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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Topographic Influence on Wetland Distribution and change in Maduo county, Qinghai-Tibet Plateau, china

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Journal of Mountain Science 2012年第3期9卷 362-371页

作者： Jay GAO lI Xilai Gary brierley School of Environment University of Auckland lo Symonds Street Auckland New Zealand college of Agriculture andAnimal Husbandry Qinghai University Xining 810016 China

Accurate information on the spatial distribution and temporal change of wetlands is vital to devise effective measures for their protection. This study uses satellite images in 1994 and 2001 to assess the effects of topography and proximity to channels on wetland change in Maduo county on the Qinghai-Tibet Plateau, western china. In 1994 wetlands in the study area extended over 6,780.0 km2. They were distributed widely throughout the county, with a higher concentration in the south, and were especially prominent close to streams. The pattern of wetlands demonstrated a bell-shaped distribution curve with elevation, ranging over hill slopes with gradients from 0-19°, the commonest gradient being around 3°. Although the aspects of these hill slopes range over all directions, there is a lower concentration of wetlands facing east and southeast. The extent of wetlands in 2001 decreased to 6,181.1 km2. Marked spatial differentiation in the pattern of wetlands is evident, as their area increased by 1,193.3 km2 at lower elevations but decreased by 1,792.2 km2 at higher ground, resulting in a net decrease of 598.8 km2. In areas with a gradient 9° the area of wetlands remained approximately consistent from 1994-2001. Newly retained wetlands are situated in relatively flat lowland areas, with no evident preference in terms of aspect. Wetlands on north-, east- and northeast-facing hillslopes with a bearing of 1-86° were more prone to loss of area than other orientations. The altered pattern of wetland distribution from higher to lower elevation on north-facing slopes coincided with the doubling of annual temperature during the same period, suggesting that climate warming could be an important cause.

关键词： Wetland change detection Topographicinfluence Remote Sensing GIS Qinghai-TibetPlateau

Geomorphology and Environmental Management of the Yellow River Source Zone

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Journal of Mountain Science 2013年第4期10卷 628-631页

作者： brierley Gary lI Xi-lai School of Environment University of Auckland Private Bag 92019Auckland New Zealand college of Agriculture and Animal Husbandry Qinghai University

Geologic,climatic and anthropogenic factors have fashioned the distinctive landscapes and ecosystems of the Yellow River source zone(brierley and Huang2013;Figure1).located at thenorth-east corner of the Qinghai-Tibet... 详细信息

关键词：黄河源区环境管理土地利用方式半干旱气候地貌生态系统生物多样性人为因素

Analysis of longitudinal Profiles along the Eastern Margin of the Qinghai-Tibetan Plateau

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Journal of Mountain Science 2013年第4期10卷 643-657页

作者： Simon J. Aiken Gary J. brierley School of Environment the University of AucklandAuckland 1010 New Zealand

Resulting from the collision of the Eurasian and Indian plates, the Qinghai-Tibetan Plateau is commonly known as the ＇roof of the world＇. collectively the Yarlung Tsangpo, Nu, laneang, Yangtze, Yalong, and Yellow River basins drain the eastern margin of the plateau. In this paper, we utilize Shuttle Radar Topography Mission elevation data to examine morphometric and relief attributes of these basins to reveal insights rates of incision. A robust into tectonic activity and technique using Maflab is proposed to alleviate errors associated with SRTM data in the derivation of river longitudinal profiles. convex longitudinal profiles are interpreted to be a product of uplift rates that exceed rates of channel incision along the entire margin of the Qinghai- Tibetan Plateau. Highest relief towards the south reflects extensive fluvial incision. High relief is also prominent along major active faults. Erosion patterns are related to distance from knickpoints. Highest rates of erosion and incision are evident towards the south, with decreasing values towards the north, suggesting a link between tectonic activity and erosion.

关键词： longitudinal profile Erosion Relief Tectonics Qinghai-Tibetan Plateau

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.clayton UK Dementia Research Institute at King’s college london LondonUK Department of Basic and clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDlINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

large shift of the Pacific Walker circulation across the cenozoic

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National Science Review 2021年第5期8卷 48-56页

作者： Qing Yan Robert Korty Zhongshi Zhang chris brierley Xiangyu li Huijun Wang Nansen-Zhu International Research centre Institute of Atmospheric PhysicsChinese Academy of Sciences Key laboratory of Meteorological Disaster Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and Technology Department of Atmospheric Sciences Texas A&M UniversityCollege Station Department of Atmospheric Science School of Environmental StudiesChina University of Geosciences NORcE Research climate Bjerknes Center for Climate Research Department of Geography University College London climate change Research center Chinese Academy of Sciences

Fluctuations in the Pacific Walker circulation(PWc), a zonally oriented overturning cell across the tropical Pacific, can cause widespread climatic and biogeochemical perturbations. It remains unknown how the PWc developed during the cenozoic era, with its substantial changes in greenhouse gases and continental positions. Through a suite of coupled model simulations on tectonic timescales, we demonstrate that the PWc was ～38?broader and ～5% more intense during the Early Eocene relative to present. As the climate cooled from the Early Eocene to the late Miocene, the width of the PWc shrank, accompanied by an increase in intensity that was tied to the enhanced Pacific zonal temperature gradient. However, the locations of the western and eastern branches behave differently from the Early Eocene to the late Miocene,with the western edge remaining steady with time due to the relatively stable geography of the western tropical Pacific; the eastern edge migrates westward with time as the South American continent moves northwest. A transition occurs in the PWc between the late Miocene and late Pliocene, manifested by an eastward shift(both the western and eastern edges migrate eastward by >12?) and weakening(by ～22%),which we show here is linked with the closure of the tropical seaways. Moreover, our results suggest that rising cO2favors a weaker PWc under the same land-sea configurations, a robust feature across the large spread of cenozoic climates considered here, supporting a weakening of the PWc in a warmer future.

关键词： Pacific Walker circulation cenozoic era paleoclimate modeling