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Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic.w.und repair

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cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： christopher O.Audu william J.Melvin Amrita D.Joshi Sonya J.wolf Jadie Y.Moon Frank M.Davis Emily c.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel wasikowski Lam c.Tsoi Sriganesh B.Sharma Tyler M.bauer James Shadiow Matthew A.corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic.w.unds,we identified increased JMJD3 in diabetic.w.und macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic.w.und tissue at later time points post-injury,regulates JMJD3 expression in diabetic.w.und macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic.w.und macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic.w.unds significantly improves diabetic.w.und repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic.w.unds.

关键词： wound healing epigenetics diabetes JMJD3 STING

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crystal structures and constitution of the binary system iridium-boron

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Science china Materials 2015年第8期58卷 649-668,594页

作者： Isolde Zeiringer 程曦月陈星秋 Ernest bauer Gerald Giester Peter Franz Rogl Institute of Materials chemistry and Research University of Vienna Shenyang National Laboratory for Materials Science (SYNL) Institute of Metal Research (IMR) Chinese Academy of Sciences (CAS) Institute of Solid State Physics Vienna University of Technology Institute of Mineralogy and crystallography University of Vienna

The constitution of the binary system Ir-B has been established between 10 and 70 at.% boron for temperatures above 700°c based on differential scanning calorimetry, electron probe microanalysis, and isothermal low temperature annealing experiments(≤1000°c). Four binary phases have been found, namely Ir4B5+x, Ir5B4+x and the high and low temperature modification of Ir4B3-x. X-ray structure analyses were performed on single crystals of Ir4B5+x(x = 0, Ir4B5 type; space group c2/m; a = 1.05200(2), b = 0.289564(6) and c = 0.60958(1) nm, β = 91.156(2)°), Ir5B4+x(x=0, Ir5B4 type; space group I41/a; a = 0.62777(1) and b = 1.02599(2) nm) and on the low temperature modification of Ir4B3-x(x=0, Ir B0.9 type; space group cmc21; a = 0.27728(1), b = 0.75742(2) and c = 0.73152(2) nm). The high temperature modification of Ir4B3-x(wc type; space group P6-m2; a = 0.28137(5) and c = 0.2828(1) nm) has been confirmed by X-ray powder diffraction. By means of the first-principle calculations, in combination with the evolutionary structural search algorithm, the compositions, structures and enthalpies of the Ir-B system have been investigated theoretically. confirming the experimental observations on Ir4B5, Ir5B4 and Ir4B3, we have investigated several metastable phases at other stoichiometries, such as Ir B, Ir B2 and Ir3B2. we also proposed three thermodynamically and dynamically stable new structures of o F28-Ir4B3, o c8-Ir B and m c10-Ir3B2, which may be synthesized under certain conditions.

关键词：晶格常数点阵参数 XPD nm

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Direct writing of anodic oxides for plastic electronics

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npj Flexible Electronics 2018年第1期2卷 189-198页

作者： christian Michael Siket Nadine Tillner Andrei Ionut Mardare Amir Reuveny carina Daniela Grill Florian Hartmann Gerald Kettlgruber Richard Moser Jan Philipp Kollender Takao Someya Achim walter Hassel Martin Kaltenbrunner Siegfried bauer Soft Matter Physics Johannes Kepler University LinzAltenberger Str.694040 LinzAustria Department of Electrical Engineering University of TokyoTokyo 113-8656Japan Institute for Technology of Inorganic Materials Johannes Kepler University LinzAltenberger Str.694040 LinzAustria christian Doppler Laboratory for combinatorial Oxide chemistry(cOMBOX) Johannes Kepler University LinzAltenberger Str.694040 LinzAustria Linz Institute of Technology LIT Johannes Kepler University LinzAltenberger Str.694040 LinzAustria

Metal oxide thin films for soft and flexible electronics require low cost,room temperature fabrication,and structuring *** here introduce an anodic printing process to realize the essential building blocks of electronic circuitry,including resistors,capacitors,field-effect transistors,diodes,rectifiers,and memristors directly on imperceptible plastic *** independent on surface properties,we achieve high-quality,few nanometer thin dielectric and semiconducting films even on rough substrates via localized anodisation of valve metals using a scanning droplet cell *** demonstrate printing-like fabrication of 3D multilayer solid-state capacitors with a record-high areal capacity of 4μF cm−*** to the whole class of valve metals and their alloys,our method provides a versatile fabrication technique for the circuits that empower the flexible and stretchable electronics of tomorrow.

