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Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.L.Gan Boyu Wang c.m.chan A.U.Weerasuriya Jack c.P.cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(cFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses cFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(AcH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the AcH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting AcH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

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肾病综合征表现的局灶性节段性肾小球硬化的远期预后分析(英文)

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中南大学学报（医学版） 2007年第6期32卷 931-937页

作者： James c.m.chan college of medicine University of VermontThe Barbara Bush Children's HospitalMaine Medical CenterPortlandMaine 04102-3175USA

本文将针对25年来治疗局灶性节段性肾小球硬化的一项区域性儿童肾脏病协作计划进行系统回顾。所有患儿经肾穿刺诊断为局灶性节段性肾小球硬化,其中大部分为美国黑人患儿,与之前报道的患同样疾病以白人为主体的患儿比较,他们的临床特点... 详细信息

本文将针对25年来治疗局灶性节段性肾小球硬化的一项区域性儿童肾脏病协作计划进行系统回顾。所有患儿经肾穿刺诊断为局灶性节段性肾小球硬化,其中大部分为美国黑人患儿,与之前报道的患同样疾病以白人为主体的患儿比较,他们的临床特点和远期预后均有不同。由于亚洲和非洲的肾病患儿局灶性节段性肾小球硬化的发生率均较高,因此中国患儿可能在疾病的临床特征、对治疗的反应和远期预后等方面与本文所讨论的美国黑人患儿类似。

关键词：局灶性节段性肾小球硬化肾病综合征肾小球硬化指数综合疗法远期预后美国黑人

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A cooperative Autonomous mechatronic System for Fault Tolerant control of material Handling Operations

A Cooperative Autonomous Mechatronic System for Fault Tolera...

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第11届粤港机械电子工程技术与应用研讨会

作者： Raymond c.m.chan Henry Y.K.Lau Department of Industrial and manufacturing Systems Engineering The University of Hong Kong Pokfulam Road Hong KongPRC

＜正＞Sustainable control of a cooperative autonomous mechatronic system is a challenging undertaking and it is one of the focuses which many researchers have been working on for *** this paper,we introduce the design of an immune-inspired decentralized sustainability control methodology for cooperative autonomous mechatronic system such as multi-agent systems （mAS） to optimize the overall performance in terns of longevity through the trade-off between maintenance activity and task *** resulting system will have favorable characteristics of good fault tolerant as well as task achievement.A design of a multi-robot system that is amenable for the experimentation of the proposed methodology is presented together with a simulation platform for investigating its performance.

关键词： multi-agent system artificial immune systems robotic control

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进行性肾脏疾病和梗阻性肾病——临床研究概述

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中华儿科杂志 2005年第6期43卷 406-409页

作者： James c.m.chan Jonathan I.Scheinman Karl S.Roth 管娜范青锋丁洁缅因州医学中心Babara Bush儿童医院研究中心美国堪萨斯大学小儿肾脏病科美国内布拉斯加州creighton大学医学院儿科

近年来，随着分子生物学技术的应用，我们对梗阻性肾病的认识取得了很大进展。目前，对肾脏形态发生的调节机制，不同因素对胚肾发育和功能的影响，以及梗阻对肾脏产生的多方面的影响已经有了较为深入的理解。许多关于梗阻性肾病的理论... 详细信息

近年来，随着分子生物学技术的应用，我们对梗阻性肾病的认识取得了很大进展。目前，对肾脏形态发生的调节机制，不同因素对胚肾发育和功能的影响，以及梗阻对肾脏产生的多方面的影响已经有了较为深入的理解。许多关于梗阻性肾病的理论有待于从细胞培养和动物模型的研究转化为对先天性泌尿道梗阻患者的临床研究。

关键词：梗阻性肾病研究概述肾脏疾病进行性分子生物学技术泌尿道梗阻调节机制形态发生临床研究动物模型肾发育先天性

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香港律师会的工作重点、计划和展望

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中国法律（中英文版） 2021年第5期 64-66,151-154页

作者：陈泽铭中国香港律师会

一、法治:香港地区律师坚守的信念中国香港律师会是香港地区律师的自我监管组织及专业团体,在香港地区法例第159章《法律执业者条例》下具有法定权力规管律师行及律师执业操守,并致力推广和维护法治环境。

关键词：法定权力法治环境自我监管香港法例律师条例

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Detection of Breaking Waves Using X-Band Pulse Radar in the Nearshore Region

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china Ocean Engineering 2013年第4期27卷 549-556页

作者： Y.c.Lin c.c.chang m.c.Lee H.c.chan J.m.Leu Department of Hydraulic and Ocean Engineering National Cheng-Kung University Department of Soil and Water conservation National Chung Hsing University Department of Hospitality management Taiwan Shoufu University

An X-band pulsed Doppler microwave radar has been used to determine the characteristics of breaking waves. Field experiments were conducted at the Shuang-Si estuary in the north of Taiwan in the winter of 2005. Analyses on maxima radar cross section and Doppler frequency shift are done to characterize wave breaking zones. Based on observations of breaking waves, the wave breaking zones are shown to be located at water depths of 1.8 to 2.2 m in the experimental site. In general, the results indicate that a radar system has the potential to delineate the spatial variation of breaking waves clearly and that this is sufficient to achieve a measurement operation for near-shore air-sea interaction events.

