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Food Production, Processing and Nutrition 2021年第1期3卷 80-91页

作者： U.c.Urbizo-Reyes J.E.Aguilar-Toalá A.M.Liceaga Protein chemistry and Bioactive Peptides Laboratory Department of Food SciencePurdue University745 Agriculture Mall DriveWest LafayetteIN 47907USA

Rising consumer concerns with synthetic drugs to treat non-communicable diseases(NcDs)have promoted a shift towards using natural biological active constituents that offer similar health *** canary seed(Phalaris canariensis L)is an emerging crop traditionally used in Mexico to treat *** liberated during simulated digestion of canary seed protein are believed to be responsible for their biological activity;however,no studies have shown the effect of controlled protein hydrolysis using commercial proteases on canary seed protein’s biological ***,this study aimed to explore the in vitro antihypertensive,antidiabetic,and anti-obesity activity of canary seed peptides derived from proteolysis with Alcalase®.Protein fractions were primarily composed of prolamins(54.07±1.8%),glutelins(32.19±3.18%),globulins(5.97±0.52%)and albumins(5.97±0.52%).Thections showed the highest inhibition capacity(pconverting enzyme(Ic50=0.028–0.032 mg/mL)lipase(Ic50=2.15–2.27 mg/mL),α-glucosidase(Ic50=0.82–1.15 mg/mL),and dipeptidyl-peptidase-IV(Ic50=1.27–1.60 mg/mL).Additionally,these peptide fractions showed high antioxidant activity against DPPH(134.22–150.66μmol TE/mg)and ABTS(520.92–813.33μmol TE/mg).These results provide an insight into the potential development of functional foods using commercial enzymatic hydrolysis of canary seed proteins for treating hypertension,type-2 diabetes,and obesity.

关键词： canary seeds Bioactive peptides Anti-obesity activity Antihypertensive activity Antidiabetic activity

Methionine adenosyltransferases in liver cancer

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World Journal of Gastroenterology 2019年第31期25卷 4300-4319页

作者： Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly c Lu Division of Digestive and Liver diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States cIc bioGUNE Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(Ciberehd)TechnologyPark of BizkaiaDerio 48160BizkaiaSpain

Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the *** systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα***1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe *** of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(Hcc)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver *** increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular *** we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their *** will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy.

关键词： Methionine adenosyltransferases S-adenosylmethionine Liver cancer Hepatocellular carcinoma cholangiocarcinoma Biomarkers Therapeutic targets

The abolitionist's daughter

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The abolitionist's daughter

Preparation and characterization of Hybrid Luminescence Mesoporous McM-48 Doped with Eu( Ⅲ ) complex

作者： Diane c. McPhail.

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Journal of Rare Earths 2004年第Z1期22卷 144-146页

作者： Meng Qingguo Li Huanrong Peng chunyun Zhang Hongjie Boutinaud P Franville A c Mahiou R Key Laboratory of Rare Earth chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des LandaisF-63177 Aubiere CedexFrance Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France Laboratoire des Materiaux Inorganiques UMR CNRS 6002 Universite Blaise-Pascal et ENSCCF 24 Avenue des Landais F-63177 Aubiere Cedex France

The preparation of hybrid mesoporous McM-48 grafted by vinyl group via post-grafting process was reported and studied by X-ray diffraction, BET and 29Si solid MAS *** organic β-diketonate Europium complex the corresp... 详细信息

关键词： mesoporous hybrid materials rare earths

Variation of basic density,calorific value and volumetric shrinkage within tree height and tree age of Ugandan grown Eucalyptus grandis wood

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Journal of Forestry Research 2021年第2期32卷 503-512页

作者： Owen Emmanuel Sseremba P.Mugabi A.Y.Banana B.c.Wessels M.Plessis Department of Forestry Biodiversity and TourismMakerere UniversityKampalaUganda Department of Forestry and Wood Science Stellenbosch UniversityStellenboschSouth Africa

Insufficient knowledge on Ugandan grown Eucalyptus grandis *** ex Maiden wood properties,high demand,and processing challenges led to a study into its physical *** obtained the variation of basic density(BD),calorific value(cV)and volumetric shrinkage(VS)within tree height and tree-age of ***,and its appropriate use based on these *** with good boles were harvested from Kabarole District in western Uganda to produce specimens as prescribed by British Standards and ASTM standard wood testing *** data reviews and statistical analysis using ANOVA,Tukey’s test and multivariate analysis were done to obtain property estimates and their variation within trees and amongst tree *** mean BD of *** is 413.6,380.5,471.0,and 501.1 kg m^(−3)at 3,6,9,and 12 years,respectively,showing significant increase with tree age(p=0.003).The pattern of BD with tree height showed a reduction with tree height although with higher values in the middle portion of the *** cV increases(p=0.014)with tree age and reduces with tree height with values of 14,560.32,15,447.3,16,079.11,and 16,932.6 kJ kg^(−1)at 3,6,9,and 12 years,*** percentage VS was 11.02,9.84,12.31,and 14.45 for 3-,6-,9-,and 12-year-old trees,respectively,and it did not vary significantly(p=0.088)with tree *** on these property values,*** wood could be used for scaffolding,light constructions and fuel wood *** seasoning needs to be longer with well monitored drying schedules to reduce seasoning defects caused by the high *** studies on strength properties,seasoning schedules,panel products properties and tree-age chemical variations would improve the knowledge about its wood quality and would enhance its efficient utilization.

