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Stay in touch with the endoplasmic reticulum

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Science china(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.zhao Xun Huang ge Yang Huaqing cai Jose c.Pastor-Pareja Liang ge chuanmao zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(McSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

Precipitation of multi-type nano-quasicrystals in a Mg-zn-Y alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 997-1008页

作者： W.z.Wang X.z.zhou L.F.zhang H.Q.Ye z.Q.Yang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji Hua Laboratory Foshan 528251China Foshan University Foshan 528231China

Mg-6zn-1Y(at.%)ribbons with strengthening precipitates of multi-type nanoquasicrystals were prepared by melt-spinning followed by aging *** evolution of the rapidly solidified ribbons during isothermal aging was comprehensively studied using various electron microscopy *** new kinds of decagonal quasicrystals were formed in aged ribbons,in addition to precipitation of nanometer icosahedral ***-resolution observations reveal that both decagonal quasicrystals can be modeled by quasiperiodic tiling with decagonal clusters of 2.5 nm in diameter,but overlap of neighboring clusters in both decagonal quasicrystals is different from the Gummelt model observed in other quasicrystals.A shell composed of complex Laves Mg-zn domains was formed surrounding each decagonal quasicrystal precipitate upon prolonged *** addition,all kinds of nanoprecipitates exhibit excellent structure and size stability at 573 *** findings may have implications for not only fundamental studies about quasicrystals,but also microstructural manipulation of high-performance Mg alloys.

关键词： Quasicrystal Mg alloys Rapid solidification Scanning-transmission electron microscopy.

The dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria

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International Journal of Biomathematics 2024年第3期17卷 265-287页

作者： Xing-Xing Yang Guo-Bao zhang ge Tian college of Mathematics and Statistics Northwest Normal University Lanzhou Gansu 730070P.R.China

In this paper,we mainly investigate the dynamics of traveling wavefronts for a model describing host tissue degradation by *** first establish the existence of spreading speed,and show that the spreading speed coincides with the minimal wave speed of traveling ***,a lower bound estimate of the spreading speed is ***,we prove that the traveling wavefronts with large speeds are globally exponentially stable,when the initial perturbation around the traveling wavefronts decays exponentially asχ→-∞,but the initial perturbation can be arbitrarily large in other *** adopted methods are the weighted energy and the squeezing technique.

关键词： Host tissue degradation bacterial infection traveling wavefronts minimal wave speed stability

Multiplicity of solutions for the semilinear subelliptic Dirichlet problem

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Science china Mathematics 2024年第3期67卷 475-504页

作者： Hua chen Hong-ge chen Jin-Ning Li Xin Liao School of Mathematics and Statistics Wuhan UniversityWuhan 430072China Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

In this paper,we study the semilinear subelliptic equation{−△Xu=f(x,u)+g(x,u)inΩ,u=0 on∂Ω,where△X=−∑m i=1 Xi∗Xi is the self-adjoint Hormander operator associated with the vector fields X=(X_(1),X_(2),...,X_(m))satisfying the Hormander's condition,f(x,u)∈c(Ω×R),g(x,u)is a carathéodory function onΩ×R,andΩis an open bounded domain in R~n with smooth *** the perturbation from the symmetry method with the approaches involving the eigenvalue estimate and the Morse index in estimating the minimax values,we obtain two kinds of existence results for multiple weak solutions to the problem ***,we discuss the difference between the eigenvalue estimate approach and the Morse index approach in degenerate *** with the classical elliptic cases,both approaches here have their own strengths in the degenerate *** new phenomenon implies that the results in general degenerate cases would be quite different from the situations in classical elliptic cases.

关键词： degenerate elliptic equations Hormander operators perturbation method Morse index

Effect of synergistic urea by nitrification inhibitor coated with resin on wheat growth and soil nitrogen supply

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Pedosphere 2024年第5期34卷 960-970页

作者： Yaru ge Yu LI Yuanjie DONG Mingrong HE Xinglong DAI college of Resources and Environment Shandong Agricultural University Agronomy college Shandong Agricultural University

combining nitrification inhibitor and urea can improve crop yield and nitrogen (N) use efficiency (NUE). However, the inhibitor easily gets inactivated in soil, making it difficult to achieve the desired effect. To develop a synergistic urea for increasing the inhibitor action time, soil N supply, and wheat growth,dicyandiamide (DcD) was coated after granulation with epoxy resin and then mixed with urea to develop new resin-coated DcD (RcD) synergistic *** electron microscopy (SEM) and hydrostatic release tests were used to evaluate the membrane microstructure and the controlled-release performance of RcD. Five fertilization treatments were set up in the field:zero-N control (cK), urea (U), urea+common DcD particles (SUD1), urea+RcD (SUD2),and urea+both common DcD particles and RcD (3:7, weight/weight)(SUD3) to investigate the effects of the DcD synergistic urea on wheat growth, yield,and NUE and soil available N content. The SEM results showed that RcD had a complete coating, smooth surface, and small and rugged channels for DcD release in the profile. The hydrostatic release test at 25?c showed that the release period of DcD was extended to ten days due to resin coating. In the three DcD synergistic urea treatments, only SUD3 resulted in a significant increase in wheat yield (18.47%) compared with U. The NUE in SUD3 was significantly higher than those in SUD2, U, and SUD1. The treatment SUD3 had higher soil available N content than the other treatments during the key wheat growth stages, while effectively reducing the risk of soil nitrate leaching during wheat maturity. In summary, SUD3, a mixture of urea, DcD particles, and RcD, was the best treatment for significantly increasing wheat growth, yield, and NUE and soil N supply.

