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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of british columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMbASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Diagenesis and its controls on reservoir quality of the Tambar oil field, Norwegian North Sea

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Energy Geoscience 2021年第1期2卷 10-31页

作者： Mohammed bukar Richard H.worden Shettima bukar Philip Shell Department of Earth and Ocean Sciences University of LiverpoolLiverpoolL693GPUK Department of Geology University of MaiduguriNigeria Saudi Aramco Al-DhahranEastern RegionSaudi Arabia

A study of the diagenetic evolution of the Late Jurassic sandstones of the shallow marine facies in the Tambar oil field,Norwegian North Sea was carried out to understand its controls on reservoir *** samples and a set of wireline logs obtained from three wells were used to carry out petrographic studies including light optics and scanning electron microscopy,well log analysis,fluid inclusions,X-ray diffraction(XRD)for whole rock samples,clay mineral extracts and stable *** Tambar reservoir sandstones range mainly from siltstone to fine-grained sandstones,exclusively arkoses cemented mainly by microcrystalline quartz,euhedral quartz overgrowth,dolomite cement,illite and *** diagenetic/eodigenetic minerals include pyrite,calcite,and microcrystalline quartz and late diagenetic/mesodiagenetic minerals include quartz overgrowth,dolomite,illite and *** d18O values of dolomite cement in the Tambar sandstone reservoir range from11.77‰to3.57‰PDb,while the d13c values of the dolomite cement are from5.07‰to1.12‰*** temperature for fluid inclusions trapped in authigenic quartz fall between 130℃ and 169℃.The reservoir quality is controlled mainly by early formed grain-coating microcrystalline quartz that precipitated from the dissolution of sponge spicules which significantly inhibits quartz overgrowth *** emplacement do not show significant control on reservoir quality because considerable quartz cementation has taken place before the onset of major oil *** the coarse-grained sands show a correlation between quartz cement volume and water ***,the interpreted temperature for dolomite cementation is significantly higher for water leg-suggested effect of oil emplacement on the late ***-standing these controls on the reservoir quality will enhance the exploration strategy for the Tambar oil field.

关键词： Diagenesis Oil-inhibition Microquartz-inhibition Anomalous porosity Permeability

Field topologies in ideal and near-ideal magnetohydrodynamics and vortex dynamics

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Science china(Physics,Mechanics & Astronomy) 2015年第1期58卷 12-31页

作者： LOW b.c. High Altitude Observatory National Center for Atmospheric Research

Magnetic field topology frozen in ideal magnetohydrodynamics （MHD） and its breakage in near-ideal MHD are reviewed in two parts, clarifying and expanding basic concepts. The first part gives a physically complete description of the frozen field topology derived from magnetic flux conservation as the fundamental property, treating four conceptually related topics： Eulerian and La- grangian descriptions of three dimensional （3D） MHD, chandrasekhar-Kendall and Euler-potential field representations, magnetic helicity, and inviscid vortex dynamics as a fluid system in physical contrast to ideal MHD. A corollary of these developments clar- ifies the challenge of achieving a high degree of the frozen-in condition in numerical MHD. The second part treats field-topology breakage centered around the Parker Magnetostatic Theorem on a general incompatibility of a continuous magnetic field with the dual demand of force-free equilibrium and an arbitrarily prescribed, 3D field topology. Preserving field topology as a global con- straint readily results in formation of tangential magnetic discontinuities, or, equivalently, electric current-sheets of zero thickness. A similar incompatibility is present in the steady force-thermal balance of a heated radiating fluid subject to an anisotropic thermal flux conducted strictly along its frozen-in magnetic field in the low-fl limit. In a weakly resistive fluid the thinning of current sheets by these general incompatibilities inevitably results field notwithstanding the small resistivity. Strong Faraday in sheet dissipation, resistive heating and topological changes in the induction drives but also macroscopically limits this mode of energy dissipation, trapping or storing free energy in self-organized ideal-MHD structures. This property of MHD turbulence captured by the Taylor hypothesis is reviewed in relation to the Sun＇s corona, calling for a basic quantitative description of the breakdown of flux conservation in the low-resistivity li

关键词： magnetic topology magnetic reconnection current sheets magnetic helicity thermal conduction solar corona magnetohy-drodynamics interstellar clouds

Split Octonion Reformulation for Electromagnetic chiral Media of Massive Dyons

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communications in Theoretical Physics 2017年第12期67卷 701-710页

作者： b.c.chanyal Department of Physics G.B.Pant University of Agriculture & Technology

