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Exercise catheterization for Hemodynamic Evaluation of Adults with coarctation of the Aorta

congenital Heart Disease 2022年第6期17卷 605-615页

作者： Irene Martin de Miguel c.charles jain Alexander c.Egbe Jason H.Anderson Heidi M.connolly William R.Miranda Department of cardiovascular Medicine Mayo ClinicRochesterMinnesotaUSA Department of Pediatric and Adolescent Medicine Division of Pediatric CardiologyMayo ClinicRochesterMinnesotaUSA

Background: coarctation of the aorta (coA) is associated with a generalized arteriopathy and long-term complicationsdespite repair. Data on invasive exercise hemodynamics in this population are lacking. Accordingly, wereviewed adults with coA undergoing exercise catheterization to assess 1. hemodynamic profile;2. feasibilityfor assessment of coA severity. Methods: Twenty patients undergoing exercise cardiac catheterization (12 armadduction and 8 supine cycle ergometry) at a quaternary care center between 2004 and 2021 were identified. Restingand exercise hemodynamic data were abstracted from the procedure logs. Results: Mean age was 43.6 ±12.0 years. Eleven patients (55%) had resting pulmonary arterial wedge pressure (PAWP) >15 mmHg;amongthose undergoing arterial catheterization, left ventricular end-diastolic pressure was >15 mmHg in 63%. Elevenpatients (55%) had pulmonary hypertension: 7 (35%) combined and 4 (20%) isolated post-capillary. At peak exercise,ΔPAWP/Δcardiac output (cO) ≥2 and Δmean pulmonary artery pressure/ΔcO ≥3 mmHg/l/min were foundin 7 (78%) and 6 (67%) patients, respectively;the composite of exercise PAWP ≥25 mmHg or ΔPAWP/ΔcO>2 was seen in 12 (86%). coA peak-to-peak gradients at baseline (n = 14) and during exercise (n = 9) were 12(3–16) and 16 mmHg (9–28), respectively. Only 2 patients had an increase in coA gradient to >20 mmHg withexercise. conclusions: Diastolic dysfunction and pulmonary hypertension were highly prevalent, with exerciseunmasking abnormal diastolic and pulmonary vascular reserve in some individuals. Most patients failed to showsignificant increases in coA peak-to-peak gradients with exercise. Further studies are warranted to establish thebest diagnostic method for coA severity assessment.

关键词： coarctation of the aorta exercise heart catheterization diastolic dysfunction hypertension

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Glass transition: from interaction potential changes to the corresponding structural and relaxation responses along the path of reaching the final equilibrium

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Science china chemistry 2018年第1期61卷 46-53页

作者： Guangcui Yuan charles c.Han center for Neutron Research National Institute of Standards and Technology USA Department of Polymer Engineering The University of Akron Institute for Advanced Study Shenzhen University

Glass transition involves a many-body interaction and relaxation process. The splk of relaxation spectrum and the extremely slow dynamics bring into considerations of non-linearity and non-equilibrium. Some of our recent findings in two measurable colloidal systems are reviewed, one with a simple attractive interparticle potential and the other with a competitive （repulsive vs. attractive） inter-particle interaction. With an approach from interaction potential changes to the corresponding structural and relaxation responses, along the path of reaching the final equilibrium, we illustrate some interesting physics in glass formation process. Also, some reviews on the popular glass transition theories are made to remind readers to avoid artifacts and misinterpretations.

关键词： glass transition slow dynamics polymer colloid

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慢生型大豆根瘤菌(Bradyrhizobium japonicum)USDA110菌株3-羟丁酸脱氢酶基因(bdhA)的克隆、序列及特性

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中国农业科学 2003年第3期36卷 292-299页

作者：戴美学,武波,柏学亮,张成刚,马庆生,Trevor c.charles 中国科学院沈阳应用生态研究所广西大学/农业部农业分子遗传重点实验室广西大学/农业部农业分子遗传重点实验室中国科学院沈阳应用生态研究所广西大学/农业部农业分子遗传重点实验室滑铁卢大学生物系沈阳110015 南宁530005 南宁530005 沈阳110015 南宁530005 滑铁卢N2L3G1 加拿大

通过功能互补试验 ,从慢生型大豆根瘤菌USDA110菌株基因文库中筛选到能互补广宿主根瘤菌NGR2 34的bdhA突变体菌株NGRPA2和苜蓿根瘤菌的bdhA突变体菌株Rm1110 7、使之恢复Hbu+ 表型的克隆 ;经酶活测定和Southern杂交证明该克隆含有bdhA... 详细信息

通过功能互补试验 ,从慢生型大豆根瘤菌USDA110菌株基因文库中筛选到能互补广宿主根瘤菌NGR2 34的bdhA突变体菌株NGRPA2和苜蓿根瘤菌的bdhA突变体菌株Rm1110 7、使之恢复Hbu+ 表型的克隆 ;经酶活测定和Southern杂交证明该克隆含有bdhA基因。测定了bdhA基因全序列 ,并在GenBank登记 (登记号为 :AY0 775 81)。该基因由 789个碱基对组成 ,编码分子量为 2 7.5 9ku、含 2 6 2个氨基酸残基的 3 羟基丁酸脱氢酶。在该基因的开放阅读框内插入interposonΩKm ,并通过同源重组构建了BradyrhizobiumjaponicumbdhA突变体 (bdhA ::ΩKm)。植株试验未显示bdhA基因的突变对结瘤、固氮有明显影响。

