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Geochemistry and depositional environment of fuchsite quartzites from sargur Group,western Dharwar craton,India

Acta Geochimica 2024年第3期43卷 555-570页

作者： c.s.sindhuja G.Harshitha c.Manikyamba K.s.V.subramanyam csIR(council of scientific and Industrial Research)-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarchean fuchsite quartzites are present in different stratigraphic positions of Dharwar craton including the oldest(~3.3 Ga)sargur Group of western Dharwar *** present study deals with the petro-graphic and geochemical characteristics of the fuchsite quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the ancient sedimentation *** major mineral assemblages include quartz,fuchsite,and feldspars along with accessory kyanite and *** geochemical com-positions are characterized by high siO_(2),Al_(2)O_(3),low MgO,caO,strongly enriched cr(1326–6899 ppm),Ba(1165–3653 ppm),sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)contents compared to the upper continental crust(Ucc).The Ucc normalized rare earth element(REE)patterns are characterized by depleted light REE[(La/sm)Ucc=0.33–0.95]compared to heavy REE[(Gd/Yb)_(Ucc)=0.42–1.65]with conspicuous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)characteristic of hydrothermal solutions evidenced through the interlayered *** overall major and trace element systematics reflect a combined mafic-felsic provenance and suggest their deposition at a passive continental margin *** comprehensivefield,petrographic,and geo-chemical studies indicate that these quartzites are infiltrated by cr-richfluids released during high-grade metamorphism of associated ultramafic *** sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tectonic settings,possibly leading to the release of cr-richfluids and the formation of fuchsite quartzite during or after the *** sug-gest a pre-existing stable crust prior to the sargur Group and the link between orogenic events and various mineral deposits in the Dharwar craton.

关键词： Dharwar craton Ghattihosahalli Fuchsite quartzite Provenance Depositional setting

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crustal stabilization:Evidence from the geochemistry and U–Pb detrital zircon geochronology of quartzites from simlipal complex,singhbhum craton,India

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Geoscience Frontiers 2022年第1期13卷 46-61页

作者： c.s.sindhuja Arijit Pahari c.Manikyamba M.santosh Li Tang Jyotisankar Ray K.s.V.subramanyam Madhuparna Paul I.Gonzalez-Alvarez P.c.sruthi csIR(council of scientific and Industrial Research)-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India school of Earth science and Resources China University of GeosciencesBeijing 100083China Department of Geology University of CalcuttaKolkataIndia csIRO Mineral ResourcesWestern AustraliaAustralia

cratonic stabilization was a critical crustal process during the Hadean to Archean for the formation of *** understanding of how and where this process took place is significant to evaluate the architecture of *** singhbhum craton of eastern India has well preserved Precambrian volcanosedimentary *** simlipal volcano-sedimentary complex of singhbhum craton consists of circular bands of mafic volcanic rocks interlayered with quartzites/shales/*** the present study,we report petrographic and geochemical characteristics of quartzites from simlipal complex coupled with U–Pb ages of detrital zircons and zircon geochemistry to understand the provenance and depositional conditions and its connection with the crustal stabilization in the singhbhum *** quartzites are texturally mature with sub-angular to sub-rounded quartz grains followed by feldspars embedded in a silty *** on modal compositions and major element ratios,these quartzites are categorized as quartz arenite and sub-lithic *** element abundances normalized to Archean Upper continental crust(AUcc)display positive anomalies at U,Zr,Hf and negative anomalies at *** patterns are characterized by negative Eu anomalies(Eu/Eu^(*)=0.47–0.97)and flat HREE suggesting felsic *** quartzites show depletion of LILE,enrichment of HFsE and transition metals relative to *** weathering indices such as cIA,PIA,and IcV are suggestive of moderate to intense chemical *** trace element ratios such as Th/cr,Th/sc,La/sc,La/co and Th/co indicate a predominantly felsic source for these *** overall geochemical signatures indicate passive margin deposition for these *** zircons from the simlipal quartzites yield U–Pb ages 3156±31 Ma suggesting Mesoarchean crustal *** trace element geochemistry of detrital zircons suggests that the zircons are magmatic in origin and possibly derived from the 3.1 Ga anorogenic grani

