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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study

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World Journal of Gastroenterology 2025年第2期31卷 102-112页

作者： Thanaboon chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj c Kariyawasam Melissa Kermeen Rupert W Leong Department of Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139New South WalesAustralia Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Faculty of Medicine and Health University of SydneySydney 2139New South WalesAustralia Department of Gastroenterology Tan Tock Seng HospitalSingapore 308433Singapore Faculty of Medicine and Health Sciences Macquarie UniversitySydney 2139New South WalesAustralia Department of Gastroenterology and Hepatology Blacktown HospitalSydney 2148New South WalesAustralia Blacktown clinical School Western Sydney UniversitySydney 2148New South WalesAustralia

BAcKGROUND Ulcerative colitis(Uc)is a chronic inflammatory condition requiring continuous treatment and *** is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is *** To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in Uc patients who have achieved sustained clinical and endoscopic remission during maintenance *** This is a post-hoc analysis of prospective randomized clinical trial(VIEWS)involving Uc patients across 8 centers in Australia from 2018 to *** in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving *** evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine *** There were 62 Uc participants with mean age of 43.4 years and 42%were *** participants received vedolizumab as maintenance therapy with 67.7%withdrew *** serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies ***-tients with clinical remission had higher trough concentrations at week *** quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%cI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving *** A positive exposure-response relationship between vedolizumab trough concentrations and Uc outcomes suggests that monitoring drug levels may be *** thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remi

关键词： Pharmacokinetic Vedolizumab Thiopurine Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases

Search for the doubly heavy baryons Ω^(0)_(bc) and E^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and E^(+)_(c)π^(-)

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chinese Physics c 2021年第9期45卷 10-21页

作者： R.Aaij c.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia c.A.Aidala S.Aiola Z.Ajaltouni S.Aka J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Beminghoff H.c.Bernstein c.bertella A.Bertolin c.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.c.R.Bishop A.Bitadze A.Bizzeti M.Bjorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer c.Bozzi M J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura c.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calefice L.calero Diaz S.cali R.calladine M.calvi M.calvo Gomez P.camargo Magalhaes A.camboni P.campana A.F.campoverde Quezada S.capelli L.capriotti A.carbone G.carboni R.cardinale A.cardini I.carli P.camiti L.carus K.carvalho Akiba A.casais Vidal G.casse M.cattaneo G.cavallero S.celani J.cerasoli A.J.chadwick M.G.chapman M.charles Ph.charpentier G.chatzikonstantinidis c.A.chavez Barajas M.chefdeville c.chen S.chen A.chernov V.chobanova S.cholak M.chrzaszcz A.chubykin V.chulikov P.ciambrone M.F.cicala X.cid Vidal G.ciezarek P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cogneras L.cojocariu P.collins T.colombo L.congedo A.contu N.cooke G.coombs G.corti c.M.costa Sobral B.couturier D.c.craik J.crkovska M.cruz Torres R.currie c.L.Da Silva E.Dall'Occo J.Dalseno c.D'Ambrosi centro Brasileiro de Pesquisas Fisicas(cBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina Institute of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofchinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHcb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

Search for the rare decay B^(0)→J/ψФ

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chinese Physics c 2021年第4期45卷 47-60页

作者： R.Aaij c.Abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial c.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.c.Bernstein c.bertella E.Bertholet A.Bertolin c.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.c.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer c.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura c.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calefice L.calero Diaz S.cali R.calladine M.calvi M.calvo Gomez P.camargo Magalhaes A.camboni P.campana D.H.campora Perez A.F.campoverde Quezada S.capelli L.capriotti A.carbonel G.carboni R.cardinale A.cardini I.carli P.carniti L.carus K.carvalho Akiba A.casais Vidal G.casse M.cattaneo G.cavallero S.celani J.cerasoli A.J.chadwick M.G.chapman M.charles Ph.charpentier G.chatzikonstantinidis c.A.chavez Barajas M.chefdeville c.chen S.chen A.chernov S.-G.chitic V.chobanova S.cholak M.chrzaszcz A.chubykin V.chulikov P.ciambrone M.F.cicala X.cid Vidal G.ciezarek P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cogneras L.cojocariu P.collins T.colombo L.congedo A.contu N.cooke G.coombs G.corti c.M.costa Sobral B.couturier D.c.craik J.crkovska M.cruz centro Brasileiro de Pesquisas Fisicas(cBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHcb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHcb

