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MANAGEMENT OF INTRAOcULAR PRES-SURE FOLLOWING UNSUccESSFULL TRABEcULEcTOMY: A RANDOMISED cOMPARATIVE STUDY OF 5 -FLUO- ROURAcIL VERSUS MEDIcAL THERAPY

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国际眼科杂志 2003年第1期3卷 8-8页

作者： P.Ferreri M.Vetrugno A.Montepara F.cantatore c.sborgia Department of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari Italy

Purpose: to compare the efficacy of subconjunctival administration of 5-fluorouracil (5FU) with medical therapy in controlling elevated intraocular pressure (IOP) following unsuccessful, low-risk trabeculectomy. Methods: the study included 50 consecutive patients (50 eyes) who underwent trabeculectomy without intraoperative antimetabolites, and who were not compensat-

关键词：小梁切除术手术失败眼内压管理 5FU 药物治疗比较研究

INFLUENcE OF cATARAcT SURGERY AND INTRAOcULAR LENS IMPLANTA-TION ON RETINAL NERVE FIBER LAYER THIcKNESS AS MEASURED BY ScANNING LASER POLARIMETRY

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国际眼科杂志 2003年第1期3卷 25-25页

作者： T.Trabucco G.Ruggeri D.Sisto M.Vetrugno c.sborgia Department of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari ItalyDepartment of Ophthalmology University of Bari Italy

Purpose: to evaluate the influence of cataract surgery and the influence of intraocular lens (IOL) material implanted on retinal nerve fiber layer (RNFL),as measured by scanning laser po-larimetry (SLP). Methods: Seventhy eyes of 70 consecutive patients (34 male and 36 female, mean age 73.2±6.31) operated on by phacoemulsification with IOL insertion, were examined

关键词：白内障手术眼内晶状体植入视网膜神经纤维层厚度影响扫描激光旋光分析法

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

comparison of perioperative parameters in one-handed rotational phacoemulsification versus conventional phacoemulsification and femtosecond laser-assisted cataract surgery

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1868-1875页

作者： Samuele Gigliola Giancarlo sborgia Alfredo Niro carmela Palmisano Pasquale Puzo Gianluigi Giuliani Luigi sborgia Dario Sisto Valentina Pastore claudio Furino Rossella Donghia Alessandra sborgia Francesco Boscia Giovanni Alessio Eye clinic Department of Medical ScienceNeuroscience and Sense OrgansUniversity of BariBari 70124Italy Eye clinic Hospital“SS.Annunziata”ASL TarantoTaranto 74121Italy National Institute of Gastroenterology“S.de Bellis”Research Hospital Castellana Grotte 70013Italy

AIM:To compare perioperative parameters of one-handed rotational phacoemulsification technique(one-handed phaco-roll)with each of other two techniques,“Divide et conquer”and femtosecond laser-assisted cataract surgery(FLAcS)METHODS:In this retrospective and comparative cohort study,eyes with uncomplicated cataract(nuclear density grade 2 to 3)treated routinely with one-handed phacoroll(n=23;Group 1)or“Divide et conquer”(n=23;Group 2)or FLAcS(n=23;Group 3)were *** parameters including effective phaco-time(EPt),ultrasound time(USt),aspiration time,surgical time,phacoemulsification(phaco)-power,balanced salt solution(BSS)use,cumulative dissipated energy(cDE)were recorded and *** outcomes including best corrected visual acuity(BcVA),corneal endothelial cell density(EcD),endothelial cell loss(EcL),central corneal thickness(ccT)and central macular thickness(cMT),were assessed and compared pre-operatively and at 1mo after ***:Aspiration and surgical time,and BSS used were lower in Group 1(Pco-power and cDE were lower in Group 1(Pcantly different from Group *** Group 1,USt was lower(Pcant difference between Group 1 and the other *** significant differences regarding all post-operative morphologic outcomes(EcD,EcL,ccT,cMT)were *** clinical complications ***:One-handed phaco-roll seems to be less time-consuming than“Divide et conquer”and FLAcS and less energy-consuming than“Divide et conquer”.Furthermore,one-handed phaco-roll seems to have an equal safety profile compared to the other two techniques.

关键词： cataract surgery phaco-rolling onehanded phacoemulsification Divide et conquer femtosecond laser-assisted cataract surgery

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Fibula fractures management

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World Journal of Orthopedics 2021年第5期12卷 254-269页

作者： Gianluca canton Andrea sborgia Guido Maritan Roberto Fattori Federico Roman Marko Tomic Massimo Max Morandi Luigi Murena Department of Medical Surgical and Life SciencesOrthopaedics and Traumatology UnitTrieste UniversityTrieste 34149Italy Department of Orthopaedic Surgery Louisiana State University Health Science CenterShreveportLA 71103United States

Isolated distal fibula fractures represent the majority of ankle *** fractures are often the result of a low-energy trauma with external rotation and supination *** is based on clinical signs and radiographic *** X-rays have a role in detecting associated mortise *** depends on fracture type,displacement and associated ankle *** simple,minimally displaced fractures without ankle instability,conservative treatment leads to excellent *** treatment must also be considered in overaged unhealthy patients,even in unstable *** treatment is indicated when fracture or ankle instability are present,with several techniques *** is excellent in most *** regarding wound healing are frequent,especially with plate fixation,whereas other complications are uncommon.

关键词： Fibula fracture Lateral malleolus Distal fibula Management Treatment Ankle

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus