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小鼠角膜上皮创伤再上皮化过程基本特征的动力学研究

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眼外伤职业眼病杂志 2008年第8期30卷 593-596页

作者：陈毓东 c.wayne smith 李志杰广东医学院眼科广东湛江524023 美国贝勒医学院休斯顿77030 暨南大学医学院眼科广东广州510630

目的研究小鼠角膜上皮机械性创伤再上皮化过程炎性细胞迁移、血小板聚集的动力学特征。方法计算小鼠角膜2 mm上皮缺损创面改变;免疫荧光染色观察角膜基底细胞分裂和中性粒细胞、血小板、γδT细胞及巨噬细胞迁移特征;电子显微镜观察角... 详细信息

目的研究小鼠角膜上皮机械性创伤再上皮化过程炎性细胞迁移、血小板聚集的动力学特征。方法计算小鼠角膜2 mm上皮缺损创面改变;免疫荧光染色观察角膜基底细胞分裂和中性粒细胞、血小板、γδT细胞及巨噬细胞迁移特征;电子显微镜观察角膜上皮细胞形态学、基质PMNs和角膜缘血小板的变化。结果创伤后24 h基本再上皮化,96 h基底细胞恢复正常;伤后18 h和30 h分裂细胞达峰值;PMNs迁移峰为12 h和30 h,血小板聚集峰于12 h;γδT细胞的两峰为6 h和24 h,MФ两峰滞后为24 h和42 h。结论角膜上皮创伤修复过程分3期。基底细胞分裂增生和PMNs、MФ以及γδT细胞迁移呈双相式;早期PMNs迁移与血小板聚集同步。

关键词：角膜上皮创伤愈合细胞迁移

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棘阿米巴角膜炎的感染免疫及防治

眼科新进展 2005年第2期25卷 101-104页

作者：李志杰 c.wayne smith 暨南大学组织移植与免疫中心眼科学教研室 Section of Leukocyte Biology Department of Pediatrics and ImmunologyBaylor College of Medicine1100BatesHoustonTX77030America

棘阿米巴角膜炎是棘阿米巴属引起的角膜表面的感染。通常由粘附于软性接触镜的棘阿米巴滋养体所传递。当寄生虫粘附于角膜上皮细胞表面时可触发感染。后来的过程包括:寄生虫介导的细胞病理效应、诱导凋亡和通过产生各种蛋白酶入侵角膜... 详细信息

棘阿米巴角膜炎是棘阿米巴属引起的角膜表面的感染。通常由粘附于软性接触镜的棘阿米巴滋养体所传递。当寄生虫粘附于角膜上皮细胞表面时可触发感染。后来的过程包括:寄生虫介导的细胞病理效应、诱导凋亡和通过产生各种蛋白酶入侵角膜基质层。滋养体也可浸润角膜神经,造成放射状角膜神经炎。棘阿米巴包囊即具有免疫原性又具有抗原性。然而,诱导针对棘阿米巴抗原的细胞介导的免疫应答对棘阿米巴角膜炎即无减轻作用又无预防效应。但是,普通粘膜免疫系统对于棘阿米巴角膜炎却具有显著的预防作用。其机制是通过IgA抗体阻断感染性滋养体与上皮层的结合。局部使用糖皮质激素对于缓解疼痛和减轻炎症反应具有显著效果,但可通过诱导静止包囊的脱包囊、增加滋养体的细胞病理效应以及麻痹初始免疫系统使疾病复燃。因此,糖皮质激素的使用是一把“双刃剑”。

关键词：棘阿米巴角膜炎感染免疫

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交感性眼炎的免疫病理学及其免疫治疗

眼科新进展 2005年第1期25卷 1-4页

作者：李志杰 c.wayne smith 暨南大学组织移植与免疫中心 Section of Leukocyte Biology Department of Pediatrics and ImmunologyBaylor College of Medicine1100 BatesRoom 6014HoustonTX 77030America

