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Microscopic colitis:A large retrospective analysis from a health maintenance organization experience

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World Journal of Gastroenterology 2009年第25期15卷 3122-3127页

作者： Kevin T Kao benito A Pedraza Amy c Mcclune David A Rios Yi-Qiong mao Robert H Zuch Michael H Kanter Sony Wirio chris N conteas Department of Gastroenterology Kaiser PermanenteLos Angeles Medical Center Los Angeles California 90027United States Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 United States Department of Pathology Southern California Kaiser Permanente Medical Group California 90027 United States

AIM： To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis （Mc） in Southern california and to determine the association of Mc with inflammatory bowel disease （IBD） and colorectal cancer. METHODS： All patients diagnosed with Mc by co- Ionic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients＇ medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnic- ity, and medications were analyzed. An age- and sex- matched standard control group was also generated. chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis （Lc）, col- lagenous colitis （cc） and the control group. RESULTS： A total of 547 cases of Mc were identified, 376 patients with Lc and 171 patients with cc. The fe- male/male ratio was 3：1 in cc and 2.7：1 in Lc patients. celiac disease （P 〈 0.001）, irritable bowel syndrome （IBS）（P 〈 0.001）, and thyroid diseases （P 〈 0.001） were found to have a higher occurrence in Mc com- pared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the Mc group and the control group. cONcLUSION： This is the largest group of patients with Mc known to the authors that has been studied to date. conditions such as celiac disease, IBS, and thyroid diseases were found to be related to Mc. Fur- thermore, neither an increased risk of colorectal cancer nor IBD was associated with Mc in this study.

关键词： collagenous colitis Inflammatory bowel disease Lymphocytic colitis Microscopic colitis

Prey availability, prey selection, and trophic niche width in the lizard Psammodromus algirus along an elevational gradient

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current Zoology 2018年第5期64卷 603-613页

作者： Gregorio MORENO-RUEDA Elena MELERO Senda REGUERA Francisco J, ZAMORA-cAmacHO Ines ALVAREZ-benito Departamento de Zoologla Facultad de Ciencias Universidad de Granada Granada E-18071 Spain Departamento de Biogeografia y carnbio Global Museo Nacional de Ciencias Naturales-CSIC C/Jose Gutierrez Abascal 2 E-28006 Madrid Spain

Mountains imply enormous environmental variation, with alpine habitats entailing harsh environ- ments, especially for ectotherms such as lizards. This environmental variability also may imply variation in prey availability. However, little is known about how lizard trophic ecology varies with elevation. In this study, we analyze diet, prey availability, prey selection, and trophic niche width in the lacertid lizard Psammodromus algirus along a 2,200-m elevational gradient in the Sierra Nevada （SE Spain）. The analysis of fecal samples has shown that Orthoptera, Formicidae, Hemiptera, coleoptera, and Araneae are the main prey, although, according to their abundance in pitfall traps, Formicidae and coleoptera are rejected by the lizard whereas Orthoptera, Hemiptera, and Araneae are preferred. Prey abundance and diversity increase with elevation and diet subtly varies along with the elevational gradient. The consumption of coleoptera increases with elevation probably as a consequence of the lizard foraging more in open areas while basking. The electivity for Araneae increases with elevation. Araneae are rejected in the lowlands--where they are rela- tively abundant--whereas, at high elevation, this lizard positively selects them, despite they being less abundant. The lizard trophic niche width expands with elevation due to concomitant greater prey diversity and hence this lizard feeds on more prey types in highlands. Although no sex difference in diet has been found, the trophic niche is broader in females than males. As a whole, alpine lizards show a trophic niche simitar to that found at lower elevat（ons, suggesting that P. algirus is well adapted to the harsh environment found in alpine areas.

关键词： alpine habitats arthropods mountain ecology niche variation hypothesis trophic ecology

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马来西亚卷柏属植物新资料

广西植物 2013年第5期33卷 588-590页

作者：张宪春 Tan c.benito 中国科学院植物研究所系统与进化植物学国家重点实验室北京100093 新加坡植物园新加坡259569

该文报道了马来西亚卷柏属2个新记录种——布朗卷柏(Selaginella braunii)、泰国卷柏(***)。凭证标本均馆藏于新加坡植物园标本馆。

关键词：布朗卷柏泰国卷柏新记录马来西亚

Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and cD4^(+) T cell activation

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cellular & Molecular Immunology 2020年第2期17卷 133-142页

