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Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury:cumulative evidence for future cardioprotective strategies

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Acta Pharmaceutica Sinica B 2023年第1期13卷 29-53页

作者： Panat Yanpiset chayodom Maneechote Sirawit Sriwichaiin Natthaphat Siri-Angkul Siriporn c.chattipakorn Nipon chattipakorn cardiac Electrophysiology Research and Training center Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand cardiac Electrophysiology Unit Department of PhysiologyFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand center of Excellence in cardiac Electrophysiology Research Chiang Mai UniversityChiang Mai 50200Thailand Department of Oral Biology and Diagnostic Sciences Faculty of DentistryChiang Mai UniversityChiang Mai 50200Thailand

cardiomyocyte death is one of the major mechanisms contributing to the development of myocardial infarction(MI)and myocardial ischemia/reperfusion(MI/R)*** to the limited regenerative ability of cardiomyocytes,understanding the mechanisms of cardiomyocyte death is ***,one of the regulated programmed cell death pathways,has recently been shown to play important roles in MI and MI/R *** is activated by damage-associated molecular patterns(DAMPs)that are released from damaged myocardial cells and activate the formation of an apoptosisassociated speck-like protein containing a cARD(ASc)interacting with NAcHT,LRR,and PYD domains-containing protein 3(NLRP3),resulting in caspase-1 cleavage which promotes the activation of Gasdermin D(GSDMD).This pathway is known as the canonical *** has also been shown to be activated in a non-canonical pathway during MI and MI/R injury via caspase-4/5/*** of GSDMD has been shown to provide cardioprotection against MI and MI/R *** the effects of MI or MI/R injury on pyroptosis have previously been discussed,knowledge concerning the roles of GSDMD in these settings remains *** this review,the evidence from in vitro,in vivo,and clinical studies focusing on cardiac GSDMD activation during MI and MI/R injury is comprehensively summarized and *** from this review will help pave the way for a new therapeutic target in ischemic heart disease.

关键词： Pyroptosis Gasdermin D Heart Ischemia Ischemia-reperfusion injury Myocardial infarction

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EFFEcT OF SUBMERGED ENTRY NOZZLE (SEN) PARAMETERS AND SHAPE ON 3-D FLUID FLOW IN MOULD FOR BEAM BLANK cONTINUOUS cASTING

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Acta Metallurgica Sinica(English Letters) 2004年第5期17卷 705-712页

作者： Y.P.Du J.W.Yang R.Shi X.c.cui SchoolofMaterialScience TaiyuanUniversityofScience＆TechnologyTaiyuan080024China SchoolofMechanism YanshanUniversityQinghuangdao066004China

According to turbulent theory and characteristics of beam blank continuous casting, 3-D model to represent the flow of beam blank mould is established. The predicted results indicate that the exit obliquity of up 15°(+15°) should be adopted, which will benefit the floatation of non-metallic inclusion and purification of the molten steel. When the nozzle angle is 120°, the flow pattern is reasonable. Proper nozzle depth can be 200mm. Turbulent kinetic of meniscus can be reduced by adopting the square nozzle and suitable area of side outlet when casting speed increases. The results are consistent with those of water model experiment, so the model is exact and reasonable. The model can provide important information for design of SEN and defining of immersion depth.

关键词： SEN parameter SEN shape beam blank continuous casting 3-D flow distribution turbulent kinetic energy

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Influence of Fluoride Addition on the composition of Solutions in Equilibrium with Acid Soils

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Pedosphere 2009年第1期19卷 60-70页

作者： A. ROMAR c. GAGO M. L. FERNNDEZ-MARcOS E. LVAREZ Departamento de Edafología y Química Agrícola University of Santiago de Compostela Campus Universitario 27002 Lugo (Spain)

