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creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cS De Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease

油气两相流工况下汽车发动机轴承气蚀磨损的模拟试验研究

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机械工程学报 2001年第2期37卷 83-86,95页

作者：安琦 Priest M Taylor c M 华东理工大学机械学院上海200237 The University of LeedsLS29JT UK

采用超声振动原理建立了一台汽车发动机滑动轴承模拟气蚀试验装置。试验研究了空气混入滑动轴承后对其气蚀磨损的影响。通过大量试验研究结果的分析比较 ,发现空气的混入会使滑动轴承的气蚀磨损降低 ,且含气率越高这种影响作用越明显。

关键词：油气两相流滑动轴承气蚀磨损汽车发动机试验装置

Variability of the useful life of reservoirs in tropical locations:A case study from the Burdekin Falls Dam, Australia

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International Journal of Sediment Research 2018年第2期33卷 93-106页

作者： Michelle cooper Stephen E.Lewis Thomas c.Stieglitz Scott G.Smithers college of Scilence and Engineering James Cook University centre for Tropical Water ε Aquatic Ecosystem Research TropWATER James Cook University

Large dam construction for irrigation, hydropower, water supply, and flood control in tropical to subtropical areas increased markedly after 1950. Many of the dams built during this period have filled with sediment and no longer perform to their original design specifications; in many cases, forecast dam life was greatly overestimated. This study investigates the useful life of Burdekin Falls Dam(BFD), northeastern Australia and compares the findings with other tropical reservoirs. Using two independent methods it is estimated that between 61 and 65 million m3 of sediment has been deposited in the reservoir over the 24 years of operation through 2011. This sediment volume equates to an average of0.15% of capacity lost per year since construction was completed. If current sediment loads/climate regimes persist, reservoir capacity will be reduced by 50% after 345 years. However, the useful life of the BFD reduces to just 276 years when drawdown data are considered; these data show reservoir use would be affected once 40% of storage was filled with sediment, with a 60% drawdown return period of 1 in 15 years. When compared to similar large tropical to sub-tropical reservoirs, the BFD has a slightly longer reservoir useful life than dams in India and a much longer half-life than for both similar-sized and larger dams in china, Brazil, and Iran. Properties of the BFD that promote a longer useful life include a lower trap efficiency, relatively low annual sediment load delivered to the reservoir, limited sediment deposition behind the dam wall(and uniform distribution of deposited sediment), and the export of highly turbid annual floodwaters before settling and deposition of any remaining sediment within the reservoir.

关键词： Reservoir half-life Lake Dalrymple Sediment trapping Trap efficiency Tropical reservoir Useful life

Structure-activity relationship of endomorphins and their analogs

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chinese Science Bulletin 2001年第13期46卷 1096-1100页

作者： HUO Xiaofeng WU Ming REN Weihua WANG Rui cHAN Albert S.c. Department of Biochemistry and Molecular Biology School of Life ScienceLanzhou UniversityLanzhou 730000China Department of Applied Biology and chemical Technology Hong Kong Polytechnic UniversityHong KongChina

To study the structure-activity relationship of endomorphins (EMs), the action of opioid receptor binding (AORB), analgesic activity and vasodilator effects of EMs and their eight analogs were investigated, which were prepared by rationally replacing the 2-/3-amino acid (Aa) of EMs. The results showed: (i) The 2-Aa was comparatively more related to the selectivity of EMs while the 3-Aa to their affinity; (ii) the analgesia and vasodilatation of EMs and their analogs were not completely dictated by their AORB (in vitro), the action of [D-Pro2]EM-2 was unusual; (iii) EMs lost their analgesia in the central nervous system and their vasodilatation in the circulatory system with different mechanisms; the former was due to the degradation of some peptidase, and the latter possibly due to the feedback inhibition.

关键词： endomorphins structure-activity relationship action of opioid receptor binding analgesia vasodilatation mechanism of inactivation.

Quantum prospects for hybrid thin-film lithium niobate on silicon photonics

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Frontiers of Optoelectronics 2022年第1期15卷 73-79页

作者： Jeremy c.Adcock Yunhong Ding center for Silicon Photonics for Optical communication Technical University of Denmark2800 Kgs.LyngbyDenmark

Photonics is poised to play a unique role in quantum technology for computation,communications and ***,integrated photonic circuits-with their intrinsic phase stability and high-performance,nanoscale components-offer a route to ***,each integrated platform has a unique set of advantages and pitfalls,which can limit their *** far,the most advanced demonstrations of quantum photonic circuitry has been in silicon ***,thin-film lithium niobate(TFLN)is emerging as a powerful platform with unique capabilities;advances in fabrication have yielded loss metrics competitive with any integrated photonics platform,while its large second-order nonlinearity provides efficient nonlinear processing and ultra-fast *** this short review,we explore the prospects of dynamic quantum circuits-such as multiplexed photon sources and entanglement generation-on hybrid TFLN on silicon(TFLN/Si)photonics and argue that hybrid TFLN/Si photonics may have the capability to deliver the photonic quantum technology of tomorrow.

