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FINITELY GENERATED cOMMUTATIVE ARcHIMEDEAN SEMIGROUPS

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Acta Mathematica Scientia 2003年第4期23卷 503-511页

作者： J.c.Rosales J.I.garcía-garcía Departamento de Algebra Universidad de Granada E-18071 Granada EspanaDepartamento de Algebra Universidad de Granada E-18071 Granada Espana

In this work commutative Archimedean finitely generated semigroups axe characterized in terms of ideal extensions.

关键词： commutative semigroups Archimedean

cO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(cu,co,Ag and Pt)

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Journal of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： J.c.Martínez-Munuera M.P.Yeste A.garcía-garcía McMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid chemistry and catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,several ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were prepared,characterised and tested for the cO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(DOc) system from a diesel engine and those encountered under gasoline exhaust(λ=1).The metals chosen are cu,co,Ag and Pt(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity despite quite similar structural and textural properties of the catalysts,showing differences among dispersion(Ag-catalyst seems to present a low level of dispersion).This catalyst seems to be characterised,as well,by a strong electronic interaction between ce and Ag centres which is suggested to yield an improved reducibility under H_(2)-TPR ***,the order in catalytic activity(cu>Ag>co≈Pt>>support) seems not to follow the order found in reducibility and the cu-catalyst seems to be the most active independently on the reaction conditions,yielding nearly overlapped cO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSc values of the ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSc parameter measured at 150℃ can be used as a relevant descriptor to evaluate the cO oxidation activity at low and medium conversions for the investigated catalysts,much better than the H_(2)-TPR measurements.

关键词： cO oxidation Low metal content ceria-zirconia copper species OSc parameter Rare earths

Fundamental Gaps in Numerical Semigroups with Respect to Their Multiplicity

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Acta Mathematica Sinica,English Series 2004年第4期20卷 629-646页

作者： J.c.ROSALES P.A.garcíA-SANcHEZ J.I.garcíA-garcíA J.A.JIMENEZMADRID DepartamentodeAlgebra UniversidaddeGranadaE-18071GranadaSpain InstitutodeAstrofisicadeAndalucia(cSIc) ApartadoPostal300418080GranadaSpain

For a numerical semigroup,we introduce the concept of a fundamental gap with respect to the multiplicity of the *** semigroup is fully determined by its multiplicity and these gaps. We study the case when a set of non-negative integers is the set of fundamental gaps with respect to the multiplicity of a numerical *** semigroups with maximum and minimum number of this kind of gaps are described.

关键词： Numerical semigroup Gap Multiplicity Frobenius number

Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications

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World Journal of Gastroenterology 2018年第33期24卷 3695-3708页

作者： Javier A garcía-Vilas Miguelángel Medina Department of Pediatrics University of AlbertaEdmonton T6G 2S2Canada Departamento de Biología Molecular y Bioquímica Facultad de CienciasAndalucía TechUniversidad de MálagaMálaga 29071Spain Unidad 741 de cIBER“de Enfermedades Raras”(cIBERER) Málaga 29071Spain Institute of Biomedical Research in Málaga Málaga 29071Spain

Hepatocellular carcinoma(Hcc) is the fifth most common cancer and is the second leading cause of cancer death. Since the diagnosis of Hcc is difficult, in many cases patients with Hcc are diagnosed advanced stage of development. Hepatocyte growth factor(HGF)/c-mesenchymal-epithelial transition receptor(c-Met) axis is a key signaling pathway in Hcc, either via canonical or non-canonical pathways. Available treatments against Hcc based upon HGF/c-Met inhibition can increase patient lifespan, but do not reach the expected therapeutic benefits. In Hcc, c-Met monomers can bind other receptor monomers, activating several noncanonical signaling pathways, leading to increased cell proliferation, invasion, motility, and drug resistance. All of these processes are enhanced by the tumor microenvironment, with stromal cells contributing to boost tumor progression through oxidative stress, angiogenesis, lymphangiogenesis, inflammation, and fibrosis. Novel treatments against Hcc are being explored to modulate other targets such as microR NAs, methyltransferases, and acetyltransferases, which are all involved in the regulation of gene expression in cancer. This review compiles basic knowledge regarding signaling pathways in Hcc, and compounds already used or showing potential to be used in clinical trials.

