检索结果-南通市图书馆

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

在线全文

学校读者我要写书评

暂无评论

低雷诺数下偏心扭转圆柱涡激振动特性研究

力学与实践 2025年第01期47卷 87-97页

作者：孙旭 suhc.Steve 张家忠中国石油大学(北京)油气管道输送安全国家工程实验室/石油工程教育部重点实验室得克萨斯农工大学机械工程系西安交通大学能源与动力工程学院

横掠外流冲击下细长圆柱结构涡激振动问题在工程中广泛存在，已有研究多关注圆柱沿横向和/或流向的振动响应，对涡激扭转振动研究较少。本文采用流-固耦合数值模拟研究了偏心扭转圆柱在层流中的涡激振动特性。首先，建立了偏心扭转圆柱... 详细信息

横掠外流冲击下细长圆柱结构涡激振动问题在工程中广泛存在，已有研究多关注圆柱沿横向和/或流向的振动响应，对涡激扭转振动研究较少。本文采用流-固耦合数值模拟研究了偏心扭转圆柱在层流中的涡激振动特性。首先，建立了偏心扭转圆柱涡激振动力学模型，推导了控制方程和边界条件。然后，将基于特征线算子分裂的有限元解法、双时间步法、边弹簧近似法、广义-α方法和松耦合迭代解法相结合，针对层流诱发刚体扭转振动开发了一种通用流-固耦合解法，并采用基准算例进行了验证。最后，通过流-固耦合数值模拟，系统分析了偏心距、雷诺数、质量比对层流中偏心扭转圆柱涡激振动振幅、频率、流体载荷的影响规律及机理。

关键词：圆柱层流涡激扭转振动流-固耦合数值模拟

Plant-substrate biochar properties critical for mediating reductive debromination of 1,2-dibromoethane

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第1期147卷 1-10页

作者： Jonathan h.Lindhardt Peter E.holm Yong-Guan Zhu changyong Lu hans christian B.hansen Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark Key lab of Urban Environment and health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Sino-Danish center for education and research China and DenmarkDalgas Avenue 4DK-8000 Aarhus C.Denmark

Dibromoethane is a widespread,persistent organic *** are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ***,the critical characteristics that determine mediator functionality are lesser *** biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry c and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination *** was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(pcorrelated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.

关键词： Environmental remediation Biochar Persistent organic pollutants(POPs) Environmental catalysis Green rust