Atmospheric emissions of fluoride from an aiuminium smelter-alumina refinery located on the northern coast of Galicia, NW Spain, increase the content of fluorine in soils and vegetation in the vicinity of the complex. The effects of the addition of fluoride solutions on the chemical properties of soil samples from the area surrounding the complex were investigated in laboratory experiments. Addition of fluoride to soils resulted in increases in pH and concentrations of Fe, A1, and organic matter in the equilibrium solutions and decreases in concentrations of ca, Mg, and K. No consistent effects were observed on the cu, Mn, or Zn concentrations. Most of the A1 in solution was bound to organic matter. Within the fraction ＂labile aluminium＇, the concentration of A1-OH complexes decreased and the A1-F complexes increased, especially A1F3 and A1F4^-, which are less toxic than Al^3＋ and A1-OH species.

关键词： aluminium speciation equilibrium soil solution fluoride pollution

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Pulsed electrolysis of carbon dioxide by large-scale solid oxide electrolytic cells for intermittent renewable energy storage

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carbon Energy 2023年第4期5卷 2-12页

作者： Anqi Wu chaolei Li Beibei Han Wu Liu Yang Zhang Svenja Hanson Wanbing Guan Subhash c.Singhal Key Laboratory of Advanced Fuel cells and Electrolyzers Technology of Zhejiang Province Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Faculty of Science and Engineering University of Nottingham Ningbo ChinaNingboZhejiangChina

cO_(2) electrolysis with solid oxide electrolytic cells(SOEcs)using intermittently available renewable energy has potential applications for carbon neutrality and energy *** this study,a pulsed current strategy is used to replicate intermittent energy availability,and the stability and conversion rate of the cyclic operation by a large-scale flat-tube SOEc are *** hundred cycles under pulsed current ranging from -100 to -300 mA/cm^(2) with a total operating time of about 800 h were carried *** results show that after 100 cycles,the cell voltage attenuates by 0.041%/cycle in the high current stage of−300 mA/cm^(2),indicating that the lifetime of the cell can reach up to about 500 *** total cO_(2) conversion rate reached 52%,which is close to the theoretical value of 54.3% at -300 mA/cm^(2),and the calculated efficiency approached 98.2%,assuming heat *** study illustrates the significant advantages of SOEc in efficient electrochemical energy conversion,carbon emission mitigation,and seasonal energy storage.

关键词： carbon dioxide cyclic electrolysis pulse current solid oxide electrolytic cells

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Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices

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Defence Technology（防务技术） 2017年第1期13卷 22-32页

作者： Arjun Singh Tirupati c.Sharma Mahesh Kumar Jaspreet Kaur Narang Prateek Kishore Alok Srivastava Terminal Ballistics Research Laboratory Defence Research&Development OrganisationMinistry of DefenceExplosive DivisionSector 30Chandigarh(UT)160030India Department of chemistry&centre for Advanced Studies in chemistry Panjab UniversityChandigarh160 014India

This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSc) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition.

关键词： Plastic bonded explosives Thermogravimetric analysis Differential scanning calorimeter Thermal decomposition Kinetics

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Response of Rice to Insect Elicitors and the Role of OsJAR1 in Wound and Herbivory-Induced JA-lle Accumulation

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Journal of Integrative Plant Biology 2013年第8期55卷 775-784页

作者： Kaori Fukumoto Kabir Md Alamgir Yuko Yamashita Izumi c.Mori Hideyuki Matsuura Ivan Galis Institute of Plant Science and Resources Okayama University Division of Applied Bioscience Research Faculty of AgricultureHokkaido University

Plants produce jasmonic acid （JA） and its amino acid conjugate, jasmonoyI-L-isoleucine （JA-Ile） as major defense signals in response to wounding and herbivory. In rice （Oryza sativa）, JA and JA-Ile rapidly increased after mechanical damage, and this increase was further amplified when the wounds were treated with oral secretions from generalist herbivore larvae, lawn armyworms （Spodoptera mauritia）, revealing for the first time active perception mechanisms of herbivore-associated elicitor（s） in rice. In the rice genome, two OsJAR genes can conjugate JA and lie and form JA-Ile in vitro; however, their function in herbivory- induced accumulation of JA-Ile has not been investigated. By functional characterization of TOS17 retrotransposon-tagged Osjarl plants and their response to simulated herbivory, we show that OsJAR1 is essential for JA-Ile production in herbivore-attacked, field-grown plants. In addition, OsJAR1 was required for normal seed development in rice under field conditions. Our results suggest that OsJAR1 possesses at least two major functions in rice defense and development that cannot be complemented by the additional OsJAR2 gene function, although this gene previously showed overlapping enzyme activity in vitro.

