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Facilitating prelithiation of silicon carbon anode by localized high-concentration electrolyte for high-rate and long-cycle lithium storage

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carbon Energy 2024年第6期6卷 216-233页

作者： Yuanxing Zhang Borong wu Jiaying Bi Xinyu Zhang Daobin mu Xin-Yu Zhang Ling Zhang Yao Xiao Feng wu School of materials Science and Engineering Beijing Institute of TechnologyBeijingChina chongqing Innovation center Beijing Institute of TechnologyChongqingChina college of New Energy Xi′an Shiyou UniversityXi′anChina Institute for carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina Key Laboratory of Advanced Energy materials chemistry(ministry of Education) Nankai UniversityTianjinChina

The commercialization of silicon-based anodes is affected by their low initial coulombic efficiency(IcE)and capacity decay,which are attributed to the formation of an unstable solid electrolyte interface(SEI)***,a feasible and cost-effective prelithiation method under a localized highconcentration electrolyte system(LHcE)for the silicon-silica/graphite(Si-SiO_(2)/c@G)anode is designed for stabilizing the SEI layer and enhancing the *** thin SiO_(2)/c layers with-NH_(2) groups covered on nano-Si surfaces are demonstrated to be beneficial to the prelithiation process by density functional theory calculations and electrochemical *** SEI formed under LHcE is proven to be rich in ionic conductivity,inorganic substances,and flexible organic ***,faster Li+transportation across the SEI further enhances the prelithiation effect and the rate performance of Si-SiO_(2)/c@G *** also leads to uniform decomposition and high stability of the SEI with abundant organic *** a result,the prepared anode shows a high reversible specific capacity of 937.5 mAh g^(-1)after 400 cycles at a current density of 1 *** 811‖Li-SSGLHcE full cell achieves a high-capacity retention of 126.15 mAh g^(-1)at 1 c over 750 cycles with 84.82%IcE,indicating the great value of this strategy for Si-based anodes in large-scale applications.

关键词： localized high-concentration electrolytes prelithiation SEI layer silicon anode

carbene-catalyzed enantioselective seleno-michael addition as access to antimicrobial active Se-containing heterocycles

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Science china chemistry 2024年第7期67卷 2199-2205页

作者： Hongyan Long Sha Zhao chunyan Jian Xiuli wu Fengfei Lu minghong Liao Fengrui che Xingxing wu Yonggui Robin chi State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Organoseleniums exhibit a diverse set of biological activities that are pivotal for drug discovery and are widely explored in synthetic chemistry and material *** many transformations have been developed for non-enantioselective c–Se bond formations,the catalyst-controlled stereoselective preparation of chiral organoseleniums continues to be of considerable *** particular,there are limited studies on the enantioselective seleno-michael addition reactions to access chiral selenium functional ***,we disclose a carbene-catalyzed highly enantioselective nucleophilic c–Se bond construction through formal[3+3]annulations between selenocarboxamides and bromoenals,affording seleno-thiazinone products with good yields and excellent *** choice of a weak inorganic base was pivotal to suppressing the unproductive racemization and decomposition of the selenium ***,the catalytically generated chiral selenium-containing heterocyclic products feature remarkable antimicrobial activities that could serve as promising lead scaffolds for further agrochemical development.

关键词： seleno-michael addition organocatalysis N-heterocyclic carbene seleno-heterocycles antimicrobial activity

correction of a cADASIL point mutation using adenine base editors in hiPscsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan wu Jinni wu Xinyao Zhou Xiaolin chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi Xueqing wu Junjiu Huang mOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China center of Reproductive medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cADASIL) is a monogenic small vessel disease caused by mutations in the NOTcH3 gene. However, the pathogenesis of cADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPScs) generated from the peripheral blood mononuclear cells of a patient with cADASIL carrying a heterozygous NOTcH3 mutation (c.1261c>T, p.R421c) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTcH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSmcs) differentiated from cADASIL hiPScs show NOTcH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSc-derived VSmcs. Furthermore, cADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. collectively, we present potential genetic therapeutic strategies for patients with cADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： cADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain

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Rare metals 2024年第7期43卷 3370-3382页

作者： min Zhou Hong-Hui wu Yuan wu Hui Wang Xiong-Jun Liu Sui-He Jiang Xiao-Bin Zhang Zhao-Ping Lu Beijing Advanced Innovation center for materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083Cnina Institute for carbon Neutrality University of Science and TechnologyBeijing 100083China Institute of materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Ab st ra ct Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary(GB) ***,this high-density characteristic induces grain coarsening at elevated temperatures,thereby limiting the widespread application of nanocrystalline *** experimental observations revealed that GB segregation and second-phase pinning effectively hinder GB migration,thereby improving the stability of nanocry stalline *** this study,a mouified phase-field model that integrates mismatch strain,solute segregation and precipitation was developed to evaluate the influence of lattice misfit on the thermal stability of nanocrystalline *** simulation results indicated that introducing a suitable mismatch strain can effectively enhance the microstructural stability of nanocrystalline *** synergizing precipitation with an appropriate lattice misfit,the formation of second-phase particles in the bulk grains can be suppressed,thereby facilitating solute segregation/precipitation at the *** concentrated solute segregation and precipitation at the GBs effectively hinders grain migration,thereby preventing grain *** findings provide a new perspective on the design and regulation of nanocrystalline alloys with enhanced thermal stability.

