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Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

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chinese journal of chemistry 2024年第6期42卷 645-651页

作者： yang feng Sheng-jun chen Bi-feng yuan key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mc) is a dynamic and reversible epigenetic modification in genomic DNA of higher *** has been well-established that the demethylation of 5mc occurs through the ten-eleven translocation (tEt)-mediated oxidation of 5mc followed by thymine DNA glycosylase (tDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA *** this pathway,tEt enzymes directly oxidize 5mc to form 5-formylcytosine (5fc) or 5-carboxylcytosine (5cac).these modified bases can undergo direct deformylation or decarboxylation,***,DNA demethylation can also occur through the deamination of 5mc and 5hmc,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** DNA demethylation pathways possess critical functional implications and roles in biological *** Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mc.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms Biological functions c—c bond cleavage Mass spectrometry

co-harvest Phase-change Enthalpy and Isomerization Energy for high-Energy heat Output by controlling crystallization of Alkyl-Grafted Azobenzene Molecules

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Energy & Environmental Materials 2024年第3期7卷 415-424页

作者： jian Gao yiyu feng Wenyu Fang hui Wang jing Ge Xiaoyu yang huitao yu Mengmeng qin Wei feng School of Materials Science and Engineering Tianjin UniversityTianjin 300350China key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002China

Photoisomerization-induced phase change are important for co-harvesting the latent heat and isomerization energy of azobenzene *** optimizing heat output and energy delivery at alternating temperatures are challenging because of the differences in crystallizability and *** article reports two series of asymmetrically alkyl-grafted azobenzene(Azo-g),with and without a methyl group,that have an optically triggered phase *** exothermic modes were designed to utilize crystallization enthalpy(△h_(c))and photothermal(isomerization)energy(△h_(p))at different temperatures determined by the ***-g has high heat output(275-303 j g^(-1))by synchronously releasing△h_(c)and△h_(p)over a wide temperature range(-79℃to 25℃).We fabricated a new distributed energy utilization and delivery system to realize a temperature increase of 6.6℃at a temperature of-8℃.the findings offer insight into selective utilization of latent heat and isomerization energy by molecular optimization of crystallization and isomerization processes.

关键词： crystallizability distributed energy utilization system energy density exothermic modes isomerization

Precise determination of the pole position of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： yun-hua chen Meng-Lin Du feng-kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China cAS key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng huanwu collaborative center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and j/ψπ^(±)invariant mass spectra for e^(+)e^(-)→j/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the j/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-kk final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

the infection kinetics and transmission potential of two Guaico culex viruses in culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-yi chen teng Zhao jing-jing Guo feng Zhu Na-Na Zhang Xiao-feng Li hai-tao Liu Fei Wang yong-qiang Deng cheng-feng qin college of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Guaico culex virus(GcXV)is a newly identified segmented jingmenvirus from culex *** in central and South *** genome of GcXV is composed of four or five single-stranded positive RNA ***,the infection kinetics and transmission capability of GcXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GcXVs(4S and 5S)that contained four and five RNA segments,respectively,in c6/36 *** in vitro characterization revealed that the two GcXVs exhibited comparable replication kinetics,protein expression and viral ***,GcXV RNAs were detected in the bodies,salivary glands,midguts and ovaries of culex quinquefasciatus at 4–10 days after oral *** addition,two GcXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GcXVs with four or five RNA segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico culex virus(GcXV) jingmenvirus culex quinquefasciatus Vertical transmission

Leflunomide: A versatile additive for defect reduction, enhanced optoelectronic properties and environmental stability of perovskite films

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Nano Research 2024年第4期17卷 2628-2637页