关键词： JAR enzyme jasmonate signaling jasmonic acid jasmonoyl-L-isoleucine rice Oryza sativa.

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Solvent extraction of zinc,manganese,cobalt and nickel from nickel laterite bacterial leach liquor using sodium salts of TOPS-99 and cyanex 272

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Transactions of Nonferrous Metals Society of china 2016年第1期26卷 301-309页

作者： R.K.MISHRA P.c.ROUT K.SARANGI K.c.NATHSARMA council of Scientific and Industrial Research Institute of Minerals and Materials TechnologyBhubaneswar 751 013OdishaIndia Academy of Scientific and Innovative Research Chermai 600113TamilnaduIndia

The extraction and separation of zinc, manganese, cobalt and nickel from nickel laterite bacteria leach liquor were carried out using sodium salts of TOPS-99 and cyanex 272 in kerosene. The unwanted metal ions were removed by precipitation method and solvent extraction was used to extract/separate Zn, Mn, co and Ni. The nickel laterite leach liquor which was obtained from bioleaching of chromite overburden samples contained 3.72 g/L Fe, 2.08 g/L Al, 0.44 g/L Ni, 0.02 g/L co, 0.13 g/L Mn, 0.14 g/L Zn and 0.22 g/L cr. From this leach liquor, 100% Fe, 96.98% Al and 70.42% cr were removed by precipitation with ca cO_3 at pH 4.4 followed by precipitation of remaining Al and cr with 50% ammonia at p H 5.4. After precipitation, the extraction of Zn from the Fe, Al and cr free leach liquor was carried out with 0.1 mol/L TOPS-99 followed by Mn extraction with 0.04 mol/L Na TOPS-99. The yields of Zn and Mn were 97.77% and 95.63%, respectively. After Mn extraction, cobalt was removed from the leach liquor using 0.0125 mol/L Na cyanex 272 and finally nickel extraction was carried out using 0.12 mol/L Na TOPS-99 with 99.84% yield. The stripping of loaded organic（LO） phases were achieved with dilute H_2SO_4.

关键词： nickel laterite manganese nickel TOPS-99 cyanex 272

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carbon monoxide production using a steel mill gas in a combined chemical looping process

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Journal of Energy chemistry 2022年第5期31卷 811-825页

作者： Varun Singh Lukas c.Buelens Hilde Poelman Mark Saeys Guy B.Marin Vladimir V.Galvita Laboratory for chemical Technology Technologiepark 125B-9052 GhentBelgium

Up to 9% of the global cO_(2) emissions come from the iron and steel industry. Here, a combined chemical looping process to produce cO, a building block for the chemical industry, from the cO_(2) -rich blast furnace gas of a steel mill is proposed. This cyclic process can make use of abundant Fe_(3)O_(4) and caO as solid oxygen and cO_(2) carriers at atmospheric pressure. A proof of concept was obtained in a laboratory-scale fixed bed reactor with synthetic blast furnace gas and Fe_(3)O_(4) /caO = 0.6 kg/kg. cO production from the proposed process was investigated at both isothermal conditions(1023 K) and upon imposing a temperature program from 1023 to 1148 K. The experimental results were compared using performance indicators such as cO yield, cO space time yield, carbon recovery of the process, fuel utilisation, and solids’ *** temperature-programmed cO production resulted in a cO yield of 0.056 ± 0.002 mol per mol of synthetic blast furnace gas at an average cO space time yield of 7.6 mmol kgFe^(-1) s^(-1) over 10 cycles, carbon recovery of 48% ± 1%, fuel utilisation of 23% ± 2%, and an average calcium oxide and iron oxide utilisation of 22% ± 1% and 11% ± 1%. These experimental performance indicators for the temperature-programmed cO production were consistently better than those of the isothermal implementation mode by 20% to 35%. Over 10 consecutive process cycles, no significant losses in cO yield were observed in either implementation mode. Process simulation was carried out for 1 million metric tonnes per year of equivalent cO_(2) emissions from the blast furnace gas of a steel mill to analyse the exergy losses in both modes of operation. comparison of the exergy efficiency of the temperature-programmed process to the isothermal process showed that the former is more efficient because of the higher cO concentration achievable,despite 20% higher exergy losses caused by heat transfer required to change temperature.

