检索结果-南通市图书馆

EMP control and characterization on high-power laser systems

High Power Laser Science and Engineering 2018年第2期6卷 55-62页

作者： P.Bradford N.c.Woolsey G.G.Scott G.Liao H.Liu Y.Zhang B.Zhu c.Armstrong S.Astbury c.brenner P.Brummitt F.consoli I.East R.Gray D.Haddock E Huggard E J.R.Jones E.Montgomery I.Musgrave E Oliveira D.R.Rusby c.Spindloe B.Summers E.Zemaityte Z.Zhang Y.Li P.McKenna D.Neely Department of Physics York Plasma InstituteUniversity of YorkHeslingtonYork YO10 5DDUK central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUK Key Laboratory for Laser Plasmas(Ministry of Education)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Beijing National Laboratory for condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics SUPA University of StrathclydeGlasgow G40NGUK ENEA-c.R.Frascati-Dipartimento FSN Via E.Fermi 4500044 FrascatiItaly Space Science Department STFC Rutherford Appleton LaboratoryDidcot OX110QXUK

Giant electromagnetic pulses(EMP) generated during the interaction of high-power lasers with solid targets can seriously degrade electrical measurements and equipment. EMP emission is caused by the acceleration of hot electrons inside the target, which produce radiation across a wide band from Dc to terahertz frequencies. Improved understanding and control of EMP is vital as we enter a new era of high repetition rate, high intensity lasers(e.g. the Extreme Light Infrastructure).We present recent data from the VULcAN laser facility that demonstrates how EMP can be readily and effectively reduced. characterization of the EMP was achieved using B-dot and D-dot probes that took measurements for a range of different target and laser parameters. We demonstrate that target stalk geometry, material composition, geodesic path length and foil surface area can all play a significant role in the reduction of EMP. A combination of electromagnetic wave and 3 D particle-in-cell simulations is used to inform our conclusions about the effects of stalk geometry on EMP,providing an opportunity for comparison with existing charge separation models.

关键词： high energy density physics high-power laser related laser components laser plasmas interaction target design and fabrication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

引用

cancer Biology & Medicine 2016年第1期13卷 87-100页

作者： Megan L.Ludwig Andrew c.Birkeland Rebecca Hoesli Paul Swiecicki Matthew E.Spector J.chad brenner Department of Otolaryngology Head and Neck SurgeryUniversity of Michigan Medical SchoolAnn ArborMI 48109USA cellular and Molecular Biology Program University of MichiqanAnn ArborMI 48109USA Department of Hematology Oncology University of Michigan Medical SchoolAnn ArborMI 48109USA comprehensive cancer center University of Michigan Medical SchoolAnn ArborMI 48109USA

Laryngeal squamous cell carcinoma(LScc) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LScc has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LScc may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LScc as a model system for organ preservation, unique and potentially targetable genetic signatures of LScc, and methods for bringing stratified, personalized treatment strategies to the 21^(st) century.

关键词： Head and neck cancer laryngeal squamous cell carcinoma genetics targeted therapy personalized medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TWO-LEVEL ADDITIVE ScHWARZ PREcONDITIONERS FOR PLATE ELEMENTS

引用

Wuhan University Journal of Natural Sciences 1996年第Z1期1卷 658-667页

作者： SUSANNE c. brenner

Abstract We present a theory of two-level additive Schwas preconditions for plate elements. It is applicable to the cases where the finite element spaces on the two levels are(I) conforming and nested,(II)conforming and nonsked, and (III) nonconforming and nonnested. The condition number of the preconditioned system is independent of the mesh sizes and the number of subdomains in the case of generous overlap.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitomycin c and capecitabine: An additional option as an advanced line therapy in patients with metastatic colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2023年第11期15卷 1913-1924页

作者： Gil Mullin Michal Sternschuss Yosef Landman Aaron Sulkes Baruch brenner Faculty of Medicine Tel-Aviv UniversityTel Aviv 6997801Israel Institute of Oncology Davidoff Cancer CenterBeilinson CampusPetah-Tikva 4941492Israel

BAcKGROUND In recent years survival of patients with metastatic colorectal cancer(mcRc),though still limited,has improved significantly;clearly,when the disease becomes refractory to standard regimens,additional treatment options are *** have shown that mitomycin c(MMc),an antitumor antibiotic,and capecitabine,a precursor of 5-fluorouracil,may act synergistically in *** efficacy of MMc/capecitabine has been demonstrated in the first-line setting,but only a few small studies have tested it in the advanced-line setting,with contradictory *** a median of 2 MMc/capecitabine cycles(range 0.5-9.0).Thirty-four patients(28.6%)experienced grade≥3 toxicity,including 2(1.7%)with grade 4;there was no drug-related *** objective response rate was 0.8%,and the disease control rate,24.4%.Median progression-free survival(PFS)was 2.1 mo(range 0.2-20.3),and median overall survival,4.8 mo(range 0.2-27.5).The 6-month overall survival rate was 44%;8.7%of patients remained *** associated with longer PFS were lower gamma-glutamyl transferase level(P=0.030)and primary tumor location in the left colon(P=0.017).Factors associated with longer overall survival were lower gamma-glutamyl transferase level(P=0.022),left-colon tumor location(P=0.044),low-to-moderate histological grade(P=0.012),Eastern cooperative Oncology Group performance status 0-1(P=0.036),and normal bilirubin level(P=0.047).cONcLUSION MMc/capecitabine is an active,available,and relatively safe regimen for use beyond standard lines of therapy in *** clinical and laboratory parameters can identify patients more likely to benefit.

