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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.clayton UK Dementia Research Institute at King’s college london LondonUK Department of Basic and clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Recent progress of interconnecting layer for tandem organic solar cells

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Science china chemistry 2017年第4期60卷 460-471页

作者： Shunmian lu Dan Ouyang Wallace c.H. choy Department of Electrical and Electronic Engineering The University of Hong Kong Pok Fu Lam Road Hong Kong China

This paper has reviewed:(1) the two unique advantages of tandem organic solar cells(OScs) compared to single OScs;(2) the challengings as well as strategies to develop qualified interconnecting layer(Icl) for tandem *** specifically,firstly,the two key advantages unique to tandem OScs as compared to single OScs,namely minimizing sub-bandgap transmission and thermalization loss as well as realizing optical thick and electrical thin structures,have been ***,the Icl,as one of the most challenging issue in tandem OScs that needs to fulfill the optical,electrical and mechanical requirements simultaneously to realize a qualified Icl has been *** one of the most challenging requirement among the three,the electrical requirement and its corresponding three different solving strategies have been discussed in detail,revealing a bright future for developing a general strategy to realizing qualified Icl composed of different hole transporting layer(HTl) and electron transporting layer(ETl).

关键词： tandem organic solar cell interconnecting layer

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDlINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Study on the pyroelectric properties of PlT/P(VDF-TrFE) nanocomposites

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chinese Science Bulletin 1998年第2期43卷 111-114页

作者： Qingqi Zhang H. l. W. chan Qifa Zhou c. l. choy Hong Kong Polytech Univ Dept Appl Phys Hung Hom Hong Kong Hong Kong Polytech Univ Mat Res Ctr Hung Hom Hong Kong

lead lanthanum titanate (PlT) nanocrystalline powder prepared by the sol_gel process was incorporated into a polyvinylidene fluoride/trifluoroethylene (P(VDF_TrEF)) copolymer matrix to form PlT/P(VDF_TrFE) nanocomposites. The permittivities (ε) of the nanocomposites as a function of volume fraction of ceramic  were modeled using the Bruggeman model. The pyroelectric coefficients (p) and figure of merit (p/ε) were measured as functions of the poling field E. The nanocomposite has p and p/ε values higher than those of the copolymer, and has good potential in pyroelectric applications.

关键词： nanocomposites pyroelectric.

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(Ec)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular Ecs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： chao Tan Junling lü chunchi Zhang Dong liang lei Yang Zegao Wang college of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of china Electronics Technology Group corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of caO with MgO in the caO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü college of Materials Science and Engineering Chongqing UniversityChongqing 400044China chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for caO on the viscosity and structure of a high-alumina caO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by caO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Metallated conjugation in small-sized-molecular donors for solution-processed organic solar cells

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Science china chemistry 2015年第2期58卷 347-356页

作者： chaohua cui Yunye Zhang Wallace c.H.choy Hua li Wai-Yeung Wong Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University Department of Electrical and Electronic Engineering The University of Hong Kong college of life and Environmental Sciences & Beijing Engineering Research center of Food Environment and Public Health Minzu University of China HKBU Institute of Research and continuing Education Shenzhen Virtual University Park

Four metallated conjugated oligothiophenes, S-1, S-2, S-3 and S-4, with platinum（II） aryleneethynylenes as the electron-rich building block were synthesized to investigate their physicochemical and photovoltaic properties. These small molecules possess fairly low-lying HOMO energy levels which match with the lUMO energy level of the electron acceptor Pc70BM （[6,6]-phenyl-c71-butyric acid methyl ester）. Using the simple process of spin-coating solution fabrication technique, S-I：Pc70BM （1：4, w/w） based organic solar cells exhibiting a high Voc of 0.913 V, with a PcE value of 0.88% were developed. In contrast, the OSc device based on S-2：Pc70BM （3：7, w/w） displayed a higher PcE of 1.59% with a higher Jsc value of 5.89 mA cm^-2. The device based on S-4：PcToBM （1：4, w/w） exhibited a PcE value of 1.56%, with a Voc of 0.917 V.

关键词： platinum acetylide photovoltaics organic solar cell oligothiophene

Transition metal oxides as hole-transporting materials in organic semiconductor and hybrid perovskite based solar cells

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Science china chemistry 2017年第4期60卷 472-489页

作者： Pingli Qin Qin He Dan Ouyang Guojia Fang Wallace c.H. choy Gang li Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Hum Kowloon Hong Kong SAR China School of Science Wuhan Institute of Technology Wuhan 430073 China college of Post and Telecommunications Wuhan Institute of Technology Wuhan 430073 China Key laboratory of Artificial Micro- and Nano-struetures of the Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 China Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong SAR China

Organic polymer solar cells （OScs） and organic-inorganic hybrid perovskite solar cells （PScs） have achieved notable progress over the past several years. A central topic in these fields is exploring electronically efficient, stable and effective hole-transporting layer （HTl） materials. The goal is to enhance hole-collection ability, reduce charge recombination, increase built-in voltage, and hence improve the performance as well as the device stability. Transition metal oxides （TMOs） semiconductors such as NiOx, cuOx, crOx, MoOx, WO3, and V2O5, have been widely used as HTls in OScs. These TMOs are naturally adopted into PSc as HTls and shows their importance. There are similarities, and also differences in applying TMOs in these two types of main solution processed solar cells. This concise review is on the recent developments of transition metal oxide HTl in OScs and PScs. The paper starts from the discussion of the cation valence and electronic structure of the transition metal oxide materials, followed by analyzing the structure-property relationships of these HTls, which we attempt to give a systematic introduction about the influences of their cation valence, electronic structure, work ftmction and film property on device performance.

关键词： hole-transporting layer transition metal oxide perovskite solar cell organic solar cell

Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science china Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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