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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU c.k.thein D.HALIM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo china Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio coulomb damping preload tension/compression isolation band/depth offset potential

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin k.Wang J.Adrian Tyndall Binu Tharakan Firas kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

current Transport in copper Schottky contacts to a−Plane/ c−Plane n-Type MoSe_(2)

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chinese Physics Letters 2011年第8期28卷 254-257页

作者： c.k.Sumesh k.D.Patel V.M.Pathak R.Srivastav Department of Physics Faculty of Technology and EngineeringCharotar University of Science and TechnologyCHANGA 388421GujaratIndia Department of Physics Sardar Patel UniversityVallabh Vidyanagar 388120GujatatIndia

We identically prepared cu-nMoSe_(2)(a−plane)and cu-nMoSe_(2)(c−plane)Schottky barrier diodes(SBDs)on the same n-type MoSe_(2) single *** effective Schottky barrier heights(SBHs)and ideality factors were obtained from the current−voltage-temperature(I–V–T)*** barrier height and ideality factor,estimated from the conventional thermionic emission model by assuming a Gaussian barrier distribution,are highly dependent on temperature.A notable deviation from the theoretical Richardson constant value is also observed in the conventional Richardson *** decrease in the experimental barrier heightΦB0 and an increase in the ideality factor n with a decrease in temperature have been explained on the basis of barrier height inhomogeneities at the metal−semiconductor *** is proven that the presence of a distribution of barrier heights is responsible for the apparent decrease of the zero bias barrier *** voltage dependence of the standard deviation causes the increase of the ideality factor at low *** value of the Richardson constant obtained without considering the inhomogeneous barrier heights is much closer than the theoretical *** cu-nMoSe_(2)(a−plane)Schottky diode shows better results in comparison with the nMoSe_(2)(c-plane)Schottky diode.

关键词： Schottky temperature ideality

coadministration of telaprevir and transcatheter arterial chemoembolization in hepatitis c virus-associated hepatocellular carcinoma

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World Journal of Hepatology 2013年第6期5卷 332-335页

作者： Harrys A Torres Parag Mahale Ethan D Miller thein H Oo catherine Frenette Ahmed O kaseb Departments of Infectious Diseases Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Departments of Gastroenterology Hepatology and Nutrition The University of Texas MD Anderson Cancer Center Section of Benign Hematology The University of Texas MD Anderson Cancer Center Liver Transplantation Weill Cornell Medical College The Methodist Hospital Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center

The use of directacting antiviral agents (e.g. , telaprevir, boceprevir) has improved response rates in patients with hepatitis c virus (HcV) genotype 1 infections. Substantial number of drug-drug interactions are anticipated with the use of telaprevir, a cytochrome P450 3A and P-glycoprotein substrate and inhibitor. Herein we describe a patient with HcV-associated hepatocellular carcinoma treated simultaneously with a telaprevir-containing regimen and localized chemo-therapy (transcatheter arterial chemoembolization) with doxorubicin. No clinically relevant interactions or adverse events developed while on antiviral therapy.

关键词： Hepatitis c virus cancer Hepatocellular carcinoma Transcatheter arterial chemoembolization Telaprevir Interactions

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Effect of bisphenol A and co-administration of bisphenol Aand vitamin c on epididymis of adult rats:A histological and biochemical study

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Asian Journal of Andrology 2003年第3期5卷 203-208页

作者： k.c.chitra k.Ramachandra Rao P.P.Mathur School of Life Sciences Pondicherry University Pondicherry 605 014 IndiaDepartment of Anatomy Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry 605 006 IndiaSchool of Life Sciences Pondicherry University Pondicherry 605014 India

Aim: To study the effect of bisphenol A on the epididymis and epididymal sperm of rats and the possible amelioration action of co-administration with vitamin c. Methods: Male Wistar rats were orally administered bisphenol A (0.2 μg·kg-1·day-1, 2 μg·kg-1·day-1 and 20 μg·kg-1·day-1) and 0.2 μg, 2μg and 20 μg bisphenol A + 40 mg vitamin c·kg-1·day-1 for 60 days. On day 61, rats were killed with anesthetic ether and sperm collected from epididymis were used for assessment of sperm count, motility and viability and biochemical studies. A 1 % homogenate of epididymis was prepared and used for biochemical estimations. caput, corpus and cauda epididymis were fixed in Bouin's fixative for histological studies. Results: Administration of bisphenol A caused a reduction in the epididymal sperm motility and count and the sperm viability remained unchanged. The activities of superoxide dismutase and glu-tathione peroxidase decreased, while the levels of lipid peroxidation increased in epididymal sperm and epididymis at all doses. co-administration with vitamin c reversed the effect of bisphenol A-induced oxidative stress in epididymal sperm and epididymis. A complete degeneration of epididymal epithelium in caput, corpus and cauda regions with reduction in the number of sperms were observed at all doses of bisphenol A-treated rats. conclusion: Bisphenol A induced oxidative stress in epididymis and caused degeneration of the epididymal epithelium of rats. co-administration with vitamin c had a protective effect against the bisphenol A-induced toxicity in epididymal sperm and epididymis.

关键词： bisphenol A epididymis spermatozoa ascorbic acid antioxidant enzymes lipid peroxidation reactive oxygen species oxidative stress

Design of a Very Small Residual Dispersion Fiber System for DWDM Operation Over the Entire c -&L-Bands of EDFA

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光学学报 2003年第S1期23卷 9-10页

作者： Ravi k. Varshney I.c. Goyal A.k. Ghatak Siny Antony c. Department of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 India

We have given design of a very small residual dispersion fiber system consisting of a small dispersion fiber (SDF) with flat modal field and a corresponding dual core coaxial dispersion compensating fiber (DcF).

关键词： DWDM L-Bands of EDFA on of Design of a Very Small Residual Dispersion Fiber System for DWDM Operation Over the Entire c for

Angular Differential cross-Section for Ionization of Helium in c^6＋ Ion collision

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chinese Physics Letters 2004年第7期21卷 1258-1261页

作者： A.c.Gagyi-Palffy I.F.Barna L.Gulyas k.Tokesi DepartmentofTheoreticalPhysics UniversityofBucharestRomania Max-Planck-InstituteforPhysicsofcomplexSystems NothnitzerStr.38O1187DresdenGermany InstituteofNuclearResearch HungarianAcademyofScience(ATOMKI)1-1-4001DebrecenPOBox51Hungary

With the help of the density operator, the angular differential cross-section for ionization of helium is calculated within the framework of the one-centre atomic-orbital close-coupling method. We consider a naked c6+ ion as projectile with an energy of 2.5MeV/a.u. Our result agrees well with the experimental data and the other theoretical calculations such as the first Born approximation, various Distorted Wave models and the classical trajectory Monte carlo simulation.

关键词： Monte carlo methods