检索结果-南通市图书馆

WOA-DNN for Intelligent Intrusion Detection and classification in MANET Services

Intelligent Automation & Soft computing 2023年第2期35卷 1737-1751页

作者： c.edwin singh S.Maria celestin Vigila Department of computer Science and Engineering Noorul Islam Centre for Higher EducationNagercoil629180India Department of Information Technology Associate ProfessorNoorul Islam Centre for Higher EducationNagercoil629180India

Mobile ad-hoc networks(MANET)are garnering a lot of attention because of their potential to provide low-cost solutions to real-world *** are more vulnerable to security *** in nodes,band-width limits,and centralized control and management are some of the ***(Intrusion Detection System)are the aid for detection,deter-mination,and identiﬁcation of illegal system activity such as use,copying,mod-iﬁcation,and destruction of *** address the identiﬁed issues,academics have begun to concentrate on building IDS-based machine learning *** learning is a type of machine learning that can produce exceptional *** study proposes that WOA-DNN be used to detect and classify incursions in MANET(Whale Optimized Deep Neural Network Model)WOA(Whale Opti-mization Algorithm)and DNN(Deep Neural Network)are used to optimize the preprocessed data to construct a system for classifying and predicting unantici-pated cyber-attacks that are both effective and efﬁ*** a result,secure data transport to other nodes is provided,preventing intruder *** invaders are found using the(Machine Learning)ML-IDS and WOA-DNN *** data is reduced in dimensionality using Principal component Analysis(PcA),which improves the accuracy of the outputs.A classiﬁer is used in forward propagation to predict whether a result is normal or *** compare the traditional and proposed models’effectiveness,the accuracy of classiﬁcation,detection of the attack rate,precision rate,and F-Measure,Recall are *** proposed WOA-DNN model has higher assessment metrics and a 99.1%accuracy ***-DNN also has a greater assault detection rate than others,resulting in fewer false *** classiﬁcation accuracy of the proposed WOA-DNN model is 99.1%.

关键词： Intrusion detection system whale optimization algorithm deep neural network mobile ad-hoc networks forward and back propagation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

引用

Neural Regeneration Research 2025年第10期20卷 2862-2871页

作者： Prajakta Deshpande Anuradha Venkatakrishnan chimata Amit singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA Integrative Science and Engineering center University of DaytonDaytonOHUSA center for Genomic Advocacy(TcGA) Indiana State UniversityTerre HauteINUSA

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and *** acetylation is a common post-translational modification pivotal to basic cellular *** to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and *** this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in ***,we have focused on N-acetyltransferase 9 and its role in microtubule *** have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative *** have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

关键词： acetyl-coenzyme A Alzheimer’s disease animal models cell death drosophila eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 neurodegeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Virtual reality based apps are the future of patient:counseling

引用

World Journal of clinical cases 2025年第6期13卷 58-60页

作者： Ranjan K Behera Arvind K Morya Parul c Gupta Arshi singh Department of Ophthalmology MMIMSR Mullana AmbalaAmbala 133207HaryānaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology Guru Nanak Eye CentreNew Delhi 110001New DelhiIndia

The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing *** can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the *** also reduces burden on nursing staff and *** and more diverse cohort studies will help us understand the wider application of this tool on the patient *** may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical ***,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for *** will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.

关键词： Nurse Patient Virtual reality counselling Healthcare

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Viscous cosmology in holographic dark energy with Granda–Oliveros cut-off

引用

communications in Theoretical Physics 2023年第2期75卷 144-156页

作者： Simran Kaur c P singh Department of Applied Mathematics Delhi Technological UniversityBawana RoadDelhi-110042India

We study the effect of bulk viscosity on holographic dark energy(HDE)with Granda–Oliveros infra-red *** focus on a generalized form of the bulk viscous coefficient which successfully describes the present-day evolution of the *** observe that the model with bulk viscosity provides an elegant description of the early and late-time evolution of the *** constrain the model through the combined observational data of the Strong Lensing System(SLS),measurements of Hubble parameter,Type Ia supernova data of Pantheon sample and local H_(0)measured by *** best-fit values obtained from two different combinations of data,we estimate the present value of Hubble’s constant H_(0)=71.567-0.848+1.448and H_(0)=69.197-1.924+1.563,the deceleration parameter q_(0)=-0.535-0.016+0.016and q_(0)=-0.536-0.016+0.016,and the equation of state w_(0)=-0.690-0.010+0.010and w_(0)=-0.691-0.011+0.011,*** HDE model with bulk viscosity exhibits the phase transition from decelerated epoch to accelerated epoch.A comparison of the model with the standardΛcDM model is discussed with the statefinder and cosmographic parameters.

关键词： viscosity holographic dark energy cosmology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

constraining the variable generalized chaplygin gas model in matter creation cosmology

引用

communications in Theoretical Physics 2024年第10期76卷 119-134页

作者： Yogesh Bhardwaj c P singh Department of Applied Mathematics Delhi Technological UniversityBawana RoadDelhi-110042India

We explore the variable generalized chaplygin gas(VGcG)model in the theory of matter creation cosmology within the framework of a spatially homogeneous and isotropic flat Friedmann—Lemai tre—Robertson—Walker *** creation cosmology is based on reinterpretation of the energy–momentum tensor in Einstein's field *** creation corresponds to an irreversible energy flow from the gravitational field to the created matter *** variable chaplygin gas(VcG)is also studied as a particular *** use the Markov chain Monte carlo method to constrain the free parameters of three models,namely,Lambda-cold-Dark matter(ΛcDM),VGcG and VcG models with and without matter creation from the latest observational data from baryon acoustic oscillations,cosmic chronometer,type Ia supernovae(Pantheon)including gamma-ray bursts,quasars and the local measurement of H_(0) from R21 *** different combinations of dataset provide a fairly tight constraint on the parameters of theΛcDM,VGcG and VcG *** present values of various cosmological parameters are obtained,which are very close to theΛcDM ***,we perform stability analysis,Bayesian evidence analysis and information criteria analysis for these models through studying the sound speed,Bayes factor,and Akaike information criteria(AIc)and Bayesian information criteria(BIc)selection *** values of sound speed for VGcG and VcG models shows that both the models are *** to AIc,it is observed that VGcG and VcG models with matter creation are supported considerably less by current observations,while BIc shows that these models are not favoured by observational data.