关键词：慢生型大豆根瘤菌 3羟丁酸脱氢酶 3-羟丁酸脱氢酶基因聚羟丁酸

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Scalable fabrication of sub-10 nm polymernanopores for DNA analysis

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Microsystems & Nanoengineering 2019年第1期5卷 532-541页

作者： Junseo choi charles c.Lee Sunggook Park Department of Mechanical&Industrial Engineering and center for BioModular Multiscale Systems for Precision Medicine Louisiana State UniversityBaton RougeLA 70803USA Department of comparative Biomedical Sciences School of Veterinary MedicineLouisiana State UniversityBaton RougeLA 70803USA

We present the first fabrication of sub-10 nm nanopores in freestanding polymer membranes via a simple,costeffective,high-throughput but deterministic fabrication *** in the range of 10 nm were initially produced via a single-step nanoimprinting process,which was further reduced to sub-10 nm pores via a post-NIL polymer reflow *** low shrinkage rate of 2.7 nm/min obtained under the conditions used for the reflow process was the key to achieving sub-10 nm pores with a controllable pore *** fabricated SU-8 nanopore membranes were successfully employed for transient current measurements during the translocation of DNA molecules through the nanopores.

关键词： process. polymer pores

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Using an Electronic Nose to Rapidly Assess Grandlure content in Boll Weevil Pheromone Lures

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Journal of Bionic Engineering 2011年第4期8卷 449-454页

作者： charles P.-c. Suh Ningye Ding Yubin Lan USDA-ARS Areawide Pest Management Research Unit College Station TX 77845 USA college of Engineering Northeast Agriculture University Harbin 150030 P. R. China

Samples of pheromone lures used in boll weevil, Anthonomus grandis （Boheman）, eradication programs are routinely analyzed by Gas chromatography （Gc） to ensure lures are adequately dosed with grandlure, the synthetic aggregation phero- mone produced by male weevils. However, preparation of Gc samples is tedious, time consuming, and requires a moderate level of experience. We examined the use of a commercially-available electronic nose （e-nose） for rapidly assessing the grandlure contents of lures. The e-nose was trained to recognize headspace collections of grandlure emitted from new lures and after lures were aged under field conditions for 4 d, 7 d, 10 d, and 14 d. Based on cross-validation of the training set, the e-nose was 82% accurate in discriminating among the different age classes of lures. Upon sampling headspace collections of pheromone from a different set of field-aged lures, the e-nose was 〈50% accurate in discriminating 4 d, 7 d, and 10 d aged lures from the other age classes of lures. However, the e-nose identified new and 14 d aged lure samples with 100% accuracy. In light of these findings, e-nose technology shows considerable promise as an alternative approach for rapidly assessing the initial grandlure contents of lures used in boll weevil eradication programs.

关键词： electronic nose cyranose 320 boll weevil grandlure pheromone lure

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In vivo study of corneal responses to increased intraocular pressure loading

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Eye and Vision 2015年第1期2卷 177-186页

作者： Ahmed Elsheikh charles W.McMonnies charles Whitford Gavin c.Boneham School of Engineering University of LiverpoolBrownlow HillLiverpool L693GHUK National Institute for Health Research(NIHR)Biomedical Research centre Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK School of Optometry and Vision Science University of New South WalesSydneyAustralia

Background:The cornea is responsible for two-thirds of the eye's refractive power which is a function of the shape and refractive *** aim of this present study is to examine human eyes in vivo for corneal shape changes in response to short-term elevation in intraocular ***:Videokeratographic and tonometric assessments at baseline were compared with the same assessments when intraocular pressure was elevated to approximately double(199±22%)the baseline levels using ophthalmodynamometer applanation of the *** maps of the cornea and limbus were created by combining topographical assessments for central,nasal,temporal,inferior and superior *** finiteelement simulations were custom built for each subject and the stiffness distribution across corneal surface modified to achieve matches between simulated and experimental ***:The stiffness distributions required to achieve simulation-experimental matches showed a consistent trend with the 2.5 mm annulus bounded by the limbus showing a mean stiffness reduction of 47.3±10.8%compared with the central cornea(P=0.001).conclusions:corneal structure appears to provide the central cornea with a greater stiffness compared with the peripheral cornea and associated greater tolerance to elevation in intraocular pressure,consistent with the need for stable corneal refraction and *** method adopted to examine corneal biomechanical performance in vivo may have applications in additional studies.

关键词： corneal biomechanics Topography Numerical simulation

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Medium-chain fatty acids and monoglycerides as feed additives for pig production:towards gut health improvement and feed pathogen mitigation

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Journal of Animal Science and Biotechnology 2020年第3期11卷 611-625页

作者： Joshua A.Jackman RDean Boyd charles c.Elrod School of chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Hanor company FranklinKY 42134USA North carolina State University RaleighNC 27695USA Natural Biologics Inc. NewfieldNY 14867USA Department of Animal Science Cornell UniversityIthacaNY 14853USA.