关键词： colorectal cancer Metastatic cancer chemotherapy Mitomycin c/capecitabine Advanced line treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

comparison of Amiodarone compliance Monitoring： Usual care, Electronic Prescribing Template and Pharmacist-Managed clinic

引用

Journal of Pharmacy and Pharmacology 2014年第10期2卷 621-626页

作者： Jeannie L. Poon Allison c. brenner Michael J. brenner Veterans Affairs Ann Arbor Healthcare System Ann Arbor 48105 MI USA

Objective： To assess whether adherence to amiodarone monitoring differed pre- and post-amiodarone restriction template and implementation of the pharmacist-managed clinic. Design： This was a retrospective chart review study. Setting： A large, academically-affiliated Veteran Affairs Healthcare System providing primary and tertiary care. Patients： 580 patients were identified as having an active prescription for amiodarone for at least 60 days from January l, 2009 to August 31, 2013 and receiving primary care at the VAAHS （Veterans Affairs Ann Arbor Healthcare System）. Results： Nearly all patients had TSH and LFTs at baseline regardless of study group. Significant associations between baseline rates for cXR, EcG, PFT, and opbthalmologic exams were found, with higher rates in the clinic and template arms compared to usual care. Similar patterns for all monitoring outcome rates were also found for both the 6- and 12-month measures. conclusions： Patients on amiodarone who are followed by a pharmacist-managed clinic or where a restricted ordering template was used had increased compliance with amiodarone monitoring guidelines compared to usual care. Use of a restricted template may be a reasonable option in place of a pharmacist-managed service.

关键词： Amiodarone pharmacist-managed monitoring Veterans Affairs usual care electronic template.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

引用

Translational Neurodegeneration 2019年第1期8卷 333-345页

作者： Hans-Peter Müller David brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M.Danzer Albert c.Ludolph William Tsao Philip c.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek Department of Neurology University of UlmOberer Eselsberg 45RKUD-89081 UlmGermany German center for Neurodegenerative Diseases(DZNE) UlmGermany core Facility Small Animal MRI University of UlmUlmGermany Department of Pathology The Johns Hopkins University School of MedicineBaltimoreUSA

Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about *** brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort *** were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal ***:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal *** loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to ***:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/*** and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker.

关键词： Diffusion tensor imaging Amyotrophic lateral sclerosis Mutant TDP-43 Fiber tracking Mouse brain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

城市地域星球

城市地域星球

引用

2019年

作者： (美)尼尔·博任纳

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

IBM Pc故障检测与维修指南

IBM PC故障检测与维修指南

引用

作者： R.c.·布伦纳(R.c. brenner)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Bremsstrahlung emission from high power laser interactions with constrained targets for industrial radiography

引用

High Power Laser Science and Engineering 2019年第2期7卷 27-33页

作者： c.D.Armstrong c.M.brenner c.Jones D.R.Rusby Z.E.Davidson Y.Zhang J.Wragg S.Richards c.Spindloe P.Oliveira M.Notley R.clarke S.R.Mirfayzi S.Kar Y.Li T.Scott P.McKenna D.Neely Department of Physics SUPA University of StrathclydeGlasgow G4ONGUK central Laser Facility STFC Rutherford Appleton LaboratoryHarwellOxford0X11OQXUK Interface Analysis centre HH Wills Physics LaboratoryTyndall AvenueBristol BS81TLUK Beijing National Laboratory for condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China centre for Plasma Physics Queen's University BelfastBelfast BT7INNUK

Laser-solid interactions are highly suited as a potential source of high energy X-rays for nondestructive imaging.A bright,energetic X-ray pulse can be driven from a small source,making it ideal for high resolution X-ray *** limiting the lateral dimensions of the target we are able to confine the region over which X-rays are produced,enabling imaging with enhanced resolution and *** constrained targets we demonstrate experimentally a(20±3)μm X-ray source,improving the image quality compared to unconstrained foil *** demonstrates that a larger sheath field envelope around the perimeter of the constrained targets increases the proportion of electron current that recirculates through the target,driving a brighter source of X-rays.

关键词： bremsstrahlung high power laser nondestructive imaging radiography X-ray

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?

引用

World Journal of Experimental Medicine 2015年第2期5卷 50-63页

作者： Dubravka Kojic Benedikt H Siegler Florian Uhle christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten brenner Department of Anesthesiology Heidelberg University Hospital Department of Internal Medicine I and clinical chemistry Heidelberg University Hospital

Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like c-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach.

关键词： clinical decision-making Biomarkers Early prediction Sepsis and mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：