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羟基磷灰石陶瓷对成骨细胞分化影响的研究

羟基磷灰石陶瓷对成骨细胞分化影响的研究

湖北省暨武汉市生物化学与分子生物学学会第八届第十七次学术年会

作者：王朝元 Boban Markovic c.rolfe howlett Hala Zreiqat 中南民族大学生命科学学院

通过定量检测在羟基磷灰石表面生长的成骨细胞骨涎蛋白和骨钙蛋白的表达,研究了羟基磷灰石陶瓷对成骨细胞的影响。研究结果表明,随着成骨细胞培养时间的延长,在羟基磷灰石表面生长的成骨细胞骨钙蛋白和骨涎蛋白的表达量相对于对照组有... 详细信息

通过定量检测在羟基磷灰石表面生长的成骨细胞骨涎蛋白和骨钙蛋白的表达,研究了羟基磷灰石陶瓷对成骨细胞的影响。研究结果表明,随着成骨细胞培养时间的延长,在羟基磷灰石表面生长的成骨细胞骨钙蛋白和骨涎蛋白的表达量相对于对照组有显著增加。由于骨钙蛋白和骨涎蛋白是成骨细胞分化晚期高度表达的两种标志性蛋白质,因此其表达量的显著提高意味着羟基磷灰石陶瓷可以诱导成骨细胞的成熟。

关键词：羟基磷灰石陶瓷成骨细胞成熟骨钙蛋白骨涎蛋白

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羟基磷灰石陶瓷诱导成骨细胞的研究

四川大学学报（自然科学版） 2003年第6期40卷 1110-1113页

作者：王朝元段友容 Boban Markovic c. Hala Zreiqat rolfe howlett 张兴栋四川大学生物材料工程研究中心 chemical Safety and Toxicology Laboratories School of Safety Science the University of New South Wales Bone Biomaterial Unit Pathology Department The University of New South Wales

通过定量检测在羟基磷灰石(HA)表面生长的成骨细胞骨涎蛋白和骨钙蛋白的表达,研究了羟基磷灰石陶瓷对成骨细胞的影响.研究结果表明,随着成骨细胞培养时间的延长,在羟基磷灰石表面生长的成骨细胞骨钙蛋白和骨涎蛋白的表达量相对于对照组... 详细信息

通过定量检测在羟基磷灰石(HA)表面生长的成骨细胞骨涎蛋白和骨钙蛋白的表达,研究了羟基磷灰石陶瓷对成骨细胞的影响.研究结果表明,随着成骨细胞培养时间的延长,在羟基磷灰石表面生长的成骨细胞骨钙蛋白和骨涎蛋白的表达量相对于对照组有显著增加.由于骨钙蛋白和骨涎蛋白是成骨细胞分化晚期高度表达的两种标志性蛋白质,因此其表达量的显著提高意味着羟基磷灰石陶瓷可以诱导成骨细胞的成熟.这一结果可进一步为理解HA陶瓷的生物相容性和生物活性提供分子生物学依据.

关键词：羟基磷灰石陶瓷成骨细胞成熟骨钙蛋白骨涎蛋白

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Where is the policy?A bibliometric analysis of the state of policy research on medical tourism

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Global Health Research and Policy 2020年第1期5卷 252-267页

作者： Altaf Virani Adam M.Wellstead Michael howlett Lee Kuan Yew School of Public Policy National University of Singapore469C Bukit Timah RoadSingapore 259772Singapore Department of Social Sciences Michigan Technological UniversityHoughtonUSA Department of Political Science Simon Fraser UniversityBurnabyBritish ColumbiaCanada