作者： Miguel Álvaro-benito Eliot Morrison Friederike Ebner Esam T.Abualrous marie Urbicht marek Wieczorek christian Freund Laboratory of Protein Biochemistry Department of BiologyChemistry and PharmacyFreie Universität BerlinThielallee 6314195 BerlinGermany Institut für Immunologie Department of Veterinary MedicineFreie Universität BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany computational Molecular Biology Group Institute for MathematicsFreie Universität BerlinBerlinGermany

classical human leukocyte antigen(HLA)molecules of the major histocompatibility classⅡ(MHcⅡ)complex present peptides for the development,surveillance and activation of cD4^(+) T *** nonclassical MHcⅡ-like protein HLA-DM(DM)catalyzes the exchange and loading of peptides onto MHcⅡmolecules,thereby shaping MHcⅡ*** variations of DM in both chains of the protein(Dma and DMB)have been hypothesized to impact peptide presentation,but no evidence for altered function has been *** we define the presence of DM allotypes in human populations covered by the 1000 Genomes Project and probe their *** functional properties of several allotypes are investigated and show strong enhancement of peptide-induced T cell activation for a particular combination of Dma and *** evidence suggests a broader pH activity profile for the new variant relative to that of the most commonly expressed DM *** analysis indicates that the compartmental activity of the new DM heterodimer extends beyond the late endosome and suggests that the natural variation of DM has profound effects on adaptive immunity when antigens bypass the canonical processing pathway.

关键词： MHc classⅡ Limited polymorphism HLA-DM,Peptide editing Epitope selection Immunopeptidome

Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis c virus infection

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World Journal of Gastroenterology 2008年第47期14卷 7149-7159页

作者： Juan R Larrubia Selma benito-martínez Miryam calvino Eduardo Sanz-de-Villalobos Trinidad Parra-cid Department of Gastroenterology Guadalajara University HospitalUniversity of AlcaláDonante de Sangre st.19002 GuadalajaraSpain Guadalajara University Hospital University of AlcaláDonante de Sangre st.19002 GuadalajaraSpain

chemokines produced in the liver during hepatitis c virus(HcV) infection induce migration of activated T cells from the periphery to infected *** milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell(Th1/Tc1) *** chemokines consist of ccL3(macrophage inflammatory protein-1α;MIP-1α),ccL4(MIP-1β),ccL5(regulated on activation normal T cell expressed and secreted;RANTES),cXcL10(interferon-γ-inducible protein-10;IP-10),cXcL11(interferon-inducible T-cell α chemoattractant;I-TAc),and cXcL9(monokine induced by interferon γ;Mig) and they recruit T cells expressing either ccR5 or cXcR3 chemokine *** and peripheral blood levels of these chemokines are increased during chronic hepatitis *** interaction between chemokines and their receptors is essential in recruiting HcV-specific T cells to control the *** the adaptive immune response fails in this task,non-specific T cells without the capacity to control the infection are also recruited to the liver,and these are ultimately responsible for the persistent hepatic *** modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection,and to maintain liver viability during the chronic phase,by impairing non-specific T cell *** chemokines and their receptors correlate with liver damage,and cXcL10(IP-10) and cXcR3 levels have shown a clinical utility as predictors of treatment response *** regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver.

关键词： chemokines chemokine receptors Hepatitis c virus Viral hepatitis pathogenesis Persistentinfection Viral escape mechanism

What is the most effective exercise protocol to improve cardiovascular fitness in overweight and obese subjects？

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Journal of Sport and Health Science 2017年第4期6卷 454-461页

作者： Eliane Aparecida castro Ana Belen Peinado Pedro Jose benito MercedeS Galindo marcela Gonzalez-Gross Rocio cupeiro Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit~cnica de Madrid Madrid 28040 Spain LFE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain Faculty of Physical Activity and Sport Sciences Universidad Politecnica de Madrid Madrid 28040 Spain ImFINE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain

Background: Increased peak oxygen consumption(VO2 peak) can reduce cardiovascular risks associated with obesity. Our aim was to analyze the effect of a weight loss program on cardiovascular fitness in overweight(W) and obese(O) ***: One hundred and sixty-seven subjects(77 males and 90 females), aged 18–50 years, performed a modified Bruce protocol before(pre)and after(post) a weight loss program of 24 weeks. This program combined physical training(strength, S; endurance, E; combined strength + endurance, SE; or physical activity recommendation, PA) 3 times per week, with a 25%–30% caloric restriction ***: VO2 peak improved in overweight and obese males(pre and post values in L/min, respectively; W = 3.2 ± 0.6 vs. 3.7 ± 0.5, p males(2.0 ± 0.3 vs. 2.3 ± 0.4, p creased for all 4 interventions in males(p cept for S in the obese group(1.6 ± 0.2 vs. 1.7 ± 0.3, p = 0.141). In females, it increased in E(0.9 ± 0.2 vs. 1.4 ± 0.3, p cts except for females in PA group(15.7 ± 0.3 min vs. 15.9 ± 0.3 min, p = 0.495).conclusion: Our results suggest that all methods, including the recommendation of physical activity, can improve cardiovascular fitness in overweight subjects and obese males.

