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焦点企业创业与集群升级实证研究——基于网络视角

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云南财经大学学报 2016年第4期32卷 132-141页

作者：姚刚蔡宁蔡瑾琰黄纯浙江大学公共管理学院杭州310018 浙江大学信息与电子工程学院杭州310058 云南师范大学信息学院昆明650030 浙江财经大学工商管理学院杭州310018

产业集群网络的研究成果为集群的升级研究提供了新的视角。然而在集群网络创业传导推动集群升级过程中,集群内部企业差异性、集群网络关系的多样性、传导路径的复杂性等特点,使得产业集群升级难以定性定量双角度研究。通过对集群升级理... 详细信息

产业集群网络的研究成果为集群的升级研究提供了新的视角。然而在集群网络创业传导推动集群升级过程中,集群内部企业差异性、集群网络关系的多样性、传导路径的复杂性等特点,使得产业集群升级难以定性定量双角度研究。通过对集群升级理论研究和对深圳龙岗鞋业产业集群的实证研究,分析基于焦点企业的集群网络特征与集群创业能力,集群创业能力与集群升级行为的内在机制,在此基础上得出科学的产业集群升级激励保障策略,为推动集群升级,促进区域经济持续发展提供理论依据。

关键词：焦点企业网络特征集群升级结构方程模型

ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis

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Genes & Diseases 2024年第2期11卷 564-567页

作者： Yi Jiang Dongfang Xiang Xianmei Wen Mingmin He yan Qin Xiaoxue Yao Zexuan yan Xiuli Geng Yong Ren Xiongwei cai Youhong Cui yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pathology General Hospital of Central Theater Command of PLAWuhanHubei 430070China Department of Obstetrics and Gynecology Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pharmacy The Hospital of 83rd Group of PLAXinxiangHenan 453000China Department of Gynecology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 400013China

Gastric cancer(GC)is the third most common cause of cancer death globally and a large portion of patients are diagnosed at advanced stages with cancer invasion and metastasis1,***,the mechanisms underlying the invasion and metastasis of GC remain to be *** plays critical roles in cell mobility via cytoskeleton regulation in various cell types.3 In this study,we further reported that ZYX promoted migration,invasion,and metastasis of GC ***,ZYX promoted WNK1 activation and SNAl1 up-regulation,inducing epithelial-mesenchymal transition(EMT)to enhance the mobility of GC *** of WNK1 impaired the mobility of GC ***,ZYX/WNK1 could be potential therapeutic targets for GC treatment.

关键词： WNK1 invasion metastasis

SimHOEPI:A resampling simulator for generating single nucleotide polymorphism data with a high-order epistasis model

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Quantitative Biology 2024年第2期12卷 197-204页

作者： Yahan Li Xinrui cai Junliang Shang Yuanyuan Zhang jin-Xing Liu School of Computer Science Qufu Normal UniversityRizhaoChina School of Information and Control Engineering Qingdao University of TechnologyQingdaoChina School of Health and Life Sciences University of Health and Rehabilitation SciencesQingdaoChina

Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex *** data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data *** this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data *** of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different *** results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.

关键词： high-order epistasis model penetrance table resampling strategy simulation single nucleotide polymorphisms

High-current pulsed electron beam modification on microstructure and performance of Cu/CuW diffusion bonding joints

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Rare Metals 2024年第6期43卷 2819-2831页

作者： Na-Na Tian Cong-Lin Zhang Peng Lyu jin-Tong Guan Jie cai Qing-Feng Guan Shun Guo School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Material Science and Engineering Yancheng Institute of TechnologyYancheng 221051China Engineering Institute of Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

This study investigates the influence of high-current pulsed electron beam(HCPEB)modification on the microstructure and shear strength of Cu/CuW *** solid-state diffusion bonding of modified-Cu(MCu)and modified-CuW(M-CuW)was achieved by HCPEB modification pretreatment at a temperature of 800-900℃and a pressure of 5 MPa for 10-50 *** demonstrate that HCPEB modification facilitates the dissolution of W and Cu,resulting in the formation of a Cu_(0.4)W_(0.6)solid solution and thus enhancing the uniform distribution of ***,HCPEB-induced defects play a beneficial role in promoting the diffusion process by providing fast diffusion paths for *** optimal joints with the maximum shear strength of 213.7 MPa were obtained through bonding M-Cu and M-CuW at 900℃and 5 MPa for 30 min,which attributes to the combined effects of fine-grained strengthening and solid solution ***,the application of HCPEB modification showcases its effectiveness in promoting element diffusion and enhancing the mechanical performance of the joints.

关键词： HCPEB Element diffusion Shear strength Crystal defects Surface modification

Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme

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Nuclear Science and Techniques 2024年第4期35卷 15-28页

作者： Xue-Chao Zhao Rui yan Gui-Feng Zhu Ya-Fen Liu Jian Guo Xiang-Zhou cai yang Zou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A molten salt reactor(MSR)has outstanding features considering the application of thorium fuel,inherent safety,sustainability,and resistance to ***,fissile material^(233)U is significantly rare at the current stage,thus it is difficult for MSR to achieve a pure thorium-uranium fuel ***,using plutonium or enriched uranium as the initial fuel for MSR is more *** this study,we aim to verify the feasibility of a small modular MSR that utilizes plutonium as the starting fuel(SM-MSR-Pu),and highlight its advantages and ***,the structural design and fuel management scheme of the SM-MSR-Pu were ***,the neutronic characteristics,such as the graphite-irradiation lifetime,burn-up performance,and coefficient of temperature reactivity were calculated to analyze the physical characteristics of the *** results indicate that plutonium is a feasible and advantageous starting fuel for a SM-MSR;however,there are certain shortcomings that need to be *** a 250 MWth SM-MSR-Pu,approximately 288.64 kg^(233)U of plutonium with a purity of greater than 90% is produced while 978.00 kg is burned every ten *** temperature reactivity coefficient decreases from -4.0 to -6.5 pcm K^(-1) over the 50-year operating time,which ensures a long-term safe ***,the amount of plutonium and accumulation of minor actinides(MAs)would increase as the burn-up time increases,and the annual production and purity of^(233)U will *** achieve an optimal burn-up performance,setting the entire operation time to 30 years is ***,more than 3600 kg of plutonium eventually accumulate in the *** research is required to effectively utilize this accumulated plutonium.

