检索结果-南通市图书馆

Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： D.LEE s.cHANG J.LEE Department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea school of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random inputs.The method consists of a generalized polynomial chaos expansion(GPcE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data set.In the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random inputs.This allows for avoiding repeated computations of invariant substructures while generating the input-output data set.combining substructuring with static condensation further improves the computational efficiency of the reanalysis without losing accuracy.consequently,the GPcE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional inputs.The numerical results obtained from a simple structure indicate that the proposed method for UQ produc.s.accurate solutions more efficiently than the GPcE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPcE) static reanalysis method static condensation substructuring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graphene derivatives as efficient hole transport materials for lead-free double perovskite(c.s.I) solar cells: a numerical study

引用

Optoelectronics Letters 2024年

作者： sARITA YADAV sARAL K GUPTA c.M.s.NEGI Department of Physical science Banasthali Vidyapith

The double perovskite cs2snI6has notable optical and electrical characteristics， rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells (Pscs). We simulated the performance of Pscs using lead-free cs2snI6double perovskite absorber layer and graphene derivatives， namely graphene oxide (GO) and reduced graphene oxide (rGO)， as hole transport layers (HTLs). Our findings show that rGO offers an excellent hole extraction property with minimal interfacial recombination compared to GO. Psc utilizing rGO as the HTL material achieved a power conversion efficiency of 19.07%， while those employing GO HTL attained only 16.9%. The superior performance of rGO is attributed to its greater charge carrier mobility of rGO and its favorable energy level alignment with the double perovskite absorber layer. In contrast， the mismatch in the charge transport properties between the absorber layer and the GO HTL resulted in poor performance. Our study showc.s.s the potential of using graphene derivative-based HTLs for realizing lead-free Pscs.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

引用

Bone Research 2024年第1期12卷 180-198页

作者： Morten s.Hansen Kaja Madsen Maria Price Kent søe Yasunori Omata Mario M.Zaiss caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark clinical cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and systems Research(IMsR)and centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK centre for Membrane Proteins and Receptors(cOMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic.s.rgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno Diabetes center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone formation.As novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment targets.This study aimed to provide an overview of transcriptional reprogramming during human osteoclast differentiation.Osteoclasts were differentiated from cD14+monocytes from eight female donors.RNA sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across donors.These patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density sNPs.Network analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional networks.The donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature osteoclasts.The expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and activity.The regulatory effec.s.of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(c5AR1),somatostatin receptor 2(ssTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating c5AR1 enhanced osteoclast formation,while activating ssTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature osteoclasts.In conclusion,we report the occurrence of transcriptional

关键词： osteoclast programming identif

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing Multicriteria-Based Recommendations by Alleviating scalability and sparsity Issues Using collaborative Denoising Autoencoder

引用

computers, Materials & continua 2024年第2期78卷 2269-2286页

作者： s.Abinaya K.Uttej Kumar school of computer science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender system(Rs)is a crucial part of several firms,particularly those involved in e-commerce.In conventional Rs,a user may only offer a single rating for an item-that is insufficient to perceive consumer preferenc.s.Nowadays,businesses in industries like e-learning and tourism enable c.s.omers to rate a product using a variety of factors to comprehend c.s.omers’preferenc.s.On the other hand,the collaborative filtering(cF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested items.However,the c.s. of these computations increases nonlinearly as the number of items and users increases.To triumph over the issues,a novel expanded stacked autoencoder(EsAE)with Kernel Fuzzy c-Means clustering(KFcM)technique is proposed with two phases.In the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the EsAE approach and users are clustered using the KFcM approach.In the next phase of online,the top-N recommendation prediction is made by the EsAE approach involving only the most similar user from multiple clusters.Hence the EsAE_KFcM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation time.An experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the EsAE_KFcM model constantly outperforms conventional Rs algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder Kernel Fuzzy c-Means clustering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

semi-analytical investigation of heat transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

引用

Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREEsHA M.L.KEERTHI Department of PG studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic visc.s.ty. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian decomposition sumudu transform method(ADsTM) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian decomposition sumudu transform method(ADsTM) trihybrid nanofluid magnetic field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies

引用

Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.scott Duncan sean M.Riordan Matthew c.Gernon Peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical sciences School of MedicineUniversity of Missouri

cannabinoids are lipophilic.s.bstanc.s.derived from cannabis sativa that can exert a variety of effec.s.in the human body.They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases.some of these include central nervous system(c.s.diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric disorders.In addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal c.s.function,and if controlled or modified,may represent an additional therapeutic avenue for c.s.diseases.This review disc.s.es in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple c.s.pathologies.In addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of c.s.diseases.cannabinoids and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

引用

chinese Physics c 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York city college of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPcM)with forbidden states,including low-lying resonanc.s.The investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonanc.s.due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 transition.We calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·b.The important role of the asymptotic constant(Ac)for the ^(15)N(p,γ0)16O proc.s. with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonanc.s.is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is found.The reaction rate is calculated and compared with the existing rates.It has negligible dependence on the variation of Ac but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonanc.s.in reference to the cNO Gamow windows,especially at low temperatures.We estimate the contribution of c.s.ade transitions to the reaction rate based on the exclusive experimental data from Phys.Rev.c.85,065810(2012).The reaction rate enhancement due to the c.s.ade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=1.3.We present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPcM and provide the temperature windows,prevalence,and significance of each proc.s..

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model cNO-cycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing Average Electric Power During the charging of Lithium-Ion Batteries Through the Taguchi Method

引用

Transactions of Tianjin University 2024年第2期30卷 152-166页

作者： Mohd H.s.Alrashdan Department of Electrical Engineering Al-Hussein Bin Talal UniversityMaan 71110Jordan

In recent times, lithium-ion batteries have been widely used owing to their high energy density, extended cycle lifespan, and minimal self-discharge rate. The design of high-speed rechargeable lithium-ion batteries fac.s.a significant challenge owing to the need to increase average electric power during charging. This challenge results from the direct influence of the power level on the rate of chemical reactions occurring in the battery electrodes. In this study, the Taguchi optimization method was used to enhance the average electric power during the charging proc.s. of lithium-ion batteries. The Taguchi technique is a statistical strategy that facilitates the systematic and efficient evaluation of numerous experimental variables. The proposed method involved varying seven input factors, including positive electrode thickness, positive electrode material, positive electrode active material volume fraction, negative electrode active material volume fraction, separator thickness, positive current collector thickness, and negative current collector thickness. Three levels were assigned to each control factor to identify the optimal conditions and maximize the average electric power during charging. Moreover, a variance assessment analysis was conducted to validate the results obtained from the Taguchi analysis. The results revealed that the Taguchi method was an eff ective approach for optimizing the average electric power during the charging of lithium-ion batteries. This indicates that the positive electrode material, followed by the separator thickness and the negative electrode active material volume fraction, was key factors significantly infl uencing the average electric power during the charging of lithium-ion batteries response. The identification of optimal conditions resulted in the improved performance of lithium-ion batteries, extending their potential in various applications. Particularly, lithium-ion batteries with average electric power of 16 W and 17 W during charging were designed and simulated in

关键词： Lithium-ion batteries Average electric power during charging Taguchi method cOMsOL Multiphysics software c rate L27 orthogonal array

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ca^(2+) binding to the c_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

引用

Protein & cell 2024年第4期15卷 305-312页

作者： Han chen Mehar Monga Qinghua Fang Loujin slitin Jakob Neef shashank s.chepurwar Regina célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch carolin Wichmann Nicola strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany collaborative Research center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIc Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging cluster of Excellence(MBExc) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHcs)employ a unique molecular machinery(see extended background in supplementary Materials).Otoferlin is a key player in this machinery and its defec.s.cause human auditory synaptopathy(Moser and starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-c_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see supplementary Materials.Otoferlin is distributed broadly within IHcs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gut microbiota in preterm infants receiving breast milk or mixed feeding

引用

World Journal of clinical Pediatrics 2024年第2期13卷 135-145页

作者： sandra Gabriela sánchez-González Bárbara Gabriela cárdenas-del-c.s.illo Elvira Garza-González Gerardo R Padilla-Rivas Isaías Rodríguez-Balderrama consuelo Treviño-Garza Fernando Félix Montes-Tapia Gerardo c Palacios-saucedo Anthony Gutiérrez-Rodríguez Manuel Enrique de-la-O-cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric.s.rgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BAcKGROUND Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several complications.Breast milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and Bifidobacteria.AIM To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or less.METHODs An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital Dr.JoséEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were classified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June 2019.Fecal samples were collected before they were introduced to any feeding type.After full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16s rRNA gene sequencing.Numerical variables were compared using student’s t-test or using the Mann–Whitney U test for nonparametric variables.Dominance,evenness,equitability,Margalef’s index,Fisher’s alpha,chao-1 index,and shannon’s diversity index were also calculated.REsULTs No significant differenc.s.were observed at the genus level between the groups.class comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(Pcounts of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(Pcteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most abundant.However,no significant differenc.s.were observed between the initial and final samples

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16s rRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：