Ongoing challenges in the swine industry,such as reduced access to antibiotics and virus outbreaks(e.g.,porcine epidemic diarrhea virus,African swine fever virus),have prompted calls for innovative feed additives to support pig ***-chain fatty acids(McFAs)and monoglycerides have emerged as a potential option due to key molecular features and versatile functions,including inhibitory activity against viral and bacterial *** this review,we summarize recent studies examining the potential of McFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed *** molecular properties and biological functions of McFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig *** latest progress in testing McFAs and monoglycerides as feed additives in pig diets is then presented,and their effects on a wide range of production issues,such as growth performance,pathogenic infections,and gut health,are *** utilization of McFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described,along with advances in molecular encapsulation and delivery ***,we discuss how McFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease *** forward,we envision that McFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

关键词： Antibiotics Feed pathogen mitigation Growth promotion Gut health Immune enhancement McFA Medium-chain fatty acids Monoglycerides

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Regional ozone pollution and key controlling factors of photochemical ozone production in Pearl River Delta during summer time

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Science china chemistry 2010年第3期53卷 650-662页

作者： cHANG chihchung cHOU c.K.charles Andreas Wahner Research center for Environmental changes Academia SinicaTaipei 11529China Forschungszentrum Juelich ICG-Ⅱ:TroposphereJuelichGermany

An intensive field campaign including measurements from the environmental monitoring network and from two super sites took place in the Pearl River Delta region in summer *** routinely measured O3 and NOx concentrations,the spatial and temporal variation of O3 and of the total oxidant concentrations was *** to the spatial variability of NO2/NO,the two super sites were found to be representative of polluted urban and downwind suburban *** addition,both sites were located in high O3 ***-depth diagnostic of photochemical ozone production processes and their key controlling factors are achieved with an observation-based model(OBM) to gain regional *** analysis and sensitivity model runs show that aldehyde and HONO chemistry had significant impacts on local photochemical ozone production *** analysis of calculated Relative Incremental Reactivities shows that photochemical ozone production rates are mainly sensitive to anthropogenic hydrocarbons(Hcs) in the polluted urban *** the suburban areas,sensitivity to nitrogen oxide(NO) concentrations *** anthropogenic Hcs in both areas are alkenes and *** differences of ozone production efficiencies are identified between the urban and suburban regions,consistent with the OBM diagnosed results.

关键词： ozone Pearl River Delta photochemical ozone productions HONO relative incremental reactivity

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SYNTHESIS OF EXFOLIATED ISOTAcTIc POLYPROPYLENE/FUNcTIONAL ALKYL-TRIPHENYLPHOSPHONIUM-MODIFIED cLAY NANOcOMPOSITES BY IN SITU POLYMERIZATION

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chinese Journal of Polymer Science 2013年第11期31卷 1501-1508页

作者： Kai Du 贺爱华 Fu-yong Bi charles c.Han Fine chemicals Department Beijing Research Institute of Chemical IndustrySINOPEC State Key Laboratory of Polymer Physics and chemistry Joint Laboratory of Polymer Science and MaterialsBeijing National Laboratory for Molecular ScienceInstitute of ChemistryChinese Academy of Sciences Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-PlasticsSchool of Polymer Science and EngineeringQingdao University of Science and Technology State Key Laboratory of Polymer Physics and chemistry Joint Laboratory of Polymer Science and MaterialsBeijingNational Laboratory for Molecular ScienceInstitute of ChemistryChinese Academy of Sciences

Diphenyl （4-hydroxyphenyl） hexadecyl phosphonium bromide （POH） -modified montmorillonite （POHMMT） was used to prepare a novel Tic14/Mgc12/POHMMT compound catalyst and exfoliated iPP/POHMMT nanocomposites were prepared by the in situ intercalative polymerization of propylene with the Tic14/Mgc12/POHMMT compound catalyst. The POH surfactants don＇t change the catalytic characteristic of the Z-N catalyst and the obtained PP presents high isotacticity, normal molecular weight and molecular weight distribution. The WAXD, SAXS and TEM results demonstrate the highly exfoliated iPP/POHMMT nanocomposites were produced by the in situ polymerization with this novel catalyst, while the intercalated iPP/Na＋MMT nanocomposites were produced with the Tic14/Mgc12/Na＋MMT compound catalyst. Through this approach, in situ propylene polymerization can actually take place between the silicate layers and lead not only to PP with high isotacticity and molecular weight, but also to highly exfoliated PP nanocomposites.

关键词： clay Nanocomposites Poly(propylene) (PP) Ziegler-Natta polymerization.

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Physical geology charles c. Plummer, David McGeary, Diane H. carlson 8th ed.

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1999年

作者： charles c. Plummer David McGeary Diane H. carlson

"Featuring the Smithsonian Institution's Journey through geology cD-ROM."

ISBN: (纸本)0697374041

"Featuring the Smithsonian Institution's Journey through geology cD-ROM."

关键词： Physical geology.

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