检索结果-南通市图书馆

Translational Neurodegeneration in the era of fast growing international brain research

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 949-950页

作者： Jialin c.zheng Shengdi chen Translational Neurodegeneration Departments of Neurology and Regenerative MedicineTongji HospitalTongji University School of MedicineShanghaiChina Translational Neurodegeneration Department of Neurology&Institute of NeurologyRui Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Another year has flown by and we have entered *** challenges in 2021 have continued to occur as we unceasingly fight against the pandemic.2021 will be remembered for the world’s perseverance and dedication to overcome extremely adverse *** the beginning of 2022,we are celebrating the 10th birthday of our journal,Translational Neurodegeneration(TN).Inaugurated in 2011 under the editorship and leader-ship of *** chen,our mission is to promote and foster rapid conversion of basic science research to clinical applications by offering a high-visibility forum for groundbreaking translational research in neurodegenera-tive diseases and to ultimately benefit not only patients but also societies.

关键词： visibility offering overcome

Extracellular vesicles,from the pathogenesis to the therapy of neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 98-128页

作者： Xiaohuan Xia Yi Wang Jialin c.zheng center for Translational Neurodegeneration and Regenerative Therapy Tongji HospitalTongji University School of MedicineShanghai 200072China Shanghai Frontiers Science center of Nanocatalytic Medicine 200331 Shang-haiChina Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration(Tongji University) Ministry of Education200065 ShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalTongji University School of Medicine200434 Shang-haiChina Translational Research center Shanghai Yangzhi Rehabilitation Hospital Affiliated to Tongji University School of MedicineShanghai 201613China collaborative Innovation center for Brain Science Tongji University200092 ShanghaiChina center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji University School of MedicineShanghai 200065China

Extracellular vesicles(EVs)are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain *** a key intercellular communicator,EVs have emerged as a key contributor to the pathogenesis of various neurodegenerative diseases(NDs)including Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease through delivery of bioactive cargos within the central nervous system(cNS).Importantly,cNS cell-derived EVs can be purified via immunoprecipitation,and EV cargos with altered levels have been identified as potential biomarkers for the diagnosis and prognosis of *** the essential impact of EVs on the pathogenesis of NDs,pathological EVs have been considered as therapeutic targets and EVs with therapeutic effects have been utilized as potential therapeutic agents or drug delivery platforms for the treatment of *** this review,we focus on recent research progress on the pathological roles of EVs released from cNS cells in the pathogenesis of NDs,summarize findings that identify cNS-derived EV cargos as potential biomarkers to diagnose NDs,and comprehensively discuss promising potential of EVs as therapeutic targets,agents,and drug delivery systems in treating NDs,together with current concerns and challenges for basic research and clinical applications of EVs regarding NDs.

关键词： Extracellular vesicle Exosome Neurodegenerative disease Therapeutics Biomarker

Proteolytic processing of SDF-1α by matrix metalloproteinase-2 impairs cXcR4 signaling and reduces neural progenitor cell migration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & cell 2012年第11期3卷 875-882页

作者： Hui Peng Yumei Wu Zhiyuan Duan Pawel ciborowski Jialin c.zheng Laboratory of Neuroimmunology and Regenerative Therapy University of Nebraska Medical CenterOmahaNE 68198USA Departments of Pharmacology and Experimental Neuroscience University of Nebraska Medical CenterOmahaNE 68198USA Departments of Pathology and Microbiology University of Nebraska Medical CenterOmahaNE 68198USA Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China

Neural stem cells and neural progenitor cells(NPcs)exist throughout life and are mobilized to replace neurons,astrocytes and oligodendrocytes after ***-omal cell-derived factor 1(SDF-1,now named cXcL12)and its receptor cXcR4,an α-chemokine receptor,are critical for NPc migration into damaged areas of the *** previous studies demonstrated that immune activated and/or HIV-1-infected human monocyte-derived-macrophages(MDMs)induced a substantial increase of SDF-1 production by human ***,matrix metalloproteinase(MMP)-2,a protein up-regulated in HIV-1-infected macrophages,is able to cleave four amino acids from the N-terminus of SDF-1,resulting in a truncated SDF-1(5-67).In this study,we investigate the diverse signaling and function induced by SDF-1α and SDF-1(5-67)in human cortical ***-1(5-67)was generated by incubating human recombinant SDF-1α with MMP-2 followed by protein determination via mass spectrometry,Western blotting and ***-1α induced time-dependent phosphorylation of extracellular signal-regulated kinases(ERK)1/2,Akt-1,and diminished cyclic adenosine monophosphate(cAMP).In contrast,SDF-1(5-67)failed to induce these ***-1α activation of cXcR4 induced migration of NPcs,an effect that is dependent on ERK1/2 and Akt-1 pathways;whereas SDF-1(5-67)failed to induce NPc *** observation provides evidence that MMP-2 may affect NPc migration through post-translational processing of SDF-1α.

