUANG Shenzhen research institute The Chinese University of Hong Kong Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatin N.T.

The existing results on the leader-following attitude consensus for multiple rigid spacecraft systems assume that all the parameters of the spacecraft systems are known exactly and the information flow among the followers is bidirectional. In this paper, we remove these two assumptions. First, by introducing a new Lyapunov function, we allow the communication network to be directed. Second, we convert the leader-following consensus problem into an adaptive stabilization problem of a well defined error system. Then, under the standard assumption that the state of the leader system can reach every follower through a directed path, we further show that this stabilization problem is solvable by a distributed adaptive control law. Moreover, we also present the sufficient condition for guaranteeing the convergence of the estimated parameters to the unknown actual parameters.

关键词： adaptive control attitude consensus multi-agent system nonlinear distributed observer parameter convergence