检索结果-南通市图书馆

Developmental and genomic architecture of plant embryogenesis: from model plant to crops

Plant communications 2021年第1期2卷 1-12页

作者： Alma Armenta-Medina c.stewart gillmor Peng Gao Javier Mora-Macias Leon V.Kochian Daoquan Xiang Raju Datla Global Institute for Food Security University of SaskatchewanSaskatoonSK S7N 4J8Canada Laboratorio Nacional de Genòmica para la Biodiversidad(Langebio) Unidad de Genòmica AvanzadaCentro de Investigaciòny Estudios Avanzados del IPN(CINVESTAV-IPN)IrapuatoGuanajuatoMéxico National Research council canada 110 Gymnasium PlaceSaskatoonSK S7N 0W9Canada

Embryonic development represents an important reproductive phase of sexually reproducing plant *** fusion of egg and sperm produces the plant zygote,a totipotent cell that,through cell division and cell identity specification in early embryogenesis,establishes the major cell lineages and tissues of the adult *** subsequent morphogenesis phase produces the full-sized embryo,while the late embryogenesis maturation process prepares the seed for dormancy and subsequent germination,ensuring continuation of the plant life *** this review on embryogenesis,we compare the model eudicot Arabidopsis thaliana with monocot crops,focusing on genome activation,paternal and maternal regulation of early zygote development,and key organizers of patterning,such as auxin and WOX transcription *** the early stages of embryo development are apparently conserved among plant species,embryo maturation programs have diversified between eudicots and *** diversification in crop species reflects the likely effects of domestication on seed quality traits that are determined during embryo maturation,and also assures seed germination in different environmental *** review describes the most important features of embryonic development in plants,and the scope and applications of genomics in plant embryo studies.

关键词： embryogenesis embryo patterning zygote genome activation transcription factors genomics transcriptomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applications and verification of a computational energy dynamics model for mine climate simulations

引用

International Journal of Mining Science and Technology 2020年第4期30卷 483-493页

作者： G.Danko D.Bahrami c.stewart Department of Mining and Metallurgical Engineering University of NevadaRenoNV 89557USA School of Mechanical Engineering University of QueenslandQueensland 4072Australia

A complete thermodynamic model is described for temperature and heat flow distribution simulation for ventilation networks in underground *** method is called the computational Energy Dynamics(cED)model of the heat,mass,and energy *** Thermal and Humidity(TH)transport elements of the full model are described for advection,convection,and accumulation,encompassing heat capacity,radiation,latent heat for evaporation,and condensation in the airways,as well as variable heat conduction and accumulation in the rock *** thermal flywheel effect for time-dependent temperature field applications is included in the model solution.A cED model validation exercise is described,directly evaluating the iterated,minimized energy balance errors for the mechanical and thermal energy components for each network branch after a converged solution is determined.A simulation example relevant to mine safety and health is shown with the cED-TH model,demonstrating its capabilities in efficiency and accuracy in comparison with measurement results.

关键词： Mine climate simulation Dynamic heat flow model coupled heat and moisture transport computational energy dynamics Mine safety and health

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ophthalmic community perception of new medication needs

引用

International Journal of Ophthalmology(English edition) 2018年第5期11卷 848-851页

作者： William c.stewart Jeanette A.stewart Lindsay A.Nelson PRN PharmaFarm LLC

AIM：To survey ophthalmologists（who have participated previously in clinical research） and ophthalmic industry professionals（who have been involved in ocular research and development） to indicate perceived needs for new pharmaceuticals in various ophthalmic ***：A prospective,industry-based survey was sent to ophthalmologists and ophthalmic industry professionals about the perceived needs for new pharmaceutical ***：This survey was sent to 559 ophthalmic pharma professionals and *** received 82（15%） *** results showed that the most commonly perceived need for new pharmaceuticals were dry and wet age-related macular degeneration,glaucoma,diabetic macular edema and dry *** was a statistical difference found between response groups（P〈0.0001）.Respondents indicated they would express their commitment to a new product they perceived as needed by recommending to colleagues（63%）,prescribing（60%）,participating as principle investigator in a related clinical trial（52%）,advising the company（52%）,lecturing on behalf of the product（43%）,investing in the product（38%）,taking no action（7%） or obtain a position in the company（1%）.cONcLUSION：Ophthalmic pharma professionals and ophthalmologists perceive the greatest need for new medicines in ophthalmology to be in dry and wet agerelated macular degeneration,glaucoma,diabetic macular edema and dry eye.

