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Alteration of β-secretase traffic by the receptor tyrosine kinase signaling pathway- a new mechanism for regulating Alzheimer's β-amyloid production

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Cell Research 2007年第5期17卷 385-386页

作者： Yun-Wu Zhang Huaxi Xu, Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, ca 92037, USA. xuh@burnham. org Center for Neuroscience and Aging Burnham Institute for Medical Research La Jolla USA

The receptor tyrosine kinases (RTKs) are a family of cellsurface proteins with diverse functions in proliferation, dif-ferentiation or cell-cell communication. When a specific li-gand binds to its cognate receptor, a conformational changeof this receptor due to the ligand-receptor interaction willlead to activation of the intrinsic tyrosine kinase residing inthe intracellular domain of the receptor. The activation ofthis tyrosine kinase is essential for transducing the signals toa cascade of its downstream molecules that eventually causerelated physiological responses [1]. For example, binding ofnerve growth factor (NGF) to its receptor TrkA is essentialfor the proper development, patterning, and maintenanceof the mammalian nervous system. This ligand and recep-tor interaction will lead to the formation of a crab-shapedhomodimeric TrkA structure [2], and the subsequent activa-tion of its intrinsic RTK will cause auto-phosphorylationof its own intracellular tyrosine residues. PhosphorylatedTrkA receptors recruit and increase the phosphorylationof PLC-γ and Shc, which leads to activation of either thePI3K/Akt pathway or Ras/raf/ERK pathway. In the brainOf Alzheimer's disease (AD) patients, alterations of nervegrowth factor (NGF) and its receptor TrkA have beenreported to associate with AD pathogenesis [3]. However,the underlying mechanisms remain elusive.

关键词： BACE amyloid production NGF Alteration of a new mechanism for regulating Alzheimer’s secretase traffic by the receptor tyrosine kinase signaling pathway TrkA RTK

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Polar Duals of Rotors

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Acta Mathematica Sinica,English Series 1996年第1期12卷 40-42页

作者： Ghandehari M. Department of Mathematics Noval Postgraduate School Monterey, ca 93943 U. S. A.

Assume K is a rotor in a regular simplex of heihgt 1 in an n-dimensional Euclidean space. Let K~* denote the polar dual of K. Then the volume V(K~*) satisfies the inequality V(K~*)≥(n+1)~nω_n, where ω_n denotes the volume of an n-dimensional unit ball. Equality holds if and only if K is a ball centered at the centroid of the simplex.

关键词： Rotor Polar dual Regulor Simplex

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Classification of rational holomorphic maps from B^2 into B^N with degree 2

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Science China Mathematics 2009年第12期52卷 2647-2667页

作者： JI ShanYu 1 & ZHANG Yuan 2 1 Department of Mathematics, University of Houston, Houston, TX 77204, USA 2 Department of Mathematics, University of california at San Diego, La Jolla, ca 92093, USA Department of Mathematics University of Houston Houston USA Department of Mathematics Rutgers University New Brunswick USA

Rational proper holomorphic maps from the unit ball in C 2 into the unit ball C N with degree 2 are classified, up to automorphisms of balls.

关键词： rational holomorphic maps between balls classification maps with degree 2

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On characterizations of isometries on function spaces

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Science China Mathematics 2008年第4期51卷 620-631页

作者： LI SongYing~(1+) RUAN YingBin~2 1 Department of Mathematics University of california Irvine ca 92697 USA 2 School of Mathematics and Computer Science Fujian Normal University Fuzhou 350007 China Department of Mathematics University of California Irvine USA School of Mathematics and Computer Science Fujian Normal University Fuzhou China

The paper gives characterization for an isometric isomorphism on little Bloch space, VMOA and holomorphic Besov space over the unit ball B_n in C^n.

关键词： ismometry Besov spaces

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Approximation to functions of several variables by superpositions of functions of fewer variables

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Chinese Science Bulletin 1997年第4期42卷 351-352页

作者： CHEN Tianping and CHEN Hong1. Department of Mathematics, Fudan University, Shanghai 200433, China 2. Sun Microsystems, Sunnyvill, ca95050. US Depamnent of Mathematics Fudan University Shanghai China Sun Microsystems Sunnyvill USA

RECENTLY, the approximation to continuous functions by the superposition of a fixed function attracts some mathematicians and engineers, because it is a basic problem in neural networks and wavelets analysis. In a series of papers, we discussed the approximation to continuous functions of several variables by the superposition of a fixed continuous function of one variable. In this letter, we announce several theorems concerned with the approximation to func-

关键词：化石感知脚气主场袭人角山公行五金跳时心场

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High sensitivity conductivity-temperature-depth sensing based on an optical microfiber coupler combined fiber loop

