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慢性肾脏病患者铁剂应用的争议：来自改善全球肾脏病预后组织(KDIGO)会议的结论

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肾脏病与透析肾移植杂志 2016年第4期25卷 363-370页

作者： Iain c.Macdougall Andreas J.Bircher Kai-Uwe Eckardt Gregorio T.Obrador carol A.Pollock Peter Stenvinkel Dorine W.Swinkels christoph Wanner Gü nter Weiss Glenn M.chertow 陈佩玲(翻译) 龚德华(审校) Department of Renal Medicine King's College Hospital London UK Allergy Unit Dermatology Clinic University Hospital Basel Basel Switzerland Department of Nephrology and hypertension Friedrich-Alexander-Universitat Erlangen-Numberg Erlangen Germany Universidad Panamericana School of Medicine Mexico City Mexico University of Sydney Sydney Australia Royal North Shore hospital Sydney Australia Division of Renal Medicine Department of Clinical Science Intervention and Technology Karolinska University Hospital Stockholm Sweden Department of Laboratory Medicine Translational Metabolic Laboratory Radboud University Medical Center Nijmegen the Netherlands Renal Division University Hospital of Wiirzburg Wiirzburg Germany Department of Internal Medicine VI Infectious Disease Immunology Rheumatology Pneumology Medical University of Innsbruck Innsbruck Austria Division of Nephrology Stanford University School of Medicine Palo Alto California USA 南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所南京210016 不详

慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使... 详细信息

慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使用的利和弊,并且提供合理使用方案以减轻急性反应及其他毒副作用。

关键词：慢性肾脏病超敏反应感染铁超载氧化应激

动态MRI的计算机辅助分析用于反映浸润型乳腺癌的病理组织学

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国际医学放射学杂志 2010年第5期 493-494页

作者： P.A.T.Baltzer T.Vag M.Dietzel S.Beger c.Freiberg M.Gajda 杨卉 Institute of Diagnostic and Interventional Radiology Friedrich Schiller University of JenaErlanger Aller 101

关键词：乳腺肿瘤 MRI DcE-MRI 计算机辅助诊断

Echoplanar diffusion - weighted MRI with intravenous gadolinium - DTPA

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中国神经肿瘤杂志 2003年第4期1卷 235-235页

作者： Fitzek c Mentzel hJ Fitzek S Sauner D Kaiser WA Reichenbach JR Institute of Diagnostic and Interventional Radiology Friedrich Schiller UniversityPhilosophenweg 307749 JenaGermany.

It is occasionally necessary to repeat diffusion weighted imaging(DWI)after giving intravenous contrast medium(cM).however,the effects of cM on DWI and apparent diffusion coefficients(ADc)have not been fully *** aim of this prospective study was to investigate whether there are any diagnostically significant dif-ferences between echo-planar imaging(EPI)-DWI before and after intravenous ***-DWI was acquiredtwice in 203 consecutive patients before and after *** blinded readers rated the diagnostic

关键词： DWI weighted MRI with intravenous gadolinium in DTPA Echoplanar diffusion with

Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153

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Bone Research 2022年第4期10卷 799-815页

作者： Yi-Nan Li chih-Wei chen Thuong Trinh-Minh honglin Zhu Alexandru-Emil Matei Andrea-hermina Györfi Frederic Kuwert Philipp hubel Xiao Ding cuong Tran Manh Xiaohan Xu christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue huang Jens Pfannstiel Min-chuan huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg h.W.Distler Department of Internal Medicine 3–Rheumatology and Immunology Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum ErlangenErlangenGermany Deutsches Zentrum für Immuntherapie Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum ErlangenErlangenGermany Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunanChina core Facility hohenheim University of HohenheimStuttgartGermany Graduate Institute of Anatomy and cell biology National Taiwan University College of MedicineTaipeiTaiwan

Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone *** inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target *** O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically *** demonstrate that dynamic changes in O-GlcNAcylation are required for *** O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast *** the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell ***αfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory *** pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental *** of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits *** findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption.

关键词： osteoclast homeostasis maintained

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结肠直肠癌姑息治疗的改进

德国医学 2001年第4期18卷 220-221页

作者： A.Wein c.Riedel B.hanke S.Lampert W.Brückl B.Reingruber W.hohenberger E.G.hahn 张林 MedizinischeKlinik I mit Poliklinik Friedrich-Alexander-Universitat Erlangen-NumbergKrankenhausstrabe 12D-91054 ErlangenGermany MedizinischeKlinik I mit Poliklinik Friedrich-Alexander-Universitat Erlangen-Numberg 华中科技大学同济医学院附属同济医院

结肠直肠癌的发病率约为50/100?000,占女性肿瘤的第二位和男性肿瘤的第三位.约20?000例病人可以形成同时或异时的转移,最常见为肝转移.这类病人是行转移灶切除术的绝对适应证,因为根治手术的5年生存率可以达到25%～38%.如果不能切除的话... 详细信息

结肠直肠癌的发病率约为50/100?000,占女性肿瘤的第二位和男性肿瘤的第三位.约20?000例病人可以形成同时或异时的转移,最常见为肝转移.这类病人是行转移灶切除术的绝对适应证,因为根治手术的5年生存率可以达到25%～38%.如果不能切除的话,应该进行其他的姑息治疗,本文对此综述如下.

关键词：结肠直肠癌外科切除术治疗方法药物治疗化疗

超快TWIST-VIBE Dixon序列与扩散加权成像的联合成为准确且便于应用的乳腺MRI肿块分类工具

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国际医学放射学杂志 2020年第4期 497-497页

作者： S.c.Peter E.Wenkel E.Weiland M.Dietzel R.Janka A.hartmann 马闻竟 Department of Radiology Erlangen University HospitalFriedrich-Alexander Universit?t Erlangen-Nürnberg (FAU)

目的本研究旨在开发一种联合超快TWISTVIBE-Dixon(TVD)动态序列与扩散加权成像(DWI)序列的乳腺MRI肿块分类工具。虽然TVD序列可以简化乳腺MRI

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Nat Genet:科学家设计新方法找到抑制癌症发育的新基因

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Jorge de la Rosa, Mathias Josef friedrich, Yilong Li, Lena Rad, hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Gary J hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan cadiñanos Jorge de la Rosa Juan cadiñanos Jorge de la Rosa carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad Aurora Astudillo María Teresa Fernández-García María Soledad Fernández-García Gary J hoffman carlos López-Otín The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton UK Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA) Oviedo Spain Departamento de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain Department of Internal Medicine II Klinikum rechts der Isar Technische Universität München München Germany German cancer consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Servicio de Anatomía Patológica Hospital Universitario Central de Asturias Oviedo Spain Unidad de histopatología Molecular Facultad de Medicina IUOPA Universidad de Oviedo Oviedo Spain School of Medicine University of Western Australia Crawley Western Australia Australia centro de Investigación Biomédica en Red de cáncer Spain.

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在... 详细信息

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径，这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。

关键词：新基因癌症发育 Nat 科学家设计肿瘤抑制基因国际学术期刊