关键词： ophthalmic ophthalmology ocular eye disease pharmaceuticals start-up development needs medication therapies future new treatments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term cost and efficacy analysis of latanoprost versus timolol in glaucoma patients in Germany

引用

International Journal of Ophthalmology(English edition) 2013年第2期6卷 155-159页

作者： Ulrich Thelen Dietmar Schnober Sonja Schlzel Michael S.Kristoffersen Lindsay A.Nelson Jeanette A.stewart William c.stewart Westfalische Wilhelms-Universitat AugenarztpraxisMünster Germany Augenarzt Werdohl Germany Department of Surgery Institutes of Molecular Medicine University of Freiburg PRN Pharmaceutical Research Network LLC Cheyenne WY USA

AIM: To evaluate 5-year effectiveness and cos between latanoprost or timolol monotherapy in a pilot ***: A retrospective, multi-center trial performed at 6 sites in Germany of patients who had a diagnosis of primary open-angle or pigmentary glaucoma, in at least one eye, initiated on monotherapy with latanoprost or timolol maleate. Qualified consecutive charts were reviewed in which 5-year efficacy, safety and cost data was ***: Seventy-seven latanoprost and 49 timolo patients were included, at the final visit no difference existed between the two groups in disc parameters including: rim area, rim area/disc area ratio, cup volume or vertical cup/disc ratio (P >0.05). There was no difference in intraocular pressure (IOP) between the initial latanoprost (17.4 ±2.6) and timolol (16.3 ±2.8mmHg) groups. There was less change in medicines over the follow-up period (0.1 vs 0.8) and fewer medications at the final visit (1.2 vs 1.8) with latanoprost compared to timolol. No patient treated with latanoprost discontinued therapy during follow-up, while 12% discontinued timolol mostly due to inadequate IOP control. cost/year was less with initial timolol ($458±236) as compared to latanoprost ($552±202). cONcLUSION: Patients begun on latanoprost o timolol and followed over 5 years may have similar clinical outcomes. However, timolol patients may require more medicines and medicine changes to control IOP for long-term, but at a lower cost.

关键词： glaucoma economic efficacy safety latanoprost timolol Germany

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effects of Zinc Sulfate on the in Vitro Digestibility of Feeds in cervids

引用

Open Journal of Animal Sciences 2024年第3期14卷 157-167页

作者： Reese J. Thibodeaux Philip M. Urso Stanley F. Kelley Marcy M. Beverly chris R. stewart Ian c. Dunn Gentech Diagnostics Dallas Texas USA Department of Animal Science South Dakota State University Brookings South Dakota USA School of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Whitetails Bedias Texas USA

The captive white-tailed deer industry has an estimated impact of 1.6 billion USD in the state of Texas alone. However, nutritional requirements for cervids are determined through research based on sheep and goats. The objective of this study was to determine the effects of zinc on differences in dry matter digestibility in vitro for white-tailed does (Odocoileus virginianus). Deer (n = 2) were ethically harvested, rumens were collected, and placed into a cooler containing warm water. Rumen contents were agitated, and fluid was filtered using cheese cloth while applying cO2. Fluid was placed into four separate incubator jars with filter bags containing a 1:1 alfalfa to coastal hay blend. Zinc doses of 0.073 mg/kg/d equivalents were added to two of the jars ( Zn), and the additional two jars received 0.00 mg/kg/d (cON). Following 48 h of incubation, in vitro true digestibility (IVTD) showed no significant differences between the control and the treatment groups. Average dry matter digested in vitro was 91.87% and 95.13%, respectively. There were no differences detected in ADF, NDF, IVTD, or OM between the treatment groups. While no detectable differences were observed in this study, this methodology did prove to be viable and functional for microbial digestion in vitro. This study can be replicated with multiple experimental units to confirm the observations of increased digestibility. Formal nutritional guidelines can be created to allow for more efficient feeding of cervids thereby reducing feed costs and continuing the growth of the captive deer industry.

关键词： Zinc IVDMD In Vitro cervids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

常规腹部cT的辐射剂量变化较大：超剂量的原因及减少剂量的小建议

引用

国际医学放射学杂志 2024年第3期 378-378页

作者： R.Smith-Bindman T.Kang P.W.chu Y.Wang c.stewart M.Das 吴玉平

摘要目的描述辐射剂量减少技术在常规腹部cT中的应用和影响。方法回顾性分析了由95家医院和成像机构提供的有大剂量登记的成人连续常规腹部cT扫描。将检查分

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chemical forms and extractability of iron in sediments of three contrasting lakes of china and UK

引用

Journal of Environmental Sciences 2003年第06期15卷 728-733页

作者： Gibson c.E.,stewart B.M. Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology chinese Academy of Sciences Department of Agricultural and Environmental Science Queen's University Belfast Shenyang 110016 china Newforge Lane Belfast BT9 5PX UK

Iron is a limiting factor for the eutrophication of lakes, especially those lakes that are enriched with phosphorus. Extractability of iron in sediments of West Lake and Taihu Lake in china and Lower Lough Erne in Northern Ireland of UK was comparatively investigated on the basis of analysing chemical forms of iron using different extractants. It was shown that extractable iron in sediments of the lakes was greatly different using various extractants. Reactive iron or easily released iron such as “active" iron oxides, total free iron oxide and water-soluble iron was not high, only accounting for 0.01%—0.15% of total iron. The efficiency of the extractants for exchangeable iron was decreased in the sequence 0.1 mol/L Hcl DTPA+TEA mixed solution > 1 mol/L NH 4OAc > 0.5 mol/L Mgcl 2 = 0.5 mol/L cacl 2. It seems that the complexion of iron by organic matter was not strong because the concentration of organically bound iron was significantly lower than the concentration it was forecasted. Extractable iron is not entirely consistent with or dependent on total iron in lake sediments. To a certain extent, phosphate can inhibit the release of iron in sediments of the lakes. The selection of extractants is thus the first key step to evaluate bioavailability of iron in lake sediments.

