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An Optimization Model for Determining Optimal Levels of Engineering characteristics in QFD under Multi-Segment Market

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An Optimization Model for Determining Optimal Levels of Engi...

Research of integrating supplier selection into product family planning

2011 chinese control and Decision conference（ccDc）

作者： c.k.kwong Department of Industrial and Systems Engineering The Hong Kong Polytechnic University

An optimization model for a multi-segment market based on quality function deployment is established to maximize customers’ overall customer *** weights of importance of market segments and development costs in the model are expressed as triangular fuzzy numbers in order to describe the imprecision caused by human subjective *** solving approach for the fuzzy optimization model is suggested.A case study is given to illustrate the feasibility of the proposed method.

关键词： quality function deployment new product development customer requirements engineering characteristics fuzzy optimization

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Research of integrating supplier selection into product fami...

Optimal product positioning based on quality function deployment

第25届中国控制与决策会议

作者： Y.cAO X.G.LUO c.k.kwong J.F.TANG Department of Systems Engineering State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Department of Industrial and Systems Engineering The Hong Kong Polytechnic University

ISBN: (纸本)9781467355339

With the economic globalization and market constantly subdivision, the life cycle of product and the development cycle increasingly shorter. In the development process of new products, more and more scholars have realized that if suppliers collectively participate in the initial stage of product development, enterprises will effectively save the cost and the time, dramatically increase the product quality and the production flexibility. Recently, several research papers proposed some relevant methods integrating supplier selection into product family design. In this paper, a one-step unified optimization model, which integrates product family design with supplier selection, is established. The optimization model with the objective of maximizing the total profits of product family is based on multinomial logit consumer choice rule, which is regarded to be more flexible and suitable to formulate consumer choice behavior. To solve the proposed optimization model, genetic algorithm is adopted. The optimization results of integrating supplier selection and product family design and that of separating supplier selection and product family design, and the optimization results under multinomial logit rule and that under the deterministic choice rule are compared respectively. Meanwhile, in the case study, sensitivity analysis of the model is also performed.

关键词： product family supplier selection multinomial logit consumer choice rule genetic algorithm.

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Optimal product positioning based on quality function deploy...

control of settlement and volume loss induced by tunneling under recently reclaimed land

2009中国控制与决策会议

作者： Xinggang Luo~1,Jiafu Tang~1,c.k.kwong~2 1.School of Information,key Laboratory of Integrated Automation of Process Industry of MOE,Northeastern University,Shenyang 110004,china 2.Department of Industrial and Systems Engineering,The Hong kong Polytechnic University,Hong kong,china

＜正＞A new method for optimal product positioning based on quality function deployment（QFD） is proposed. Perceptual mapping and house of quality（HoQ） are introduced to link the consumer perceptual space,product attribute space and product engineering *** degree of overall customer satisfaction is introduced in the rule of consumer choice *** optimal product positioning model is established based on *** algorithms are applied to achieve the optimal value settings of a new product’s engineering ***,an example of optimal positioning is given to illustrate the feasibility of the proposed model and algorithm.

关键词： product positioning quality function deployment genetic algorithm

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Underground Space 2019年第4期4卷 289-301页

作者： A.k.L.kwong c.c.W.Ng A.Schwob AEcOM Hong KongChina Dragages-Bouygues Joint Venture Hong KongChina

The proposed Tuen Mun-chek Lap kok Link(TM-cLkL)project comprises a 9-km-long dual two-lane carriageway between Tuen Mun and North Lantau,Hong *** of the two tunnels at the Northern Landfall Fall was carried out by two TBMs:the northbound is referred to as ML03 and has an excavated diameter of 17.63 m,and the southbound is referred to as ML02 and has an excavated diameter of 14.00 *** use of TBMs minimized the amount of dredging and removal of soft marine deposits,resulting in less impact to the environment within and near the work site of the *** treatment in the form of deep vibro-compaction was carried out at the sand fill and band drains installed in the marine deposit.A surcharge was also added above the final formation level to limit the residual settlement and differential settlement of the reclaimed land to less than 500 mm and 1 in 300,respectively,for a design life of 50 *** element analyses were performed to predict the settlement trough under different confinement pressures along the tunnel *** monitoring of the ground movement was carried out during the driving of the two TBMs to ensure that the design confinement pressure of the slurry would not cause excessive settlement,heave,or blow out at the shallow tunnel sections or different facilities along the tunnel *** monitoring data was then used to back-calculate the percentage of volume loss,which is a key index describing the behavior of the ground during *** monitoring data showed that the measured settlement and back-calculated volume loss were much lower than the predicted values.