关键词： Eucalyptus grandis Age calorificvalue Basic density Volumetric shrinkage Wood

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Adaptive control of MIMO Mechanical Systems with Unknown Actuator Nonlinearities Based on the Nussbaum Gain Approach

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IEEE/cAA Journal of Automatica Sinica 2016年第1期3卷 26-34页

作者： ci chen Zhi Liu Yun Zhang c.L.Philip chen Shengli Xie School of Automation Guangdong University of Technology IEEE Faculty of Science and Technology University of Macao Guangdong Key Laboratory of IoT Information Processing

This paper investigates MIMO mechanical systems with unknown actuator nonlinearities. A novel Nussbaum analysis tool for MIMO systems is established such that unknown time-varying control coefficients are tackled. In contrast to existing literatures on continuous-time systems, the newly-developed Nussbaum tool focuses on extending the traditional Nussbaum result from one dimensional case to the multiple one. Specifically, not only the multiple unknown input coefficients are extended to the time-varying, but also the limitation of the prior knowledge of coefficients' upper and lower bounds is removed. Furthermore, an adaptive robust controller associated with the proposed tool is presented. The asymptotic tracking of MIMO mechanical systems is guaranteed with the help of the Lyapunov Theorem. Finally, a simulation example is provided to examine the validity of the proposed scheme. © 2014 chinese Association of Automation.

关键词： Actuators Adaptive control systems control nonlinearities Mechanical actuators Mechanics MIMO systems Time varying control systems

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Perinatal transmission in infants of mothers with chronic hepatitis B in california

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World Journal of Gastroenterology 2017年第27期23卷 4942-4949页

作者： Jennifer c Burgis Darryl Kong catheryn Salibay Jennifer Zipprich Kathleen Harriman Samuel So Department of Pediatrics Stanford University california Department of Public Health Immunization Branch Asian Liver center Stanford University

To evaluate maternal hepatitis B virus (HBV) DNA as risk for perinatal HBV infection among infants of HBV-infected women in california. METHODSRetrospective analysis among infants born to hepatitis B surface antigen (HBsAg)-positive mothers who received post vaccination serologic testing (PVST) between 2005 and 2011 in california. Demographic information was collected from the california Department of Public Health Perinatal Hepatitis B Program databaseand matched to birth certificate records. HBV DNA level and hepatitis B e antigen (HBeAg) status were obtained from three large commercial laboratories in california and provider records if available and matched to mother infant pairs. Univariate analysis compared infected and uninfected infants. Multivariate analysis was restricted to infected infants and controls with complete maternal HBV DNA results using a predefined high HBV DNA level of > 2 × 107 IU/mL, a 5:1 ratio of cases to controls and a two-sided confidence level of 95%. RESULTSA total of 17687 infants were born to HBsAg positive mothers in california between Jan 1 2005 and Dec 31, 2011. Among 11473 infants with PVST, only 125 (1.1%) were found to be HBV infected. Among these infected infants, lapses in Advisory committee on Immunization Practices recommended post exposure prophylaxis (PEP) occurred in only 9 infants. However, PEP errors were not significantly different between infected and uninfected infants. Among the 347 uninfected and infected infants who had maternal HBeAg and HBV DNA level, case-control analysis found HBeAg positivity (70.4% vs 28.9%, OR = 46.76, 95%cI: 6.05-361.32, P 7 IU/mL (92.6% vs 18.5%, OR = 54.5, 95%cI: 12.22-247.55, P ciated with perinatal HBV infection. In multivariate logistic regression, maternal HBV DNA level ≥ 2 × 107 IU/mL was the only significant independent predictor of perinatal HBV infection. cONcLUSIONIn california, tra

关键词： Perinatal transmission Hepatitis B virus DNA Pregnancy Hepatitis B Vaccination Post-vaccine serology testing

Potential fly-ash utilization in agriculture:A global review

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Progress in Natural Science:Materials International 2009年第10期19卷 1173-1186页

作者： Manisha Basu Manish Pande P.B.S.Bhadoria S.c.Mahapatra Agriculture & Food Services SGS India Pvt. Ltd. Department of Agricultural and Food Engineering Indian Institute of Technology Rural Development centre Indian Institute of Technology

