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高血压和动脉粥样硬化与脑卒中和冠心病发作:流行病学及治疗

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新疆医科大学学报 1983年第1期 22-24页

作者： Donald c.harrison 何秉贤美国斯坦福大学医学院心脏科主任美国心脏病学会主席教授

***教授是美国斯坦福大学医学院心脏科主任,现任美国心脏病学会主席,应中华医学会新疆分会的邀请来乌鲁木齐,于1982年8月23日上午在新疆医学院作了本题目的学术报告。内容有:(1)美国心血管疾病的变化情况;(2)脑卒中和心肌梗塞的危险因素... 详细信息

***教授是美国斯坦福大学医学院心脏科主任,现任美国心脏病学会主席,应中华医学会新疆分会的邀请来乌鲁木齐,于1982年8月23日上午在新疆医学院作了本题目的学术报告。内容有:(1)美国心血管疾病的变化情况;(2)脑卒中和心肌梗塞的危险因素;(3)动脉粥样硬化的病因;(4)高血压病的治疗。

关键词：冠心病冠状动脉病脑卒中心肌梗塞动脉粥样硬化动脉硬化高血压冠心病发病率阻滞剂森林阻火剂

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抗心律失常药物的现代分类方法

药学研究 1986年第3期 35-36页

作者： Donald c.harrison 吕松风

在过去的二十年里所提出的抗心律失常药物的几种分类方法,都是基于它们的化学结构、细胞内及在完整心脏内的电生理性质而划分的。而其中大多数并无助于药物的使用,相反却在临床医师和研究者之间引起了激烈的争论。将抗心律失常药物分类... 详细信息

在过去的二十年里所提出的抗心律失常药物的几种分类方法,都是基于它们的化学结构、细胞内及在完整心脏内的电生理性质而划分的。而其中大多数并无助于药物的使用,相反却在临床医师和研究者之间引起了激烈的争论。将抗心律失常药物分类只是在近几来才变得必要了。在三十和四十年代,奎尼丁这个唯一用于临床的药物被用来防止风湿性心

关键词：抗心律失常药物细胞内复极极期抗心律失常药不应性电生理学家分类方法归类法

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骨折检测中的人工智能：系统评价和荟萃分析

国际医学放射学杂志 2022年第5期 600-600页

作者： R.Y.L.Kuo c.harrison T.A.curran B.Jones A.Freethy D.cussons 刘玲玲

摘要急诊中常见的骨折病人在影像学检查中可能被误诊，越来越多的研究将人工智能（AI）技术应用于骨折检测，并作为临床医生诊断的辅助手段。目的采用系统评价和荟

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植物凝集素类受体激酶研究进展

热带亚热带植物学报 2024年

作者：熊圭 John Seymour HESLOP-harrison 刘青植物多样性与特色经济作物全国重点实验室广东省应用植物学重点实验室中国科学院华南植物园华南国家植物园中国科学院大学莱斯特大学遗传学和基因组生物学系

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和c型，凝集素类受体激酶参与... 详细信息

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和c型，凝集素类受体激酶参与植物的生长发育和环境响应调控。该文总结凝集素类受体激酶的研究历史、结构和分类，阐述植物LecRLKs的发育调控和胁迫响应功能，对功能明确的LecRLKs基因进行归类。提出凝集素类受体激酶研究中存在的不足之处，包括该家族演化历史研究极其缺乏、信号传导途径及其潜在配体亟待开展等方面。在此基础上，提出未来深入研究的方向，以期为植物凝集素类受体激酶基因家族的定向育种提供理论支持。

关键词：凝集素类受体蛋白激酶生长发育生物/非生物胁迫免疫

应用3.0 T脂肪和血液抑制序列的臂丛神经MR研究

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国际医学放射学杂志 2017年第4期 467-467页

作者： X.Z.Wang c.harrison Y.K.Mariappan K.Gopalakrishnan A.chhabra R.E.Lenkinski 张伶 Department of Radiology UT Southwestern Medical Center

摘要目的为了增强神经的显示,在临床允许的采集时间内,利用3.0 T稳态脂肪和血液抑制技术,开展和评估臂丛神经的MR神经成像。材料与方法该前瞻性研究符合HIPAA,获得伦理委员会批准,签署知情同意书。在相同的参数下使用部分回波联合相位...

摘要目的为了增强神经的显示,在临床允许的采集时间内,利用3.0 T稳态脂肪和血液抑制技术,开展和评估臂丛神经的MR神经成像。材料与方法该前瞻性研究符合HIPAA,获得伦理委员会批准,签署知情同意书。在相同的参数下使用部分回波联合相位保留的改良同步重建技术,采用改良低聚焦翻转角3D快速自旋回波序列(TSE)同时获得化学位移(Dixon)重建需要的同相位和反相位回波。该多回波TSE改良Dixon序列(mDixon)采用了模拟研究和对3名健

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Profiling elite male 100-m sprint performance:The role of maximum velocity and relative acceleration

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Journal of Sport and Health Science 2022年第1期11卷 75-84页

作者： Robin Healy Ian c.Kenny Andrew J.harrison Department of Physical Education and Sport Sciences University of LimerickV94 T9PXIreland Department of Sport and Health Sciences Athlone Institute of TechnologyN37 HD68Ireland Health Research Institute University of LimerickLimerickV94 T9PXIreland

Purpose:This study aimed to determine the accuracy of a 4 split time modelling method to generate velocity-time and velocity-distance variables in elite male 100-m sprinters and subsequently to assess the roles of key sprint parameters with respect to 100-m sprint ***,this study aimed to assess the differences between faster and slower sprinters in key sprint variables that have not been assessed in previous ***:Velocity-time and velocity-distance curves were generated using a mono-exponential function from 4 split times for 82 male sprinters during major athletics *** race variables-maximum velocity,the acceleration time constant(τ),and percentage of velocity lost(vLoss)-were derived for each *** were divided into tertiles,based on 100-m time,with the first and third tertiles considered to be the faster and slower groups,respectively,to facilitate further ***:Modelled split times and velocities displayed excellent accuracy and close agreement with raw measures(range of mean bias was-0.2%to 0.2%,and range of intraclass correlation coefficients(Iccs)was 0.935 to 0.999)except for 10-m time(mean bias was 1.6%±1.3%,and the Icc was 0.600).The 100-m sprint performance time and all 20-m split times had a significant near-perfect negative correlation with maximum velocity(r≥-0.90)except for the 0 to 20-m split time,where a significantly large negative correlation was found(r=-0.57).The faster group had a significantly higher maximum velocity andτ(pcant difference was found for vLoss(p=0.085).conclusion:coaches and researchers are encouraged to utilize the 4 split time method proposed in the current study to assess several key race variables that describe a sprinter’s performance capacities,which can be subsequently used to further inform training.

关键词： Deceleration Modelling Race phases Reaction time Split times

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Role of alcohol in the regulation of iron metabolism

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World Journal of Gastroenterology 2007年第37期13卷 4924-4930页

作者： Duygu Dee harrison-Findik Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE 681985820 United States

Patients with alcoholic liver disease frequently exhibit increased body iron stores, as reflected by elevated serum iron indices (transferrin saturation, ferritin) and hepatic iron concentration. Even mild to moderate alcohol consumption has been shown to increase the prevalence of iron overload. Moreover, increased hepatic iron content is associated with greater mortality from alcoholic cirrhosis, suggesting a pathogenic role for iron in alcoholic liver disease. Alcohol increases the severity of disease in patients with genetic hemochromatosis, an iron overload disorder common in the caucasian population. Both iron and alcohol individually cause oxidative stress and lipid peroxidation, which culminates in liver injury. Despite these observations, the underlying mechanisms of iron accumulation and the source of the excess iron observed in alcoholic liver disease remain unclear. Over the last decade, several novel iron-regulatory proteins have been identified and these have greatly enhanced our understanding of iron metabolism. For example, hepcidin, a circulatory antimicrobial peptide synthesized by the hepatocytes of the liver is now known to play a central role in the regulation of iron homeostasis. This review attempts to describe the interaction of alcohol and iron-regulatory molecules. Understanding these molecular mechanisms is of considerable clinical importance because both alcoholic liver disease and genetic hemochromatosis are common diseases, in which alcohol and iron appear to act synergistically to cause liver injury.

关键词： Alcoholic liver disease c/EBP alpha Divalentmetal transporter 1 Ferroportin Hepcidin

Reliability-based design in rock engineering: Application of Bayesian regression methods to rock strength data

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 612-627页

作者： Nezam Bozorgzadeh John P.harrison Department of civil Engineering GeoEngineering Centre at Queen’s-RMC(Royal Military College of Canada)KingstonCanada Department of civil and Mineral Engineering University of TorontoTorontoCanada

Reliability-based design (RBD) is being adopted by geotechnical design codes worldwide, and it is therefore necessary that rock engineering practice evolves to embrace RBD. This paper examines the Hoek-Brown (H-B) strength criterion within the RBD framework, and presents three distinct analyses using a Bayesian approach. Firstly, a compilation of intact compressive strength test data for six rock types is used to examine uncertainty and variability in the estimated H-B parameters m and σc, and corresponding predicted axial strength. The results suggest that within- and between-rock type variabilities are so large that these parameters need to be determined from rock testing campaigns, rather than reference values being used. The second analysis uses an extensive set of compressive and tensile (both direct and indirect) strength data for a granodiorite, together with a new Bayesian regression model, to develop joint probability distributions of m and σc suitable for use in RBD. This analysis also shows how compressive and indirect tensile strength data may be robustly used to fit an H-B criterion. The third analysis uses the granodiorite data to investigate the important matter of developing characteristic strength criteria. Using definitions from Eurocode 7, a formal Bayesian interpretation of characteristic strength is proposed and used to analyse strength data to generate a characteristic criterion. These criteria are presented in terms of characteristic parameters mk and σck, the values of which are shown to depend on the testing regime used to obtain the strength data. The paper confirms that careful use of appropriate Bayesian statistical analysis allows the H-B criterion to be brought within the framework of RBD. It also reveals that testing guidelines such as the International Society for Rock Mechanics and Rock Engineering (ISRM) suggested methods will require modification in order to support RBD. Importantly, the need to fully understand the implications of

关键词： Reliability-based design(RBD) Hoek-Brown(HeB)criterion Bayesian regression Indirect tensile strength characteristic strength criterion

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TLR4 signaling and the inhibition of liver hepcidin expression by alcohol

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World Journal of Gastroenterology 2014年第34期20卷 12161-12170页

作者： Emily Zmijewski Sizhao Lu Duygu Dee harrison-Findik Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198-5820United States

AIM: To understand the role of toll-like receptor 4 (TLR4) signaling in the regulation of iron-regulatory hormone, hepcidin by chronic alcohol consumption.

关键词： Iron Small heterodimer partner protein Nuclear factor-κB Alcoholic liver disease Inflammation