Deep view of composite SNR cTA1 with LhAASO in γ-rays up to 300 TeV

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2025年

作者： Zhen cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.cao W.Y.cao Zhe cao J.chang J.F.chang A.M.chen E.S.chen h.X.chen Liang chen Lin chen Long chen M.J.chen M.L.chen Q.h.chen S.chen S.h.chen S.Z.chen T.L.chen Y.chen N.cheng Y.D.cheng M.c.chu M.Y.cui S.W.cui X.h.cui Y.D.cui B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.h.Fan Y.Z.Fan J.Fang J.h.Fang K.Fang c.F.Feng h.Feng L.Feng S.h.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao c.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge T.T.Ge L.S.Geng G.Giacinti G.h.Gong Q.B.Gou M.h.Gu F.L.Guo J.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.han O.A.hannuksela M.hasan h.h.he h.N.he J.Y.he Y.he Y.K.hor B.W.hou c.hou X.hou h.B.hu Q.hu S.c.hu c.huang D.h.huang T.Q.huang W.J.huang X.T.huang X.Y.huang Y.huang Y.Y.huang X.L.Ji h.Y.Jia K.Jia h.B.Jiang K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li c.M.Li cheng Li cong Li D.Li F.Li h.B.Li h.c.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu c.Liu D.Liu D.B.Liu h.Liu h.D.Liu J.Liu J.L.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao Z.Min W.Mitthumsiri h.J.Mu Y.c.Nan A.Neronov K.c.Y.Ng L.J.Ou P.Pattarakijwanich Z.Y.Pei J.c.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu h.c.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata P.h.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian L.h.Wan c.Wang c.B.Wang G.W.Wang h.G.Wang h.h.Wang J.c.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.h.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.h.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen c.Y.Wu h.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.h.Yan J.Z.Yan T.Yan c.W.Yang c.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.Z.Yang W.X.Yang Y.h.Yao Z.G.Yao L.Q.Yin N.Yin X.h.You Z.Y.You Y.h Southwest Jiaotong University School of Astronomy and Space Science Nanjing University center for Astrophysics Guangzhou University Tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Institute for Nuclear Research of Russian Academy of Sciences hebei Normal University University of Science and Technology of china LhAASO collaboration State Key Laboratory of Particle Detection and Electronics Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory chinese Academy of Sciences Research center for Astronomical computing Zhejiang Laboratory Key Laboratory for Research in Galaxies and cosmology Shanghai Astronomical Observatory chinese Academy of Sciences School of Physics and Astronomy Key Laboratory of Particle Astrophysics & Experimental Physics Division & computing center Yunnan University Key Laboratory of cosmic Rays (Tibet University) Ministry of Education Department of Physics The chinese University of hong Kong Key Laboratory of Radio Astronomy and Technology National Astronomical Observatories chinese Academy of Sciences School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Institute of high Energy Physics Institute of Frontier and Interdisciplinary Science Shandong University APc Université Paris cité cNRS/IN2P3 cEA/IRFU Observatoire de Paris Department of Engineering Physics & Department of Astronomy Tsinghua University School of Physics and Microelectronics chinese Academy of Sciences Zhengzhou University Yunnan Observatories chinese Academy of Sciences china center of Advanced Science and Technology college of Physics Sichuan University School of Physics Peking University Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and Technology University of chinese Academy of Sciences Guangxi University Department of Physics Faculty of Science Mahidol University Moscow Institute

The ultra-high-energy（UhE） gamma-ray source 1LhAASO J0007+7303u is positionally associated with the composite SNR cTA1 that is located at high Galactic Latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PWN） and supernova remnant（SNR） at UhE. This paper conducted a dedicated data analysis of 1LhAASO J0007+7303u using the data collected from December 2019 to July 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the PWN of PSR J0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PWN terminal shock. combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PWN is likely dominated by the advection process under the free-expansion phase assumption.

关键词：

LhAASO detection of very-high-energy γ-ray emission surrounding PSR J0248+6021

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2025年

We report the detection of an extended very-high-energy(VhE) γ-ray source coincident with the location of middle-aged(62.4 kyr) pulsar PSR J0248+6021, by using the LhAASO-WcDA data of live 796 d and LhAASO-KM2A data of live 1216d. A significant excess of γ-ray induced showers is observed both by WcDA in energy bands of 1-25 Te V and KM2A in energy bands of >25 TeV with 7.3σ and 13.5σ, respectively. The best-fit position derived through WcDA data is R.A. = 42.06°± 0.12°and Dec. = 60.24°± 0.13°with an extension of 0.69°±0.15°and that of the KM2A data is R.A.= 42.29°± 0.13°and Dec. =60.38°± 0.07°with an extension of 0.37°±0.07°. No clear extended multiwavelength counterpart of this LhAASO source has been found from the radio band to the GeV band. The most plausible explanation of the VhE γ-ray emission is the inverse compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo.

关键词：

Observation of the γ-ray emission from W43 with LhAASO

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2025年

In this paper, we report the detection of the very-high-energy (VhE, 100 Ge V100 TeV) γ-ray emissions from the direction of the young star-forming region W43, observed by the Large high Altitude Air Shower Observation (LhAASO). The extended γ-ray source was detected with a significance of～16σby KM2A and～17σby WcDA, respectively. The angular extension of this γ-ray source is about 0.5 degrees, corresponding to a physical size of about 50pc. We discuss the origin of the γ-ray emission and possible cosmic ray acceleration in the W43 region using multi-wavelength data. Our findings suggest that W43 is likely another young star cluster capable of accelerating cosmic rays (cRs) to at least several hundred TeV.

