检索结果-南通市图书馆

c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi wang Xiaofei Niu Yingkai wang yang Liu cheng yang Xuyi chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional chinese Medicine TianjinChina characteristic Medical center of People’s Armed Police Forces TianjinChina Fujian Maternity and child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 pathway c-c motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the c–c coupling between cO2 and HcHO driven by photoelectrocatalysis

在线全文

学校读者我要写书评

暂无评论

Journal of Energy chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu wang Yifei Gao Yatao yang Jia Li Xiaojin Han Yan cui Zhanggen Huang National Key Laboratory of High Efficiency and Low carbon Utilization of coal Institute of Coal Chemistry Chinese Academy of Science University of chinese Academy of Science Shenyang University of chemical Technology

Photoelectrocatalytic coupling cO2and volatile organic compounds （VOcs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of cO2and the competitive hydrogen evolution of ***,a modified g-c3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,cO2and HcHO were absorbed at Zn site and N site,***,*cO generated from cO2and HcHO was converted to*cH3O and*cHO on the dual-active-site *** detailed reaction mechanism experiments indicated that c–c coupling only occurred between*cO and*cH3O in electrocatalysis *** from the“*cO+*cH3O”path,another“*cO+*cHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between cO2and HcHO simultaneously driven by light and electricity.

关键词： Ethanol

cOMPARISON OF K-ε AND K-ω TURBULENcE MODELS FOR SIMULATION OF SHALLOw REcIRcULATING FLOwS IN AN OPEN cHANNEL

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 1998年第2期10卷 74-86页

作者： Zhang, Yifan Li, c.w. Nanjing Hydraulic Research Inst Nanjing China

The paper describes the comparison of commonly used k-ε and k-ω turbulence models for simulating the recirculating flows behind a sudden expansion in a straight open channel. The depth-average numerical model and the quasi three-dimensional multilayer model are presented respectively. The governing equations are split into three parts in the finite difference approach: advection, dispersion and propagation. comparison of the results computed with the k-ε and k-ω models shows that the two turbulence models have strong robustness in simulating the reattachment length of the recirculating flows. The computed results are found in good agreement with the measured data.

关键词： turbulence k-ω modek k-ε model finite difference channel expansion

在线全文

学校读者我要写书评

暂无评论

在广州发现的恙虫热立克次体的研究

微生物学报 1953年第1期 42-56页

作者：赵树萱赵春芳许兆奎吴啓文杨淑英中央生物制品研究所

绪论广州市的恙虫热(Tsutsugamushi Fever,Scrub typhus)自从1946—1948年开始为医学工作者所注意。彭淑景,谢敏贞根据数百例的血清检查,发现对于OXK 有19—44%阳性率,并将临床上疑似恙虫热患者的血液接种于小白鼠腹腔有2例发见有类似... 详细信息

绪论广州市的恙虫热(Tsutsugamushi Fever,Scrub typhus)自从1946—1948年开始为医学工作者所注意。彭淑景,谢敏贞根据数百例的血清检查,发现对于OXK 有19—44%阳性率,并将临床上疑似恙虫热患者的血液接种于小白鼠腹腔有2例发见有类似恙虫熟立克次体的小体。施复晋及朱师晦等也相继报告了恙虫热患者的临床症状和在广州流行的情况。1950年7月作者之一奉派到广州

关键词：小白鼠卵黄囊立克次腹腔内注射卵黄膜豚鼠荷兰猪皮内注射胞内增殖渗出液

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin Zhong wenwen yang Peng Gao Lezhi yang Jilei Liu college of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University changsha Research Institute of Mining & Metallurgy co. LTD.

Hard carbon （Hc） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more Bc3and less B–c–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1c-5Mnmedium manganese steel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang wenhao Li yangfei chen yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10c-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase cγ-ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth compatibility

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 401-416页

作者： chen Li Leilei Liang Baoshan Zhang Yi yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China college of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@c/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@c/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth wrinkled MXene Magneto-dielectric synergy Multifunction

Stress analysis of anisotropic thick laminates in cylindrical bending using a semi-analytical approach

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第11期8卷 1740-1745页

作者： LU chao-feng LIM c.w. XU Feng Department of civil Engineering Zhejiang University Hangzhou 310027 China） Department of Building and construction City University of Hong Kong Kowloon Hong Kong China Zhejiang Tiandi Environmental Protection Engineering co. Ltd. Hangzhou 310012 China

Semi-analytical elasticity solutions for bending of angle-ply laminates in cylindrical bending are presented using the state-space-based differential quadrature method (SSDQM). Partial differential state equation is derived from the basic equations of elasticity based on the state space concept. Then, the differential quadrature (DQ) technique is introduced to discretize the longitu- dinal domain of the plate so that a series of ordinary differential state equations are obtained at the discrete points. Meanwhile, the edge constrained conditions are handled directly using the stress and displacement components without the Saint-Venant principle. The thickness domain is solved analytically based on the state space formalism along with the continuity conditions at interfaces. The present method is validated by comparing the results to the exact solutions of Pagano’s problem. Numerical results for fully clamped thick laminates are presented, and the influences of ply angle on stress distributions are discussed.

关键词： Semi-analytical elasticity solution State-space-based differential quadrature method (SSDQM) Angle-ply laminates cylindrical bending