检索结果-南通市图书馆

Electrospun fibers:a guiding scaffold for research and regeneration of the spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第11期11卷 1764-1765页

作者： nicholas J.Schaub National Institute of Standards & Technology Biosystems and Biomaterials Division

The challenge to regenerating the nervous system compared to other tissues in the body is the complexity of the tissue. For example, a small amount of scar tissue formation after an injury to the skin may have few negative side effects, but any scar tissue in the central nervous system is a major physical and chemical barrier to nerve regeneration （Sofroniew, 2009）.

关键词： Electrospun fibers

Shaping Taste: The Molecular Discovery of Rice Genes Improving Grain Size, Shape and Quality

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2015年第11期42卷 597-599页

作者： nicholas P.Harberd Department of Plant Sciences University of Oxford

Modern-day human life is absolutely dependent upon the food that we derive from our crop plants. We eat grains, fruits, roots, tubers and other structures, all of which are constructed via coordinated organ growth. Whilst plant organ identity is first established in apical meristems （vegetative and floral shoot meristems and root meristems）, and in other meristematic regions, the final size and shape of organs are defined by subsequent coordination of organ expansion in longitudinal and transverse axes.

关键词： QTLs Shaping Taste The Molecular Discovery of Rice Genes Improving Grain Size Shape and Quality gene

Testing for temperature acclimation of plant carbon exchange:a comment on‘Global patterns of the responses of leaf-level photosynthesis and respiration in terrestrial plants to experimental warming’by liang et al.

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2015年第3期8卷 333-334页

作者： nicholas G.Smith Department of Biological Sciences Purdue University915 West State StreetWest LafayetteIN 47907USA

In a recent issue of Journal of Plant Ecology,Liang et al.(2013)use meta-analytical techniques to analyze the leaf carbon exchanges responses to experimental warming and,in part,observe that leaf dark respiration,but not photosynthesis,acclimates to the warming *** authors should be commended for putting together and analyzing such a large data *** of the results provide fine syntheses for understanding leaf carbon exchange responses to ***,the acclimation analyses are,in my opinion,flawed and are not appropriate for supporting their results.

关键词： exchange carbon supporting

Excited electronic states and internal conversion in cyanocobalamin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese chemical Letters 2015年第4期26卷 439-443页

作者： Theodore E.Wiley Brenden c.Arruda nicholas A.Miller Michael Lenard Roseanne J.Sension Department of chemistry University of Michigan

cyanocobalamin （cNcbl） is a paradigm system for the study of excited electronic states and biological cofactors including the B12 vitamers, The photophysics of cNcbl has been thoroughly investigated using both ultrafast spectroscopy and time dependent density functional theory （TD-DFT）. Here we review the spectroscopic and theoretical investigations of cNcbl with emphasis on the nature of S1, the lowest excited electronic state, and extend the spectroscopic measurements to include the ultraviolet region of the spectrum. Ultrafast transient absorption measurements in the visible αβ band region and in the mid- infrared led to assignment of the S1 state to a ligand-to-metal charge transfer （LMcT） with lengthened axial bonds and a ~3 kcal/mol harrier for internal conversion to the ground state. The present measurements encompassing the y band region of the spectrum provide further support for the assignment of the S1 state. The experiments are in good agreement with the results of TD-DFT calculations which confirm the expected lengthening of the axial bonds in S1 and account for the observed barrier for internal conversion back to the ground state,

关键词： cyanocobalaminExcited electronic statesUltrafast spectroscopyTime dependent density functional theoryLigand-to-metal charge transfer

chebfun and numerical quadrature

在线全文

学校读者我要写书评

暂无评论

Science china Mathematics 2012年第9期55卷 1749-1760页

作者： HALE nicholas TREFETHEN Lloyd N Mathematical Institute University of OxfordOxford OX1 3LBUK

chebfun is a Matlab-based software system that overloads Matlab's discrete operations for vectors and matrices to analogous continuous operations for functions and *** begin by describing chebfun's fast capabilities for clenshaw-curtis and also Gauss-Legendre,-Jacobi,-Hermite,and-Laguerre quadrature,based on algorithms of Waldvogel and Glaser,Liu and *** we consider how such methods can be applied to quadrature problems including 2D integrals over rectangles,fractional derivatives and integrals,functions defined on unbounded intervals,and the fast computation of weights for barycentric interpolation.