关键词： coated DcD controlled-release fertilizer N fertilizer N use efficiency soil available N wheat yield

cross-diffusion induced Turing instability of Hopf bifurcating periodic solutions in the reaction-diffusion enzyme reaction model

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International Journal of Biomathematics 2024年第4期17卷 133-150页

作者： Haicheng Liu Wenshuo Yuan Bin ge Jihong Shen college of Mathematical Sciences Harbin Engineering University Harbin 150001 HeilongjiangP.R.China

Aiming at the spatial pattern phenomenon in biochemical reactions,an enzyme-reaction Sporns-Seelig model with cross-diffusion is chosen as study *** the central manifold theory,normal form method,local Hopf bifurcation theorem and perturbation theory,we study Turing instability of the spatially homogeneous Hopf bifurcation periodic *** last,the theoretical results are verified by numerical simulations.

关键词： Sporns-Seelig model diffusion Hopf bifurcation periodic solutions Turing instability

cross-Project Software Defect Prediction Based on SMOTE and Deep canonical correlation Analysis

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computers, Materials & continua 2024年第2期78卷 1687-1711页

作者： Xin Fan Shuqing zhang Kaisheng Wu Wei zheng Yu ge School of Software Nanchang Hangkong UniversityNanchang330063China Software Testing and Evaluation center Nanchang Hangkong UniversityNanchang330063China

cross-Project Defect Prediction(cPDP)is a method that utilizes historical data from other source projects to train predictive models for defect prediction in the target ***,existing cPDP methods only consider linear correlations between features(indicators)of the source and target *** models are not capable of evaluating non-linear correlations between features when they exist,for example,when there are differences in data distributions between the source and target *** a result,the performance of such cPDP models is *** this paper,this paper proposes a novel cPDP method based on Synthetic Minority Oversampling Technique(SMOTE)and Deep canonical correlation Analysis(DccA),referred to as *** correlation Analysis(ccA)is employed to address the issue of non-linear correlations between features of the source and target projects.S-DccA extends ccA by incorporating the MlpNet model for feature extraction from the *** redundant features are then eliminated by maximizing the correlated feature subset using the ccA loss ***,cross-project defect prediction is achieved through the application of the SMOTE data sampling *** Under curve(AUc)and F1 scores(F1)are used as evaluation *** paper conducted experiments on 27 projects from four public datasets to validate the proposed *** results demonstrate that,on average,our method outperforms all baseline approaches by at least 1.2%in AUc and 5.5%in F1 *** indicates that the proposed method exhibits favorable performance characteristics.

关键词： cross-project defect prediction deep canonical correlation analysis feature similarity

cross-species transmission and host range genes in poxviruses

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Virologica Sinica 2024年第2期39卷 177-193页

作者： chen-Hui Yang A-Ling Song Ye Qiu Xing-Yi ge college of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410012China

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread ofMPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-likesymptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods tovertebrates. cross-species transmission of poxviruses among different hosts has been frequently reported andresulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodeshundreds of proteins. genes related to the host range of poxvirus are called host range genes (HRGs). This reviewbriefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes thecurrent knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus aredescribed and their impacts on viral host range are discussed in depth. We hope that this review will provide acomprehensive perspective about the current progress of researches on cross-species transmission and HRGvariation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

关键词： Poxvirus Host range gene(HRG) Host spectrum cross-species transmission

A hybrid data-mining framework for train rescheduling strategy pattern discovery

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Transportation Safety and Environment 2024年第1期6卷 56-67页

作者： Ruirui chen Xuekai ge Ping Huang chao Wen School of Transportation&Logistics Southwest Jiaotong UniversityChengdu 611756China Department of IT Operational Technology CN RailWaterloo N2V2R1Canada

This study presents a hybrid data-mining framework based on feature selection algorithms and clustering methods to perform the pattern discovery of high-speed railway train rescheduling strategies(RSs).The proposed model is composed of two *** the first state,decision tree,random forest,gradient boosting decision tree(GBDT)and extreme gradient boosting(XGBoost)models are used to investigate the importance of *** features that have a high influence on RSs are first *** the second state,a K-means clustering method is used to uncover the interdependences between RSs and the influencing features,based on the results in the first *** proposed method can determine the quantitative relationships between RSs and influencing *** results clearly show the influences of the factors on RSs,the possibilities of different train operation RSs under different situations,as well as some key time periods and key trains that the controllers should pay more attention *** research in this paper can help train traffic controllers better understand the train operation patterns and provides direction for optimizing rail traffic RSs.

关键词： high-speed railway rescheduling strategy pattern discovery feature identification clustering algorithm