关键词： Quartzites simlipal complex singhbhum craton U-Pb geochronology crustal stablilization

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Optimal Deep Belief Network Based Lung cancer Detection and survival Rate Prediction

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computer systems science & Engineering 2023年第4期45卷 939-953页

作者： sindhuja Manickavasagam Poonkuzhali sugumaran Department of Information Technology Rajalakshmi Engineering CollegeChennai600125TamilnaduIndia Department of computer science and Engineering Rajalakshmi Engineering CollegeChennai600125TamilnaduIndia

The combination of machine learning(ML)approaches in healthcare is a massive advantage designed at curing illness of millions of *** efforts are used by researchers for detecting and providing primary phase insights as to cancer *** cancer remained the essential source of disease connected mortality for both men as well as women and their frequency was increasing around the *** disease is the unrestrained progress of irregular cells which begin off in one or both *** previous detection of cancer is not simpler procedure however if it can be detected,it can be curable,also finding the survival rate is a major challenging *** study develops an Ant lion Optimization(ALO)with Deep Belief Network(DBN)for Lung cancer Detection and classification with survival rate *** proposed model aims to identify and classify the presence of lung ***,the proposed model undergoes min-max data normalization approach to preprocess the input ***,the ALO algorithm gets executed to choose an optimal subset of *** addition,the DBN model receives the chosen features and performs lung cancer ***,the optimizer is utilized for hyperparameter optimization of the DBN *** order to report the enhanced performance of the proposed model,a wide-ranging experimental analysis is performed and the results reported the supremacy of the proposed model.

关键词： Lung cancer feature selection ant lion optimization classification disease diagnosis metaheuristics

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status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Non-invasive sensing techniques to phenotype multiple apple tree architectures

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Information Processing in Agriculture 2023年第1期10卷 136-147页

作者： chongyuan Zhang sara serra Juan Quiro´s-Vargas Worasit sangjan stefano Musacchi sindhuja sankaran Department of Biological systems Engineering Washington State UniversityPullmanWA 99164USA Tree Fruit Research&Extension center Washington State UniversityWenatcheeWA 98801USA Department of Horticulture Washington State UniversityPullmanWA 99164USA

Tree fruit architecture results from combination of the training system and pruning and thinning processes across multiple growth and development ***,the tree fruit architecture contributes to the light interception and improves tree growth,fruit quality,and fruit yield,in addition to easing the process of orchard management and *** tree architectural traits are measured manually by researchers or growers,which is labor-intensive and *** this study,the remote sensing techniques were evaluated to phenotype critical architectural traits with the final goal to assist tree fruit breeders,physiologists and growers in collecting architectural traits efficiently and in a standardized *** this,a consumer-grade red–green–blue(RGB)camera was used to collect apple tree side-images,while an unmanned aerial vehicle(UAV)integrated RGB camera was programmed to image tree canopy at 15 m above ground level to evaluate multiple tree fruit *** sensing data were compared to ground reference data associated with tree orchard blocks within three training systems(spindle,V-trellis,Biaxis),two rootstocks(‘WA 38 trees grafted on G41 and M9-Nic29)and two pruning methods(referred as bending and click pruning).The data were processed to extract architectural features from ground-based 2D images and UAV-based 3D digital surface *** traits extracted from sensing data included box-counting fractal dimension(DBs),middle branch angle,number of branches,trunk basal diameter,and tree row volume(TRV).The results from ground-based sensing data indicated that there was a significant(Pce in DBs between spindle and V-trellis training systems,and correlations between DBs with tree height(r=0.79)and total fruit yield per unit area(r=0.74)were significant(Pcorrelations between average or total TRV and ground reference data,such as tree height and total fruit yield per unit area,were significant(P<0.05).With the r