关键词： Molten salt fuel Plutonium utilization ^(233)U TRUs mole fraction Temperature feedback coefficient

Laser-assisted grinding of RB-SiC composites:Laser ablation behavior and mechanism

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Chinese Journal of Aeronautics 2024年第1期37卷 362-376页

作者： Zhigang DONG Wenchao SUN Xintong cai Feng yanG yan BAO Renke KANG Dongjiang WU Guangyi MA Fangyong NIU Key Laboratory for Precision and Non-traditional Machining Technology of the Ministry of Education School of Mechanical EngineeringDalian University of TechnologyDalian 116024China

Laser ablation is an important process during Laser-Assisted Grinding(LAG)of hard and brittle *** realize controllable material removal during laser ablation of RB-SiC composites,ablation experiments under different Laser Energy Density(LAED)and LAG experiments are *** rules and mechanism of physical phase,ablation morphology and crack characteristics caused by laser irradiation are *** forces of LAG and Conventional Grinding(CG)are *** results show that ablation surface changes from slight oxidation to obvious material removal with LAED increasing,and ablation depth increases *** ablation products change from submicron SiO_(2)particles to nanoscale particles and *** LAED promotes SiC decomposition and sublimation,which leads to the increase of C *** SiC phase forms corrugated shape in recast layer and columnar shape in Heat Affected Zone(HAZ)at 56 J/mm^(2).The cold and heat cycle leads to formation of fishbone *** ablation specimen under 30 J/mm^(2),the grinding force can be reduced by a maximum of 39%and brittle damage region is *** material removal and microcrack generated will significantly reduce the hardness and improve machinability,which can promote grinding efficiency.

关键词： RB-SiC Laser Ceramic Composites Grinding

Complementary multicolor electrochromic devices with excellent stability based on porous tin oxide nanosheet scaffold

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Nano Research 2024年第4期17卷 3035-3042页

作者： Chenchen Bian jinhui Wang Huanhuan Liu Yin yan Ping Zhang Weilong yang Sensen Jia Xiaodan Guo Guofa cai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Materials and Engineeringand Collaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China

Electrochromic devices(ECDs)have been extensively investigated as promising candidates in broad cutting-edge applications,such as smart windows,electronic labels,adaptive camouflage,***,they have suffered from either inadequate color variations or poor cycling stability for a long ***,we developed a general strategy to boost the cyclic stability and enrich the color variations of ECDs by scrupulous design of the composition and nanostructure of electrodes,in which porous tin oxide(SnO_(2))nanosheets serve as the scaffold and typical metal oxides or conducting polymers as the active electrochromic *** electrochromic composite materials,including polyaniline(PANI)@SnO_(2),V2O5@SnO_(2),and WO_(3)@SnO_(2) heterostructured nanoarrays were prepared by the facile wet-chemical *** composite electrodes exhibit remarkable electrochromic performances,e.g.,superior cycling stability(more than 2000 cycles),rich color variations(more than 5 colors for PANI@SnO_(2)),and enlarged optical *** excellent performances account for the heterogenous porous nanoarrays,which not only facilitate the intercalation/extraction of ions but also relieve the stress generated during the electrochemical *** addition,diverse prototypes of complementary multicolor ECD with excellent cycling stability(over thousands of cycles)and rich color variations(8 colors)were realized for the first *** believe that our work put forward a general strategy for developing high-quality multicolor complementary electrochromic devices.

关键词： electrochromism tin oxide metal oxide cycling stability multicolor complementary device

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan jin Yi Chen cai Chang TANG Hou Lin QIN Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

A Real-time Lithological Identification Method based on SMOTE-Tomek and ICSA Optimization

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 518-530页

作者： DENG Song PAN Haoyu LI Chaowei yan Xiaopeng WANG Jiangshuai SHI Lin PEI Chunyu cai Meng College of Petroleum Engineering Changzhou UniversityChangzhouJiangsu 213000China

In petroleum engineering,real-time lithology identification is very important for reservoir evaluation,drilling decisions and petroleum geological exploration.A lithology identification method while drilling based on machine learning and mud logging data is studied in this *** method can effectively utilize downhole parameters collected in real-time during drilling,to identify lithology in real-time and provide a reference for optimization of drilling *** the imbalance of lithology samples,the synthetic minority over-sampling technique(SMOTE)and Tomek link were used to balance the sample number of five ***,this paper introduces Tent map,random opposition-based learning and dynamic perceived probability to the original crow search algorithm(CSA),and establishes an improved crow search algorithm(ICSA).In this paper,ICSA is used to optimize the hyperparameter combination of random forest(RF),extremely random trees(ET),extreme gradient boosting(XGB),and light gradient boosting machine(LGBM)*** addition,this study combines the recognition advantages of the four *** accuracy of lithology identification by the weighted average probability model reaches *** study of this paper realizes high-precision real-time lithology identification method,which can provide lithology reference for the drilling process.

关键词： mud logging data real-time lithological identification improved crow search algorithm petroleum geological exploration SMOTE-Tomek