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chinese Physics c 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb c.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia c.Agapopoulou c.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Benane G.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.c.Bernstein c.bertella A.Bertolin c.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.c.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc J.E.Blank S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev c.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer c.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke c.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calefice S.cali R.calladine M.calvi M.calvo Gomez P.campana D.H.campora Perez A.F.campoverde Quezada S.capelli L.capriotti A.carbone G.carboni R.cardinale A.cardini P.carniti L.carus A.casais Vidal R.caspary G.casse M.cattaneo G.cavallero V.cavallini S.celani J.cerasoli D.cervenkov A.J.chadwick M.G.chapman M.charles Ph.charpentier c.A.chavez Barajas M.chefdeville c.chen S.chen A.chernov S.chernyshenko V.chobanova S.cholak M.chrzaszcz A.chubykin V.chulikov P.ciambrone M.F.cicala X.cid Vidal G.ciezarek G.ciullo P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cognera centro Brasileiro de Pesquisas Físicas(cBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universitéclermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHcb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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chinese Physics c 2020年第2期44卷 13-23页

作者： R.Aaij c.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia c.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez cartelle A.A.Alves Jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.c.Bernstein c.bertella E.Bertholet A.Bertolin c.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock c.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura c.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calero Diaz S.cali R.calladine M.calvi M.calvo Gomez P.camargo Magalhaes A.camboni P.campana D.H.campora Perez A.F.campoverde Quezada L.capriotti A.carbone G.carboni R.cardinale A.cardini I.carli P.carniti K.carvalho Akiba A.casais Vidal G.casse M.cattaneo G.cavallero S.celani R.cenci J.cerasoli M.G.chapman M.charles Ph.charpentier G.chatzikonstantinidis M.chefdeville V.chekalina c.chen S.chen A.chernov S.-G.chitic V.chobanova S.cholak M.chrzaszcz A.chubykin P.ciambrone M.F.cicala X.cid Vidal G.ciezarek F.cindolo P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cogneras L.cojocariu P.collins T.colombo A.comerma-Montells A.contu N.cooke G.coombs S.coquereau G.corti c.M.costa Sobral B.couturier D.c.craik J.crkovska A.crocombe M.cruz Torres R.currie c.L.Da Silva E.Dall'Occo J.Dalseno c.D' centro Brasileiro de Pesquisas Físicas(cBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universitéclermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4c and the rapidity range2.0 详细信息

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4c and the rapidity range2.0correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHcb experiment during *** ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QcD

Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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chinese Physics c 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb c.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi H.Afsharnia c.Agapopoulou c.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez cartelle S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.c.Bernstein c.bertella A.Bertolin c.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.c.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev N.Bondar S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer c.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura L.Buonincontri A.T.Burke c.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calefice S.cali R.calladine M.calvi M.calvo Gomez P.camargo Magalhaes P.campana D.H.campora Perez A.F.campoverde Quezada S.capelli L.capriotti A.carbone G.carboni R.cardinale A.cardini I.carli P.carniti L.carus A.casais Vidal R.caspary G.casse M.cattaneo G.cavallero V.cavallini S.celani J.cerasoli D.cervenkov A.J.chadwick M.G.chapman M.charles Ph.charpentier c.A.chavez Barajas M.chefdeville c.chen S.chen A.chernov S.chernyshenko V.chobanova S.cholak M.chrzaszcz A.chubykin V.chulikov P.ciambrone M.F.cicala X.cid Vidal G.ciezarek G.ciullo P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cogneras L.cojocariu P.collins T.colombo L.congedo A.contu N.cooke centro Brasileiro de Pesquisas Físicas(cBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universitéclermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHcb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QcD B physics charm physics spectroscopy

creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cS De Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease