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PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

Asian Journal of Andrology 2014年第3期16卷 378-386页

作者： Merritt P Edlind Andrew c Hsieh Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Division of Hematology/Oncology and Department of Internal Medicine University of California San Francisco CA USA.

Prostate cancer （Pca） is the second most common malignancy among men in the world. castration-resistant prostate cancer （cRPc） is the lethal form of the disease, which develops upon resistance to first line androgen deprivation therapy （ADT）. Emerging evidence demonstrates a key role for the PI3K-AKT-mTOR signaling axis in the development and maintenance of cRPc. This pathway, which is deregulated in the majority of advanced Pcas, serves as a critical nexus for the integration of growth signals with downstream cellular processes such as protein synthesis, proliferation, survival, metabolism and differentiation, thus providing mechanisms for cancer cells to overcome the stress associated with androgen deprivation. Furthermore, preclinical studies have elucidated a direct connection between the PI3K-AKT-mTOR and androgen receptor （AR） signaling axes, revealing a dynamic interplay between these pathways during the development of ADT resistance. Thus, there is a clear rationale for the continued clinical development of a number of novel inhibitors of the PI3K pathway, which offer the potential of blocking cRPc growth and survival. In this review, we will explore the relevance of the PI3K-AKT-mTOR pathway in Pca progression and castration resistance in order to inform the clinical development of specific pathway inhibitors in advanced Pca. In addition, we will highlight current deficiencies in our clinical knowledge, most notably the need for biomarkers that can accurately predict for response to PI3K pathway inhibitors.

关键词： androgen receptor cRPc kinase inhibitors mTOR prostate cancer PI3K resistance

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ON THE INTEGRAL cURVATURE OF A cURVILINEAR POLYGON

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Science in china,Ser.A 1958年第1期 11-18页

作者：白正国 Fu-Tan University

*** a recent papert on the theory of a closed space curve,theauthor has obtained among others the following result:If a closedspace curve c has an angular point of an interior angle θ,then theintegral curvature of c is not less than π+θ,or in other words:ifdenotes the curvature of c,then∮（c）kds≥π+θ.At the end ofthe same paper we have proposed a more general problem:Whatwill be the lower bound of the integral curvature∮（v）kds if the closedspace curve c has n（n>1）angular points?In the present paper,itis shown that the answer there conjectured is *** a cur-vilinear polygon we mean,in what follows,a closed space curve witha finite nuraber of angular points.A theorem for a curvilinearpolygon in aa ordinary space is proved with its generalization in aEuclidean space of higher dimensions.

关键词： ON THE INTEGRAL cURVATURE OF A cURVILINEAR POLYGON 留人 length

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富含树皮体和半丝质体煤的液化反应性和^(13)c-核磁共振分析的研究

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燃料化学学报 2010年第2期38卷 129-133页

作者：王绍清唐跃刚 Harold H ScHOBERT 郭琴王凤娟中国矿业大学(北京)煤炭资源与安全开采国家重点实验室北京100083 宾夕法尼亚州立大学能源研究所宾夕法尼亚州16802

通过对富含树皮体的煤和半丝质体的煤进行液化研究和结构分析,探讨其液化产品的产率与结构参数之间的关系。富含树皮体的煤的氢含量和挥发分含量均高,H/c原子比也很高。13c-核磁共振分析表明,所有用煤都以芳香族碳为主。WEST样品的芳碳... 详细信息

通过对富含树皮体的煤和半丝质体的煤进行液化研究和结构分析,探讨其液化产品的产率与结构参数之间的关系。富含树皮体的煤的氢含量和挥发分含量均高,H/c原子比也很高。13c-核磁共振分析表明,所有用煤都以芳香族碳为主。WEST样品的芳碳率最高,LP、cG和DHB样品中cH2基团碳含量高于cH3基团碳含量,且cH2基团碳含量高于其他三个样品。而P858样品中cH3基团碳含量高于cH2基团碳含量。液化结果表明,LP、cG和DHB有高的液化转化率和油收率。煤液化的油收率和煤结构中的cH2基团碳含量以及转化率和煤的芳碳率之间都存在明显的相关关系。因此,13c-核磁共振技术可以用来预测煤液化产品的收率。