关键词： TBM excavation Settlement trough Volume loss Ground treatment confinement pressure

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin k.Wang J.Adrian Tyndall Binu Tharakan Firas kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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可伸缩产品平台优化设计的质量功能展开方法

机械工程学报 2011年第12期47卷 175-184页

作者：雒兴刚王福斌 kwong c k 东北大学信息学院沈阳110819 东北大学机械工程与自动化学院沈阳110819 香港理工大学工业与系统工程系

为使基于产品平台的系列产品更好的满足顾客需求,提出一种基于质量功能展开的方法,可以优化设计可伸缩产品平台。该方法的主要思路是应用质量功能展开技术,建立单个产品的质量屋,确定其最优工程特性值,对每个工程特性进行敏感性分析,并... 详细信息

为使基于产品平台的系列产品更好的满足顾客需求,提出一种基于质量功能展开的方法,可以优化设计可伸缩产品平台。该方法的主要思路是应用质量功能展开技术,建立单个产品的质量屋,确定其最优工程特性值,对每个工程特性进行敏感性分析,并根据所得的工程特性敏感性指标建立优化模型,求得最优的平台工程特性值和非平台工程特性值。优化模型的目标是最大化一个产品族中所有产品变体的顾客满意度的均值,约束主要包括顾客需求和工程特性之间的函数关系以及工程特性之间的自相关函数关系。模型中采用了线性函数形式,并采用回归方法来估计函数中的参数。给出一个工业卡钳的例子来验证所提方法的可行性,案例分析的结果表明,该方法比传统的两阶段方法能获得更好的顾客满意度。

关键词：质量功能展开产品平台顾客满意度

Wash water in waterworks:contaminants and process options for reclamation

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Journal of Environmental Sciences 2008年第11期20卷 1300-1305页

作者： c B chidambara Raj Tan Ee kwong Soh Hoo Tiong Paul Stefan klose centre for Advanced Water Technology Singapore Utilities International Pte Ltd.82 Toh Guan Road East # C4-03Singapore 608575 Public Utilities Board Water Supply (Plants) Department40 Scotts Road #14-00Singapore 228231

Reclamation of clean water from filter backwash water was studied through pilot-scale *** pilot plant consisted of clarification,sand-filtration,and ultrafiltration modules in sequence,with a provision to bypass the sand *** water that conformed to World Health Organization (WHO) guidelines on Potable Quality was ***,aluminum and iron were found to be critical contaminants in process selection and ***,followed by sand filtration,was found to be the minim...

关键词： filter backwash clarification water treatment aluminium Giardia

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

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Liver Research 2019年第1期3卷 19-24页

作者： Eric.k.kwong Huiping Zhou Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVAUSA McGuire VA Medical center RichmondVAUSA

The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and ***,dyslipidemia and metabolic disorders are of increasing public health concern worldwide,and novel therapeutics that target both the liver and the GI tract(gut-liver axis)are much *** addition to aiding fat digestion,bile acids act as important signaling molecules that regulate lipid,glucose and energy metabolism via activating nuclear receptor,G protein-coupled receptors(GPcRs),Takeda G protein receptor 5(TGR5)and sphingosine-1-phosphate receptor 2(S1PR2).Sphingosine-1-phosphate(S1P)is synthesized by two sphingosine kinase isoforms and is a potent signaling molecule that plays a critical role in various diseases such as fatty liver,in-flammatory bowel disease(IBD)and colorectal *** this review,we will focus on recent findings related to the role of S1P-mediated signaling pathways in the gut-liver axis.

关键词： Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(Sphk2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases

On the Integrability of the Abel and of the Extended Liénard Equations

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 722-736页

作者： Man kwong Mak Tiberiu HARkO Departamento de Fsica Facultad de Ciencias Naturales Universidad de Atacama Copayapu 485 Copiapo Chile Department of Physics Babes-Bolyai University Kogalniceanu Street Cluj-Napoca 400084 Romania School of Physics Sun Yat-Sen University Guangzhou 510275 China

We present some exact integrability cases of the extended Liénard equation y′′+ f(y)(y′)n +k(y)(y′)m + g(y)y′+ h(y) = 0, with n > 0 and m > 0 arbitrary constants, while f(y), k(y), g(y), and h(y) are arbitrary functions. The solutions are obtained by transforming the equation Liénard equation to an equivalent first kind first order Abel type equation given bydv/dy= f(y)v3-n+ k(y)v3-m+ g(y)v2+ h(y)v3, with v = 1/y′.As a first step in our study we obtain three integrability cases of the extended quadratic-cubic Liénard equation,corresponding to n = 2 and m = 3, by assuming that particular solutions of the associated Abel equation are known. Under this assumption the general solutions of the Abel and Liénard equations with coefficients satisfying some differential conditions can be obtained in an exact closed form. With the use of the chiellini integrability condition, we show that if a particular solution of the Abel equation is known, the general solution of the extended quadratic cubic Liénard equation can be obtained by quadratures. The chiellini integrability condition is extended to generalized Abel equations with g(y) ≡ 0 and h(y) ≡ 0, and arbitrary n and m, thus allowing to obtain the general solution of the corresponding Liénard equation. The application of the generalized chiellini condition to the case of the reduced Riccati equation is also considered.

关键词： Abel equation Liénard equation general solutions integrability conditions