Background:It is imperative that researchers studying medical tourism connect their work with policy,so that its real-world challenges can be better understood,and more effectively *** article gauges the scope and evolution of policy thinking in medical tourism research through a bibliometric review of published academic literature,to establish the extent to which researchers apply public policy theories and frameworks in their investigation of medical tourism,or consider the policy imperatives of their ***:A Boolean search of the Web of Science(WoS)core collection was performed to identify policy-related publications on medical *** analyzed the results using bibliometrics and a data visualization software called VOSviewer to identify patterns in knowledge production and underlying network linkages in policy research on the ***:Our findings suggest that only a small proportion of medical tourism research explicitly addresses policy issues or applies policy paradigms in their study ***-specialized journals serving practitioners publish less research as compared to interdisciplinary social and health policy ***,there are significant geographical and disciplinary disparities in the policy-orientation of research,and a predilection towards select policy areas such as reproductive and transplant tourism to the neglect of more holistic governance and health system ***:This article is a call to action for greater engagement by policy scholars on medical tourism,and for health researchers to more explicitly consider how their research might contribute to the understanding and resolution of contemporary policy challenges of medical *** to clearly and consistently make the policy connection is a lost opportunity for researchers to frame the public debate,and influence policy thinking on medical tourism.

关键词： Medical tourism Health tourism Healthcare tourism Policy research Policy thinking Bibliometric analysis

conversion coatings of Mg-alloy AZ91D using trihexyl(tetradecyl) phosphonium bis(trifluoromethanesulfonyl)amide ionic liquid

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Science china chemistry 2012年第8期55卷 1598-1607页

作者： howlett P. c. GRAMET S. LIN J. EFTHIMIADIS J. cHEN X. B. BIRBILIS N. FORSYTH M. ARc centre of Excellence for Electromaterials Science Institute for Frontier Materials Deakin Univerxlty Burwood Campus Burwood Victoria 3125 Australia cAST cooperative Research centre Department of Materials Engineering Monash University Melbourne Victoria 3800 Australia

This work reveals the performance of a trihexyl(tetradecyl)phosphonium bis(trifluoromethanesulfonyl)amide ([P6,6,6,14][NTf2]) ionic liquid (IL) conversion coating upon AZ91D. Such conversion coatings represent a novel avenue for chromate replacement. An optimization of coating performance was pursued by careful alloy pretreatment to generate a surface on which the coating performs best, as the AZ91 substrate is distinctly different from pure or dilute Mg alloys. The results reveal that a functional conversion coating can be achieved, retarding anodic dissolution kinetics, causing a significant decrease in corrosion rate. The coating efficacy is closely tied to the pretreatment performed, which dictates both the microstructural and electrochemical heterogeneity of the surface. The resulting coatings were found to contain MgxFx and phosphonium cation related components, the proportions of which were dependent on the pretreatment.

关键词： AZ91D corrosion conversion coating ionic liquid pretreatment

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Biopsy of parotid masses:Review of current techniques

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World Journal of Radiology 2016年第5期8卷 501-505页

作者： Sananda Haldar Joseph D Sinnott Kemal M Tekeli Samuel S Turner David c howlett Department of Radiology East Sussex Healthcare Trust Department of ENT Surgery East Sussex Healthcare Trust Department of Maxillofacial Surgery Royal Sussex County Brighton Department of Surgery Royal Free Hospital

Definitive diagnosis of parotid gland masses is required optimal management planning and for prognosis. There is controversy over whether fine needle aspiration cytology(FNAc) or ultrasound guided core biopsy(UScB) should be the standard for obtaining a biopsy. The aim of this review is to assess the current evidence available to assess the benefits of each technique and also to assess the use of intra-operative frozen section(IOFS). Literature searches were performed using pubmed and google scholar. The literature has been reviewed and the evidence is presented. FNAc is an accepted and widely used technique. It has been shown to have variable diagnostic capabilities depending on centres and experience of staff. UScB has a highly consistent diagnostic accuracy and can help with tumour grading and staging. However, the technique is more invasive and there is a question regarding potential for seeding. Furthermore, UScB is less likely to be offered as part of a one-stop clinic. IOFS has no role as a first line diagnostic technique but may be reserved as an adjunct or for lesions not amenable to percutaneous biopsy. On balance, UScB seems to be the method of choice. The current evidence suggests it has superior diagnostic potential and is safe. With time, UScB is likely to supplant FNAc as the biopsy technique of choice, replicating that which has occurred already in other areas of medicine such a breast practice.