关键词：

Tectonic evolution of the Tombel graben basement, southwestern cameroon

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Episodes 2005年第1期28卷 37-41页

作者： M.S.Njome c.E.suh DepartmentofGeologyandEnvironmentalScience UniversityofBueaP.O.Box63SouthWestProvinceCameroon

Planar structures (foliations and fractures) around the Tombel graben (southwestern end of the central African Shear zone system) have been investigated and analyzed with the aim of unraveling the tectonic evolution of the basement. The foliations show two major trends, an older N-S-trending gneissose layering of uncertain agereworked by a later Pan-African (600 + 50 Ma) NE-SW ductile trend that is contemporaneous with sinistral shearing and mylonitization. The brittle phase characterized by NW-SE-trending open and partially filled fractures is younger than the mylonitization event and although it has not been dated, it is suggested that the origin of these fractures is linked to the onset of volcanism along the cameroon volcanic line-31 m.y. *** mylonitic foliation is recognized for the first time and supports a tectonic evolution model for the Tombel graben in which ductile non-coaxial deformation was succeeded by brittle failure.

关键词：喀麦隆西南地区构造演化 Tombel地堑地质基岩

Edge supercurrent in Josephson junctions based on topological materials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2025年第2期68卷 1-12页

作者： Junjie Qi chui-Zhen chen Juntao Song Jie Liu Ke he Qing-Feng Sun X.c.Xie Beijing Academy of Quantum Information Sciences Beijing 100193China School of Physical Science and Technology Soochow UniversitySuzhou 215006China Institute for Advanced Study Soochow UniversitySuzhou 215006China college of Physics and hebei Advanced Thin Films Laboratory Hebei Normal UniversityShijiazhuang 050024China School of Physics Xi’an Jiaotong UniversityMinistry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed MatterXi’an 710049China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Frontier Science center for Quantum Information Beijing 100084China hefei National Laboratory Hefei 230088China International center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Interdisciplinary center for Theoretical Physics and Information Sciences Fudan UniversityShanghai 200433China

The interplay between novel topological states and superconductivity has garnered substantial interest due to its potential for topological quantum *** Josephson effect serves as a useful probe for edge superconductivity in these hybrid topological *** Josephson junctions based on topological materials,supercurrents exhibit unique quantum interference patterns,including the conventional Fraunhofer oscillations,theΦ_(0)-periodic oscillation,and the 2Φ_(0)-periodic oscillation in response to the external magnetic field(Φ_(0)=h/2e is the flux quantum,h the Planck constant,and e the electron charge).These interference patterns stem from varied Andreev reflection mechanisms and the associated current density *** review seeks to comprehensively examine the theoretical and experimental advancements in understanding the quantum interference patterns of edge supercurrents in Josephson junctions based on quantum spin hall,quantum hall,and quantum anomalous hall systems.

关键词： quantum hall effect quantum spin hall effect quantum anomalous hall effect Josephson junction edge supercurrent Andreev reflection

Improving signature quality for network application identification

在线全文

学校读者我要写书评

暂无评论

Digital communications and Networks 2019年第3期5卷 139-146页

作者： Justin Tharp Sang c·suh hyeonkoo cho Jinoh Kim Department of computer Science Texas A&M University-Commerce P.O. Box 3011 Commerce TX 75429 USA Sysmate Inc. 41 Yuseong-daero 1184 beon-gil Yuseong-gu Daejeon 34109 North Korea

Network application identification is one of the core elements in network operations and management to provide enhanced network service and security. For accurate identification, an approach using common patterns called "signatures" is widely used to compensate the limitations of the traditional transport-layer port-based classification. however, our simulation results indicate that using the signatures generated from a set of well known algorithms may lead to very poor identification performance, with less than 60% of true positives even in an optimal case. To improve the quality of signatures, we present a technique in this paper, which consists of two steps:(i) pairwise merging to consider every possible combination of the initially collected signatures to reduce their specificity that causes the signatures to be less common;and (ii) signature reduction to identify effective signatures with greater importance from a large set of signatures produced in the merging step, so as to manage the space/time complexity in the identification process for greater scalability. Our experimental results show that the proposed technique can dramatically improve the performance, even with a small number of signatures (e.g., 95% true positives rate with 30 signatures per application) which is more compact than the initial signature set.

关键词： Network application identification Application signatures Pairwise merging Signature reduction Explicit string patterns