关键词： iron chemical form extractability lake sediment eutrophication

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Therapeutic implications of advanced age at time of spinal cord injury

引用

Neural Regeneration Research 2019年第11期14卷 1895-1896页

作者： Andrew N. stewart John c. Gensel Bei Zhang Spinal cord and Brain Injury Research center Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA college of Public Health Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina

A recent demographic shift towards increased age at time of spinal cord injury (ScI), as well as decreased functional recovery following ScI in older populations, create the need to investigate how age effects ScI pathology and repair (Scivoletto et al., 2003). While decreased neuroplasticity or physical strength with age may contribute to functional deficits, work from our lab and others have identified exacerbated acute inflammatory events as contributors to age-dependent secondary injury. Specifically, our recent paper identified that increased production of reactive oxygen species (ROS) from macrophage nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) with age exacerbates secondary injury after ScI (Zhang et al., 2019).

关键词： spinal cord injury nicotinamide adenine dinucleotide phosphate(NADPH) reactive oxygen species(ROS)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The friction of diamond-like carbon coatings in a water environment

引用

Friction 2013年第3期1卷 210-221页

作者： D.c.SUTTON G.LIMBERT D.stewart R.J.K.WOOD National centre for Advanced Tribology at Southampton(ncATS) Engineering SciencesFaculty of Engineering and the EnvironmentUniversity of SouthamptonSouthamptonSO171BJUK Bioengineering Science Research Group Engineering SciencesFaculty of Engineering and the EnvironmentUniversity of SouthamptonSouthamptonSO171BJUK Materials Chemistry and CorrosionRolls-RoyceDerbyDE217XXUK

Diamond-like carbon(DLc)coatings are known to provide beneficial mechanical and tribological properties in harsh *** combination of high wear resistance and low friction has led to their extensive use in any number of *** tribological performance of a DLc coating is varied however,and the frictional response is known to be strongly dependent on the surrounding environment,as well as the material composition and bonding structure of the DLc *** paper presents an up-to-date review on the friction of DLc coatings in a water environment,with a special focus on transfer layer formation and tribochemistry.

关键词： friction diamond-like carbon(DLc) water transfer layer tribochemistry review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Lead on pH and Temperature-Dependent Substrate-Activation Kinetics of ATPase System and its Protection by Thiol compounds in Rat Brain

引用

Biomedical and Environmental Sciences 1991年第4期4卷 441-451页

作者： B.RAJANNA c.S.cHETTY T.c.stewart S.RAJANNA Department of Natural Science.Selma University Selma Al 36701 U. S. ADepartment of Natural Science.Selma University Selma Al 36701 U. S. ADepartment of Natural Science.Selma University Selma Al 36701 U. S. ADepartment of Computer Science and Mathematics Selma University Selma Al 36701 U. S. A

Lead (Pb) inhibited the activities of Na+ -K+ ATPase (Ic50= 2.0×10^(-6) M), K + -Para-Nitrophenyl phosphatase (PNPPase) (Ic50= 3.5×10^(-6) M) and [3H]-ouabain binding (Ic50 = 4.0×10^(-5) M) in rat brain P2 fraction. A variable temperature or pH significantly elevated the inhibition of Na+-K+ ATPase by Pb in buffered acidic, neutral and alkaline pH ranges. Noncompetitive inhibition with respect to activation of Na+ -K+ ATPase by ATP was indicated by a variation in Vmax values with no significant changes in Km values at any temperature studied. In the presence of Pb, for Na+ -K+ ATPase at pH 6.5 and 8.5, Vmax was decreased with an increase in Km values suggesting a mixed type of inhibition. Sulfhydryl agents such as dithiothreitol (DTT) and cvsteine (cyst), but not glutathione (GSH) offered varied levels of protection against Pb-inhibition of Na + -K+ ATPase at pH 7.5 and 8.5. The present data suggest that inhibition of Na+ -K+ ATPase by Pb is both temperature and pH-dependent. These results also indicate that Pb inhibited Na + -K + ATPase by interfering with phosphorylation of enzyme molecule and dephosphorylation of the enzyme-phosphoryl complex and exerted an effect similar to that of SH-blocking agents.

关键词： Effects of Lead on pH and Temperature-Dependent Substrate-Activation Kinetics of ATPase System and its Protection by Thiol compounds in Rat Brain ATPase pH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：