关键词： Parotid Biopsy Fine needle aspiration cytology Mass Fine needle aspiration cytology corebiopsy Ultrasound Diagnosis

Increasing Employees’ Fruit consumption through Access and Peer Support at Work

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Food and Nutrition Sciences 2013年第10期4卷 88-95页

作者： Amanda D. Hutchinson Georgina howlett carlene Wilson Flinders centre for Innovation in cancer Flinders University Adelaide Australia cancer council South Australia Adelaide Aus- tralia School of Psychology Flinders University Adelaide Australia.

Objective: To assess the effect of providing free fruit and peer support in the workplace, on employees’ consumption of fruits and high fat snacks at work and home. Methods: Three worksites, including 75 employees, were randomly assigned to a free fruit condition (Group A), a free fruit and peer education and modelling condition (Group B), and a control group (Group c). Groups A and B had free fruit delivered to their workplace each morning for four weeks. consumption of fruit and high fat snacks was measured pre- and post-intervention, and after a two week maintenance period. Results: Despite a small sample, the intervention increased employees’ fruit intake at work, decreased high fat snacks and was more successful in those who were not currently meeting the recommendations of two pieces of fruit per day. Peer support led to increased fruit consumption at work and sustained decreases in unhealthy snacks post-intervention. conclusions: The provision of fruit in the workplace with peer support is a simple and effective method for improving fruit consumption at work in the short-term, particularly in those not meeting current recommendations. In addition, those participating in the intervention reduced their consumption of high fat snacks. Further research is necessary to determine whether a longer larger scale intervention can sustain dietary changes and thereby reduce risk for chronic disease in the Australian population.

关键词： Workplace Peer Education Health Promotion Fruit

Haematology and biochemistry values of captive sand cats(Felis margarita)in Al Ain Wildlife Park and Resort,United Arab Emirates

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Journal of coastal Life Medicine 2013年第2期 141-144页

作者： Stephen chege Arshad Toosy Judith howlett Ahmed Saker John Kagira Al Ain Wildlife Park and Resort Life Sciences DepartmentVeterinary Section PO Box 1204Al AinUAE Jomo Kenyatta University of Agriculture and Technology PO Box 62000-00200NairobiKenya

Objective:To investigate the haematology and biochemistry values of apparently healthy captive sand cats kept in Al Ain Wildlife Park and Resort,United Arab Emirates,with a view to establishing baseline ***:Blood was collected from the femoral vein using aseptic techniques,kept in a cool box and sent to laboratory for *** blood was analysed for haematological and biochemical values using veterinary hematology and chemistry analysers(ABX ABc Vet,Horiba ABX SAS^(®)Montpellier,France).Results:Haematological values were within the normal ranges recorded in domestic cats and there was no statistical difference between values found in males and *** aminotransferase values were higher(Pcompared to female *** protein,creatinine and glucose values for females were significantly(Pctate dehydrogenase levels were higher than those reported for normal domestic cat,but there was no statistical difference(P>0.05)between males and females ***:Our results present reference ranges for haematology and biochemistry parameters in captive sand *** values will be important for diagnosis of various diseases and monitoring of treatments.

