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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-ha jeong jarno hiemstra Patrick v.Blokzijl rebeca Damian-Ferrara Danilo Martins dos Santos jéssica h.L.da Fonseca Min-ho Kang jihyun Kim Dilara Yilmaz-Aykut Mei L.L.cham-Pérez jeroen Leijten Su ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(ncaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink colloidal gels Extrusion printing Oxygen-generating microparticle

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Synthesis of coral-like structures of Pr-Yb co-doped YIG: Structural,optical, magnetic and antimicrobial properties

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journal of rare Earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francisca P.Araujo Y.Guerra S.castro-Lopes j.Matilla-Arias Idglan S.de Lima Edson c.Silva-Filho josy A.Osajima F.Guerrero r.Pena-Garcia Federal University of Piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal rural University of Pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal University of Piaui Department of PhysicTeresinaPBrazil Federal University of Pernambuco Graduate Program in Materials ScienceRecifePEBrazil University of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal University of Amazonas Department of PhysicManausAMBrazil Federal University of Pernambuco Department of PhysicRecifePEBrazil

coral-like structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. Structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIr) and raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(EDS) spectra and textural properties show corallike structures, peaks associated with Pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(K_(1)) and coercive field(h_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with Pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of Pr^(3+) cations favored the activity against S. aureus, therefore, a new biological property for YIG doped with rare earths is presented.

关键词： Yttrium iron garnet(YIG) coral-like structures rare earths Band gap energy Magnetic properties Antimicrobial properties

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Metrology for sub-rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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high Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.M.jeong S.Singh P.hadjisolomou O.Finke G.M.Grittani M.Nevrkla c.M.Lazzarini A.velyhan T.hayakawa Y.Fukuda j.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.v.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar j.Nejdl D.Margarone P.v.Sasorov S.Weber M.Kando h.Kiriyama Y.Kato G.Korn K.Kondo S.v.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary research Initiatives Osaka UniversityOsakaJapan hB11 Energy holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina collaborative Innovation center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AScr PragueCzech Republic FZU-Institute of Physics AScr PragueCzech Republic czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ Ar YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 j total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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SArS-cov-2 variants are associated with different clinical courses in children with MIS-c

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World journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno rojas Emelia Bainto helen harvey Adriana h.Tremoulet jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background recent infection with SArS‑cov-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SArS‑cov-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at rady children’s hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20j(Gamma).The third wave had Delta strains(clades 21A,21I,and 21j),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SArS-cov-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOvID-19 MIS-c SArS-cov-2 variants

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rescattering of stimulated raman side scattering in nonuniform plasmas

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Matter and radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.Wang Y.chen W.B.Yao c.Z.Xiao j.F.Myatt School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

rescattering of stimulated raman side scattering(SrSS)is observed for the first time via two-dimensional(2D)particle-in-cell(PIc)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order SrSS and estimate its *** rescattering process is identified by the 2D PIc simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SrSS propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order SrSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SrSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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hydromechanical characterization of gas transport amidst uncertainty for underground nuclear explosion detection

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journal of rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2019-2032页

作者： Wenfeng Li chelsea W.Neil j William carey Meng Meng Luke P.Frash Philip h.Stauffer Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNM87544USA Department of Mineral Engineering New Mexico TechSocorroNM87801USA

Given the challenge of definitively discriminating between chemical and nuclear explosions using seismic methods alone,surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions(UNEs).however,the migration of signature radionuclide gases between the nuclear cavity and surface is not well understood because complex processes are involved,including the generation of complex fracture networks,reactivation of natural fractures and faults,and thermo-hydro-mechanical-chemical(ThMc)coupling of radionuclide gas transport in the *** this study,we provide an experimental investigation of hydro-mechanical(hM)coupling among gas flow,stress states,rock deformation,and rock damage using a unique multi-physics triaxial direct shear rock testing *** testing system also features redundant gas pressure and flow rate measurements,well suited for parameter uncertainty *** porous tuff and tight granite samples that are relevant to historic UNE tests,we measured the Biot effective stress coefficient,rock matrix gas permeability,and fracture gas permeability at a range of pore pressure and stress *** Biot effective stress coefficient varies from 0.69 to 1 for the tuff,whose porosity averages 35.3%±0.7%,while this coefficient varies from 0.51 to 0.78 for the tight granite(porosityrhaps an underestimate).Matrix gas permeability is strongly correlated to effective stress for the granite,but not for the porous *** experiments reveal the following key engineering implications on transport of radionuclide gases post a UNE event:(1)The porous tuff shows apparent fracture dilation or compression upon stress changes,which does not necessarily change the gas permeability;(2)The granite fracture permeability shows strong stress sensitivity and is positively related to shear displacement;and(3)hydromechanical coupling among stress states,rock damage,and gas flow appears to be