关键词： Steel industry cO_(2)capture calcium oxide cO_(2)sorbent Reverse water gas shift circular economy Process intensification

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反铁磁耦合记录介质的一级翻转曲线

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物理学报 2008年第11期57卷 7287-7291页

作者：阴津华 c.H.Hee 潘礼庆北京科技大学物理系 Data Storage Institute 5 Engineering Drive 1Singapore 117608

用实验测量和微磁计算的方法得到了反铁磁耦合记录介质的一级翻转曲线.利用微磁计算的目的是便于正确地理解一级翻转曲线分布图.因为它可以把一级翻转曲线分布图中不同部分与相应的磁化翻转联系起来.这样一级翻转曲线就能被用来分析复... 详细信息

用实验测量和微磁计算的方法得到了反铁磁耦合记录介质的一级翻转曲线.利用微磁计算的目的是便于正确地理解一级翻转曲线分布图.因为它可以把一级翻转曲线分布图中不同部分与相应的磁化翻转联系起来.这样一级翻转曲线就能被用来分析复杂磁化翻转及其相互作用的细节,而这种手段可以提供比通常用的ΔM方法更多的信息.

关键词：反铁磁耦合记录介质一级翻转曲线微磁学模拟

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Groundwater occurrence and flow patterns in the Ishiagu mining area of southeastern Nigeria

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Frontiers of Earth Science 2012年第1期6卷 18-28页

作者： I.c.EZEKWE E.ODUBO G.N.cHIMA I.S.ONWUcHEKWA Department of Geography and Environmental Management Niger Delta UniversityWilberforce IslandPMB 071YeneganaNigeria Department of Geography and Planning Abia State UniversityPMB 2000UtumNigeria

The Ishiagu area is a water scarce region and has played host to mining activities for more than four decades. Mining-related activities have become a threat to potable water supply in the area. This paper is an attempt to show the extent of this threat and in particular, investigate the regional groundwater occurrence and flow pattem based on GPS, water well and geological data. This basin- wide model can be used for further groundwater assess- ment, pollution control and contaminant management. Groundwater occurs between 2.4 and 9 m in the Lekwesi- Lokpaukwu area; 1.5-3.7 m in the Ndi-Ugbugbor-Ayaragu axis and 1.2-4.6 m in the Ishiagu area. Recharge areas include the Leru-Amaubiri-Lekwesi sandstone hills and the Ihetutu-Ugwuajirija mine field. While the ultimate sink of contamiants is the Ivo River system, other discharge axis is the Ishiagu-Ayaragu axis and the Ogwor Ndi- Ugbugbor zone. An unconfined and a confined （〉 10） circulation groundwater system was inferred, and flow model reveals that a large part of Ishiag-Ayaragu and Ndi- Ugbugbor part of the study area suffer polluted recharge from the Pb/Zn mining area. Groundwater was also subjected to hierarchical cluster analysis and the existence of 3-4 hydrological regimes, which revealed： Unpolluted recharge areas, areas affected by polluted recharge, a deep water and shallow water circulation and mine effluents.

关键词： groundwater flow mining heavy metals,pollution cluster analysis Ishiagu Nigeria

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