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Journal of Environmental Sciences 2024年第6期140卷 319-330页

作者： Zhouxiang cai Liting Hu Di chen Ying Zhang Xuekun Fang college of Environmental&Resource Sciences Zhejiang UniversityHangzhou 310058China center for Global change Science Massachusetts Institute of TechnologyCambridgeMA 02139United States Anji Meteorological Bureau Anji 313300China

To achieve carbon neutrality,the chinese government needs to gain a comprehensive understanding of the sources and drivers of greenhouse gas(GHG)emissions,particularly at the county level.Anji county in eastern china is a typical example of an industrial transformation from quarrying to a low-carbon economy.This study analyzed the decoupling types and structural characteristics of GHG emissions and the driving factors of carbon dioxide(cO_(2))emissions in the Anji from 2006 to 2019,and explored the differences between countylevel and provincial-level or city-level results.It was observed that energy-related activities are the main source of GHG emissions in Anji and that economic development is the driving factor behind the increasing cO_(2)emissions.However,industrial transformation and upgradation coupled with the alternative use of clean energy limit the growth of GHG emissions.This study details the GHG emissions of county during the industrial transformation stage and provides corresponding policy recommendations for county governments.

关键词： county GHG emissions Decoupling Driving factors Policy recommendations

characterization of Fe-containing particles in chengdu,southwest china,using single-particle aerosol mass spectrometry

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Journal of Environmental Sciences 2024年第2期136卷 110-120页

作者： Renjiang He Junke Zhang Luyao chen Wei Zhang Yingwei Xi School of Public Health Southwest Medical UniversityLuzhou 646000China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China Sichuan Environmental Monitoring center Chengdu 610074China

Single-particle aerosol mass spectrometry was used to study the characteristics of Fecontaining particles during winter in chengdu,southwest china.The mass concentrations of PM_(2.5)and PM_(10)during the study period were 64±38 and 89±49μg/m~3,respectively,and NO_(2)and particulate matter were high compared with most other regions of china.The Fecontaining particles were divided into seven categories with different mass spectra,sources and aging characteristics.The highest contribution was from Fe mixed with carbonaceous components(Fe-c,23.1%)particles.Fe was more mixed with sulfate than nitrate and therefore the contribution of Fe mixed with sulfate(Fe-S,20.7%)particles was higher than that of Fe mixed with nitrate(Fe-N,12.5%)particles.The contributions from Fe-containing particles related to primary combustion were high in the small particle size range,whereas aged Fecontaining particles and dust-related particles were mostly found in the coarse particle size range.The air masses mainly originated from the west and east of chengdu,and the corresponding PM_(2.5)concentrations were 79±36 and 55±36μg/m~3,respectively.The west and east air masses showed stronger contributions of Fe-containing particles related to biomass burning(Fe-B)and fossil fuel combustion(Fe-c and Fe-S)particles,respectively.The southwest area contributed the most Fe-containing particles.Future assessments of the effects of Fe-containing particles during heavy pollution period should pay more attention to Fe-c and Fe-S particles.Emission-reduction of Fe-containing particles should consider both local emissions and short-distance transmission from the surrounding areas.

关键词： Fe-containing particles Particle composition Potential source areas Evolution chengdu

Exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： Yue Dai Yi cheng Renkai Ge Ke chen Liming Yang Key Lab of Adolescent Health Assessment and Exercise Intervention of Ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health care East China Jiaotong UniversityNanchang 330013China Key Laboratory of High confidence Software Technologies of Ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external stimuli.In particular,how these neurons respond to physical exercise has long been an area of active research.Studies of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during exercise.In this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein synthesis.Our hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise Ion channel modulation Neuron adaptation

Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1436-1442页

作者： Guo-Feng chen Jun Wang Yu Yan Song Xu Jian chen Department of Gastroenterology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina cancer center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BAcKGROUND Pulmonary lymphoepithelioma-like carcinoma(PLELc)is a rare type of nonsmall-cell lung cancer.Stomach lymphoepithelioma-like carcinoma(LELc)metastasis secondary to PLELc has not been reported recently.cASE SUMMARY A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left PLELc.Positron emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia region.Upper gastrointestinal endoscopy confirmed a large mass at the stomach fundus.Immunohistochemistry(IHc)of the biopsy suggested metastatic stomach LELc.Proximal gastrectomy showed that this 6.5 cm×5.0 cm mass was located in the stomach fundus near the cardia.Histopathological examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration.IHc demonstrated that the tumor was positive for cK(AE1/AE3),p63,p40,p53,Ki-67(70%),and EGFR(3+)and negative for cK7,cK20,Her2,and cD10.In situ hybridization analysis showed positive staining Epstein-Barr virus-encoded RNA.Tumor programmed cell death ligand 1(PD-L1)expression score was 98%,and the combined positive score was 100,with no evidence of microsatellite instability.Thus,the patient was unequivocally diagnosed with metastatic stomach LELc secondary to pulmonary LELc.After discharge,this patient underwent PD-1 inhibitor treatment(toripalimab,240 mg)every 3 wk for ten cycles,and she has had no tumor recurrence.cONcLUSION For gastric LELc metastasis,PD-1 inhibitor therapy could become a new therapeutic approach,though there is still no evidence from large data sets to support this.