关键词： Tree training systems Tree row volume Unmanned aerial vehicle Image analysis

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A network based efficient drug repurposing strategy for targeting diabesity

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Genes & Diseases 2023年第2期10卷 340-343页

作者： subhajit Dutta Ted Natoli Deep chanda sindhuja Rajavelu Debojyoti De Laboratory of cellular Differentiation & Metabolic Disorder Department of BiotechnologyNational Institute of TechnologyDurgapurWest Bengal 713209India cancer Program Broad Institute of MIT and HarvardCambridgeMA 02142USA

Type II diabetes and obesity are two of the most prevalent metabolic disorders effecting a huge population throughout the world. Research over the last decade has unequivocally established considerable molecular links between them and hence they are often described in conjugation as ‘diabesity’. The hallmarks of type II diabetes are primarily reduced insulin sensitivity, progressive insulin resistance and consequent hyperinsulinemia.1 Whereas, hyperinsulinemia promotes a plethora of fat synthesis from excess circulating carbohydrate and hyperactive fat storage mechanisms, ultimately inducing hepatic steatosis, myosteatosis and pancreatic steatosis.1 This in turn, aggravates the insulin sensitivity further, inflicting more insulin resistance and even more hyperinsulinemia. Needless to mention that the vicious process in turn, promotes uncontrolled weight gain1 and many secondary metabolic disorders. The prevalent anti-diabetic and anti-obesity medications comes with several limitations ranging from inefficiency to adverse side effects.2 Here, we report an efficient strategy of repositioning previously approved drugs with novel indication in the context of diabesity by investigating deregulated signalling axes affecting patients with both the disorders. Our approach relies extensively on deciphering the strength of gene association in various interactomes, as it is known that within networks, genes linked to similar disease phenotypes tend to be functionally similar3 and remain proximal to each other.4 Moreover, the potential drug targets associated to a disease pathway also cluster proximal to the disease pathways.

关键词： hence primarily network

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Generalized Linear Model with Elastic Net Regularization and convolutional Neural Network for Evaluating Aphanomyces Root Rot severity in Lentil

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Plant Phenomics 2020年第1期2卷 378-388页

作者： Afef Marzougui Yu Ma Rebecca J.McGee Lav R.Khot sindhuja sankaran Department of Biological systems Engineering Washington State UniversityPullmanWAUSA Department of Horticulture Washington State UniversityPullmanWAUSA United states Department of Agriculture-Agricultural Research service Grain Legume Genetics and Physiology Research UnitWashington State UniversityPullmanWAUSA

Phenomics technologies allow quantitative assessment of phenotypes across a larger number of plant genotypes compared to traditional phenotyping *** utilization of such technologies has enabled the generation of multidimensional plant traits creating big ***,to harness the power of phenomics technologies,more sophisticated data analysis methods are *** this study,Aphanomyces root rot(ARR)resistance in 547 lentil accessions and lines was evaluated using Red-Green-Blue(RGB)images of *** created a dataset of 6,460 root images that were annotated by a plant breeder based on the disease *** approaches,generalized linear model with elastic net regularization(EN)and convolutional neural network(cNN),were developed to classify disease resistance categories into three classes:resistant,partially resistant,and *** results indicated that the selected image features using EN models were able to classify three disease categories with an accuracy of up to 0:91±0:004(0:96±0:005 resistant,0:82±0:009 partially resistant,and 0:92±0:007 susceptible)compared to cNN with an accuracy of about 0:84±0:009(0:96±0:008 resistant,0:68±0:026 partially resistant,and 0:83±0:015 susceptible).The resistant class was accurately detected using both classification ***,partially resistant class was challenging to detect as the features(data)of the partially resistant class often overlapped with those of resistant and susceptible ***,the findings provided insights on the use of phenomics techniques and machine learning approaches to provide quantitative measures of ARR resistance in lentil.

关键词： classify Elastic roots

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged fromcells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBAsE,Ovid MEDLINE,Web of science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(sIRT1/P Gc-1α),sIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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