关键词： cosmological model matter creation chaplygin gas model dark energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells

引用

International Journal of Ophthalmology(English edition) 2017年第5期10卷 696-704页

作者： Mahavir singh Suresh c Tyagi Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

AIM：To test whether homocysteine（Hcy） can influence the transcriptional profile, we hypothesized that Hcy can lead to the induction of proinflammatory molecules in the retinal cells of aging ***：An unbiased in vitro inflammatory pathway focused study was designed employing retinal pigment epithelial（RPE） cell line, ARPE-19. cells were cultured in the presence or absence of Hcy to capture target genes＇ expression profile. Three different concentrations of Hcy were added in the culture medium of confluent monolayers. c RNAs were made from the isolated total RNAs and the labeled c RNA probes were hybridized to microarrays specific for human disease pathway inflammatory cytokines, chemokines and their receptor gene micro-array panels as per manufacture＇s recommendations. Two Hcy up-regulated molecules：IL6 and cEBPB were further validated via Western blot analysis. Hcy＇s effect on ARPE-19 cellular morphology and genomic DNA integrity were also ***：Gene microarray analyses of RPE cells in response to Hcy treatment revealed alterations in the expressions of several inflammatory gene transcripts such as ccL5, cEBPB, IL13RA2, IL15 RA, IL6, IL8 and cXcL3 that were up-regulated. The transcripts for c3, ccL2, IL11 RA and IL18 genes exhibited down-regulation. The IL6 and cEBPB expressions were subsequently validated at the protein levels. Treatment of the retinal cells with increasing Hcy concentration influenced their density in culture however their morphology and DNA integrity remained unaffected. cONcLUSION：These findings suggest that Hcy can potentially mediate the expression of chemokines,cytokines and interleukins receptors in the retinal cells without having any debilitating effects on their morphology and the genomic DNA integrity.

关键词： chemokine choroidal neovascularization cytokine gene expression hyperhomocysteinemia inflammation macular degeneration retinal remodeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

引用

International Journal of Ophthalmology(English edition) 2018年第1期11卷 117-134页

作者： Mahavir singh Suresh c Tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine

Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.

关键词： cRISPR/cas9 precision medicine genetic ophthalmology genome engineering inflammation single nucleotide polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

引用

World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay K Thakur Anil K Sinha Santosh K Sharma Aarzoo Jahan Dinesh K Negi Ruchika Gupta Sompal singh Regional Blood Transfusion centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BAcKGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis c virus(HcV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HcV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HcV and HIV/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HcV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HcV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBV,HcV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HcV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis c virus Malaria parasite Syphilis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

引用

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir singh Suresh c Tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vascular plants distribution in relation to topography and environmental variables in alpine zone of Kedarnath Wild Life Sanctuary,West Himalaya

引用

Journal of Mountain Science 2018年第9期15卷 1936-1949页

作者： cHANDRA Sudeep singh Ankit singh c.P. NAUTIYAL M.c. RAWAT L.S. High Altitude Plant Physiology Research centre(HAPPRc)H.N.B.Garhwal University Srinagar Garhwal-246174UttarakhandIndia Space Applications centre (Indian Space Research Organization)Ahmedabad 380015India Govind Ballabh Pant National Institute of Himalayan Environment&Sustainable Development Garhwal Unit Srinagar Garhwal-246174UttarakhandIndia

The present study was carried out in Tungnath alpine meadows of Kedarnath Wild Life Sanctuary, Western Himalaya from subalpine to upper alpine zone. A total of four summits were selected along an altitudinal gradient and sampled for detailed vegetation analysis using multi summit approach as per Global observation research initiative in alpine environments(GLORIA). Species richness, diversity, and evenness among four summits as well as the interaction between environmental variables with plant communities were assessed. Monthly mean soil temperature was calculated using data retrieved from geo-precision temperature logger in order to identify the trend of soil temperature among different season and altitudinal gradient and its implications to plant communities. Soil samples were analyzed fromeach summit by collecting randomized composite soil samples. The indirect non-metric multidimensional scaling(NMDS) and direct canonical correspondence analysis(ccA) tools of ordination techniques to determine the linkage between plant species from various sample summits and biotic/abiotic environmental gradients were used in the present study. The results of the study demonstrated increase in species richness as soil temperature increases, the ecotone representing summits were found most warm summits followed by highest species richness. Annual soil temperature increased by 1.43°c at timberline ecotone. Whereas, at upper alpine zone the soil temperature increased by 0.810 c from year 2015 to 2016. S?rensen's similarity index was found to be increased between subalpine and upper alpine zone with increase in the presence of subalpine plant species at upper alpine zone. Both the ordination tools separate the subalpine summit and their respective vegetation from summits representingtimberline ecotone and upper alpine zone. Soil p H, altitude, soil cation exchange capacity were found as the key abiotic drivers for distribution of plant species.

关键词： GLORIA Non-metric multidimensionalscaling (NMDS) canonical correspondence analysis(ccA) Ecotone West Himalaya

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：