关键词： Underground nuclear explosion uncertainty quantification radionuclide transport Biot effective stress coefficient Fracture permeability Matrix permeability

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Ab initio valence-space in-medium similarity renormalization group calculations for neutron-rich P,cl,and K isotopes

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chinese Physics c 2024年第7期48卷 181-190页

作者：谢萌冉沈留媛李健国李红蕙袁琪左维 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Neutron-rich P,cl,and K isotopes,particularly those with neutron numbers of approximately N=28,have attracted extensive experimental and theoretical *** utilize the ab initio valence-space in-medium similarity renormalization group approach,based on chiral nucleon-nucleon and three-nucleon forces,to investigate the exotic properties of these *** calculations of the low-lying spectra are performed.A key finding is the level inversion between 3/2_(1)^(+)and 1/2_(1)^(+)states in odd-A isotopes,attributed to the inversion ofπ0xod_(3/2) andπls_(1/2) single-particle *** ab initio calculations,which incorporate the three-nucleon forces,correlate closely with existing experimental *** calculations of effective proton single-particle energies provide deeper insights into the shell evolution for Z=14 and 16 *** results indicate that the three-body force plays important roles in the shell evolution for Z=14 and 16 sub-shells with neutron numbers ranging from 20 to ***,systematic ab initio calculations are conducted for the low-lying spectra of odd-odd *** results correspond with experimental data and provide new insights for future research into these isotopes up to and beyond the drip line.

关键词： ab initio calculations shell evolution low-lying spectra

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Individual and geospatial factors associated with receipt of colorectal cancer screening:a state-wide mixed-level analysis

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Family Medicine and community health 2024年第S2期12卷 18-25页

作者： jennifer E Bayly Mara A Schonberg Marcia c castro Kenneth j Mukamal Beth Israel Deaconess Medical center BostonMassachusettsUSA harvard Medical School BostonMassachusettsUSA Department of Global health and Population Harvard T H Chan School of Public HealthBostonMassachusettsUSA

Background colorectal cancer(crc)is the second leading cause of cancer death in US adults but can be reduced by *** roles of individual and contextual factors,and especially physician supply,in attaining universal crc screening remains *** We used data from adults 50-75 years old participating in the 2018 New York(NY)Behavioural risk Factor Surveillance System linked to county-level covariates,including primary care physician(PcP)density and gastroenterologist(GI)*** were analysed in *** analyses included(1)ecological and geospatial analyses of county-level crc screening prevalence and(2)individual-level Poisson regression models of receipt of screening,adjusted for socioeconomic and county-level contextual *** Mean prevalence of up-to-date crc screening was 71%(95%cI 70%to 73%)across NY’s 62 ***-level crc screening demonstrated significant spatial patterning(Global Moran’s I=0.14,p=0.04),consistent with the existence of county-level contextual *** both county-level and individual-level analyses,lack of health insurance was associated with lower likelihood of up-to-date screening(?−1.09(95%cI−2.00 to-0.19);adjusted prevalence ratio 0.68(95%cI 0.60 to 0.77)),even accounting for age,race/ethnicity and *** contrast,county-level densities of both PcPs and GIs were completely unassociated with screening at either the county or individual *** expected,other determinants at the individual level included education status and *** In this state-wide representative analysis,physician density was completely unassociated with crc screening,although health insurance status remains strongly *** similar screening environments,broadened insurance coverage for crc screening is likely to improve screening far more effectively than increased physician supply.

