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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

Rapid spontaneous resolution of lumbar ganglion cysts: A case report

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World Journal of Orthopedics 2020年第1期11卷 68-75页

作者： Vito chiarella Alessandro Ramieri Marco giugliano Maurizio Domenicucci Department of Neurological and Psychiatric Sapienza University of RomeRome 00185Italy Orthopaedic Division Don Gnocchi FoundationMilan 20148Italy

BAcKGROUND To discuss the rare event of spontaneous resolution of a lumbar ganglion cyst,a personal case report and 25 cases culled from the literature were described in *** focused on demographic,classification,clinical and radiological findings,treatment,outcome and radiological *** SUMMARY A 51-year-old man presented to our observation with complaints of low back and right leg *** magnetic resonance imaging(MRI).showed a L4-L5 ganglion *** patient was referred to medical therapy and *** 4 wk,he showed a complete resolution of *** complete spontaneous resolution of the cyst was demonstrated by the followed-up *** Spontaneous resolution of lumbar ganglion is very rare and only 26 cases,including ours,were reported in *** degrees of biomechanical impairment seem to play a fundamental role in the *** symptoms are essentially represented by low back and/or radicular pain,without significant neurological ***-inflammatory drugs,light unloading exercises and brace could be recommended to administrated pain and decrease facet *** time for clinical improvement was 7 mo,while MRI disappearance occurred in an average time of 11 ***,surgery should be applied when conservative treatment,prolonged at least 6 mo,fails.

关键词： Lumbar ganglion cyst Spontaneous resolution conservative treatment Radiological disappearance case report

Abdominal and gastrointestinal manifestations in cOVID-19 patients: Is imaging useful?

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World Journal of Gastroenterology 2021年第26期27卷 4143-4159页

作者： Piero Boraschi Luigi giugliano Giuseppe Mercogliano Francescamaria Donati Stefania Romano Emanuele Neri Department of Diagnostic Imaging Second Division of RadiologyAzienda Ospedaliero-Universitaria Pisana-University of PisaPisa 56124Italy Department of Radiology University of Naples“Federico II”Naples 80131Italy Department of Diagnostic Imaging Santa Maria delle Grazie HospitalNaples 80078Italy Diagnostic and Interventional Radiology Department of Translational Research and of New Surgical and Medical TechnologiesUniversity of PisaPisa 56126Italy

coronavirus disease 2019(cOVID-19)can be considered a systemic disease with a specific tropism for the vascular system,in which the alterations of the microcirculation have an important pathogenetic *** lungs are the main organ involved in cOVID-19,and severe progressive respiratory failure is the leading cause of death in the affected patients;however,many other organs can be involved with variable clinical *** abdominal manifestations,the gastrointestinal tract and the hepatobiliary system are mainly affected,although the pancreas,urinary tract and spleen may also be *** most common gastrointestinal symptoms are loss of appetite,followed by nausea and vomiting,diarrhea and abdominal *** imaging findings include bowel wall thickening,sometimes associated with hyperemia and mesenteric thickening,fluid-filled segments of the large bowel and rarely intestinal pneumatosis and *** involvement manifests as an increase in the enzymatic levels of alanine aminotransferase,aspartate aminotransferase,serum bilirubin andγ-glutamyl transferase with clinical manifestations in most cases mild and *** most frequent radiological features are hepatic steatosis,biliary sludge and *** acute pancreatitis,kidney infarct and acute kidney injury from acute tubular necrosis have been described more rarely in ***,splenic involvement is characterized by splenomegaly and by the development of solitary or multifocal splenic infarcts with classic wedge shaped or even rounded morphology,with irregular or smooth *** summary,the abdominal radiological findings of cOVID-19 are nonspecific and with poor pathological correlation reported in the *** and particularly computed tomography with multiphasic acquisition are the diagnostic methods mainly utilized in cOVID-19 patients with abdominal clinical symptoms and *** radiological signs are not specific of abdom

关键词： cOVID-19 SARS-coV-2 Abdominal findings Gastrointestinal findings computed tomography Ultrasound

Properties of carbon nanotube-dispersed Sr-hydroxyapatite injectable material for bone defects

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Regenerative Biomaterials 2016年第1期3卷 13-23页

作者： M.G.Raucci M.Alvarez-Perez D.giugliano S.Zeppetelli L.Ambrosio Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyMostra D’oltremare Pad.20-Viale Kennedy 54Naples 80125Italy Tissue Bioengineering Laboratory DEPeIFaculty of DentistryNational Autonomous University of MexicoMexico DF 04510Mexico Department of chemical Sciences and Materials Technology National Research Council of Italy(DSCTM-CNR)P.Le Aldo Moro 7Rome 00185Italy

This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite(Sr-HA)at different compositions obtained by sol–gel technology and their influence on human-bone-marrow-derived mesenchymal stem ***,an evaluation of the influence of nanotubes and Strontium on physico-chemical,morphological,rheological and biological properties of hydroxyapatite gel was also *** analysis(scanning electron microscopy)shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of *** biological investigations proved that Sr-HA/carbon nanotube gel containing 0–20 mol(%)of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic ***,the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.

关键词： nanobiomaterials sol-gel tecnology biomaterial-cell interaction bioceramics bone tissue engineering

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHcb

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chinese Physics c 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb c.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia c.Agapopoulou c.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Benane G.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.c.Bernstein c.Bertella A.Bertolin c.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.c.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc J.E.Blank S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev c.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer c.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke c.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.cadeddu H.cai R.calabrese L.calefice S.cali R.calladine M.calvi M.calvo Gomez P.campana D.H.campora Perez A.F.campoverde Quezada S.capelli L.capriotti A.carbone G.carboni R.cardinale A.cardini P.carniti L.carus A.casais Vidal R.caspary G.casse M.cattaneo G.cavallero V.cavallini S.celani J.cerasoli D.cervenkov A.J.chadwick M.G.chapman M.charles Ph.charpentier c.A.chavez Barajas M.chefdeville c.chen S.chen A.chernov S.chernyshenko V.chobanova S.cholak M.chrzaszcz A.chubykin V.chulikov P.ciambrone M.F.cicala X.cid Vidal G.ciezarek G.ciullo P.E.L.clarke M.clemencic H.V.cliff J.closier J.L.cobbledick V.coco J.A.B.coelho J.cogan E.cognera centro Brasileiro de Pesquisas Físicas(cBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universitéclermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHcb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction