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Journal of Materials Science & Technology 2023年第4期135卷 1-12页

作者： J.christudasjustus M.R.Felde c.S.Witharamage J.Esquivel A.A.Darwish c.winkler R.K.Gupta Department of Materials Science and Engineering North Carolina State UniversityRaleighNC 27606United States Department of chemical Biomolecular and Corrosion EngineeringThe University of AkronAkronOH 44325United States

The effect of age-hardening on microstructure,hardness,and corrosion of an Al-5at.%V alloy,produced us-ing high-energy ball milling and subsequent cold compaction,has been *** alloy exhibited a grain size below 100 nm and extremely high solid solubility of V in Al(3.1 at.%).The age-hardening was carried out at 150,200,and 250℃.The peak-aged condition of 150℃ demonstrated the highest hardness-transpired from grain refinement,precipitation,and solid solution *** corrosion re-sistance of the Al-5at.%V alloy was studied as a function of aging *** peak-aged condition retained the corrosion resistance while it deteriorated in the over-aged ***,the cor-rosion resistance of the ball-milled Al alloys in all the aging conditions was superior to that of pure *** passive film structure and origin of corrosion were studied using scanning/transmission electron mi-croscopy(S/TEM).The high corrosion resistance of the alloy was attributed to the V enrichment at the film/metal interface and deposition of V on the cathodic phases,which suppresses the dissolution of Al within the pit and therefore promotes repassivation in the early stages of corrosion.

关键词： Al alloys Nanocrystalline alloy Age-hardening Ball milling corrosion Hardness

功能MR成像无创性定量分析肺段过敏原激发的气道炎症:一项概念验证型研究

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国际医学放射学杂志 2015年第2期 172-173页

作者： J.Renne J.Hinrichs c.Schonfeld M.Gutberlet c.winkler c.Faulenbach 赵芳 Department of diagnostic and interventional radiology Hannover Medical School Biomedical research in endstage and obstructive lung disease hanover (BREATH) Member of the German Center for Lung Research OE 8220 Carl -Neuberg -Str 1 30625 Hannover Germany

摘要目的评估氧气增强T1-mapping MR成像可以作为一种无创性的方法来可视化和量化经肺段过敏原激发的哮喘病人的局部炎症。材料与方法 9例哮喘病人和4名正常

关键词：气道炎症 MR成像肺段哮喘病人局部炎症验证型嗜酸性粒细胞标准剂量弛豫时间知情同意书

A Smallness condition Ensuring Boundedness in a Two-dimensional chemotaxis-Navier-Stokes System involving Dirichlet Boundary conditions for the Signal

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Acta Mathematica Sinica,English Series 2022年第6期38卷 985-1001页

作者： Yu Lan WANG Michael winkler Zhao Yin XIANG School of Science Xihua UniversityChengdu 610039P.R.China Institut fur Mathematik Universitat Paderborn33098 PaderbornGermany School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731P.R.China

The chemotaxis-Navier-Stokes system{nt+u・∇n=Δn−∇・(n∇c),ct+u・∇c=Δc−nc,ut+(u・∇)u=Δu+∇P+n∇φ,∇・u=0is considered in a smoothly bounded planar domainΩunder the boundary conditions(∇n−n∇c)・ν=0,c=c,u=0,x∈∂Ω,t>0,with a given nonnegative constant c_(*).It is shown that if(n_(0),c_(0),u_(0))is sufficiently regular and such that the product||n_(0)||L^(1)(Ω)||c_(0)||^(2)L^(∞)(Ω)is suitably small,an associated initial value problem possesses a bounded classical solution with(n,c,u)|_(t=0)=(n_(0),c_(0),u_(0)).

关键词： chemotaxis Navier-Stokes system Dirichlet boundary condition

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Synthesis of Ta c and Ta_2c from tantalum and graphite in the laser-heated diamond anvil cell

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chinese Science Bulletin 2014年第36期59卷 5283-5289页

作者： Lkhamsuren Bayarjargal Bjrn winkler Alexandra Friedrich Erick A.Juarez-Arellano Institut fr Geowissenschaften Universitt FrankfurtAltenh ferallee 1 60438 Frankfurt am Main Germany Universidad del Papaloapan Circuito Central 200 Parque Industrial 68301 Tuxtepec Mexico

The pressure dependence of the onset of the formation of Ta c and Ta2 c from the elements has been investigated by in situ X-ray diffraction and *** c has been synthesized by the reaction of Ta and graphite at pressures between 8.6 and 14.3 GPa and at temperatures up to 2,300 K using a laser-heated diamond anvil cell. The products were characterized by X-ray diffraction. Ta and graphite begin to react around 1,100 K at ambient pressure conditions, and the reaction temperature increases with increasing pressure. A linear extrapolation of these data is consistent with recent observations of the formation of Ta c at 90 GPa and 3,600 K. We show that diffusion of carbon into tantalum significantly changes the lattice parameter of up to 2 % in the pressure range of up to19 GPa. In some experiments, Ta2 c was formed concomitantly. The experimentally determined bulk modulus of Ta2 c is B0;exp:= 286(5) GPa. Other tantalum carbide phases were not observed.