关键词： Hepatocellular carcinoma Hepatocyte growth factor/c-MET Tumor microenvironment c-Met

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Further the liquid biopsy:Gathering pieces of the puzzle of genometastasis theory

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World Journal of clinical Oncology 2017年第5期8卷 378-388页

作者： Ana garcía-casas Dolores c.garcía-Olmo Damián garcía-Olmo Universidad complutense de Madrid centre de Recerca Experimental Biomèdica Aplicada(cREBA) IRBLLEIDA Department of Surgery Universidad Autónoma de MadridInstituto de Investigación SanitariaFundación Jiménez Díaz

Metastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism,not yet fully *** is almost beyond doubt is that circulatory system is crucial for cancer *** this system,much attention has been recently paid to liquid *** technique is aimed to detect circulating tumor cells (cTcs) and circulating nucleic acids so it can be used as a tool for diagnostic,prognostic and follow-up of *** cTcs tend to be scarce in serum and plasma from cancer patient,abundant circulating nucleic acids can be detected in the same *** fact,together with the genetic origin of cancer,stands out the relevance of circulating nucleic acids and shed light into the role of nucleic acids as drivers of metastasis,a recently discovered phenomenon called *** innovative theory supports the transfer of oncogenes from cancer cells to normal and susceptible cells located in distant target organs through circulatory *** is more,many biological processes haven been described to deliver and secrete circulating nucleic acids into the circulation which can allow such horizontal transfer of *** this review,we focus not only on these mechanisms but also we demonstrate its putative role in cancer propagation and give insights about possible therapeutic strategies based on this *** objective is to demonstrate how findings about cell-to-cell communications and previous results can agree with this unprecedented theory.

关键词： Genometastasis cancer metastasis circulating Nucleic acids:circulating tumor cells Liquid biopsy Exosomes Virtosomes

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.J.garcíA-garcíA P.FARINAS-ALVARINO Department of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the purely turbulent component(PTc),and the contributions are analyzed separately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for plane-parallel laminar flows is reported,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow

Long-Term Effect of Organic and Mineral Fertilization on Soil Physical Properties Under Greenhouse and Outdoor Management Practices

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Pedosphere 2011年第4期21卷 443-453页

作者： J.F.HERENcIA P.A.garcíA-GALAVíS c.MAQUEDA Instituto de Investigación y Formación Agraria y Pesquera "Las Torres-Tomejil" Sevilla (IFAPA) Carretera Sevilla-Cazalla de la Sierrra km 12.241200 Alcalá del RíoSeville (Spain) Instituto de Recursos Naturales y Agrobiología (cSIc) Apdo.1052.41080-Sevilla (Spain)

To evaluate the use of organic amendments as an alternative to conventional fertilization,a 10-year experiment on a loam soil was conducted under a crop rotation system in both greenhouse and outdoor plots applied with chemical fertilizers (NPK) and vegetal compost (organic fertilizer) in the Guadalquivir River Valley,*** effect of these two different fertilization regimes on the soil physical properties was *** organic carbon (Oc),soil bulk density (BD),soil water retention (WR),available water content (AWc),aggregate stability (AS),and soil physical quality (Dexter's index,S) were *** use of organic fertilizer increased Oc and resulted in a significant increase in AS and a decrease in BD compared to the mineral fertilizer application in both greenhouse and outdoor *** outdoor plots showed the lowest BD values whereas the greenhouse plots showed the highest AS *** the last years of the 10-year experiment the S parameter was significantly higher in organic fertilizer plots,especially for greenhouse *** the end of the study period,there were no significant differences in WR at field capacity (Fc) between treatments in both systems;the AWc was also similar in the greenhouse plots but higher in the mineral outdoor *** mineral fertilizer treatments,a small improvement in the physical properties was also observed due to the utilization of less aggressive tillage compared with the previous intensive cropping *** soil properties were correlated with soil *** sustainable management techniques such as the use of organic amendments and low or no tillage improved soil physical properties,despite the differences in management that logically significantly affected the results.

关键词： aggregate stability bulk density organic matter vegetal compost water retention