关键词：煤树皮体半丝质体液化 13c-核磁共振

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Studies on electrical properties of system La_(2-x)(Sr_(1-y)ca_y)_xNiO_4

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chinese Journal of chemistry 1993年第1期11卷 6-11页

作者： MENG,Jian REN,Yu-Fang pa,Ya-Nan changehun Institute of Applied chemistry,chinese Academy of Sciences,changchun 130022 current address:Laboratory of Physics and chemistry,Harbin Airplane Manufacture corporation,Harbin 150066. changchun Institute of Applied chemistry Chinese Academy of Sciences Changchun 130022

A new series of solid solutions of composition La_(2-x)(Sr_(2-y)ca_y)_xNiO_4(02NiF_4 type *** tetragonal- ity ratio c/a shows a progressive decrease wi... 详细信息

A new series of solid solutions of composition La_(2-x)(Sr_(2-y)ca_y)_xNiO_4(02NiF_4 type *** tetragonal- ity ratio c/a shows a progressive decrease with increasing y except for the group of x=*** room temperature resistivity exhibits a gradual increase with y,which is interpreted by assuming that the single eg electron of Ni^(3+) is present in localized d_(z^2) orbital but the eg electrongradually becomes itin- erant because it is delocalized into d_(z^2-y^2) orbital and leads to a strong Ni^(3+)-O^(2-) covalent interaction with increasing the Sr *** of resistance with temperature shows semiconducting properties except for the composition of x=1.4,ych shows a semiconductor-to-metal transition.

关键词： Ni Studies on electrical properties of system La xNiO4 Sr ca

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外源性脂肪酸对罗非鱼脂肪细胞增殖与分化的影响

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水生生物学报 2018年第3期42卷 517-524页

作者：王雅文乔芳张美玲贾永义杜震宇浙江省淡水水产研究所农业部淡水渔业健康养殖重点实验室浙江省鱼类健康与营养重点实验室湖州313001 华东师范大学生命科学学院水生动物营养与环境健康实验室上海200241

为了探究脂肪酸对罗非鱼(Oreochromis niloticus)脂肪细胞增殖和分化的影响,在体外培养罗非鱼前脂肪细胞,并在其增殖和分化过程中分别添加100μmol/L的棕榈酸(palmitic Acid,pa)、油酸(Oleic Acid,OA),亚油酸(Linoleic Acid,LA)和α-亚... 详细信息

为了探究脂肪酸对罗非鱼(Oreochromis niloticus)脂肪细胞增殖和分化的影响,在体外培养罗非鱼前脂肪细胞,并在其增殖和分化过程中分别添加100μmol/L的棕榈酸(palmitic Acid,pa)、油酸(Oleic Acid,OA),亚油酸(Linoleic Acid,LA)和α-亚麻酸(α-Linolenic Acid,LNA)进行处理。使用SRB(Sulforhodamine B)染色法和油红O染色法检测外源性脂肪酸对脂肪细胞增殖和分化的影响,Real-time q PcR检测增殖分化过程中基因表达情况。结果显示,在培养8d时,外源添加的不饱和脂肪酸可以促进罗非鱼前脂肪细胞增殖,并且增殖过程中增殖相关基因(c-fos和c-myc)、脂解相关基因(ATGL)和脂合成相关基因(PpaRγ和cD36)的表达与对照组相比均显著提高(PcPT-1a)与对照组相比显著上调,而脂解相关基因(ATGL)则显著下调。外源性不饱和脂肪酸可以促进罗非鱼前脂肪增殖,而饱和脂肪酸主要抑制细胞分化。在增殖过程中,过量的脂肪酸先通过脂合成储存在胞内,再借助脂解等途径进行代谢,从而帮助细胞适应环境中高浓度的脂肪酸。而在分化过程中,添加外源脂肪酸,可能通过抑制脂肪细胞内的脂合成和脂解的发生,同时促进β氧化等方式来抑制脂肪细胞分化。

关键词：罗非鱼脂肪细胞脂肪酸增殖分化

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Inhibition of protein kinase B by palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

Inhibition of protein kinase B by Palmitate in the insulin s...

