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class c G protein-coupled receptors: reviving old couples with new partners

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Biophysics Reports 2017年第Z2期 57-63页

作者： Thor c.m?ller David moreno-Delgado Jean-Philippe Pin Julie Kniazeff Institut de Génomique Fonctionnelle (IGF) CNRSINSERMUniv. Montpellier

G protein-coupled receptors(GPcRs) are key players in cell c.mmunication and are encoded by the largest family in our genome. As such, GPcRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPcRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPcRs, the class F includes the frizzled receptors, and the class c includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. class c receptors are far more c.mplex than other GPcRs, being mandatory dimers, with each subunit being c.mposed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class c GPcRs, and how this brings information for many other GPcRs.

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Discovery of the New Isotope^(251)Lr

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ImP & HIRFL Annual Report 2022年第1期 38-38页

作者： Huang Tianheng D.Seweryniak B.B.Back P.Bender m.P.carpenter P.chowdhury R.m.clark P.copp X.-T.He R.D.Herzberg D.Ho H.Jayatissa T.L.Khoo F.G.Kondev G.morgan ch.morse A.Korichi T.Lauritsen c.muller-gatermann D.Potterveld W.Reviol A.Rogers S.Saha G.Savard K.Sharma S.Stolze S.Waniganeththi G.Wilson J.Wu Y.-F.Xu S.Zhu Institute of modern Physics Chinese Academy of SciencesLanzhou 730000China Argonne National Laboratory ArgonneIL 60439USA University of massachusetts LowellMA 01854USA Lawrence Berkeley National Laboratory BerkeleyCA 94720USA college of materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China University of Liverpool LiverpoolUK Louisiana State University Baton RougeLA 70803USA IJcLab IN2P3-CNRSFrance Brookhaven National Laboratory UptonNY 11973USA

The products of the^(203,205)Ti(^(50)Ti,2n)fusion-evaporation reactions were studied by using the recently c.mmissioned Argonne Gas-Filled Analyzer(AGFA)at Argonne National Laboratory.

关键词： 2n Argonne

Expert perspectives on GIS use in Spanish geographic education

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International Journal of Digital Earth 2022年第1期15卷 1204-1218页

作者： I.J.Buzo-Sánchez c.mínguez m.L.De Lázaro-Torres IES San Roque BadajozSpain Geography Department Universidad Complutense de MadridMadridSpain Geography Department UNEDMadridSpain

The emergence of new technological tools for territorial analysis,such as cloud-based GIS,or GIS viewers,c.mpels us to closely examine its usefulness in geographic education. Specifically,it raises the professors and teachers’ questions: what to teach? how to teach? and what will students learn? This research responds to these three questions by interviewing Spanish experts who know how to use these tools to teach geography at university and secondary school levels. The Delphi technique was applied to achieve this,which established consensus and led to the following results from experts’ own experience: (1) that GIS help to understand territory in an experiential and non-memoristic way and (2) they enable the development of spatial thinking. This paper concludes that changes in methodologies and integrate technical knowledge into teacher training are needed.

关键词： Geography Delphi GIS c.mpetencies spatial thinking

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage bec.mes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic.molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a c.mprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less c.mmon types of acquired hearing *** etiology of these conditions is c.mplex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EmBASE,Ovid mEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Robotic pancreaticoduodenectomy after the learning curve-a new hope

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 489-491页

作者： Philip c.müller Beat P.müller-Stich Thilo Hackert Felix Nickel Swiss HPB and Transplantation center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

First,we would like to congratulate Liu et *** their successful multicenter study including 1,032 patients undergoing robotic pancreaticoduodenectomy(RPD)and 1,154 open pancreaticoduodenectomy(OPD)in seven high volume centers in china over an 8 year period(1).To ensure the best possible outc.mes of both techniques,RPD was performed by five surgeons from three centers after overc.ming the individual learning curve that was defined as having performed>40 *** the other hand,OPD was performed by 9 surgeons from 6 centers after reaching the individual learning curve,defined as an experience of>60 OPD.

关键词： centers learning after

multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

multiple sclerosis(mS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with mS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： Philip c.muller matthias Pfister Dilmurodjon Eshmuminov Kuno Lehmann Department of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELm)is still in *** c.mparing LT with liver resection(LR)for NELm are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of *** sources:A scoping literature search on LT and LR for NELm was performed with Pubmed,including English articles up to march ***:International guidelines rec.mmend LR for NELm in resectable,well-differentiated tumors in the absence of extrahepatic.metastatic disease with superior results of LR c.mpared to systemic or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the milan criteria)with unresectable NELm,oncologic results of LT are *** factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELm within the milan criteria resulted in improved disease-free survival and overall survival c.mpared to *** benefits of LT were lost in patients beyond the milan ***:With adherence to strict selection criteria especially tumor biology,LT for NELm is bec.ming a valuable option providing oncologic benefits c.mpared to *** evidence suggests even stricter selection criteria with regard to tumor biology.

关键词： Liver transplantation Neuroendocrine liver metastases Liver resection Selection criteria Tumor biology

Evaluation of stereology for snow microstructure measurement and microwave emission modeling:a case study

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International Journal of Digital Earth 2021年第10期14卷 1316-1336页

作者： Jinmei Pan m.T.Durand Z.courville B.J.Vander Jagt N.P.molotch S.A.margulis E.J.Kim m.Schneebeli c.mätzler State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingPeople’s Republic of China School of Earth Science and Byrd Polar Research center The Ohio State UniversityColumbusOHUSA US Army corps of Engineers cold Regions Research and Engineering Laboratory HanoverNHUSA Geography Department and Institute of Arctic and Alpine Research University of ColoradoBoulderCOUSA Department of civil and Environmental Engineering University of CaliforniaLos AngelesCAUSA Hydrospheric and Biospheric Sciences Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA WSL Institute for Snow and Avalanche Research SLF Davos DorfSwitzerland Institute of Applied Physics and Oeschger centre for climate change Research University of BernBernSwitzerland

Reliablemicrostructuremeasurement of snow is a requirement for microwave radiative transfer model *** specific surface area(SSA)can be measured using stereological methods,in which snow samples are cast in the field and photographed in the *** stereology photographs manually by counting intersections of test cycloids with air-ice boundaries reduces the problems in binary *** paper is a case study to evaluate the repeatability of the manually stereology interpretation by two independent research *** further assessed how uncertainty in snow SSA influences simulated brightness temperature(TB)driven by the microwave Emission model of Layered Snowpacks(mEmLS),and how stereology c.mpares to Near Infrared(NIR)c.mera and hand *** was obtained from two alpine snow profiles from Steamboat Springs,*** showed that stereological SSA values measured by two groups are highly consistent,and the ground radiometer measured T_(B)at 19 and 37 GHz was successfully predicted(RmSEmulations using NIR SSA and hand-lens geometric grain size(Dg)measurements have larger *** conclusion was not sensitive to uncertainty in the free parameters of TB modeling.

关键词： microwave radiometry snow stereology snow microstructure mEmLS