关键词： proteolysis chemokine neurogenesis and migration

Reprogrammed mouse astrocytes retain a“memory”of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein & cell 2011年第2期2卷 128-140页

作者： changhai Tian Yongxiang Wang Lijun Sun Kangmu Ma Jialin c.zheng Laboratory of Neuroimmunology and Regenerative Therapy University of Nebraska Medical CenterOmahaNE 68198-5930USA Departments of Pharmacology/Experimental Neuroscience University of Nebraska Medical CenterOmahaNE 68198-5930USA Departments of Pathology/Microbiology University of Nebraska Medical CenterOmahaNE 68198-5930USA

Direct reprogramming of a variety of somatic cells with the transcription factors Oct4(also called Pou5f1),Sox2 with either Klf4 and Myc or Lin28 and Nanog generates the induced pluripotent stem cells(iPScs)with marker similarity to embryonic stem ***,the difference between iPScs derived from different origins is *** this study,we hypothesized that reprogrammed cells retain a“memory”of their origins and possess additional potential of related tissue *** reprogrammed primary mouse astrocytes via ectopic retroviral expression of OcT3/4,Sox2,Klf4 and Myc and found the iPScs from mouse astrocytes expressed stem cell markers and formed teratomas in ScID mice containing derivatives of all three germ layers similar to mouse embryonic stem cells besides semblable *** test our hypothesis,we compared embryonic bodies(EBs)formation and neuronal differentiation between iPScs from mouse embryonic fibroblasts(MEFsiPScs)and iPScs from mouse astrocytes(mAsiPScs).We found that mAsiPScs grew slower and possessed more potential for neuronal differentiation compared to *** results suggest that mAsiPScs retain a“memory”of the central nervous system,which confers additional potential upon neuronal differentiation.

关键词： mouse astrocytes induced pluripotent stem cells neural progenitor cells neuronal differentiation

Mechanical properties of 65Mn chiral structure with three ligaments

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2019年第1期35卷 88-98,I0003页

作者： X.W.Su D.M.Zhu c.zheng M.M.Tomovic School of Technology Beijing Forestry UniversityBeijing 100083China School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083 China Batten college of Engineering and Technology Old Dominion University Norfolk VA 23529 USA

chiral honeycomb structures have been developed in recent years, showing excellent mechanical properties, including in-plane deformation and out-of-plane bearing and vibration isolation. In this study, the 65Mn chiral structure with three ligaments was modeled and analyzed using the finite element (FE) method. The effects of the dimensionless ligament length and dimensionless ligament thickness on the in-plane equivalent elastic modulus, equivalent Poisson's ratio, and out-of-plane shear modulus were studied. The numerical results indicate that increase of the dimensionless ligament length leads to decrease of the equivalent elastic modulus and increase of the equivalePoisson's ratio, whereas the out-of-plane equivalent shear modulus decreases. The results also indicate that increase of the dimensionless ligament thickness leads to in crease of the equivalent elastic modulus, whereas the equivalent Poisson's ratio remains nearly unchanged and the out-of-plane equivalent shear modulus shows a linear in crease. The numerical results are verified by comparis on with published experime ntal data. These results will provide a reference for the application of chiral structures with three ligaments in the aerospace field.