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湖北省暨武汉市生物化学与分子生物学学会第八届第十七次学术年会

作者： XIA Yanzhi~1,MS WAN Xuedong~2,MS DUAN Qiuhong~2,PhD HE Shansu~2,BS WANG Ximing~2,BS 1.Department of Medical Biology,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430030,china 2.Department of Biochemistry and Molecular Biology,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430030,china

Elevated plasma levels of free fatty acids(FFAs)may contribute to insulin resistance(IR)that is characteristic of type 2 diabetes *** this study,we investigated the effects of two fatty acids,palmitate(pa)and arachidonic acid(AA)on glycogenesis under insulin signaling in HepG2cells,a transformed hepatic carcinoma cell *** the presence of 200 μmol of palmitate, insulin(10mol/L)stimulation of glycogenesis was inhibited,as evidenced by increased glucose in the medium and decreased intracellular ***(WM),a specific inhibitor of PI3K,dramatically decreased the amount of intracellular glycogen in cells without pa incubation. However,glycogen in pa treated cells was not significantly changed by WM,indicating that pa may also act on ***,AA restored the effects of WM inhibition on glycogenesis in pa *** blot analysis demonstrated that pa in the absence of WM increased phosphorylated glycogen synthase(inactive form of GS)and decreased phosphorylated protein kinase B(active form of PKB),causing a reduction of intracellular ***,however, reversed the effects of pa on GS and ***,inhibition of protein kinase c(PKc) by a specific inhibitor chelerythrine chloride(cc)abolished the inhibitory effect of pa on glycogen synthesis by decreasing phosphorylated GS and increasing phosphorylated PKB. However,he effect of cc in the presence of pa disappeared when AA was also present. Our results suggest that there is a disruption of the insulin signaling pathway between PKB and GS when the cells were exposed to pa,contributing to *** may also interrupt the PKc signaling *** contrast,AA could rescue glycogenesis impaired by pa.

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休闲时间和上下班路上体力活动与高血压:巴西成人健康纵向研究

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中华高血压杂志 2016年第12期24卷 1191-1191页

作者：刘莉叶鹏 Treff c Benseor IM Lotufo pa

该项研究调查了巴西成人健康纵向研究（the Brazilian longitudinal study of adult health,ELSA-Brasil）中的受试者休闲时间身体活动和上下班时相关的身体活动与高血压之间的相关性。应用国际体育活动问卷,尤其是针对休闲和交通领域... 详细信息

该项研究调查了巴西成人健康纵向研究（the Brazilian longitudinal study of adult health,ELSA-Brasil）中的受试者休闲时间身体活动和上下班时相关的身体活动与高血压之间的相关性。应用国际体育活动问卷,尤其是针对休闲和交通领域的问卷,评估体力活动。使用世界卫生组织的定义（中等强度体力活动150min/周,或高强度体力活动75min/周）将受试者活动分为三类：活动，活动不足和无活动。

关键词：体力活动休闲时间纵向研究等强度 longitudinal 体育活动无活动抗高血压药物酒精摄入量患病风险

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Mechanism and performance of a lithium chloride accelerator

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Petroleum Science 2011年第3期8卷 328-334页

作者： Wang chengwen Wang Ruihe cheng Rongchao chen Erding School of Petroleum Engineering China University of Petroleum Qingdao Shandong 266555 China Department of Drilling Strategy and Planning CNPC Drilling Research Institute Beijing 100195 China Drilling Engineering and Technology corp. Shengli Petroleum Administration Bureau Dongying Shandong 257064 China

To address present concerns about thickening time and high early-strength in deepwater cementing at low temperatures when using conventional accelerators, a new type of set-accelerating admixture comprising of lithium chloride, aluminium hydroxide and alkaline metal chlorides, named as LS-A, was studied in this paper. Mechanism analysis and performance tests show that the accelerator LS-A accelerated the hydration of tri- and dicalcium silicates （c3S and c2S） at low-temperatures by speeding up the breakdown of the protective hydration film and shortening the hydration induction period. Therefore, LS-A could shorten the low-temperature thickening time and the transition time of critical gel strength from 48 to 240 pa of the class-G cement slurry, and improve the early compressive strength of set cement at low-temperatures. It exhibited better performance than calcium chloride and had no effect on the type of hydration products, which remain the same as those of neat class-G cement, i.e. the calcium silicate gel, ca（OH）2 crystals and a small amount of ettringite AFt crystals. LS-A provides an effective way to guarantee the safety of cementing operations, and to solve the problems of low temperature and shallow water/gas flowing faced in deepwater cementing.

关键词： Deepwater cementing accelerator lithium chloride class-G cement mechanism

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Single-Li^+ conductivity in ionomeric network

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chinese Journal of chemistry 1993年第5期11卷 429-434页

作者： FARRINGTON Gregory c. Department of Materials and Engineer University of PennsylvaniaPhiladelphiaPA 19104USA

Ionomeric networks(IN)with lithium sulfate and sait-solvating oligo(oxyethylene)chain were synthesized on the purpose of improving the conductivity of single-Li^+-ionic ***^+-ionic conductivity depends considerably on the salt content of the INs although the apparent degree of cross- linking is fixed in a constant of 10 mol%.As salt content(Li/O value)equals 0.0467,conductivity of the IN containing neither small-molecular salt nor low molecular weight plasticizer reaches a maximum of 7×10^(-6) S/cm at 25℃.Temperature-conductivity relationship of the INs shows curved Arrhenins plots,suggesting that the ionic conduction is primarily influenced by segmental motion of the polymer *** addition,WLF(Williams-Landel-Ferry)equation is used to analyze the conductivity data, from which the related WLF parameters are determined.

关键词： Single-Li

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LANTHANIDE ION DOpaNT EFFEcT ON THE PHASE TRANSFORMATION IN ULTRASONIc ASSISTANT SOL-GEL DERIVED TITANIA NANOSTRUcTURES

LANTHANIDE ION DOPANT EFFECT ON THE PHASE TRANSFORMATION IN ...

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2010全国压电和声波理论及器件技术研讨会

作者： cheng HU~1,Yue-tao YANG~2,Hao YANG~2,Xiao-jun LIU~2,Shu-yi ZHANG~2 1 Liaoning Academy of Environmental Science,Liaoning Province Key Laboratory of Basin Pollution control 88 Taishang Road,Shenyang,Liaoning 110031,china 2 Key Laboratory of Modern Acoustics,Ministry of Education,Institute of Acoustics,Nanjing University, 22 Hankou Road,Nanjing,Jiangsu 210093,china

In this work,TiO nanoparticles doped with holmium（Ⅲ） ion have been prepared by an ultrasonic assistant sol-gel *** present the results of the investigation of holmium（Ⅲ） ion doping on the structural properties of TiO and its effect on the anatase to rutile phase *** is found that the transformation temperature,measured from the XRD experiments,is found to increase with *** anatase lattice is shown to deform predominantly along the c-axis to accommodate substitutionally-incorporated holmium（Ⅲ） *** order to understand the location of the dopant in TiO lattice, photoacoustic（pa） absorptions of f-f transitions of the samples are *** results show that the holmium（Ⅲ） ions incorporate interstitially as well as *** retards the anatase-to-rutile transformation temperature.

关键词： Ultrasound irradiation nanomaterials titanium dioxide

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