关键词： Al Ain Wildlife Park and Resort Apparently healthy Biochemistry Haematology Sand cats

英国国家审计署评估影像导向或影像辅助的肝活检的研究结果。第一部分.程序方面,诊断的充分性和准确性

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国际医学放射学杂志 2013年第1期 75-76页

作者： D.c.howlett K.J.Drinkwater D.Lawrence S.Barter T.Nicholson 霍晓婷 Department of Radiology Eastbourne District General HospitalKings DriveEastbourneEast SussexEngland BN21 2UD

目的评估英国全国范围内肝脏活检的程序,诊断的充分性和准确性。材料与方法在英国此类研究无需伦理委员会的批准。所有参与这项回顾性的审计者,均为皇家放射医师协会注册的医师,由放射科任命负责科室内的审计。选择2008年进行影像导向... 详细信息

目的评估英国全国范围内肝脏活检的程序,诊断的充分性和准确性。材料与方法在英国此类研究无需伦理委员会的批准。所有参与这项回顾性的审计者,均为皇家放射医师协会注册的医师,由放射科任命负责科室内的审计。选择2008年进行影像导向或影像辅助肝活检的连续的前50例病人。关于活检程序方面,参照已公布的数据确定取材的充足性和准确性的审计标准。计算其敏感度、特异度、阳性预测值、阴性预测值和准确度。考查与诊断样本质量相关的组织和临床因素。结果 210个科室中的87个(41%)审计人员为这项研究提供了3496例病例(1225例局灶性,2262例非局灶性,9例未确诊)。超声导向是局灶性和非局灶性病灶中最常用的技术(2808/3490例,96.38%)。采样充足率的标准(98%)在实践中稍差(3401/3472例,97.96%),但是诊断准确度的标准(90%)能够满足要求(3187/3234例,98.55%)。研究发现活检后规定的依从性较差。结论这项审计中大部分的肝活检是放射医生在影像导向或辅助下完成,常采用超声手段。活检具有高度的准确性。一些活检的术后方面不能达到规定的标准,需在实际情况改变后再次审计。

关键词：肝活检充分性程序导向

影像导引下或影像辅助下肝活检的英国国家审计评估调查第二部分:轻微和严重并发症及术后死亡率

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国际医学放射学杂志 2013年第2期 166-166页

作者： D.c. howlett K.J. Drinkwater D. Lawrence S. Barter T. Nicholson 高飞 Department of Radiology Eastbourne DistrictGeneral Hospital Kings Dr Eastbourne East Sussex EnglandBN21 2UD

目的确定影像导引下和(或)影像辅助下肝脏活检后出现并发症和死亡的概率,并识别与并发症或死亡发生风险相关的因素。材料与方法在英国,本研究无需机构伦理委员会审核。本研究邀请经英国放射学会认证的皇家学院放射科医生参加。研究首先... 详细信息

目的确定影像导引下和(或)影像辅助下肝脏活检后出现并发症和死亡的概率,并识别与并发症或死亡发生风险相关的因素。材料与方法在英国,本研究无需机构伦理委员会审核。本研究邀请经英国放射学会认证的皇家学院放射科医生参加。研究首先包括50例在2008年进行过肝组织活检的病人。预设的调查标准包括轻微疼痛(<30%)、严重疼痛(<3%)、血管迷走神经性低压(<3%)、大量出血(<0.5%)、胆道出血(<0.1%)、穿刺到其他器官(<0.1%)和死亡(<0.1%)。统计调查组织管理、临床和凝血因素的变化与并发症和(或)死亡的关系。结果数据源自210个放射科中的87个(41%)。审计标准包括疼痛、低血压、出血、胆道出血、穿刺到其他器官。4例因出血死亡,勉强达标[实际概率,0.11%(4/3486例)]。另有15例病人至少发生过一次严重并发症。有3%(97/2951例)的病人缺少国际标准化比率(INR),1%(32/2986例)的病人缺少血小板计数,8%(229/2888例)的病人的INR值是1周前测量,10%(291/2955)病人的血小板计数是1周前测量。结论该调查结果证实,在英国放射科内进行的影像导引或影像辅助下肝脏活检操作是安全的,并发症发生率在预期范围内。某些病例如果操作前凝血评估结果不佳,需要再次复查。

关键词：影像导引严重并发症肝脏活检英国大不列颠及北爱尔兰联合王国