作者： Dingyue Sun Ming Peng taijin Wang Longju yi Shizuo Zhang feng Liu Gary j.cheng the Institute of technological Sciences Wuhan UniversityWuhan 430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906USA

the development of perovskite photoelectric devices with excellent performance is largely dependent on the defects in the perovskite *** address this issue,a specific drug,leflunomide(LF,c_(12)h_(9)F_(3)N_(2)O_(2)),was incorporated into the perovskite to reduce defects and improve its photoelectric *** is believed that the c=O bond on LF molecule can interact with the uncoordinated Pb2+of the perovskite,thereby reducing non-radiative *** novel approach of incorporating LF into perovskite films has the potential to revolutionize the development of high-performance perovskite photoelectric *** trifluoromethyl functional(–cF_(3))group on LF can form a protective layer on the surface of the perovskite film,shielding it from water ***,LF can be utilized to alter the nucleation position of perovskite,thus minimizing the number of defects and optimizing the film ***,the LF-doped perovskite film displays low trap density and high photoelectric *** LF-doped perovskite film showed a trap density of 8.28×10^(11),which is notably lower than the 2.04×10^(12) of the perovskite film without *** responsivity and detectivity of the LF-doped perovskite photodetector were 0.771 A/W and 2.81×10^(11) jones,respectively,which are much higher than the 0.23 A/W and 1.06×10^(10) jones of the LF-undoped perovskite ***,the LF-doped photodetector maintained an initial photocurrent of 86%after 30 days of storage in air,indicating drastically increased environmental *** strongly suggests that LF is an effective additive for perovskites utilized in optoelectronic devices with high performance.

关键词： leflunomide additive engineering defect passivation perovskite

carbon steel anticorrosion performance and mechanism of sodium lignosulfonate

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Rare Metals 2024年第1期43卷 356-365页

作者： Bo-kai Liao Rui-Xuan quan Ping-Xian feng huan Wang Wei Wang Li Niu School of chemistry and chemical Engineering Guangzhou Key Laboratory of Sensing Materials and DevicesJoint Institute of Guangzhou University and Institute of Corrosion Science and TechnologyGuangzhou UniversityGuangzhou 510006China

Lignin is a typical biological macromolecule with a three-dimensional network structure and abundant functional groups. It has excellent ionic complexation ability and amphiphilic molecular structure *** this study, the carbon steel anticorrosion performance of sodium lignosulfonate(SLS) in an acid solution was evaluated using the weight loss method, electrochemical measurements, scanning vibration electrode technique(SVEt), and surface characterization methods. SLS exhibited excellent corrosion inhibition efficiency for q235carbon steel in 1 mol·L^(-1) hcl, reaching a maximum value of 98%. A low SLS concentration of 20 mg·L^(-1) resulted in the maximum corrosion inhibition efficiency, which remained nearly constant at higher SLS *** SVEt test demonstrated that the formation of an SLS adsorption film can impede corrosion. this study confirms the significance of the application of green biomass resources in the field of metal corrosion protection and green functional materials.

关键词： Lignin Sodium lignosulfonate corrosion inhibitor carbon Steel

Optimization of the methane production in batch anaerobic digestion of maize straw by adjustment of total solid and substrate-to-inoculum ratio based on kinetics

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International journal of Agricultural and Biological Engineering 2024年第1期17卷 225-231页

作者： feng Zhen tao Xing Lianhua Li yongming Sun hongqiong Zhang Guangzhou Institute of Energy conversion Chinese Academy of SciencesGuangzhou 510640China Guangdong Provincial key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China college of Engineering Northeast Agricultural UniversityHarbin 150030China

Anaerobic digestion(AD)operating under conditions of organic overload stress typically exacerbates the potential for process instability,thereby resulting in significant economic and ecological *** this investigation,an augmented substrate-to-inoculum ratio(S/I)along with varying total solid content(tS)levels was employed to replicate diverse organic loadings,utilizing maize straw and cattle *** findings reveal that a moderate augmentation in S/I and tS proves advantageous in augmenting methane yield,while an excessive substrate loading diminishes methane yield,hampers the kinetics of methane production,and even induces severe process *** study also displayed the variation of the model parameters for the first-order model,the modified Gompertze model,and the transfer function *** the modified Gompertze model and transfer function model exhibited the same environmental stress ***,both the increase in particulate content and the increase in S/I had a substantial effect on the substrate conversion rate to *** analysis demonstrates the dominant influence of Firmicutes and Methanosarcina under different organic loading *** both a kinetic and a microbiological point of view,this work provides novel insights into the fundamental processes that regulate anaerobic digestion(AD)under varying loading ***,it has significant implications for improving the operating efficiency of AD,which is a significant benefit.

