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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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溶解有机质N/c比值的分布格局及其对湖泊增温和营养富集的响应

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湖泊科学 2025年第1期37卷 97-111页

作者：陈铭胡盎韩磊王建军湖南农业大学资源学院长沙410128 中国科学院南京地理与湖泊研究所湖泊与流域水安全重点实验室南京211135

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/c等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/c比值,通过Meta分析从宏观角... 详细信息

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/c等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/c比值,通过Meta分析从宏观角度考察全球湖泊、河流、海洋和泥炭地等多生境N/c比值的全球分布情况。结果表明,河流水体、沉积物和污水等生境的N/c均值(分别为0.050±0.062、0.050±0.014和0.083±0.084)均显著高于泥炭地(0.026±0.037);水体N/c比值主要受海拔(即温度)、pH、氨氮和溶解有机碳等显著影响,而泥炭地等陆地N/c比值主要受pH、总溶解有机氮和溶解有机碳的影响。进一步,依托云南老君山海拔梯度开展模拟温度变化和营养富集的微宇宙实验定量解析其影响机制,并根据沉积物DOM分子转换数将总分子划分为高活性和低活性两类,探究总分子及其两类组分的N/c比值对温度和营养富集的响应规律。溶解有机质N/c均值为0.112±0.020,其中高活性分子(0.119±0.017)显著高于低活性分子(0.109±0.034)。总分子N/c比值主要受亚硝酸盐和硝酸盐等营养盐的影响,相对总贡献率为63.43%;高活性分子N/c比值主要受营养盐和能量供应(比如溶解有机碳、总有机碳和叶绿素a等)的影响,而低活性分子N/c比值主要受营养盐的影响。结构方程模型分析表明,营养富集对总分子N/c比值的影响高于温度,主要通过能量供应和营养盐的间接作用而产生影响;对于高活性分子,营养盐主要通过能量供应的间接作用影响N/c比值;而对于低活性分子,主要通过营养盐发挥直接作用。本研究结果首次探讨了全球不同生境N/c比值的分布格局,揭示了沉积物溶解有机质N/c比值对全球变暖和营养富集的响应规律和机制,为更好理解和预测未来全球变化背景下溶解有机碳稳定性提供科学参考。

关键词：溶解有机质氮碳比湖泊沉积物全球变暖富营养化

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Broadband strong optical dichroism in topological Dirac semimetals with Fermi velocity anisotropy

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chinese Physics B 2020年第7期29卷 128-134页

作者： j Lim K j A Ooi c Zhang L K ang Yee Sin ang Science Math and TechnologySingapore University of Technology and DesignSingapore School of Energy and chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia college of chemistry and chemical Engineering Xiamen UniversityXiamen 361005China School of Physics University of WollongongNorthfields AvenueNew South Wales 2522Australia

Prototypical three-dimensional(3D)topological Dirac semimetals(DSMs),such as cd3As2 and Na3Bi,contain electrons that obey a linear momentum-energy dispersion with different Fermi velocities along the three orthogonal momentum *** being extensively studied in recent years,the inherent Fermi velocity anisotropy has often been neglected in the theoretical and numerical studies of 3D *** this omission does not qualitatively alter the physics of light-driven massless quasiparticles in 3D DSMs,it does quantitatively change the optical coefficients which can lead to nontrivial implications in terms of nanophotonics and plasmonics *** we study the linear optical response of 3D DSMs for general Fermi velocity values along each *** the signature conductivity-frequency scaling,σ(ω)∝ω,of 3D Dirac fermion is well-protected from the Fermi velocity anisotropy,the linear optical response exhibits strong linear dichroism as captured by the universal extinction ratio scaling law,Λi j=(vi/v j)^2(where i=j denotes the three spatial coordinates x,y,z,and vi is the i-direction Fermi velocity),which is independent of frequency,temperature,doping,and carrier scattering *** cd3As2 and Na3Bi3,an exceptionally strong extinction ratio larger than 15 and covering a broad terahertz window is *** findings shed new light on the role of Fermi velocity anisotropy in the optical response of Dirac semimetals and open up novel polarization-sensitive functionalities,such as photodetection and light modulation.

