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利用还原剂预处理提高药物蛋白稳定性

生物工程学报 2008年第12期24卷 2142-2143页

作者： Lin Zhang Murray Moo-Young c. perry chou Department of chemical Engineering University of Waterloo Waterloo Ontario N2L 3G1 Canada

开发蛋白药的一个主要问题是蛋白质的不稳定性。本研究利用对蛋白质进行还原剂预处理的策略,提高了具有潜在治疗活性的重组人胞外域cD83蛋白的稳定性。在生理条件下,蛋白治疗产品易于变性,形成聚集和沉淀,并最终被降解。由此证明还原剂... 详细信息

开发蛋白药的一个主要问题是蛋白质的不稳定性。本研究利用对蛋白质进行还原剂预处理的策略,提高了具有潜在治疗活性的重组人胞外域cD83蛋白的稳定性。在生理条件下,蛋白治疗产品易于变性,形成聚集和沉淀,并最终被降解。由此证明还原剂预处理可以有效改善蛋白质的稳定性。

关键词：降解蛋白稳定性人胞外域的cD83蛋白还原剂预处理

Global warming projections using the human–earth system model BNU-HESM1.0

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Science Bulletin 2016年第23期61卷 1833-1838页

作者： Shili Yang Wenjie Dong Jieming chou Jinming Feng Zhigang Wei Yan Guo Xiaohang Wen Ting Wei Di Tian Xian Zhu Zhiyong Yang State Key Laboratory of Earth Surface processes and Resource Ecology Beijing Normal University Beijing 100875 China Business School Beijing Normal University Beijing 100875China Zhuhai Joint Innovative center for climate-Environment-Ecosystem Future Earth Research Institute Beijing Normal University Zhuhai 519087 China Atmospheric Science School Sun Yat-sen UniversityGuangzhou 510000 China Key Laboratory of Regional climate-Environment for East Asia Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029 China plateau Atmosphere and Environment Key Laboratory of Sichuan province College of Atmospheric Sciences Chengdu University of Information Technology Chengdu 610225 China chinese Academy of Meteorological Sciences Beijing 100081China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography Hangzhou 310012 China

Future climate change is usually projected by coupled earth system models under specific emission sce- narios designed by integrated assessment models （IAMs）, and this offline approach means there is no interaction between the coupled earth system models and the IAMs. This paper introduces a new method to design possible future emission scenarios and corresponding climate change, in which a simple economic and climate damage component is added to the coupled earth system model of Beijing Normal University （BNU-ESM）. With the growth of population and technological expertise and the declining emission-to-output ratio described in the Dynamic Inte- grated climate-Economy model, the projected carbon emission is 13.7 Gt c, resulting in a 2.4℃ warming by the end of the twenty-first century （2080-2099） compared with 1980-1999. This paper also suggests the importance of the land and ocean carbon cycle in determining the cO2 con- centration in the atmosphere. It is hoped that in the near future the next generation of coupled earth system models that include both the natural system and the social dimension will be developed.

关键词： coupled earth system model Globalchange climate projection Economic dimension

Isobutane dehydrogenation over chromia alumina catalysts prepared from MIL-101: Insight into chromium species on activity and selectivity

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Journal of Energy chemistry 2014年第6期23卷 708-716页

作者： Huahua Zhao Huanling Song Zhichao Miao Lingjun chou State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of Sciences Institute of Nano-Tech and Nano-Bionics University of chinese Academy of Sciences

Various mesoporous chromia alumina catalysts were prepared by five different methods based on a metal-organic framework MIL-101 and their catalytic.p.rformances over isobutane dehydrogenation were investigated. The highly dispersed chromium species were produced on catalyst KcrAI-I1 with largest specific surface area of 198 m2-g-1 prepared with aluminium isopropoxide （Al（i-Oc3HT）3） by ultrasonic im- pregnation method. However, the catalyst KcrAI-I2 synthesized by stirring impregnation possessed crystalline a-cr203 phase, which was poorly dispersed. Two types of cr-rich and Al-rich crzA12_zO3 solid solutions, designated as crAI-I and crAI-II phase, were formed over the catalysts KcrAI-I3 （prepared by Al（i-Oc3HT）3 with nitric acid regulation）, KcrA1-c4 （prepared by aluminium chloride hexahydrate） and KcrA1-N5 （prepared by aluminium nitrate nonahydrate）. catalytic evaluation results revealed that KcrAI-I1 exhibited the high isobutane con- version due to its highly dispersed chromium species. However, KcrAI-I3, KcrA1-c4 and KcrA1-N5 showed the higher isobutene selectivity （95.2%-96.4%） on account of the formation of chromia alumina solid solutions in the catalysts. Moreover, the solid solution over the chromia alumina catalysts could greatly suppress the coke formation.

关键词： isobutane dehydrogenation chromia alumina solid solution metal organic framework MIL-IO1

Topography,structure,and formation kinetic mechanism of carbon deposited onto nickel in the temperature range from 400 to 850°c

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 574-583页

作者： Zhi-yuan chen Liu-zhen Bian Li-jun Wang Zi-you Yu Hai-lei Zhao Fu-shen Li Kuo-chih chou State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing collaborative Innovation center of Steel Technology University of Science and Technology Beijing School of Materials Science and Engineering University of Science and Technology Beijing

The carbon deposition behavior on nickel particles was observed within the temperature range from 400 to 800°c in a pure methane atmosphere. The topography, properties, and molecular structure of the deposited carbon were investigated using field-emission scanning electron microsc.p. (FESEM), temperature-programmed oxidation (TpO) technology, X-ray diffraction (XRD), and Raman spectrosc.p.. The deposited carbon is present in the form of a film at 400-450°c, as fibers at 500-600°c, and as particles at 650-800°c. In addition, the structure of the deposited carbon becomes more ordered at higher temperatures because both the TpO peak temperature of deposited carbon and the Raman shift of the G band increase with the increase in experimental temperature, whereas the intensity ratio between the D bands and the G band decreases. An interesting observation is that the carbon deposition rate is suppressed in the medium-temperature range (M-T range) and the corresponding kinetic mechanism changes. correspondingly, the FWHM of the G and D1 bands in the Raman spectrum reaches a maximum and the intensities of the D2, D3, and D4 bands decrease to low limits in the M-T range. These results indicate that carbon structure parameters exhibit two different tendencies with respect to varying temperature. Both of the two group parameters change dramatically as a peak function with increasing reaction temperature within the M-T range.