关键词： Phase field model mismatch strain Second-phase precipitation Grain boundary segregation Nanocrystalline alloys

Radiative decays D*(s)→ D(s)γ in covariant confined quark model

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chinese Physics c 2024年第2期48卷 45-56页

作者： c.T.Tran m.A.Ivanov P.Santorelli Q.c.Vo Department of Physics HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisica"E.Pancini" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisica Nucleare Sezione di Napoli80126 NapoliItaly University of Science 700000 Ho Chi Minh CityVietnam

Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative couplings gD*Dγencoding nonperturbative QcD effects are calculated in the framework of the covariant confined quark model developed by *** compare our results with other theoretical studies and experimental *** couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light-cone sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattice QcD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QcD sum rules.

关键词： covariant quark model radiative decay charmed meson

Transition-metal-Free Allylic Defluorination cross-Electrophile coupling Employing Rongalite

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chinese Journal of chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-Long chen chun-Yan wu Dong-Sheng Yang Bo-cheng Tang Huai-Yu Wang Zhi-cheng Yu Anling Li Yan-Dong wu An-Xin wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

comprehensive Summary The conversion of cF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer c-c coupling Redox reactions cross-coupling

magnesium oxide(mgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.c.S.Perera V.Gurunanthanan Anoop Singh m.m.m.G.P.G.mantilaka G.Das Sandeep Arya Department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(mgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of mgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of mgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of mgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of mgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for mgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of mgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to mgO ***,there is a need to investigate the use of mgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： mgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption Synthesis methods

Early Growth Response Gene-1 Deficiency Interrupts TGFβ1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis mice

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Neuroscience Bulletin 2024年第3期40卷 283-292页

作者： Yunyi Lan Xinyan Han Fei Huang Hailian Shi Hui wu Liu Yang Zhibi Hu Xiaojun wu Shanghai Key Laboratory of compound chinese medicines The Ministry of Education Key Laboratory for Standardization of Chinese MedicinesThe State Administration of TCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai201203China central Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200021China

Early growth response protein 1(Egr-1)triggers the transcription of many genes involved in cell growth,differentiation,synaptic plasticity,and ***,its mechanism in neuronal survival and degeneration is still poorly *** study demonstrated that Egr-1 was down-regulated at mRNA and protein levels in the central nervous system(cNS)of experimental autoimmune encephalomyelitis(EAE)***-1 knockout exacerbated EAE progression in mice,as shown by increased disease severity and incidence;it also aggravated neuronal apoptosis,which was associated with weakened activation of the BDNF/TGFβ1/mAPK/Akt signaling pathways in the cNS of EAE ***,Egr-1 siRNA promoted apoptosis but mitigated the activation of BDNF/TGFβ1/mAPK/Akt signaling in SH-SY5Y *** results revealed that Egr-1 is a crucial regulator of neuronal survival in EAE by regulating TGFβ1-mediated signaling activation,implicating the important role of Egr-1 in the pathogenesis of multiple sclerosis as a potential novel therapy target.

关键词： Early growth response protein 1 Transforming growth factor-beta 1 multiple sclerosis Experimental autoimmune encephalomyelitis Neurodegeneration

Laser-induced graphene-coated wearable smart textile electrodes for biopotentials signal monitoring

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Frontiers of materials Science 2024年第1期18卷 95-111页

作者： c.m.Vidhya Yogita maithani Sakshi Kapoor J.P.Singh Department of Physics Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper describes how to produce a wearable dry electrode at a reasonable cost and how to use it for the monitoring of biopotentials in *** textiles in wearable technologies have made a great advancement in the health care management and living standards of *** was manufactured using the low-cost single-step process,laser ablation of polyimide,a commercial *** dispersions were made using solvent isopropyl alcohol which has low boiling point,nontoxicity,and environmental *** successive coating of the graphene dispersion on the cotton fabric to make it conductive,the sheet resistance of the resulting fabric dropped to 3% of its initial *** laser-induced graphene(LIG)cotton dry electrodes thus manufactured are comparable to Ag/Agcl wet electrodes in terms of the skin-to-electrode impedance,measuring between 78.0 and 7.2 kΩ for the frequency between 40 Hz and 1 *** LIG cotton electrode displayed a signal-to-noise ratio of 20.17 *** to its comfort,simplicity,and good performance over a longer period of time,the textile electrode appears suited for medical applications.

关键词： biopotential electrocardiogram electromyogram flexible electrode textile porous graphene