关键词： Quantum photonics Quantum information Quantum communications Lithium niobate(LN) Silicon photonics

SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 589-598页

作者： Landry E Nfonsam Jana Jandova Hunter c Jecius Pamela N Omesiete Valentine N Nfonsam Department of Genetics Children’s Hospital of Eastern OntarioOttawaOntario K1H 8L1Canada Department of Surgery University of ArizonaTucsonAZ 85724United States

BAcKGROUND colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of *** affects 1.2 million people around the world and is responsible for about 0.6 million deaths every *** decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(creted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon ***4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient *** SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of california Santa cruz cancer Browser *** SFRP4 was found to be co-expressed with the EMT-linked markers cDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and ***4 expression negatively correlated with the EMTlinked suppressors cLDN4,cLDN7,TJP3,MUc1,and *** expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon ***,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).cONcLUSION considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy.

关键词： Secreted frizzled-related protein 4 Epithelial mesenchymal transition colon cancer Survival

Heterogeneous transfer functions multi-layer perceptron (MLP) for meteorological time series forecasting

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International Journal of Modeling, Simulation, and Scientific computing 2015年第2期6卷 49-55页

作者： c.Voyant M.L.Nivet cPaoli M.Muselli G.Notton University of corsica SPE CNRS UMR 613420250 CorteFrance University of Galatasaray computer Engineering Department No:36 34357 Ortak¨oyIstanbulTurkey

In this paper,we propose to study four meteorological and seasonal time series(TS)coupled with a multi-layer perceptron(MLP)*** chose to combine two transfer functions for the nodes of the hidden layer,and to use a temporal indicator(time index as input)in order to take into account the seasonal aspect of the studied *** results of the prediction concern two years of measurements and the learning step,eight independent *** show that this methodology can improve the accuracy of meteorological data estimation compared to a classical MLP modeling with a homogenous transfer function.

关键词： Artificial neural network meteorology time series transfer function

Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience

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World Journal of Gastroenterology 2013年第7期19卷 1091-1097页

作者： Stephen J Halpin P John Hamlin Daniel P Gree Lisa Warren Alexander c Ford Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom r Leeds Institute of Molecular Medicine University of LeedsLeedsWest Yorkshire LS9 7TFUnited Kingdom

AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical ***:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were *** were extracted from clinical records in order to assess response to IFX *** primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse *** and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were ***:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative *** median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with 2 years of follow-up post-first infusion of ***,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of *** was one death from post-operative sepsis,20 d after a single IFX *** rates were generally lower among those "bridging" to *** 18 patients "bridged" to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study *** predictors of response were ***:IFX is effective for acute severe ulcerative colitis in real-life clinical ***-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission.

关键词： Ulcerative colitis Severe Azathioprine Infliximab Remission

Oncologic aspects of the decision-making process for surgical approach for colorectal liver metastases progressing during chemotherapy

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 877-886页

作者： Raphael L c Araujo camila G c Y carvalho carlos T Maeda Jean Michel Milani Diogo G Bugano Pedro Henrique Z de Moraes Marcelo M Linhares Department of Surgery Universidade Federal de São PauloSão Paulo 04024-002Brazil Department of Oncology Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Department of Surgical Oncology Hospital e Maternidade Brasil Rede D'Or São LuizSanto André09030-590São PauloBrazil

colorectal cancer represents the third most diagnosed malignancy in the *** liver is the main site of metastatic disease,affected in 30%of patients with newly diagnosed *** resection is considered the only potentially curative treatment for colorectal liver metastasis(cRLM),with a 5-year survival rate ranging from 35%to 58%.However,up to 80%of patients have initially unresectable disease,due to extrahepatic disease or bilobar multiple liver *** availability of increasingly effective systemic chemotherapy has contributed to converting patients with initially unresectable liver metastases to resectable disease,improving long-term outcomes,and accessing tumor *** recent years,response to preoperative systemic chemotherapy before liver resection has been established as a major prognostic *** studies have demonstrated that patients with regression of hepatic metastases while on chemotherapy have improved outcomes when compared to patients with stabilization or progression of the *** if disease progression during chemotherapy represents an independent negative prognostic factor,some patients may still benefit from surgery,given the role of this modality as the main treatment with curative intent for patients with *** selected cases,based on size,the number of lesions,and tumor markers,surgery may be offered despite the less favorable prognosis and as an option for non-chemo responders.

关键词： colorectal liver metastases Oncology Disease progression Surgery Liver resection Hepatectomy