关键词： chebfun clenshaw-curtis quadrature Gauss quadrature barycentric interpolation formula Riemann-Liouville integral fractional calculus

Inavolisib-Based Therapy in PIK3cA-Mutated Advanced Breast cancer

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第11期46卷 2501-2501页

作者： nicholas c Turner Mass General cancer center Department of Medicine Harvard Medical School Boston Winship cancer Institute at Emory University Atlanta the Department of Medicine University of Parma Parma and the Medical Oncology and Breast Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori” Meldola — both in Italy the Key Laboratory of carcinogenesis and Translational Research Ministry of Education Department of Breast Oncology Peking University Cancer Hospital and Institute Beijing Harbin Medical University Harbin Maria Skłodowska-curie Institute of Oncology Warsaw Poland London and Roche Welwyn Garden City Genentech San Francisco the Breast and Early Drug Development Service Department of Medicine Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College — both in New York

Background:Inavolisib is a highly potent and selective inhibitor of the alpha isoform of the p110 catalytic subunit of the phosphatidylinositol 3-kinase complex(encoded by PIK3cA)that also promotes the degradation of mutated p110α.Inavolisib plus palbociclib-fulvestrant has shown synergistic activity in preclinical models and promising antitumor activity in early-phase trials.

关键词： PIK3cA Breast cancer

Artificial intelligence in gastroenterology:where are we heading?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2020年第4期14卷 511-517页

作者： Joseph JY Sung nicholas cH Poon Institute of Digestive Disease Faculty of MedicineThe Chinese University of Hong KongHong KongChina Big Data Decision Analytic cancer The Chinese University of Hong KongHong KongChina

Artificial intelligence(AI)is coming to medicine in a big *** making diagnosis in various medical conditions,following the latest advancements in scientific literature,suggesting appropriate therapies,to predicting prognosis and outcome of diseases and conditions,AI is offering unprecedented possibilities to improve care for *** is a field that AI can make a significant *** is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures(endoscopy and radiology).AI-assisted image analysis can make accurate assessment and provide more information than conventional *** integration of genomic,epigenetic,and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized *** managing relapsing and remitting diseases such as inflammatory bowel disease,irritable bowel syndrome,and peptic ulcer bleeding,convoluted neural network may formulate models to predict disease outcome,enhancing treatment *** and surgical robots can also assist surgeons in conducting gastrointestinal *** the advancement and new opportunities are exciting,the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

关键词： artificial intelligence endoscopy robotics gastrointestinal diseases

A review on the coordinative structure of human walking and the application of principal component analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第7期8卷 662-670页

作者： Xinguang Wang nicholas O'Dwyer Mark Halaki Discipline of Exercise and Sport Science The University of Sydney School of Science and Health The University of Western Sydney School of Human Movement Studies Charles Sturt University

Walking is a complex task which includes hundreds of muscles, bones and joints working together to deliver smooth movements. With the complexity, walking has been widely investigated in order to identify the pattern of multi-segment movement and reveal the control mechanism. The degree of freedom and dimensional properties provide a view of the coordinative structure during walking, which has been extensively studied by using dimension reduction technique. In this paper, the studies related to the coordinative structure, dimensions detection and pattern reorganization during walking have been reviewed. Principal component analysis, as a popular technique, is widely used in the processing of human movement data. Both the principle and the outcomes of principal component analysis were introduced in this paper. This technique has been reported to successfully reduce the redundancy within the original data, identify the physical meaning represented by the extracted principal components and discriminate the different patterns. The coordinative structure during walking assessed by this technique could provide further information of the body control mechanism and correlate walking pattern with injury.

关键词： neural regeneratJon reviews human walking coordinative structure pattern, synergy principalcomponent analysis dimension reduction gender walking speed correlation linear systemanalysis coherence neuroregeneration

Surgical reconstruction of spinal cord circuit provides functional return in humans

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第12期12卷 1960-1963页

作者： Thomas carlstedt nicholas James Marten Risling The Wolfson centre for Age-Related Diseases King's College London Department of Neuroscience Karolinska Institutet

This mini review describes the current surgical strategy for restoring function after traumatic spinal nerve root avulsion in brachial or lumbosacral plexus injury in man. As this lesion is a spinal cord or central nervous injury functional return depends on spinal cord nerve cell growth within the central nervous system. Basic science, clinical research and human application has demonstrated good and useful motor function after ventral root avulsion followed by spinal cord reimplantation. Recently, sensory return could be demonstrated following spinal cord surgery bypassing the injured primary sensory neuron. Experimental data showed that most of the recovery depended on new growth reinnervating peripheral receptors. Restored sensory function and the return of spinal reflex was demonstrated by electrophysiology and functional magnetic resonance imaging of human cortex. This spinal cord surgery is a unique treatment of central nervous system injury resulting in useful functional return. Further improvements will not depend on surgical improvements. Adjuvant therapy aiming at ameliorating the activity in retinoic acid elements in dorsal root ganglion neurons could be a new therapeutic avenue in restoring spinal cord circuits after nerve root avulsion injury.

关键词： plexus injury root avulsion spinal cord surgery motor sensory recovery adjuvant therapy