关键词： anodic printing metals

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锌铝涂层的电化学研究

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电镀与涂饰 2016年第12期35卷 619-625页

作者： P.Hülser c.Donner G.bauer S.Hahn 陆文龙刘振民安美特化学有限公司安美特(中国)化学有限公司上海511356

比较了几种锌铝涂层系统和锌电镀层在50 g/L Na cl溶液中的电化学腐蚀行为。结果发现,锌铝涂层系统早期的腐蚀产物能够抑制进一步的腐蚀,从而使其拥有更好的自我保护性能,也阻碍了阴极的氧化还原反应。

关键词：电镀锌锌镍合金锌铝涂层氯化钠溶液电化学行为腐蚀

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烧结过程废气净化方案比较

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烧结球团 1982年第4期 74-78页

作者： c.D.bauer c.R.Skalos 李希超

前言美国的铁矿烧结厂的废气排放规程需要与联邦、州及当地的排放规程相一致。所有规程要求把对粉尘排放的控制作为工厂生产的一项指标。允许的排放量一般由流程含量表或公式来确定。这两种方法一般都要求从

关键词：电除尘器集尘袋干式电除尘集尘极板洗涤器清洗器分离设备水处理系统方案比较烧结过程

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Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria

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International Journal of Oral Science 2011年第1期3卷 13-20页

作者： chu-hong Hu Jian He Randal Eckert Xiao-yang wu Li-na Li Yan Tian Renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet bauer Maxwell H. Anderson wen-yuan Shi School of Dentistry University of California Los Angeles USA c3 Jian Inc Inglewood USA UcLA School of Nursing University of California Los Angeles USA

Dental caries （tooth decay） is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineraI in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound （Glycyrrhizol A）, from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops （twice a day for ten days） led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods.

关键词： antimicrobial therapy licorice Streptococcus mutans

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应用酶放大电极的免疫测定

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化学传感器 2002年第2期22卷 1-29页

作者： F.w.Scheller c.G.bauer A.Makower U.wollenberger A.warsinke F.F.Bier 章宗穰德国波茨坦大学生物化学与分子生理学研究所美国BAS生物分析系统公司德国IBMT生物医学技术研究所

该文评述了应用酶放大电极的免疫测定法的进展,从原理和应用两方面进行了探讨。着重介绍了作者所在实验室在90年代以来的相关工作。

关键词：应用酶放大电极免疫测定进展原理

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Radiationless anapole states in on-chip photonics

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Light(Science & Applications) 2021年第11期10卷 2161-2172页

作者： Evelyn Diaz-Escobar Thomas bauer Elena Pinilla-cienfuegos Angela I.Barreda Amadeu Griol L.Kuipers Alejandro Martinez Nanophotonics Technology center Universitat Politecnica de ValènciaCamino de Vera s/n46022ValenciaSpain Department of Quantum Nanoscience Kavli Institute of NanoscienceDelft University of Technology2600 GADelftThe Netherlands Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University JenaAlbert-Einstein-Straße 1507745JenaGermany

High-index nanoparticles are known to support radiationless states called anapoles,where dipolar and toroidal moments interfere to inhibit scattering to the far *** order to exploit the striking properties arising from these interference conditions in photonic integrated circuits,the particles must be driven in-plane via integrated ***,we address the excitation of electric anapole states in silicon disks when excited on-chip at telecom *** contrast to normal illumination,we find that the anapole condition-identified by a strong reduction of the scattering-does not overlap with the near-field energy maximum,an observation attributed to retardation *** experimentally verify the two distinct spectral regions in individual disks illuminated in-plane from closely placed waveguide terminations via far-field and near-field *** finding has important consequences concerning the use of anapole states and interference effects of other Mie-type resonances in high-index nanoparticles for building complex photonic integrated circuitry.