关键词： radar Doppler effect wave breaking coastal zone

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Differential signaling of Flt3 activating mutations in acute myeloid leukemia:a working model

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Protein & cell 2011年第2期2卷 108-115页

作者： Perry m.chan Neuroscience Research Partnership Biomedical Sciences Instituteaffiliated with Institute of Molecular and Cell BiologyASTARSingapore 138673Singapore

Receptor tyrosine kinases couple a wide variety of extracellular cues to cellular *** class III subfamily comprises the platelet-derived growth factor receptor,c-Kit,Flt3 and c-Fms,all of which relay cell proliferation signals upon ligand ***,mutations in these proteins that confer ligand-independent activation are found in a subset of *** mutations cluster in the juxtamembrane(Jm)and catalytic tyrosine kinase domain(TKD)*** the case of acute myeloid leukemia(AmL),the juxtamembrane(named ITD for internal tandem duplication)and TKD Flt3 mutants differ in their spectra of clinical *** the mechanism of aberrant activation has been largely elucidated by biochemical and structural analyses of mutant kinases,the differences in disease presentation cannot be attributed to a change in substrate specificity or signaling strength of the catalytic *** review discusses the latest literature and presents a working model of differential Flt3 signaling based on mis-localized juxtamembrane autophosphorylation,to account for the disease *** will have bearing on therapeutic approaches in a complex disease such as AmL,for which no efficacious drug yet exists.

关键词： acute myeloid leukemia receptor tyrosine kinase oncogenic mutation autoinhibition intracellular traf-ficking

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Assessment of cOVID-19 aerosol transmission in a university campus food environment using a numerical method

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Geoscience Frontiers 2022年第6期13卷 265-278页

作者： m.Zhao c.Zhou T.chan c.Tu Y.Liu m.Yu Laboratory of Aerosol Science and Technology China Jiliang UniversityHangzhouChina Department of mechanical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina college of modern Science China Jiliang UniversityHangzhouChina

With the prevalence of cOVID-19,the phenomenon of viruses spreading through aerosols has become a focus of *** in university dining halls have a high risk of exposure to respiratory droplets from others without the protection of face masks,which greatly increases the risk of cOVID-19 ***,the transmission mechanism of respiratory droplets in extremely crowded dining environments should be *** this study,a numerical simulation of coughing at dining tables under two conditions was performed,namely the presence and absence of protective partitions,and the evaporation and condensation of aerosol droplets in the air were *** using the numerical method,we analyzed and verified the isolation effect of dining table partitions in the propagation of aerosol *** effect of changes in room temperature on the diffusion of coughed aerosols when partitions were present was *** demonstrated how respiratory droplets spread through coughing and how these droplets affect ***,we proposed a design for a dining table partition that minimizes the transmission of cOVID-19.

关键词： cOVID-19 transmission University dining hall cough Table partition computational fluid dynamics

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Laser Surface modification of Lean-alloyed Austenitic Stainless Steel for corrosion Resistance

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腐蚀与防护 2012年第S1期33卷 55-61页

作者： chan W K Kwok c T chan m c Lo K H University of macao Av.Padre Tomás Pereira Taipa macao China

In order to reduce the cost of the austenitic stainless steels(ASSs),the expensive austenite former(nickel) is often substituted by ***,manganese is generally seen to have a detrimental effect on the corrosion *** the present study,the feasibility of laser surface modification of a lean-alloyed ASS(Fecrmn) for enhancing pitting corrosion resistance was *** surface modification of Fecrmn was successfully achieved by a 2.3 kW high power diode laser(HPDL).cyclic polarization tests for Fecrmn after laser surface modification in 3.5% Nacl solution at 25 ℃ were performed by using a *** pitting resistance of the laser-modified specimens was found to be significantly improved as reflected by the noble shift in pitting *** could be attributed to redistribution of manganese sulphide leading to a more homogenous and refined *** corrosion resistance of the laser-treated Fecrmn followed by subsequent citric acid passivation was found to be further improved as reflected by the noble shift in pitting potential to 0.18 V.

关键词： laser surface melting HPDL lean-alloyed austenite stainless steel pitting corrosion citric acid passivation

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Principles of Nanoparticle Delivery to Solid Tumors

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Biomedical Engineering Frontiers 2023年第1期4卷 177-186页

作者： Warren c.W.chan Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada.Terrence Donnelly Center for Cellular&Biomolecular ResearchUniversity of TorontoTorontoON M53E1Canada.Department of ChemistryUniversity of TorontoTorontoON M5S 3H6Canada

The effective treatment of patients with cancer hinges on the delivery of therapeutics to a tumor *** provide an essential transport *** present 5 principles to consider when designing nanoparticles for cancer targeting:(a)Nanoparticles acquire biological identity in vivo,(b)organs compete for nanoparticles in circulation,(c)nanoparticles must enter solid tumors to target tumor components,(d)nanoparticles must navigate the tumor microenvironment for cellular or organelle targeting,and(e)size,shape,surface chemistry,and other physicochemical properties of nanoparticles influence their transport process to the *** review article describes these principles and their application for engineering nanoparticle delivery systems to carry therapeutics to tumors or other disease targets.

关键词： organs cancer carry

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