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Response Evaluation Using contrast-Enhanced Ultrasound for Unresectable Advanced hepatocellular carcinoma Treated With Tyrosine Kinase Inhibitors Plus Anti-PD-1 Antibody Therapy

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Synchronized off-harmonic probe laser with highly variable pulse duration for laser-plasma interaction experiments

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao c.-K. Guan X. Pu y.-y. Zhou B.-y. Wang L.-F. Sun y.-K. yin h.-h. Xia h.-S. Wang X. han h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (cEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (hcc) treated with tyrosine kinase inhibitors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody therapy. Methods: A prospective cohort of consecutive patients with hcc who received combined TKI/anti-PD-1 antibody treatment for unresectable hcc between January 2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and cEUS examinations before treatment and at follow-up. changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on cEUS were evaluated. Response Evaluation criteria in Solid Tumors (REcIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography (MRI/cT) and modified REcIST (mREcIST) with cEUS and cEMRI/cT were used to assess treatment response. Results: A total of 24 hcc patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona clinic Liver cancer stage c, 62.5%; 29 intrahepatic target tumors) were studied. calculations of degree of necrosis in the target tumors revealed no significant differences between cEUS and cEMRI/cT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between REcIST version 1.1 of unenhanced US and mREcIST-cEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mREcIST-cEUS and mREcIST-cEMRI/cT (κ coefficient = 0.812). conclusion: cEUS proved to be superior to baseline US and is comparable to cEMRI/cT in defining treatment outcome for combined TKI/anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody contrast-enhanced ultrasound hepatocellular carcinoma

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high Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.hornung y.Zobus h.Lorenté c.Brabetz B.Zielbauer V.Bagnoud GSI helmholtzzentrum für Schwerionenforschung Gmbh DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Physik Technische Universität DarmstadtDarmstadtGermany

This paper presents the development and experimental utilization of a synchronized off-harmonic laser system designed as a probe for ultra-intense laser±plasma interaction experiments. The system exhibits a novel seed-generation design,allowing for a variable pulse duration spanning over more than three orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. This makes it suitable for various plasma diagnostics and visualization techniques. In a side-view configuration, the laser was employed for interferometry and streaked shadowgraphy of a laser-induced plasma while successfully suppressing the self-emission background of the laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for this setup. These properties enable the probe to yield valuable insights into the plasma dynamics and interactions at the PhELIX facility and to be deployed at various laser facilities due to its easy-to-implement design.

关键词： interferometry laser-plasma interaction off-harmonic probe laser streaked shadowgraphy

construction of 2D/2D Ti_(3)c_(2)T_(x)MXene/cdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.huang Z.yang S.y.yang Z.h.Dai y.J.Liu J.h.Liao G.y.Zhong Z.J.Xie y.P.Fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)c_(2)T_(x)MXene/cdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)cdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of cdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure heterostructure Photothermal effect Photocatalyst hydrogen evolution

Trial characteristics and treatment effect estimates in randomized controlled trials of chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty h.Wang ya-li Lin yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire c.W.Zhong Mary y.Jiang chen Mao Xiao-bo yang Vincent c.h.chung Irene X.y.Wu Jockey club School of Public health and Primary care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public health Central South UniversityChangsha 410006Hunan ProvinceChina School of chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of clinical Research on Traditional chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina hunan Provincial Key Laboratory of clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RcTs).Nevertheless,it remains unclear if similar associations exist in RcTs on chinese herbal medicine(chM).Further,chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on chM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on chM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RcTs of chM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RcTs using the cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (cI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RcTs were *** binary outcomes,RcTs incorporated with syndrome differentiation (ROR:1.23;95%cI:[1.07,1.39]),adopting chinese medicine formula (ROR:1.19;95%cI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%cI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%cI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%cI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RcTs with chinese medicine diagnostic criteria (dSMD:0.23;95%cI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%cI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Search for production of dark fermion candidates in association with heavy neutral gauge boson dec.y.ng to dimuon in proton-proton collisions at√s=8 TeV using cMS open data

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chinese Physics c 2024年第4期48卷 6-13页

作者： y.Mahmoud h.Abdallah M.T.hussein S.Elgammal centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the cMS experiment during run-I of the Lhc in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the cMS open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the cMS open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider cMS open data search for new physics dark fermion

hepatitis B virus genotypes in precision medicine of hepatitis Brelated hepatocellular carcinoma:Where we are now

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： caecilia h c Sukowati Sri Jayanti Turyadi Turyadi David h Muljono claudio Tiribelli Eijkman Research center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and health University of SydneySydney 2050Australia

hepatitis B virus(hBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(hcc).hBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the *** diversity may be associated with the precision medicine for hBV-related hcc and the success of therapeutical approaches against hcc,related to different pathogenicity of the virus and host *** Editorial discusses recent updates on whether the classification of hBV genetic diversity is still valid in terms of viral oncogenicity to the hcc and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.

关键词： hepatitis B virus hepatocellular carcinoma Genotypes Pathogenesis Precision medicine

Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang yanmei Zhang howard h.W.Wong Leo c.h.Tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.h.Luk Jenson c.h.ho Wing yan Li Amos M.T.Lee Jennifer h.y.Lam Sau Man chan Wilfred h.S.Wong Issan y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu T.W.huang K.Jiang c.N.Wu h.Peng P.c.hen R.Li h.B.Zhuo c.T.Zhou Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

Deformable microlaser force sensing

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Light(Science & Applications) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Joseph Shill Jonathan h.h.Booth Anna Popc.y. Stefan R.Pulver Malte c.Gather Marcel Schubert centre of Biophotonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK humboldt centre for Nano-and Biophotonics Department of ChemistryUniversity of CologneKölnGermany School of Psychology and Neuroscience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of catalonia BarcelonaSpain

Mechanical forces are key regulators of cellular behavior and function,affecting many fundamental biological processes such as cell migration,embryogenesis,immunological responses,and pathological *** force sensors and imaging techniques have been developed to quantify these otherwise invisible forces in single cells and in ***,current techniques rely heavily on high-resolution microscopy and do not allow interrogation of optically dense tissue,reducing their application to 2D cell cultures and highly transparent biological ***,we introduce DEFORM,deformable microlaser force sensing,a spectroscopic technique that detects sub-nanonewton forces with unprecedented spatio-temporal *** is based on the spectral analysis of laser emission from dye-doped oil microdroplets and uses the force-induced lifting of laser mode degeneracy in these droplets to detect nanometer *** validation by atomic force microscopy and development of a model that links changes in laser spectrum to applied force,DEFORM is used to measure forces in 3D and at depths of hundreds of microns within tumor spheroids and late-stage Drosophila *** furthermore show continuous force sensing with single-cell spatial and millisecond temporal resolution,thus paving the way for non-invasive studies of biomechanical forces in advanced stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion otherwise hundreds