关键词： state screening county

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recent ventures in Interdisciplinary Arctic research:The ArcPATh Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.j.OGILvIE Leslie A.KING Noel KEENLYSIDE François cOUNILLON Brynhildur DAvIÐSDÓTTIr Níels EINArSSON Sergey GULEv Ke FAN Torben KOENIGK james r.McGOODWIN Marianne h.rASMUSSON Shuting YANG Institute of Arctic and Alpine research(INSTAAr) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland royal roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and remote Sensing centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia chinese Academy of Sciences Beijing 100045China Swedish Meteorological and hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic climate Predictions: Pathways to resilient Sustainable Societies-ArcPATh(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, russia, china, the United States, and canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ArcPATh made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ArcPATh was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ArcPATh served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： recent ventures in Interdisciplinary Arctic research:The ArcPATh Project

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Evidence for particle acceleration approaching Pev energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LhAASO collaboration Zhen cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.j.Bi Y.j.Bi W.Bian A.v.Bukevich Q.cao W.Y.cao Zhe cao j.chang j.F.chang A.M.chen E.S.chen h.X.chen Liang chen Lin chen Long chen M.j.chen M.L.chen Q.h.chen S.chen S.h.chen S.Z.chen T.L.chen Y.chen N.cheng Y.D.cheng M.Y.cui S.W.cui X.h.cui Y.D.cui B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.h.Fan Y.Z.Fan j.Fang j.h.Fang K.Fang c.F.Feng h.Feng L.Feng S.h.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao c.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.h.Gong Q.B.Gou M.h.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.han M.hasan h.h.he h.N.he j.Y.he Y.he Y.K.hor B.W.hou c.hou X.hou h.B.hu Q.hu S.c.hu D.h.huang T.Q.huang W.j.huang X.T.huang X.Y.huang Y.huang X.L.ji h.Y.jia K.jia K.jiang X.W.jiang Z.j.jiang M.jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li c.M.Li cheng Li cong Li D.Li F.Li h.B.Li h.c.Li jian Li jie Li K.Li S.D.Li W.L.Li W.L.Li X.r.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.j.Lin B.Liu c.Liu D.Liu D.B.Liu h.Liu h.D.Liu j.Liu j.L.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo h.K.Lv B.Q.Ma L.L.Ma X.h.Ma j.r.Mao Z.Min W.Mitthumsiri h.j.Mu Y.c.Nan A.Neronov L.j.Ou P.Pattarakijwanich Z.Y.Pei j.c.Qi M.Y.Qi B.Q.Qiao j.j.Qin A.raza D.ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu h.c.Song Yu.v.Stenkin v.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun j.Takata P.h.T.Tam Q.W.Tang r.Tang Z.B.Tang W.W.Tian c.Wang c.B.Wang G.W.Wang h.G.Wang h.h.Wang j.c.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.h.Wang r.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.h.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen c.Y.Wu h.r.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.r.Xiong Z.Xiong D.L.Xu r.F.Xu r.X.Xu W.L.Xu L.Xue D.h.Yan j.Z.Yan T.Yan c.W.Yang c.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang r.Z.Yang W.X.Yang Y.h.Yao Z.G.Yao L.Q.Yin N.Yin X.h.You Z.Y.You Y.h.Yu Q.Yuan h.Yue h.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang h.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Beijing 100049China TIANFU cosmic ray research center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear research of russian Academy of Sciences Moscow 117312Russia hebei Normal University Shijiazhuang 050024China University of Science and Technology of china Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China research center for Astronomical computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for research in Galaxies and cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of cosmic rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APc UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(crs)accelerated by the shock of supernova remnant(SNr)W51c and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51c for crs remains *** on observations conducted with the Large high Altitude Air Shower Observatory(LhAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LhAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 Tev and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 Tev or a power-law break at~200 Tev in the cr proton spectrum,most likely providing the first evidence of SNrs serving as cr accelerators approaching the Pev ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme cr accelerators within the W51 complex and provide new insights into the origin of Galactic crs.

关键词： UhE c-ray cosmic rays SNr W51c Star clusters

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