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Chinese Optics Letters 2020年第1期18卷 34-39页

作者：曹亮于洋肖民杨俊波张学亮孟洲 College of Meteorology and Oceanology National University of Defense TechnologyChangsha 410073China Unit 45 No.91388 Troops of PLAZhanjiang 524022China College of Liberal Arts and Sciences National University of Defense TechnologyChangsha 410073China Hunan Aerospace Institute of Electromechanical Devices and Special Material Changsha 410073China

In order to meet the practical needs of all-fiber conductivity-temperature-depth sensors with high sensitivity,compact structure,and easy packaging,this Letter uses a microfiber coupler combined with fiber loop(MCFL)reflective photonic device to conduct salinity,temperature,and deep sensing *** MCFLs’dynamic range and resolution of salinity,temperature,and depth can meet the requirements of actual marine environment *** structure opens up a new design idea for the practical research of microfiber coupler-based marine environmental parameter sensors.

关键词： microfiber coupler(MC) fiber loop salinity temperature and depth sensing cross sensitivity conductivity-temperature-depth measurement system

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正常受试者的小剂量铁耐受试验和机体铁含量

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国外医学（医学地理分册） 1992年第3期13卷 119-120页

作者： Libe.,ca 姚海英

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ASPECTS OF FATIGUE CRACK GROWTH IN INTERMET ALLIcaLLOYS

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中国有色金属学会会刊：英文版 1999年第S1期9卷 214-227页

作者： R.O.Ritchie Department of Materials Science and Mineral Engineering, University of california, Berkeley, ca 94720 1760, U.S.A.

The mechanisms of fatigue crack propagation in intermetallics alloys, specifically γ TiAl, Nb 3Al and MoSi 2, were compared with corresponding behavior in brittle ceramics and ductile metals. This was achieved by considering the process of fatigue crack growth as a mutual competition between intrinsic mechanisms of crack advance ahead of the crack tip (e.g., alternating crack tip blunting and resharpening), which promote crack growth, and extrinsic mechanisms of crack tip shielding behind the tip (crack closure and bridging), which impede it. The differing nature of these mechanisms in brittle and ductile materials and their specific dependence upon the alternating and maximum driving forces (e.g., Δ K and K max ) provided a useful distinction of the process of fatigue crack propagation in these different classes of materials.

关键词： TiAl Nb 3Al MoSi 2 fatigue crack propagation growth

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高分辨力超声波诊断在皮肤科的应用

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国外医学（皮肤性病学分册） 1994年第1期20卷 22-24页

作者： Gropper ca 顾恒

近20年来,超声诊断已在皮肤科推广应用,它提供了一个无创伤性多部位皮肤检查的手段。该文重点复习有关适用于皮肤科的超声技术,叙述有关超声在皮肤科的特殊应用,并讨论了皮肤科超声应用的前景。

关键词：皮肤病超声波诊断

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FRACTURE TOUGHNESS OF ORDERED INTERMETALLIC COMPOUNDS FROM SMALL DISKSHAPED SPECIMENS

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中国有色金属学会会刊：英文版 1999年第S1期9卷 106-116页

作者： Alan J.Ardell Department of Materials Science and Engineering, University of california, Los Angeles, ca 90095 1595, U.S.A.

The miniaturized disk bend test(MDBT) can be used to measure the fracture toughness at “infinite" crack length, K ∞, of ordered intermetallic compounds. The specimens tested are disks 3 mm in diameter and typically range in thickness from 250 to 400 μm. A Vickers indentation is impressed within ±10 μm of the center of a metallographically polished disk under a known load, F . The specimen is then subjected to biaxial loading, with the indented side in tension, and tested to failure. In completely brittle intermetallics the fracture stress, σ f, is calculated using a standard formula and measured experimentally as a function of F . When plasticity intervenes prior to fracture it is necessary to calculate the stress using finite element modeling (FEM), the FEM program NIKE2D has been used. Whether or not the specimens deform plastically, the resulting data on σ f vs F are analyzed using established equations of fracture mechanics in conjunction with an empirical rising R curve equation that characterizes the increase in fracture resistance, K R( c ), with crack length, c . Results are presented on several ordered intermetallic compounds. These include Ni 3Ge and Ti 5Si 3, which exhibit no ductility prior to fracture, and NiAl and a complex TiAl alloy, which both exhibit limited ductility before fracturing. The values of K ∞ determined with the MDBT are in very good agreement with values of K IC measured using conventional methods.

关键词： ordered intermetallics Ni 3Ge Ti 5Si 3 TiAl fracture toughness miniature disk bend test

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