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扩散加权MRI对肾移植术后早期肾功能的评价

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国际医学放射学杂志 2010年第4期 404-404页

作者： U.Eisenberger H.c.Thoeny T.Binser M.Gugger F.J.Frey c.boesch 郭丽君 Department of clinical Research/AMSM University BernPavillon 52InselspitalP.O.Box 353010 BernSwitzerland

目的肾移植术后早期对移植肾行扩散加权MRI(DW-MRI),旨在探讨病人间表观扩散系数(ADc)的差异以及对微循环的影响,并初步了解组织学证实的急性排斥反应(AR)时两者测量值

关键词：扩散加权 MRI 肾移植术后

颈椎MRI诊断急性症状性挥鞭伤是否具有特异性:4名经验丰富阅片者的前瞻性盲法对照研究

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国际医学放射学杂志 2012年第2期 182-182页

作者： S.E.Anderson c.boesch H.Zimmermann A.Busato J.Hodler R.Bingisser 颜荣华 Department of Medical Imaging School of Medicine SydneyUniversity of Notre Dame Australia160 Oxford StDarlinghurstNSW 2010Australia

目的比较急性症状性挥鞭伤病人与正常对照者的颈椎MRI表现。材料与方法本研究为前瞻性多中心性对照研究,2005年—2008年共100例连续病人在车祸伤后48h内进行了1.5T颈椎MRI检查,将结果与100名年龄、

关键词： MRI 挥鞭伤症状性特异性颈椎对照研究盲法

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标准化MR颈椎椎管管径

国际医学放射学杂志 2014年第3期 286-286页

作者： E.J.Ulbrich c.Schraner c.boesch J.Hodler A.Busato S.E.Anderson S.Eigenheer 许玉峰 Department of Diagnostic Interventional and Pediatric RadiologyUniversity Hospital and University of BernInselspitalBernSwitzerland

摘要目的提出相对于脊柱水平、年龄、性别和身高的多个层面颈椎椎管和脊髓管径的正常值。材料与方法本研究由学院审查委员会批准,所有健康志愿者均签署了知情同

关键词：颈椎椎管脊髓身高性别脑人体测量 MR 管径

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Differential effects of oilseed protein hydrolysates in attenuating inflammation in murine macrophages

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Food Bioscience 2022年第5期49卷 196-205页

作者： Ruixian Han Alan JHern´andez´Alvarez Joanne Maycock Brent S.Murray christine boesch Nutritional Sciences and Epidemiology School of Food Science and NutritionUniversity of LeedsLS29JTLeedsUK Food colloids and Bioprocessing School of Food Science and NutritionUniversity of LeedsLS29JTLeedsUK

Proteins from underutilized defatted oilseed meals have been proposed as promising sources of bioactive peptides. This study was conducted to determine the anti-inflammatory activities of five oilseed proteins (flaxseed, rapeseed, sunflower, sesame and soybean) hydrolysed via alcalase, pepsin (at pH 1.3 and pH 2.1), respectively, and to compare these against two dairy proteins (whey, casein). The potential of protein hydrolysates of three different molecular weight fractions (Mw > 10 kDa, 3-10 kDa, clear factor kappa B (NF- κB) signalling was screened via RAW-Blue™ reporter cells. Fractions with Mw cted to validate anti-inflammatory properties in RAW 264.7 macrophages. Rapeseed fractions showed greatest potency to attenuate inflammation, via efficiently down-regulating the expression of IL-6 (-49.1%), IL-1β (-58.6%), iNOS (-41.9%) and cOX-2 (-58.7%) and up-regulating the IL- 10 (+47.2%) mRNA level at 2000 μg peptides/mL. Rapeseed, sesame and casein demonstrated marked repression of NF-κB pathway, through down-regulating NF-κB1, p65 and/or IκBα mRNA levels. In addition, rapeseed, sesame and soybean reduced the expression of TLR4 and/or cD14 associated with attenuated LPS recognition. In addition, it was confirmed that rapeseed and soybean hydrolysates showed capabilities to bind 43.9 and 52.4% of LPS in solution, thereby weakening inflammatory response;an effect that could at least partially be related to the presence of hydrophobic amino acids. To summarize, current data demonstrate differing capacity of plant protein hydrolysates to interact with inflammatory signalling, indicating the need for further research into the molecular mechanisms of peptide action.

关键词： Oilseeds Ultrafiltration Protein hydrolysate Bioactive peptide Inflammation Anti-inflammatory properties LPS binding

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

A New TanSat XcO2 Global Product towards climate Studies

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Advances in Atmospheric Sciences 2021年第1期38卷 8-11页

作者： Dongxu YANG Yi LIU Hartmut boesch Lu YAO Antonio DI NOIA Zhaonan cAI Naimeng LU Daren LYU Maohua WANG Jing WANG Zengshan YIN Yuquan ZHENG Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Earth Observation Science School of Physics and AstronomyUniversity of LeicesterLeicestershire LE17RHUK National centre for Earth Observation University of LeicesterLeicestershire LE17RHUK National Satellite Meteorological center China Meteorological Administration Beijing 100081China Shanghai Engineering center for Microsatellites Shanghai 201210China changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China

The 1st chinese carbon dioxide(cO2)monitoring satellite mission,TanSat,was launched in *** 1st TanSat global map of cO2 dry-air mixing ratio(XcO2)measurements over land was released as version 1 data product with an accuracy of 2.11 ppmv(parts per million by volume).In this paper,we introduce a new(version 2)TanSat global XcO2 product that is approached by the Institute of Atmospheric Physics carbon dioxide retrieval Algorithm for Satellite remote sensing(IAPcAS),and the European Space Agency(ESA)climate change Initiative plus(ccI+)TanSat XcO2 product by University of Leicester Full Physics(UoL-FP)retrieval *** correction of the measurement spectrum improves the accuracy(−0.08 ppmv)and precision(1.47 ppmv)of the new retrieval,which provides opportunity for further application in global carbon flux studies in the ***-comparison between the two retrievals indicates a good agreement,with a standard deviation of 1.28 ppmv and a bias of−0.35 ppmv.

关键词： TanSat cO2 remote sensing carbon flux climate change