关键词： Stomach neoplasm Pulmonary lymphoepithelioma-like carcinoma Metastasis Immune checkpoint inhibitor case report

An extended numerical model of the first exothermic peak for three dimensional printed cement-based materials

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Frontiers of Structural and civil Engineering 2024年第1期18卷 80-88页

作者： Wei JIANG Wenqian LI Xi chen School of Materials Science and Engineering Tongji UniversityShanghai 200092China School of civil Engineering Tongji UniversityShanghai 200092China

The first exothermic peak of cement-based material occurs a few minutes after mixing,and the properties of three dimensional(3D)printed concrete,such as setting time,are very sensitive to this.Against this background,based on the classical Park cement exothermic model of hydration,we propose and construct a numerical model of the first exothermic peak,taking into account the proportions of c_(3)S,c_(3)A and quicklime in particular.The calculated parameters are calibrated by means of relevant published exothermic test data.It is found that this developed model offers a good simulation of the first exothermic peak of hydration for c_(3)S and c_(3)A proportions from 0 to 100% of cement clinker and reflects the effect of quicklime content at 8%-10%.The unique value of this research is provision of an important computational tool for applications that are sensitive to the first exothermic peak of hydration,such as 3D printing.

关键词： 3D printed cement-based materials cement hydration the first exothermic peak liquid quick-setting agent numerical model

Different timing for abdominal paracentesis catheter placement and drainage in severe acute pancreatitis complicated by intraabdominal fluid accumulation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 134-142页

作者： Rui chen Hua-Qiang chen Rui-Die Li Hui-Min Lu Department of General Surgery Chengdu Sixth People’s HospitalChengdu 610058Sichuan ProvinceChina West china center of Exellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest ChinaDivision of Pancreatic SurgeryDepartment of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina HospitalSichuan University

BAcKGROUND Non-surgical methods such as percutaneous drainage are crucial for the treatment of patients with severe acute pancreatitis(SAP).However,there is still an ongoing debate regarding the optimal timing for abdominal paracentesis catheter place-ment and drainage.AIM To explore the influence of different timing for abdominal paracentesis catheter placement and drainage in SAP complicated by intra-abdominal fluid accumu-lation.METHODS Using a retrospective approach,184 cases of SAP complicated by intra-abdominal fluid accumulation were enrolled and categorized into three groups based on the timing of catheter placement:group A(catheter placement within 2 d of symptom onset,n=89),group B(catheter placement between days 3 and 5 after symptom onset,n=55),and group c(catheter placement between days 6 and 7 after symptom onset,n=40).The differences in progression rate,mortality rate,and the number of cases with organ dysfunction were compared among the three groups.RESULTS The progression rate of group A was significantly lower than those in groups B and groups c(2.25%vs 21.82%and 32.50%,Pction in group A was significantly lower than those in groups B and groups c(41.57%vs 70.91%and 75.00%,Pc were similar(P>0.05).At postoperative day 3,the levels of c-reactive protein(55.41±19.32 mg/L vs 82.25±20.41 mg/L and 88.65±19.14 mg/L,Pcalcitonin(1.36±0.51 ng/mL vs 3.20±0.97 ng/mL and 3.41±0.98 ng/mL,Pcrosis factor-alpha(15.12±6.63 pg/L vs 22.26±9.96 pg/L and 23.39±9.12 pg/L,Pcantly lower in group A compared to those in groups B and group c.The length of hospital stay in group A was significantly lower than

关键词： Abdominal paracentesis catheter drainage Timing Severe acute pancreatitis Intra-abdominal fluid Application value

Analysis of environmental selection pressure of superoxide dismutase in deep-sea sea cucumber

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Journal of Oceanology and Limnology 2024年第3期42卷 893-904页

作者： Yanan LI Zongfu chen Haibin ZHANG Ruoyu LIU Shuichun chen Li LIN Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhou 510222China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China college of Marine Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Zhanjiang Tianli Sea cucumber New Technology Development co. Ltd.Zhanjiang 524000China