关键词： nickel carbon deposition kinetic mechanisms solid oxide fuel cells

Insect Flight from the perspective of a Force Element Theory Using a Simplified Model

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Insect Flight from the Perspective of a Force Element Theory...

2003和2004年春季台北大气悬浮物中的水溶性离子(英文)

2009年度海峡两岸工程力学研讨会

作者： chien c.chang chin-chou chu cheng-Ta Hsieh Institute of Applied Mechanics National Taiwan University Division of Mechanics Applied SciencesAcademia Sinica

Bird or insect flight has been of great interest to general audience,not only to *** works have been devoted to the study of aerodynamics of insect wings,for example,the hovering *** is generally considered that the lift supporting the insect comes from the unsteadiness of the ***,the term "unsteadiness" itself is loose and imprecise at *** may include several unsteady components:the motion of wing,vortex in the flow as well as the surface *** various contributions are now examined from the perspective of a force element theory to gain more insight into the mechanisms of generating lift.

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干旱区资源与环境 2004年第S1期18卷 173-177页

作者： Shih-chun candice Lung charles c-K chou Shaw c. Liu Institute of Earth Sciences Academia Sinica P. O. BOX 1-55 Nankang Taipei Taiwan 11529 R.O.CpresenterInstitute of Earth Sciences Academia Sinica Nankang Taipei Taiwan 115Institute of Earth Sciences Academia Sinica Nankang Taipei Taiwan 115

performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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chinese physics c 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya c. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.p.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert p. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov c. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B.M.M. Allbrooke J.F. Allen c.A. Allendes Flores p.p. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves cardoso M.G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c.G. Ames D. Amidei S.p. Amor Dos Santos K.R. Amos V. Ananiev c. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi c. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi pozo M.A. Aparo L. Aperio Bella c. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val c. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani p.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea p. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin p. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow p. Baron D.A. Baron Mo The ATLAS collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

Growth and characterizations of nonpolar [10-10] and [11-20] ZnO on LiGaO2 substrate by chemical vapor deposition

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Growth and characterizations of nonpolar [10-10] and [11-20]...

Future temperature changes over the critical Belt and Road region based on cMIp5 models

第15届全国晶体生长与材料学术会议

作者： Mitch M.c. chou Yen-Hsiang Liao Shih chuanWang Department of Materials Science & Opto-electronic Engineering National Sun Yat-Sen University

Nonpolar ZnO epitaxial film was successfully grown on LiGaO2 (LGO) substrate by a simple chemical vapor deposition method. [10-10] and [11-20] oriented ZnO films are deposited on LGO (001) and (010). LGO single crystal was grown by czochralski(cz) method. The dependence of growth characteristics on the growth temperatures were investigated. The surface morphologies of ZnO films were studied by a scanning electron microsc.p.. The orientation of the ZnO thin films were identified by X-ray diffraction pattern. Optical properties examined by room temperature photoluminescence spectra exhibit a strong near-band-edge emission peak at 378.1 nm .

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Advances in climate change Research 2018年第1期9卷 57-65页

作者： DONG Tian-Yun DONG Wen-Jie GUO Yan chou Jie-Ming YANG Shi-Li TIAN Di YAN Dong-Dong State Key Laboratory of Earth Surface processes and Resource Ecology Beijing Normal UniversityBeijing 100875China School of Atmospheric Sciences Sun Yat-Sen UniversityGuangzhou 510275China Zhuhai Joint Innovative center for climate-Environment-Ecosystem Future Earth Research InstituteBeijing Normal UniversityZhuhai 519087China Business School Beijing Normal UniversityBeijing 100875China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyHangzhou310012China

Based on data of 22 models from the coupled Model Inter-comparison project phase 5(cMIp5),the performance of climate simulation is assessed and future changes under Rcp2.6,Rcp4.5 and Rcp8.5 are projected over critical Belt and Road *** with observations,the cMIp5 models simulate the linear trend and spatial distribution of the annual mean surface air temperature(SAT)better in the north(NBR)and south(SBR)of the Belt and Road *** trend of the 22-model ensemble mean(cMIp5 MME)is 0.70/0.50 c.p.r 100 years from 1901 to 2005,and the observed trend is 1.11/0.77 c.p.r 100 years in the NBR/SBR *** 1971,the relative error between cMIp5 MME and observations is 22%/15%in the NBR/SBR ***/nine models are selected in the NBR/SBR to project future SAT changes under three Rcp *** 2081e2100,warming in the NBR/SBR is projected to be(1.16±0.29)/(0.72±0.32)c,(2.41±0.54)/(1.55±0.44)c,and(5.23±1.02)/(3.33±0.65)c for Rcp2.6,Rcp4.5,and Rcp8.5,*** the Rcp scenarios,the NBR region shows greater warming than the SBR *** most significant warming is expected in Kazakhstan and the northern part of the *** associated uncertainty generally increases with time under the three Rcp ***,increases in warming over the Belt and Road region are more remarkable under higher-emission scenarios than lower-emission ones.

关键词： cMIp5 models The Belt and Road region Temperature projection Rcps