关键词：细胞合成激光加热碳化钽金刚石石墨原位X射线衍射压力依赖性反应温度

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Reduced nitrogen availability during growth improves quality in red oak lettuce leaves by minimizing nitrate content, and increasing antioxidant capacity and leaf mineral content

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Agricultural Sciences 2011年第4期2卷 477-486页

作者： Dario Stefanelli Sonja winkler Rod Jones 不详

Overuse of N in lettuce production can lead to environmental problems caused by leaching and the accumulation of harmful nitrates in edible tissues. This study investigated the effect of applied nitrogen (N) concentrations between 40 and 2400 mg·L–1 on growth, nitrate accumulation, mineral leaf content, and antioxidant capacity in Oak Leaf lettuce cv. “Shiraz” grown under hydroponic conditions in Australia. Yield (g FW) increased with nitrogen (N) application rate up to 1200 mg·L–1, as did leaf N content, while c:N declined. Nitrogen Utilization Efficiency (NUtE) increased rapidly from 40 to 75 mg·L–1 applied N, leveling at 150 mg·L–1 with no subsequent effect of N concentrations between 400 and 2400 mg·L–1. Nitrate content rose significantly with increased N, particularly at 1200 and 2400 mg·L–1. Leaf total plant phenolic content (TPP) and antioxidant capacity (measured by ferric reducing antioxidant power—FRAP) were both maximal at 75 and 400 mg·L–1 applied N, while highest oxygen radical absorption capacity (ORAc) values were found in leaves supplied with low N (40 to 400 mg·L–1). Applied N as calcium nitrate also significantly affected leaf mineral content as B, Mg, Mn, and Zn significantly decreased with increasing N. These results indicate that N applications of 1200 mg·L–1 or higher can result in reduced antioxidant capacity and mineral content in lettuce leaves.

关键词： Lactuca sativa L. Hydroponic Phenolic content Zinc Manganese Magnesium

Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo[a]pyrene exposure: cellular and transcriptomic insights

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Journal of Environmental Sciences 2023年第5期127卷 336-348页

作者： Jiezhang Mo Miles Teng Wan DorisWai-Ting Au Jingchun Shi Nathan Tam Xian Qin Napo K.M.cheung Keng Po Lai christoph winkler Richard Yuen-chong Kong Frauke Seemann Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510000China Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity Research Centre for the Oceans and Human HealthShenzhen Research InstituteCity University of Hong KongShenzhen 518057China State Key Laboratory of Marine Pollution and Department of chemistry City University of Hong KongHong Kong SARChina Laboratory of Environmental Pollution and Integrative Omics Guilin Medical UniversityHuan Cheng North 2nd Road 109Guilin 541004China Department of Biological Sciences National University of Singapore119077Singapore center for coastal Studies and Department of Life Sciences Texas A&M University-Corpus ChristiCorpus ChristiTexas 78412USA

Benzo[a]pyrene(BaP),a ubiquitous pollutant,raises environmental health concerns due to induction of bone toxicity in the unexposed *** of F0 ancestor medaka(Oryzias latipes)to 1μg/L BaP for 21 days causes reduced vertebral bone thickness in the unexposed F3 male *** reveal the inherited modifications,osteoblast(OB)abundance and molecular signaling pathways of transgenerational BaP-induced bone thinning were *** analysis showed a reduction in OB *** of the miRNA and mRNA transcriptomes revealed the dysregulation of Wnt signaling(frzb/ola-miR-1–3p,sfrp5/ola-miR-96–5p/miR-455–5p)and bone morphogenetic protein(Bmp)signaling(bmp3/ola-miR-96–5p/miR-181b-5p/miR-199a-5p/miR-205–5p/miR-455–5p).Both pathways are major indicators of impaired bone formation,while the altered Rank signaling in osteoclasts(c-fos/miR-205–5p)suggests a potentially augmented bone ***,a typical BaP-responsive pathway,the Nrf2-mediated oxidative stress response(gst/ola-miR-181b-5p/miR-199a-5p/miR-205),was also ***,mRNA levels of epigenetic modification enzymes(e.g.,hdac6,hdac7,kdm5b)were found *** findings indicated that epigenetic factors(e.g.,miRNAs,histone modifications)may directly regulate the expression of genes associated with transgenerational BaP bone toxicity and warrants further *** identified candidate genes and miRNAs may serve as potential biomarkers for BaP-induced bone disease and as indicators of historic exposures in wild fish for conservation purposes.

关键词： Polycyclic aromatic hydrocarbons (PAHs) Transcriptome Impaired bone formation Molecular pathways MicroRNAs Medaka(Oryzias latipes)

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Dynamics of freshwater snails and Schistosoma infection prevalence in schoolchildren during the construction and operation of a multipurpose dam in central côte d’Ivoire

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Infectious Diseases of Poverty 2017年第1期6卷 810-818页

作者： Nana R.Diakite Mirko S.winkler Jean T.coulibaly Negnorogo Guindo-coulibaly Jürg Utzinger Eliezer K.N’Goran Laboratoire de Zoologie et Biologie Animale Unitede Formation et de Recherche BiosciencesUniversite Felix Houphouët-Boigny22 BP 522Abidjan 22Cote d’Ivoire Swiss Tropical and Public Health Institute P.O.BoxCH-4002BaselSwitzerland University of Basel P.O.BoxCH-4003BaselSwitzerland Departement Environnement et Sante Centre Suisse de Recherches Scientifiques en Cote d’Ivoire01 BP 1303Abidjan 01Cote d’Ivoire

Background:The construction and operation of small multipurpose dams in Africa have a history of altering the transmission of water-based diseases,including *** current study was designed to investigate the abundance and dynamics of schistosomiasis intermediate host snails and Schistosoma infections in humans during the construction and the first years of operation of a small multipurpose dam in côte d’***:The study was carried out in Raffierkro and four neighbouring villages in central côte d’Ivoire between 2007 and *** were collected by two experienced investigators using scoops and forceps for 15 min at each *** were identified at genera and,whenever possible,species level,and subjected to testing for cercarial *** aged 6-15 years were examined once every year for Schistosoma haematobium and *** infection,using urine filtration and duplication Kato-Katz thick smears,***,551 adults were examined for Schistosoma infection before(June 2007)and 359 individuals 2 years after dam construction(June 2009).Results:Overall,1700 snails belonging to nine different genera were collected from 19 sampling ***(potential intermediate host snails of ***)and Pila were the most common genera,whereas Biomphalaria(potential intermediate host snail of ***),Lymnaea,Physa and Melanoides were found in two *** the first-year sampling period,65 snails were collected,of which 13(20%)were schistosomiasis intermediate *** subsequent years,out of 1635 snails collected,1079(66%)were identified as potential intermediate host for schistosomiasis,but none were shedding *** prevalence of *** among adults in the study area was low(0.4%in 2007 and 0.3%in 2009),whereas the prevalence of *** declined from 13.9%to 2.9%in this two-year ***:The low prevalence of schistosomiasis in humans and the absence of infected intermediate host s

关键词： Schistosomiasis Intermediate host snail Transmission Water resources development and management Multipurpose dam cote d’Ivoire

Reduction in Nitrogen Prior to Harvest Increases Phenolic content of Baby Red Lettuce Leaves

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Agricultural Sciences 2014年第6期5卷 546-554页

作者： Dario Stefanelli Sonja winkler christine Frisina Rod Jones Department of Environment and Primary Industries Agriculture Research Division Victoria Australia

This study investigated baby red lettuce leaves grown in an inert media and fertigated with 300 or 1000 mg·L-1 caNO3-N (19% ca;15.5% N), and the effects of altering caNO3-N concentrations in the last 7 days prior to harvest on yield, antioxidant capacity, TPP and vitamin c content. Plants receiving 1000 mg·L-1 caNO3-N had a significantly higher leaf FW than those fertilized with 300 mg·L-1 caNO3-N after both 21 and 28 days. Pulsing plants with 1000 mg·L-1 caNO3-N for 7 days after 21 days at 300 mg·L-1 caNO3-N resulted in a significant increase in FW of 14%, compared with plants receiving 300 mg·L-1 caNO3-N. After 28 days plants fertilized with nitrogen at 300 mg·L-1 caNO3-N were significantly higher in TPP than those fertilized with 1000 mg·L-1 caNO3-N. While there was no significant effect on TPP of a 7-day 1000 mg·L-1 caNO3-N pulse added to 300 mg·L-1 caNO3-N, a 7-day pulse of 300 mg·L-1 caNO3-N added to 1000 mg·L-1 caNO3-N resulted in a significant increase in TPP. These results indicate that reducing the N availability for 7 days prior to harvest can result in a significant increase in plant phenolic content with no adverse effect on yield.

关键词： Yield Production Vitamin c Antioxidant capacity