关键词： scattering waveguide states

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内源性葡萄膜炎患者体内病毒B19DNA及细小病毒B19特异性抗体的患病率

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 51-52页

作者： Heinz c. Plentz A. bauer D. 王文军 Department of Ophthalmology St. Franziskus Hospital Muenster Hohenzollernring 54 48145 Muenster Germany

Background: Parvovirus B19 causes erythema infectiosum (fifth disease) in children. The virus has been associated with several autoimmune diseases and has been found in synovium or serum from patients with long-standing arthritis or other rheumatic diseases. we investigated serum and aqueous fluid samples of patients with endogenous uveitis. Methods: Sera of 70 consecutive uveitis patientswere investigated for IgG against structural proteinsVP1 and VP2 and non-structural protein NS1 by western blot technique. Viral DNA in serum was assessed by quantitative PcR. Simultaneous DNA analysis was also performed on aqueous fluid samples from 11 uveitis patients and 10 patients without uveitis during routine cataract extraction. Results: In 15 (21.4%; healthy population: 16 of 10,000) of the 70 serum samples (mean age 42.69 years, range 9-82 years; 48 women, 22 men), viral DNA was detected. IgG directed against structural protein VP1 or VP2 was found in 60 patients (85.7%; healthy population: 80%) and IgG against non-structural protein NS1 in 33 patients (47.1%; healthy population: 22%). In none of the patients was IgM antibody as a serological marker for acute parvovirus infection found. Patients with posterior uveitis (n=11) had detectable serum DNA in 54.5%(p=0.021). This group displayed the highest rate of deterioration of visual acuity (>2 Snellen lines), at 72.7%(all patients: 58.6%; p=0.219). In 2 of the 11 aqueous fluid samples, viral DNA was detected. Antibodies against parvovirus B19 were found in both samples, whereas viral DNA was absent in the serum. In the control group of 10 healthy cataract patients, 3 had detectable DNA in the aqueous humor; 1 of these 3 also had detectable levels of viral DNA in serum. conclusions: Prevalence of IgG antibodies against NS1 protein in serum samples and DNA in serum is increased in uveitis patients compared with the normal population, suggesting a persistent infection. The presence of DNA in aqueous humor samples shows, for t

关键词：葡萄膜炎色素膜炎葡萄膜疾病 B19DNA B19 患者细小病毒细小脱氧核糖核酸病毒特异性抗体内源性

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基质金属蛋白酶在实验性单纯疱疹性角膜炎中的分布表达

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眼科研究 2003年第5期21卷 489-492页

作者：杨燕宁 Dirk bauer 邢怡桥 Arnd Heiligenhaus 武汉大学人民医院眼科 Department of Ophthalmology University of Essen45122 EssenGermany

目的明确角膜感染Ⅰ型单纯疱疹病毒(HSV-1)后基质金属蛋白酶(MMPs)及其组织抑制剂(TIMPs)在角膜中的分布。方法 HSV-1(KOS株)接种于BALB/c小鼠角膜上。分别收集正常眼球及感染后第2、7、14及28d的感染眼球行石蜡包埋,并应用抗MMP-2、-8... 详细信息

目的明确角膜感染Ⅰ型单纯疱疹病毒(HSV-1)后基质金属蛋白酶(MMPs)及其组织抑制剂(TIMPs)在角膜中的分布。方法 HSV-1(KOS株)接种于BALB/c小鼠角膜上。分别收集正常眼球及感染后第2、7、14及28d的感染眼球行石蜡包埋,并应用抗MMP-2、-8、-9及TIMP-1、-2的抗体免疫染色角膜切片。结果感染后第2d,MMP-2、-9及TIMP-1、-2的表达比未感染眼增加且表达主要位于浅表基质层及上皮下的炎性细胞中。感染后第14d及28d可见坏死性角膜炎及角膜溃疡形成,角膜基质中及浸润的炎性细胞中尤其是溃疡处可见MMP-2、-9及TIMP-1、-2表达显著增加。溃疡区域可见大量MMP-8阳性染色的中性粒细胞。结论 HSV-1角膜感染后由角膜细胞及浸润的炎性细胞分泌产生的MMPs对于上皮性角膜炎及溃疡形成过程可能起重要作用。

关键词：基质金属蛋白酶实验单纯疱疹性角膜炎 Ⅰ型单纯疱疹病毒基质金属蛋白酶抑制剂

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