关键词： chiral structure with three ligaments Mechanical properties Finite elemern method

Emerging roles of extracellular vesicles in mediating RNA virus infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2021年第2期1卷 179-185页

作者： Xiaohuan Xia Yi Wang Jialin c.zheng center for Translational Neurodegeneration and Regenerative Therapy Shanghai Tenth Peopled Hospital affiliated to Tongji University School of MedicineShanghai 200072China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital affiliated to Tongji University School of MedicineShanghai 200434China collaborative Innovation center for Brain Science Tongji UniversityShanghai 200092China Departments of Pharmacology and Experimental Neuroscience University of Nebraska Medical CenterOmahaNE 68198-5930United States

The sudden outbreak of cOVID-19 has once again shrouded people in the enormous threat of RNA *** vesicles(EVs),eukaryotic cells-derived small bi-layer vesicles mainly consisting of exosomes and microvesicles,share many properties with RNA viruses including structure,size,generation,and *** evidence has implicated the involvement of EVs in the pathogenesis of infectious diseases induced by RNA *** can transfer viral receptors(e.g.,AcE 2 and cD9)to recipient cells to facilitate viral infection,directiy transport infectious viral particles to adjacent cells for virus spreading,and mask viruses with a host structure to escape immune ***,w e examine the current status of EVs to summarize their roles in mediating RNA virus infection,together with a comprehensive discussion of the underlying mechanisms.

关键词： Extracellular vesicle Exosome RNA virus cOVID-19 HIV SARS-coV-2 ZIKA

cognitive dysfunction of patients infected with SARS-coV-2 omicron variant in Shanghai,china

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 511-513页

作者： Ping Yuan Yong Bi Yu Luo Quan Tao Sugang Gong Yi Wang Lize Xiong Xiaohuan Xia Jialin c.zheng Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China Department of cardio-Pulmonary circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200081China center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji UniversityShanghai 200081China Department of Anesthesiology and Perioperative Medicine School of MedicineShanghai Fourth People’s Hospital Affiliated to Tongji UniversityShanghai 200081China Department of Radiology Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China Shanghai Frontiers Science center of Nanocatalytic Medicine Tongji University School of MedicineShanghai 200081China center for Translational Neurodegeneration and Regenerative Therapy Yangzhi Rehabilitation Hospital Affiliated to Tongji UniversityShanghai 200081China collaborative Innovation center for Brain Science Tongji UniversityShanghai 200081China clinical Research center for Anesthesiology and Perioperative Medicine Tongji UniversityShanghai 200081China

Previous studies have reported that nearly one-fourth of coronavirus disease 2019(cOVID-19)survivors suf-fer from persistent cognitive impairment,including impaired memory,attention,concentration,executive function,and speed of information processing[1-3].Omicron is the latest severe acute respiratory syndrome coronavirus 2(SARS-coV-2)variant of concern(VOc)reported in November 2021[4],characterized by a large number of spike mutations,great transmissibility in the presence of other VOcs,and an ability to spread in populations with high level of immunity[4].However,whether patients infected with Omicron cOVID-19 variant develop cognitive impairment,similar to those infected with other VOcs,remains unclear.

关键词： infected patients impaired

Neural stem cell-derived extracellular vesicles mitigate Alzheimer’s disease-like phenotypes in a preclinical mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第7期8卷 3232-3235页

作者： Ge Gao congcong Li Yizhao Ma Zhanping Liang Yun Li Xiangyu Li Shengyang Fu Yi Wang Xiaohuan Xia Jialin c.zheng center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of MedicineShanghai 200065China Translational Research center Shanghai Yangzhi Rehabilitation Hospital affiliated to Tongji University School of MedicineShanghai 201613China Shanghai Frontiers Science center of Nanocatalytic Medicine Tongji UniversityShanghai 200331China

Dear Editor,Alzheimer’s disease(AD)is the most common neurodegenerative disorder and the No.1 cause of dementia in elderly with no effective treatments.1 The application of stem cell-derived extracellular vesicles(EVs)has emerged as a promising therapeutic strategy for AD.2 EVs are small bilipid layer-enclosed vesicles that display blood-brain barrier(BBB)penetrating ability and similar potency to their parental cells.

关键词： Alzheimer clinical extracellular

Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 40-43页

作者： Huili chen Shengyang Fu Xiangyu Li Meng Shi Jiazhen Qian Shu Zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin c.zheng center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of Medicine200065 ShanghaiChina Department of cardio-Pulmonary circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine200434 ShanghaiChina

Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely ***,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4–6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4 Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4,7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4–6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question.

关键词： involvement inflammation media