关键词： topological Dirac semimetal optical anisotropy linear dichroismn linear response theory

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Tuning the porosity of {co12IIco8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science china chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-ang Nan Qing Li Xiufang Li Zi-Xiu Lu Linzhe Lü jin Liu Luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （cOFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and cOFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[coII1+12coIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=clO?4or cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[coII12coIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[coII12coIII8（μ3-OH）24（clO4）L12)]·（cl）4·（HcO2）7（1）,[coII12coIII8L12（μ3-OH）24（cl）]·（clOI4）4·（cl）6·（HcO2）·（H2O）10（2）,and[coI12coIII8L12（μ3-OH）24（cl）]·（cl）11·（H2O）12（3）.The different stacking patterns of the[coII12coIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Phenotypic nutrient up-take differences in an alley cropping system in semi-arid Machakos, Kenya

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journal of Environmental Sciences 2001年第2期13卷 164-169页

作者： D.N. Mungai c.L.coulson c.j. Stigter j.K. Ng’ang’a D.N.Mugendi Department of Geography University of NairobiNairdbiKenya Department of Botany University of NairobiNairobiKenya Department of Enviromnental Sciences Graduate School of Productian EcologyWageningen UniversityDuivendaal 26701 APThe Netherlands Department of Meteorology University of NairobiNairobiKenya Kenya Forestry Research Instiute(KEFRI NairobiKanya)

Alley cropping of cassia siamea and maize was studied in semi arid Kenya for soil fertility improvement. Katumani composite maize was planted except in the short rains of 1988 (SR88) when a hybrid variety was sown. Therefore the grain yield per row increased differently in the alley cropped maize (cM). Sole maize (SM) and cM yields were higher in SR88 than in the long rains of 1988 (LR88) by 62% and 38%, while yields from the same treatments in LR89 were only 21% and 45% of those in SR88 These differences in relative maize yields are attributed to differences between the two maize varieties in competition under nutrient stress conditions.

关键词： alley cropping cassia siamea maize nutrients maize yield semi arid condition soil moisture Kenya

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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数字经济、创新能力与经济高质量发展

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江苏商论 2025年第1期 22-27,36页

作者：臧守芳盐城师范学院数学与统计学院盐城数字经济研究院数字金融研究所江苏盐城224002

当前,中国经济已经由高速发展转向高质量发展,数字经济作为经济发展的新动能,正成为推动经济高质量发展的重要引擎。文章基于2011—2019年省级面板数据,通过构建综合评价指标体系,利用固定效应模型,从创新视角出发,探究数字经济影响高... 详细信息

当前,中国经济已经由高速发展转向高质量发展,数字经济作为经济发展的新动能,正成为推动经济高质量发展的重要引擎。文章基于2011—2019年省级面板数据,通过构建综合评价指标体系,利用固定效应模型,从创新视角出发,探究数字经济影响高质量发展的内在机制。结果表明,数字经济有效推动了经济高质量发展;创新能力在其中发挥了正向调节作用。这种影响作用存在区域异质性,中西部地区相较于东部地区更为明显。因此,文章提出了加强科技创新,持续推进数字产业化和产业数字化建设,施行差异化数字转型策略,并加强风险防范的建议。

关键词：创新能力数字经济高质量发展

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Motor skills matter to physical activity——At least for children

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journal of Sport and Health Science 2013年第1期2卷 58-59页

作者： ang chen Department of Kinesiology University of North Carolina at GreensboroGreensboroNC 27412USA

Physical activity(PA) is an effective means of curbing the prevalence of child obesity,and fundamental skills are hypothesized to be an important factor that determines physically active or inactive behavior in *** evidence suggests that adolescents and young adults with proficient motor skills in sport-related activities are more likely to have a physically active lifestyle.1 Because

关键词：学龄前儿童运动体力预测能力生活方式成年人患病率肥胖症

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Exercise facilitates memory:Implications for helping youngsters learn in school

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journal of Sport and Health Science 2012年第1期1卷 5-6页

作者： ang chen Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNorth Carolina 27412USA

Up to this day I still can vividly remember a routine in my elementary school:the daily school-wide morning calisthenics. It started at about 7:45 am in the school *** physical education teacher stood on the concrete stage where our principal would give her talk at school *** children and teachers would follow the teacher’s lead to do the eight-segment national calisthenics in unison with loud music from loudspeakers affixed on trees around the *** I visited the school last May,I saw that students still performed the routine faithfully but with a different set of

关键词： helping routine remember morning visited elementar

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