检索结果-南通市图书馆

Recent progress in photocatalytic NAD(P)H regeneration for photocatalytic-enzymatic-coupling system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of chemical Science and engineering 2024年第4期18卷 1-24页

作者： Wei lan Maodi Wang Huicong Dai Qihua Yang Key Laboratory of the Ministry of Education for Advanced catalysis Materials Zhejiang Key Laboratory for Reactive Chemistry on Solid SurfacesInstitute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

The enzymatic redox reactions in natural photosynthesis rely much on the participation of cofactors,with reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate(NADH/NADPH)or their oxidized form(NAD+/NADP+)as an important redox *** photocatalytic regeneration of expensive and unstable NADH/NADPH in vitro is an important process in enzymatic reduction and has attracted much research *** different types of photocatalysts have been developed for photocatalytic NADH/NADPH regeneration,the efficiency is still relatively *** elucidate the key factors affecting the performance of photocatalytic NADH/NADPH regeneration is helpful to rationally design the photocatalyst and improve the photocatalytic *** this paper,we overview the recent progress in photocatalytic NADH/NADPH regeneration with the focus on the strategies to improve the visible light adsorption,the charge separation and migration efficiency,as well as the surface reaction,which jointly determine the overall photocatalytic regeneration *** potential development of photocatalytic NADH/NADPH regeneration and photocatalyticenzymatic-coupling system is prospected finally.

关键词： photocatalytic-enzymatic coupling NAD(P)H regeneration photocatalysis efficiency

New γ-Ray Sources Identified in All-sky Surveys Based on Fermipy's Advanced Algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第10期24卷 81-91页

作者： Yunchuan Xiang Peng Feng Xiaofei lan School of Physics and Astronomy China West Normal UniversityNanchong 637009China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China

We employ an efficient method for identifying γ-ray sources across the entire sky,leveraging advanced algorithms from Fermipy,and cleverly utilizing the Galactic diffuse background emission model to partition the entire sky into72 regions,thereby greatly enhancing the efficiency of discovering new sources throughout the sky through multithreaded parallel *** confirming the reliability of the new method,we applied it for the first time to analyze data from the Fermi Large Area Telescope(Fermi-LAT)encompassing approximately 15.41 yr of all-sky *** this analysis,we successfully identified 1379 new sources with significance levels exceeding 4σ,of which 497 sources exhibited higher significance levels exceeding 5σ.Subsequently,we performed a systematic analysis of the spatial extension,spectra,and light variation characteristics of these newly identified *** identified 21 extended sources and 23 sources exhibiting spectral curvature above 10 ***,we identified 44 variable sources above 1 GeV.

关键词： gamma-rays:diffuse background methods:data analysis catalogs gamma-rays:general

Object Helps U-Net Based change Detectors

在线全文

学校读者我要写书评

暂无评论

IEEE/cAA Journal of Automatica Sinica 2024年第2期11卷 548-550页

作者： lan Yan Qiang Li Kenli Li college of computer Science and Electronic engineering Hunan UniversityChangsha 410082China State Key Laboratory for Management and control of complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter focuses on leveraging the object information in images to improve the performance of the U-Net based change *** detection is fundamental to many computer vision *** existing solutions based on ... 详细信息

关键词： Net computer networks

Nanoparticle targeting cGAS-STING signaling in disease therapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7315-7336页

作者： lan Zhou Yu Huang Yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F cells by Reversing ADAMTS18 Gene Methylation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： XU Ben ZHANG Jia-en YE Lin YUAN chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTS18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(col-I)and alpha-smooth muscle actin(α-SMA)mRNA and protein expressions were analyzed by real-time PcR(RT-PcR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dc,demethylation agent)for 72 *** of curcumin on extracellular matrix(EcM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTS18 small interfering RNA and grouped into a normal control,ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(Pent concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(Pchemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,col-I andα-SMA(Pcurcumin and 5-zaz-dc had synergistic effects,promoting ADAMTS18 expression,removing ADAMTS18 methylation,and reducing EcM ***18 knockdown promoted EcM accumulation,and curcumin reversed this process(Pconclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin chinese medicine ADAMTS18 methylation modification

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining Ke en Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Experimental and numerical flutter analysis of a folding fin with multiple asymmetric free-plays

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Aeronautics 2024年第5期37卷 332-348页

作者： chenyu LIU chao AN changchuan XIE Xin ZHANG lan YANG School of Aeronautic Science and engineering Beihang UniversityBeijing 100191China Beijing Institute of Electronic System engineering Beijing 100854China Beijing Institute of Astronautical Systems engineering Beijing 100076China

Experimental folding fin models with an adjustable free-play are tested in a wind *** fin structure is modeled using the free-interface component mode synthesis method,and its free-play is modeled as four independent nonlinear springs with asymmetric stiffness.A nonplanar unsteady vortex-lattice method considering compressibility is employed to address nonlinear deformation and high subsonic *** spline interpolation is improved through projection and *** aeroelastic characteristics of folding fins with different free-play magnitudes,initial conditions and elastic-axis positions are analyzed using an established time-marching method because of its relatively small computation scale and high *** results show good consistency among the presented method,the wind tunnel test and the harmonic balance *** is a negative correlation between the critical speed of divergent motion and the ratio of the initial condition to the free-play *** either the free-play magnitude or the initial condition is extreme(tiny or vast),the system nonlinearity degenerates to ***,the flutter prevention design of a linear model can be applied to a nonlinear model,such as moving the elastic-axis position *** presented fin configuration exhibits an unstable limit cycle oscillation because the orders of coupled flutter modes do not change with variations in equivalent linear stiffness.

关键词： Free-play Limit cycle oscillation Flutter component mode synthesis Vortex-lattice method

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-Yu chen Xiang-Yu Lyu en-Kun Li Yi-Ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

Alarm Log Data Augmentation Algorithm Based on a GAN Model and Apriori

在线全文

学校读者我要写书评

暂无评论

Journal of computer Science & Technology 2024年第4期39卷 951-966页

作者： Yang Yang Yu-Ting Li Yong-Hua Huo Zhi-Peng Gao lan-lan Rui State Key Laboratory of Network and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China The 54th Research Institute of china Electronics Technology Group corporation Shijiazhuang 050081China

The complexity of alarm detection and diagnosis tasks often results in a lack of alarm log *** to the strong rule associations inherent in alarm log data,existing data augmentation algorithms cannot obtain good results for alarm log *** address this problem,this paper introduces a new algorithm for augmenting alarm log data,termed APRGAN,which combines a generative adversarial network(GAN)with the Apriori *** generates alarm log data under the guidance of rules mined by the rule ***,we propose a new dynamic updating mechanism to alleviate the mode collapse problem of the *** addition to updating the real reference dataset used to train the discriminator in the GAN,we dynamically update the parameters and the rule set of the Apriori algorithm according to the data generated in each *** extensive experimentation on two public datasets,it is demonstrated that APRGAN surpasses other data augmentation algorithms in the domain with respect to alarm log data augmentation,as evidenced by its superior performance on metrics such as BLEU,ROUGE,and METEOR.

关键词： data augmentation alarm log data Apriori generative adversarial network(GAN)