Though in last four decades various alternate energy sources have come into the limelight, the hyperbolic use of coal as a prime energy source cannot be counterbalanced. Disposal of high amount of fly-ash from thermal power plants absorbs huge amount of water, energy and land area by ash ponds. In order to meet the growing energy demand, various environmental, economic and social problems associated with the disposal of fly-ash would continue to increase. Therefore, fly-ash management would remain a great concern of the century. Fly-ash has great potentiality in agriculture due to its efficacy in modification of soil health and crop performance. The high concentration of elements (K, Na, Zn, ca, Mg and Fe) in fly-ash increases the yield of many agricultural crops. But compared to other sectors, the use of fly-ash in agriculture is limited. An exhaustive review of numerous studies of last four decades took place in this paper, which systematically covers the importance, scope and apprehension regarding utilization of fly-ash in agriculture. The authors concluded that though studies have established some solutions to handle the problems of radioactivity and heavy metal content in fly-ash, long-term confirmatory research and demonstration are necessary. This paper also identified some areas, like proper handling of dry ash in plants as well as in fields, ash pond management (i.e., faster decantation, recycling of water, vertical expansion rather than horizontal), monitoring of soil health, crop quality, and fate of fly-ash in time domain, where research thrust is required. Agricultural lime application contributes to global warming as Intergovernmental Panel on climate change (IPcc) assumes that all the carbon in agricultural lime is finally released as cO2 to the atmosphere. It is expected that use of fly-ash instead of lime in agriculture can reduce net cO2 emission, thus reduce global warming also.

关键词： coal fly-ash Agriculture Soil health crop yield Radioactivity Global warming

长波紫外线1和可见光对皮肤色素沉着相对贡献的定量比较分析

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中华皮肤科杂志 2023年第12期56卷 1181-1182页

作者： Marionnet c Piffaut V Sasai J 欧莱雅法国研发和创新中心欧莱雅日本研发和创新中心法国尼斯大学附属医院

340~400nm波段的长波紫外线1(UVA1)和400~700nm波段的可见光均能诱发皮肤色素沉着,产生即时性黑化和持续性黑化。可见光按照能量从高到低又分为蓝光(400~500nm)、绿光(500~600nm)和红光(600~700 nm),其中400~450nm又称为高能可见光(HEV... 详细信息

340~400nm波段的长波紫外线1(UVA1)和400~700nm波段的可见光均能诱发皮肤色素沉着,产生即时性黑化和持续性黑化。可见光按照能量从高到低又分为蓝光(400~500nm)、绿光(500~600nm)和红光(600~700 nm),其中400~450nm又称为高能可见光(HEV)。有学者发现与630nm发光二极管(LED)红光相比,415nmLED蓝光能有效诱导色素沉着,且这一效应与人黑素细胞表达的感受器视蛋白3(opsin3)有关。有色防晒霜能阻断可见光从而对其诱发的皮肤色素沉着起到防护作用。

关键词：皮肤色素沉着长波紫外线防晒霜黑化视蛋白可见光感受器持续性

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Larvicidal activity of Dregea volubilis and Bombax malabaricum leaf extracts against the filarial vector culex quinquefasciatus

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 436-441页

作者： Emdad Hossain Anjali Rawani Goutam chandra Subhash c.Mandal Jayanta Kumar Gupta Pharmacy college AzamgarhItauraPO:ChandeshwarAzamgarh 276128Uttar PradeshIndia Department of Zoology Mosquito Research UnitParasitology LaboratoryThe University of BurdwanBurdwan 713104West BengalIndia Department of Pharmaceutical Technology Jadavpur UniversityKolkata 700032India

Objective:To analyze the larvicidal activity of two plant leaf powder and leaf-extracts, Dregea volubilis and Bombax malabaricum against culex ***:The larvicidal bioassay was done for powdered leaves of Dregea volubilis and Bombax malabaricum individually and their methanol extracts against first-,second-,third- and fourth-instar larval forms of culex *** rate was recorded after 24,48 and 72 h of postexposure. Lc50 and LG90 values were calculated at different time intervals for third instar larvae. Results:All the graded concentration（0.1%,0.2%,0.3%,0.4%,0.5%） of powdered leaves showed significant（P c extracts of both the plants against culex *** corresponding c50 values were 56.97 ppm and 48.85 ppm,respectively after 24 h of *** is no mortality of non-target organism such as chironomous circumdatus,Oreochromis niloticus niloticus and Diplonichus annulatum within 72 h of post exposure to 0.1%,0.2%,0.3%crude powdered leaves and methanolic extracts of both the two individual plants under the laboratory *** results of preliminary qualitative phytochemical analysis of both the plants revealed the presence of many bioactive principles such as steroids,tannins,flavonoids,triterpenoids,saponins,etc. that may be responsible for their bio-control ***:The results have shown potential and eco-friendly use of both plant extracts against larva of culex quinquefasciatus for the first time.

关键词： Bombax malabaricum culex quinquefasciatus Dregea volubilis Larvicidal activity