关键词： maize straw dry anaerobic digestion methane production microbial characteristics kinetic model

comparing the temperature sensitivity of organic matter decomposition in oxic and oxygen-deprived soils

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Soil Ecology Letters 2024年第1期6卷 29-32页

作者： Zhenhui jiang Xin Wang ting Liu Xiaojuan feng State key Laboratory of Vegetation and Environmental change Institute of BotanyChinese Academy of SciencesBeiing 100093China University of chinese Academy of Sciences Bejing 100049China State key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China henan key Laboratory of Ecological Environment Protection and Restoration of yellow River Basin Yellow River Institute of Hydraulic ResearchZhengzhou 450003China

No consistent variation was found in soil respiration q10 under various O2 *** c quality had a strong effect on q10 in oxic soils.N limitation had a large impact on q10 in soils under O2 *** studies on the temperature sensitivity(q10)of soil organic matter(SOM)decomposition mainly focus on aerobic ***,varia-tions and determinants of q10 in oxygen(O2)-deprived soils remain *** we incubated three grassland soils under oxic,suboxic,and anoxic conditions subjected to varying temperatures to compare variations in q10 in relation to changing *** consistent variation was found in q10 under various O2 *** analysis of edaphic properties demon-strated that substrate carbon quality showed a strong influence on q10 in oxic soils,whereas nitrogen limitation played a more important role in suboxic and anoxic *** results suggest that substrate carbon quality and nitrogen limitation may play roles of varying importance in determining the temperature sensitivity of SOM decomposition under various O2 conditions.

关键词： oxygen-limited conditions temperature sensitivity soil respiration carbon substrate nitrogen limitation

Serum amylase as a novel prognostic marker of organophosphorus poisoning: a retrospective study

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Emergency and critical care Medicine 2024年第3期4卷 111-116页

作者： Guo X. chen Z. feng k. Zeng S. Zhang j. Ma Z. yuan c. School of clinical Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emergency Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Background: this study aims to explore the significance of serum amylase levels in patients with organophosphorus pesticide (OP) poisoning and to provide a new perspective for evaluating the severity and prognosis of OP poisoning. Methods: the clinical data of 67 patients with acute OP poisoning, who had been treated in the emergency department of the General hospital of Ningxia Medical University between September 2020 and August 2022, were retrospectively analyzed. Using Spearman rank correlation, serum amylase levels during admission and severity of poisoning correlated with discharge outcomes. Based on serum amylase levels, receiver operating characteristic curves were plotted to predict the severity and mortality of patients who experience organophosphate poisoning. the optimal threshold serum amylase level at admission was determined based on the maximum youden index. Results: Using Spearman rank correlation analysis, serum amylase levels at admission positively correlated with the severity of poisoning and discharge outcomes, but the degree of correlation was weak (rs: 0.344; 0.264; P the patients’ serum amylase levels at admission had receiver operating characteristic area under the curve values of 0.726 and 0.735 to predict the degree of severe poisoning and death, respectively. Based on the maximum youden index, the optimal threshold of serum amylase were 97.8 and 194.1 U/L when the degree of poisoning was severe and the discharge outcome of patients was died. In comparison to patients with serum amylase levels ≤194.1 U/L at admission, the OR values of death in patients with serum amylase levels >194.1 U/L at admission was 15.944 (95% cI: 1.825–139.274). conclusion: Serum amylase levels in patients with organophosphate poisoning correlate with the degree of poisoning and discharge outcomes. higher serum amylase level was a risk factor for organophosphorus poisoning death. © Wolters kluwer health, Inc. All rights reserved.

关键词： Amylase Emergency department Organophosphorus pesticide poisoning Prognosis