Manganese superoxide dismutase(MnSOD)is an antioxidant that exists in mitochondria and can effectively remove superoxide anions in mitochondria.In a dark,high-pressure,and low-temperature deep-sea environment,MnSOD is essential for the survival of sea cucumbers.Six MnSODs were identified from the transcriptomes of deep and shallow-sea sea cucumbers.To explore their environmental adaptation mechanism,we conducted environmental selection pressure analysis through the branching site model of PAML software.We obtained night positive selection sites,and two of them were significant(97F→H,134K→V):97F→H located in a highly conservative characteristic sequence,and its polarity c hange might have a great impact on the function of MnSOD;134K→V had a change in piezophilic a bility,which might help MnSOD adapt to the environment of high hydrostatic pressure in the deepsea.To further study the effect of these two positive selection sites on MnSOD,we predicted the point mutations of F97H and K134V on shallow-sea sea cucumber by using MAESTROweb and PyMOL.Results show that 97F→H,134K→V might improve MnSOD’s efficiency of scavenging superoxide a nion and its ability to resist high hydrostatic pressure by moderately reducing its stability.The above results indicated that MnSODs of deep-sea sea cucumber adapted to deep-sea environments through their amino acid changes in polarity,piezophilic behavior,and local stability.This study revealed the correlation between MnSOD and extreme environment,and will help improve our understanding of the organism’s adaptation mechanisms in deep sea.

关键词： Holothuroidea environmental adaptation positive selection point mutation

Towards efficient generative AI and beyond-AI computing:New trends on ISScc 2024 machine learning accelerators

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Journal of Semiconductors 2024年第4期45卷 12-15页

作者： Bohan Yang Jia chen Fengbin Tu Department of Electronic and computer Engineering The Hong Kong University of Science and TechnologyHong KongChina AI chip center for Emerging Smart Systems The Hong Kong University of Science and TechnologyHong KongChina School of the Gifted Young University of Science and Technology of ChinaHefei 230026Chin

compared to the last decade when the convolution neu-ral network(cNN)dominated the research field,machine learn-ing(ML)algorithms have reached a pivotal moment called the generative artificial intelligence(AI)era.With the emer-gence of large-scale foundation models[1],such as large multi-modal model(LMM)GPT-4[2]and text-to-image generative model DALL·E[3].

关键词： ISScc beyond AI

Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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chinese chemical Letters 2024年第2期35卷 335-340页

作者： Xin Wu Xinmei chen Xinyu Wang Haisheng He Jianming chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Shanghai Wei Er Lab Shanghai 201707China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor solubility.Liposomes are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and biodegradability.However,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal formulations.To address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14c),palmitic acid(PA,16c)and stearic acid(SA,18c),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,respectively.All liposomes show high stability and drug loadings,as well as sustained drug release.The chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal PTX.Neither rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of PTX.Among all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion rate.Witnessing its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release chemotherapy

Enhanced hydrogen evolution performance by 3D ordered macroporous Ru-coP@Nc electrocatalysts

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Rare Metals 2024年第3期43卷 1095-1107页

作者： chen-chen Zhang Sheng Wei Li-Xian Sun Yi-Fang Ouyang Fen Xu Hai-Liang chu Hong-GePan Li-Xin chen Xue-Zhang Xiao School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of chemistry and chemical Engineering Guangxi UniversityNanning530004China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055GuangdongChina Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an710021China School of Materials Science and Engineering Zhejiang UniversityHangzhou310058China

Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel cells.However,the main challenge is to develop high performance,low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction(HER).Herein,a three-dimensional hierarchically ordered macroporous Ru-coP@Nc electrocatalyst(3DOM Ru-coP@Nc)derived from ordered macro-microporous metal-organic frameworks has been prepared using the precursor@template and double-solvent methods.The prepared 3DOM Ru-coP@Nc catalyst exhibits an overpotential of 15 mV(j=10 mA·cm^(-2))and a reaction Tafel slope of 38 mV·dec^(-1)in alkaline electrolyte,which are superior to commercial Pt@c catalyst.Additionally,the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec^(-1),respectively.The outstanding HER activities of 3DOM Ru-coP@Nc catalysts are ascribed to the 3D highly interconnectedreticular nanospaces that can increase effective reaction active sites.The N dope d carbon framework improves the electronic properties and conductivity.Moreover,the strong interaction of Ru and coP nanoparticles also boosts the HER process.These results indicate that 3DOM Ru-coP@Nc catalysts with high catalytic activities have a broad application prospect in the future.

关键词： Hydrogen evolution reaction Template method 3D ordered macroporous Ru-coP@Nc