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Journal of Magnesium and Alloys 2022年第8期10卷 2173-2184页

作者： M.A.Grigoroscuta G.V.Aldica M.Burdusel V.sandu A.Kuncser I.Pasuk A.M.Ionescu T.S.Suzuki O.Vasylkiv P.Badica National Institute of Materials Physics 405A Street AtomistilorMagurele 077125Romania National Institute for Materials Science 1-2-1 SengenIbarakiTsukuba 305-0047Japan

The paper presents fabrication and characterization of spark plasma sintered textured(001) MgB_(2)with a record degree of orientation of about 40% and 16% by high-energy ultra-sonication and slip casting in high magnetic field(12 T) and 0 T magnetic field, *** characterization was performed by X-ray diffraction, and electron microscopy. The analysis revealed unexpected preferred orientation also in the MgO secondary phase due to the epitaxial growth of(111) MgO on(001) MgB_(2). The influence of oriented microstructure on the superconducting characteristics expressed by critical current density(J_(c)), irreversibility field(H_(irr)), and on the pinning properties were assessed. High anisotropy versus sample orientation in applied magnetic field, H, was observed for J_(c), Hirr, pinning activation energy(U^(*))extracted from relaxation measurements. The zero-field critical current, J_(c0)and F_(p),maxare weakly or not dependent on the direction of H,while the other indicated parameters are significantly influenced. Results enable control of superconducting parameters by further optimization of microstructure through MgB_(2) texturing as a novel and viable strategy for development of bulk MgB2with enhanced properties when taking advantage of its anisotropy.

关键词： Textured MgB_(2)bulk Slip casting Spark plasma sintering critical current density Pinning force Pinning activation energy

Study of the Hydro-chemical and Bacteriological Well Water characteristics of M’Bahiakro (central-Eastern cote d’Ivoire)

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Journal of Geoscience and Environment Protection 2020年第4期8卷 32-46页

作者： HervéA.N’cho Innocent K.Kouame Kouadio Koff Lazare K.Kouassi Séraphin K.Konan Ruth Bai Andrei sandu Ion sandu Laboratory of Geosciences and Environment UFR Science and Environmental ManagementNangui Abrogoua UniversityAbidjanCote d’Ivoire Laboratory of Water and Environmental Engineering UFR EnvironmentJean Lorougnon GuédéUniversity of DaloaDaloaCote d’Ivoire Faculty of Materials Science and Engineering Gheorghe Asachi Technical University of IasiIasiRomania center of Excellence Geopolymer&Green Technology(ceGeoGTech) School of Material EngineeringUniversiti Malaysia Perlis(UniMAP)KangarPerlisMalaysia Arheoinvest centre Institute of Interdisciplinary ResearchDepartment of ScienceAlexandru Ioan Cuza UniversityIasiRomania

The use of well water by disadvantaged populations in most African cities often presents health risks. The purpose of this study is to determine the physico-chemical and microbiological quality of M’bahiakro well water. A series of physico-chemical, microbiological and piezometric analyses were carried out on the well water in the area. The results of these analyses were processed using Piper and Schoeller-Berkaloff diagrams and the software R 3.1.2 for Principal component Analysis. Physico-chemical analysis results show that the water has an average temperature of 28°c. They are acidic, with a pH that generally varies from 4 to 6. M’bahiakro well waters are highly mineralized, with an average electrical conductivity of 369.1 μS/cm and 984.1 μS/cm and pass from sodium and potassium chlorinated facies in the dry season (February) to sodium chlorinated facies in the rainy season (October) with K+, Na+ and NO3- ions dominating. These ions would be the result of soil rainfall and the intervention of anthropogenic activities in the pollution of shallow groundwater. Bacteriological results exploitation shows that the well waters studied host high densities of enteritis bacteria (E. coli, Fecal streptococcus, and clostridium perfringens) during the rainy period (October). M’Bahiakro’s well water is of poor quality and unsuitable for human consumption without prior treatment. However, they deserve particular attention and would require further treatment in rainy periods.

关键词： Well Groundwater Hydrochemistry Microbiology

Potential Groundwater Pollution Risks by Heavy Metals from Agricultural Soil in Songon Area(Abidjan,cote d’Ivoire)

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Journal of Environmental Protection 2013年第12期4卷 1441-1448页

作者： Innocent K.Kouame Lazare K.Kouassi Brou Dibi Kouame M.Adou Ioan D.Rascanu Gheorghe Romanescu Issiaka Savane Ion sandu Laboratoire de Geosciences et Environnement Universite Nangui AbrogouaAbidjanCote d’Ivoire Alexandru Ioan cuza University ARHEOINVEST Interdisciplinary PlatformScientific Research and Conservation of Cultural Heritage LaboratoryIasiRomania Universite Jean Lorougnon Guede DaloaCote d’Ivoire Romanian Waters National Administration Prut-Barlad Water BranchIasiRomania

The soil samples were collected taking into account the land use in Songon area. The hydraulic conductivity (K) of soils was characterized in-situ when specific yield (Sy), pHw and concentrations of cooper, Iron, Zinc, cadmium, chromium and Lead were measured in the laboratory. Pollution load indices (PLI) were calculated to evaluate the soil contamination levels. The soils were neutral and alkaline (6.7≤ pH ≤ 9.20), permeable (1.9 í 10-5?m·s-1?≤ K ≤ 8.2 í 10-4?m·s-1), with a high specific yield (13.33% ≤ Sy ≤ 33.33%) which can favor the pollutants transfer. The heavy metals (Fe, cu, Zn, cd, cr and Pb) have very high concentrations in soils. The integrated pollution indices (PLI) indicate that almost 70% of Songon soils are moderately contaminated by the investigated heavy metals, with windows presenting high indices of pollution related to the intensive use of fertilizers and pesticides. The establishment of new boreholes in the Songon area should consider these heavy metals, so as to avoid the risk of groundwater pollution due to the physical properties of soils.

关键词： Songon Soil Heavy Metals Pollution Indices Groundwater Pollution Risk Abidjan

由同一献血员所致的丙型肝炎病毒感染者病情及病毒自然清除率的调查分析

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中华肝脏病杂志 2014年第4期22卷 251-254页

作者：刘三都程明亮任红穆茂杨庆坤贵州省黔南州人民医院感染科 558000 贵阳医学院附属医院感染科重庆医科大学附属第二医院

目的了解因输血传播HcV感染患者的临床特征及病毒自然清除率。方法采用回顾f生与横断面相结合的调查方法，对1998年1月至2002年12月在贵州某地接受同一位献血员血液的96例HcV感染者进行临床资料分析。对HcV感染者作抗-HcV、HcVRNA、HBV... 详细信息

目的了解因输血传播HcV感染患者的临床特征及病毒自然清除率。方法采用回顾f生与横断面相结合的调查方法，对1998年1月至2002年12月在贵州某地接受同一位献血员血液的96例HcV感染者进行临床资料分析。对HcV感染者作抗-HcV、HcVRNA、HBV标志物、肝脏生物化学指标检测，腹部B型超声、肝脏弹性超声检查。使用SPSS13．0统计软件对数据进行统计学处理，计数资料用石。检验。结果96例受血者抗-HcV均阳性，67例符合慢性丙型肝炎诊断标准，HcVRNA≥1．0X103拷贝／ml，慢性化率为69．7％，其中男性34例，女性33例。67例慢性丙型肝炎患者中12例有轻度乏力、纳差和腹胀，11例血清ALT升高，平均为（116．3±24．7）U／L，3例血清总胆红素轻度异常，平均为（32．6±5．3）umol／L，肝脏弹性检测值5．1～35．3kPa，平均值为（10．3士6．8）kPa，15例腹部B超检查显示为慢性肝炎征象，1例为肝硬化。无肝细胞癌病例。献血员及96例HcV感染者HcV基因检测均为HcVlb型。随访时间86～135个月，平均随访时间为（122．6±26．5）个月。HcV自然清除率为30．2％（29／96），男性为19．0％（8／42），女性为38．9％（21／54），男性明显低于女性，xk4．41，P=0．023，差异有统计学意义；病毒自然清除率：40岁以下年龄组为36．9％（24／65），41岁以上年龄组为16．1％（5／31），40岁以下年龄组明显高于41岁以上年龄组，x^2=4．30，P=0．028，差异有统计学意义；HcV慢性感染率，40岁以下年龄组为63．1％（41／65），41岁以上年龄组为83．9％（26／31），41岁以上年龄组明显高于40岁以下年龄组，x^2=6．67，P=0．028，差异有统计学意义。结论输血后感染HcV患者病程经过隐匿，病毒自然清除率与眭别和受感染时的年龄有关。

关键词：肝炎病毒,丙型肝炎,丙型,慢性输血病毒自然清除

恩替卡韦对乙型肝炎肝硬化患者血清sTRAIL的影响及疗效分析

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广州医科大学学报 2015年第5期43卷 40-44页

作者：陈典颜林丹刘三都黔南州人民医院贵州都匀558000 海南医学院附属医院海南海口570100

目的:探讨HBV感染导致肝硬化的过程中可溶性肿瘤坏死因子相关凋亡诱导配体(s TRAIL)介导的免疫损伤及恩替卡韦通过影响s TRAIL及抑制HBV-DNA复制,延缓或阻止乙型肝炎肝硬化发展的作用。方法:选取2013年1月至2014年1月海南医学院附属医... 详细信息

目的:探讨HBV感染导致肝硬化的过程中可溶性肿瘤坏死因子相关凋亡诱导配体(s TRAIL)介导的免疫损伤及恩替卡韦通过影响s TRAIL及抑制HBV-DNA复制,延缓或阻止乙型肝炎肝硬化发展的作用。方法:选取2013年1月至2014年1月海南医学院附属医院中医科乙型肝炎肝硬化患者40例为治疗组,健康体检者45例为对照组。治疗组予恩替卡韦(0.5 mg,每日一次)口服,疗程48周。两组患者分别于治疗前、治疗12、24、48周使用ELISA检测血清中s TRAIL水平,RT-PcR检测血清中HBV-DNA载量的变化,全自动生化分析仪检测肝功能,全自动血凝仪检测凝血酶原时间。同时在治疗组中随机选取16例患者,child-Pugh分级分别为A级6例,B级5例,c级5例,于恩替卡韦治疗前及治疗24周时进行肝脏穿刺组织病理检查。结果:治疗组治疗前s TRAIL、HBV DNA及ALT水平均高于健康对照组,差异有统计学意义(P<0.05);经线性相关分析,治疗组患者血清s TRAI与ALT含量呈显著正相关(r=0.736,P=0.000),血清s TRAIL与HBV-DNA载量无相关性(r=-0.0127,P=0.382)。恩替卡韦治疗后,治疗组血清s TRAIL水平下降,ALT恢复正常,HBV-DNA载量降低,肝脏组织病理学改善,与治疗前比较,差异有统计学意义(P<0.05)。结论:s TRAIL介导乙型肝炎肝硬化患者肝脏的免疫损伤过程。经恩替卡韦治疗后s TRAIL与ALT降低,HBV-DNA复制抑制,肝脏组织病理学改善,从而延缓或阻止肝硬化的发展。在恩替卡韦抗病毒过程中动态监测s TRAIL的变化有助于肝硬化预后的判断。

关键词：乙型肝炎肝硬化可溶性肿瘤细胞坏死因子相关凋亡诱导配体(s TRAIL) 恩替卡韦疗效分析

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干制石榴皮多酚的抗氧化活性研究

武夷学院学报 2015年第12期34卷 28-31页

作者：张婷婷谢三都邹美玲卓清菊武夷学院茶与食品学院福建武夷山354300 福建师范大学闽南科技学院福建泉州362332

采用超声波萃取技术从干制石榴皮中提取石榴皮多酚。以羟自由基（OH·）、超氧阴离子（O2·）的清除率和油脂过氧化值为指标,研究了干制石榴皮多酚的抗氧化活性。结果表明：石榴皮多酚具有较强的自由基清除能力和一定的抗油脂氧化效果,... 详细信息

采用超声波萃取技术从干制石榴皮中提取石榴皮多酚。以羟自由基（OH·）、超氧阴离子（O2·）的清除率和油脂过氧化值为指标,研究了干制石榴皮多酚的抗氧化活性。结果表明：石榴皮多酚具有较强的自由基清除能力和一定的抗油脂氧化效果,在0.26~0.45mg/mL时,石榴皮多酚对羟基自由基（OH·）的清除效果不及Vc;但在0.46~0.60mg/mL时,石榴皮多酚则优于Vc;在相同浓度下石榴皮多酚对超氧阴离子的清除效果总是略高于Vc;抗油脂过氧化效果仅略低于BHT。

关键词：干石榴皮多酚抗氧化活性

肝爽颗粒对肝硬化患者肝储备功能及肝纤维化指标的影响

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中国医学创新 2023年第13期20卷 111-114页

作者：陈典颜刘三都舒德云杨庆坤汤郁贵州省黔南州人民医院贵州都匀558000

目的:探究及观察肝爽颗粒对肝硬化患者肝储备功能及肝纤维化指标的影响。方法:将2019年1月-2022年3月黔南州人民医院收治的108例肝硬化患者根据随机数字表法分为对照组和观察组,每组54例。对照组进行常规肝硬化治疗,观察组在对照组的基... 详细信息

目的:探究及观察肝爽颗粒对肝硬化患者肝储备功能及肝纤维化指标的影响。方法:将2019年1月-2022年3月黔南州人民医院收治的108例肝硬化患者根据随机数字表法分为对照组和观察组,每组54例。对照组进行常规肝硬化治疗,观察组在对照组的基础上加用肝爽颗粒进行治疗。比较两组治疗总有效率、肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)及血清总胆红素(STB)]、肝储备相关指标[吲哚菁绿15 min滞留率(IcG R15)、肝有效血流量(EHBF)及肝功能分级(child-Turcotte-Pugh评分,cTP评分)]及肝纤维化指标[Ⅲ型前胶原(PcⅢ)、Ⅳ型胶原(cⅣ)、透明质酸(HA)及层粘连蛋白(LN)]。结果:观察组总有效率显著高于对照组,差异有统计学意义(P0.05);治疗12、24周后观察组ALB及EHBF均显著高于对照组,其他肝功能指标、肝储备相关指标及肝纤维化指标均显著低于对照组,差异均有统计学意义(P<0.05)。结论:肝爽颗粒在肝硬化患者中的应用效果较好,可显著改善患者的肝储备功能及肝纤维化状态。

关键词：肝硬化肝爽颗粒肝储备功能肝纤维化指标