交感性眼炎是一眼穿透性外伤后发生的双侧肉芽肿性葡萄膜炎。其主要病理特征为葡萄膜的弥散性非坏死性肉芽肿性炎症反应。免疫病理学研究证实 :T淋巴细胞在发病机制中起着重要的作用。疾病早期的T淋巴细胞主要为cD4 + 细胞 ,而晚期则以c... 详细信息

交感性眼炎是一眼穿透性外伤后发生的双侧肉芽肿性葡萄膜炎。其主要病理特征为葡萄膜的弥散性非坏死性肉芽肿性炎症反应。免疫病理学研究证实 :T淋巴细胞在发病机制中起着重要的作用。疾病早期的T淋巴细胞主要为cD4 + 细胞 ,而晚期则以cD8+ 细胞为主。B细胞占脉络膜浸润细胞的 2 0 %以下 ,可能与疾病的慢性过程相关。另外 ,局部还存在黏附分子、MHc和FasL等免疫相关分子的表达增加。交感性眼炎患者具有一定的遗传倾向 ,与宿主的HLA状态存在某种关联性。其治疗原则是使用免疫抑制剂尽快控制眼内炎症 ,但应密切观察其相应的毒副作用。另外 ,还讨论了有关眼球摘除的问题。

关键词：交感性眼炎免疫机制免疫疗法

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趋化因子、白细胞迁移与眼部炎症

眼科新进展 2004年第3期24卷 221-223页

作者：徐志钢李志杰李辰 c.wayne smith 暨南大学眼科学教研室广东省广州市510632

趋化因子在白细胞迁移过程中起着重要的作用。眼部炎症 ,如感染、过敏反应、自身免疫病等的显著特点就是白细胞浸润。在多种眼部炎症中发现许多趋化因子的存在 ,并与白细胞的浸润水平高度相关。

关键词：趋化因子白细胞迁移眼炎症

comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

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Ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.Eggleton cody J.Salzmann Joseph E.Kaiser Shannon c.F.smith Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish commission Virginia Institute of Marine Science

Background Since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. Fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp Silver carp Aquatic nuisance species Fish assemblage Oxbow lake Large river

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

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Photonics Research 2024年第3期12卷 411-422页

作者： DARcY L.smith LINH V.NGUYEN MOHAMMAD I.REJA ERIK P.ScHARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID J.OTTAWAY STEPHEN c.WARREN-smith Institute for Photonics and Advanced Sensing and School of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research council centre of Excellence for Gravitational Wave Discovery(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia Laser Physics and Photonics Devices Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental *** properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the ***,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far *** this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved *** leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved

cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

Thermodynamic analysis of metal segregation in dual phase high entropy ceramics

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Journal of Materiomics 2024年第4期10卷 889-895页

作者： Steven M.smith II William G.Fahrenholtz Gregory E.Hilmas Stefano curtarolo Missouri University of Science and Technology Materials Science and Engineering DepartmentRollaMO65409USA Duke University Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke University Center of Autonomous Materials DesignDurhamNC27708USA

Equilibrium Gibbs'free energy calculations were used to determine metal segregation trends between boride and carbide solid solutions containing two metals that are relevant to dual phase high entropy *** model predicted that Ti had the strongest tendency to segregate to the boride phase followed by Zr,Nb,Mo,V,Hf,and Ta,which matches experimental results of measured *** ratio of a metal in the carbide phase to the content of the same metal in the corresponding metal boride had a linear trend with the change in standard Gibbs'free energy of reaction for a metal carbide reacting with B_(4)c to produce its corresponding metal boride and *** proposed model was used to predict the changes in standard Gibbs'free energy for crc→crB_(2) to be−260 kJ and Wc→WB_(2) to be 148 kJ,which indicates that cr has the strongest segregation to the boride and W has the strongest segregation to the *** proposed model can be used to estimate the segregation of metals in dual phase high entropy boride-carbide ceramics of any boride/carbide ratio or metal content.

关键词： Dual phase High entropy ceramic Boride carbide Thermodynamics