关键词： combined training Endurance training Obesity Oxygen consumption Physical activity Strength training Ventilatory threshold

Singapore-Its Biodiversity, conservation and Resource management

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Singapore-Its Biodiversity, Conservation and Resource Manage...

costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis c

中国-东盟热带生物资源保护与生物技术应用研讨会

作者： benito c.Tan Tan Swee Hee Raffles Museum for Biodiversity Research Department of Biological Sciencesnational University of SingaporeSingapore 119260 Raffles Museum for Biodiversity Research Department of Biological Sciencesnational University of SingaporeSingapore 119260

＜正＞ The small island of the Republic of Singapore, with about 574 sq km, still possesses a diverse flora and fauna today. The last count of its relatively rich biota reported a total of 8,140 species, including 2,948 species of plants, 1006 species of fungi and 4,186 species of animals. This diversity is found scattered among the remnants of primary rain forests and old secondary forests, coastal mangrove communities, and shrinking coral reef formations. In addition, the island country has documented in recent years the invasion of alien species - some 138 vascular plant species, 2 bryophytes, 18 birds, 5 mammals and 20 fishes. At present, there are four legislated nature reserves, which comprise about 1% of the total land area but protect more than 50% of the country’s total biodiversity of plants and animals. A recent calculation of the rate extinction of organisms over a century of urbanization on the island showed that the loss of biodiversity was about 5-43% depending on the group of animals, and about 26-45% for the various plant groups. Organisms in Singapore that still lack a fundamental inventory of the diversity are the macrofungi, lichens, marine algae and coelenterates, dipterans, coleopterans, forest and soil arthropods, nematodes, and protozoans. As a signatory country of the Rio de Janeiro convention of Biological Diversity （cBD）, the government is doing is best to complete the inventory of local fauna and flora, managing the remaining natural resources for sustainable uses, such as ecotourism, and strictly prohibiting the trading of cITES listed organisms.

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World Journal of Gastroenterology 2009年第41期15卷 5129-5140页

作者： Juan Ramón Larrubia Selma benito-martínez Joaquín Miquel Miryam calvino Eduardo Sanz-de-Villalobos Trinidad Parra-cid Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Hepatitis c virus（HcV）-specific cD8^＋ T cells play an important role in the resolution of HcV infection. Nevertheless, during chronic hepatitis c these cells lack their effector functions and fail to control the virus. HcV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 （PD-1）. This molecule is upregulated on intrahepatic and peripheral HcV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HcV-specific cD8^＋ T cells are exhausted with impairment of several effector mechanisms, such as： type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand （PD-L1）. After this blockade, HcV-specific cD8^＋ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-l-expressing intrahepatic HcV-specific cD8^＋ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HcV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TcR stimulation by a high level of HcV antigens could favour early PD-1 induction, but the interaction between HcV core protein and gclq receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response aclainst HcV to succeed in clearing the infection.

关键词： chronic hepatitis Exhaustion Hepatitis c virus core Hepatitis c virus Programmed death-1 Programmed death-1 ligand

Geometrodynamical Analysis to characterize the Dynamics and Stability of a Molecular System through the Boundary of the Hill’s Region

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Applied mathematics 2014年第16期5卷 2630-2642页

作者： Alberto Vergel Rosa M. benito Juan c. Losada Florentino Borondo Grupo de Sistemas complejos Departamento de Física y Mecánica Escuela Técnica Superior de Ingenieros Agrónomos Universidad Politécnica de Madrid Madrid Spain Instituto de ciencias matemáticas (IcmaT) Madrid Spain Departamento de Química Universidad Autónoma de Madrid Madrid Spain

In this paper we study the dynamics and stability of a two-dimensional model for the vibrations of the LicN molecule making use of the Riemannian geometry via the Jacobi-Levi-civita equations applied to the Jacobi metric. The Stability Geometrical Indicator for short times is calculated to locate regular and chaotic trajectories as the relative extrema of this indicator. Only trajectories with initial conditions at the boundary of the Hill’s region are considered to characterize the dynamics of the system. The importance of the curvature of this boundary for the stability of trajectories bouncing on it is also discussed.

关键词： Geometrodynamical Analysis Molecular Nonlinear Dynamics Stability Geometrical Indicator Riemannian Geometry Hamiltonian Systems