In an explicit, unified, and covariant formulation of an octonion algebra, we study and generalize the electromagnetic chiral fields equations of massive dyons with the split octonionic representation. Starting with 2 × 2 Zorn's vector matrix realization of split-octonion and its dual Euclidean spaces, we represent the unified structure of split octonionic electric and magnetic induction vectors for chiral media. As such, in present paper, we describe the chiral parameter and pairing constants in terms of split octonionic matrix representation of Drude-born-Fedorov constitutive relations. We have expressed a split octonionic electromagnetic field vector for chiral media, which exhibits the unified field structure of electric and magnetic chiral fields of dyons. The beauty of split octonionic representation of Zorn vector matrix realization is that, the every scalar and vector components have its own meaning in the generalized chiral electromagnetism of dyons. correspondingly, we obtained the alternative form of generalized Proca–Maxwell's equations of massive dyons in chiral media. Furthermore, the continuity equations, Poynting theorem and wave propagation for generalized electromagnetic fields of chiral media of massive dyons are established by split octonionic form of Zorn vector matrix algebra.

关键词： octonions Zorn vector matrix chiral media constitutive relations Poynting theorem

Artificial neural network approach for rheological characteristics of coal-water slurry using microwave pre-treatment

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International Journal of Mining Science and Technology 2017年第2期27卷 379-386页

作者： b.K.Sahoo S.De b.c.Meikap Department of chemical Engineering Indian Institute of Technology Research and Development centre for Iron and Steel Steel Authority of India Limited chemical Engineering School of Engineering Howard College University of Kwazulu-Natal

Detailed experimental investigations were carried out for microwave pre-treatment of high ash Indian coal at high power level(900 W) in microwave oven. The microwave exposure times were fixed at60 s and 120 s. A rheology characteristic for microwave pre-treatment of coal-water slurry(cWS) was performed in an online bohlin viscometer. The non-Newtonian character of the slurry follows the rheological model of Ostwald de Waele. The values of n and k vary from 0.31 to 0.64 and 0.19 to 0.81 Pa·sn,respectively. This paper presents an artificial neural network(ANN) model to predict the effects of operational parameters on apparent viscosity of cWS. A 4-2-1 topology with Levenberg-Marquardt training algorithm(trainlm) was selected as the controlled ANN. Mean squared error(MSE) of 0.002 and coefficient of multiple determinations(R^2) of 0.99 were obtained for the outperforming model. The promising values of correlation coefficient further confirm the robustness and satisfactory performance of the proposed ANN model.

关键词： Microwave pre-treatment coal-water slurry Apparent viscosity Artificial neural network back propagation algorithm

controlling Excitation Inversion of a cooper Pair box Interacting with a Nanomechanical Resonator

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chinese Physics Letters 2012年第8期29卷 20-24页

作者： c.Valverde H.c.b.de Oliveira A.T.Avelar b.baseia Instituto de Química Universidade de Brasília70919-970BrasíliaDFBrazil Universidade Estadual de Goiás Rod.BR 15375132-903 AnápolisGOBrazil Universidade Paulista Rod.BR 153km 774845-090 GoianiaGOBrazil Instituto de Física Universidade Federal de Goiás74001-970 GoianiaGOBrazil

We investigate the action of time-dependent detunings upon the excitation inversion of a cooper pair box interacting with a nanomechanical *** method employs the Jaynes–cummings model with damping,assuming different decay rates of the cooper pair box and various fixed and time-dependent *** is shown that,when the presence of damping plus constant detunings destroys the collapse/revival effects,convenient choices of time-dependent detunings allow one to reconstruct such events in a perfect *** is also shown that the mean excitation of the nanomechanical resonator is more robust against damping of the cooper pair box for convenient values of time-dependent detunings.

关键词： cooper tuning excitation

black hole shadows in Einstein-bel-Robinson gravity

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chinese Physics c 2024年第5期48卷 272-283页

作者： b.Hamil b.c.Lütfüoğlu Laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order scalar curvature corrections are believed to bear important consequences. Einstein-bel-Robinson (EbR) gravity with quartic curvature modification motivated Sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS black hole shadows in EbR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.

关键词： black hole shadows Einstein-bel-Robinson gravity plasma

Investigation of Ti6Al4V and AA7075 alloy embedded nanofluid flow over longitudinal porous fin in the presence of internal heat generation and convective condition

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communications in Theoretical Physics 2020年第2期72卷 23-29页

作者： G Sowmya b J Gireesha S Sindhu b c Prasannakumara Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta-577451KarnatakaIndia Department of Mathematics Davangere UniversityDavangere-577002KarnatakaIndia

The thermal attributes of porous fin due to radiation and natural convection have been carried out in the presence of nanofluid *** geometry of the fin taken for the analysis is rectangular profiled longitudinal *** temperature-dependent internal heat generation condition is also considered along with Darcy’s *** two types of nanofluid containing titanium alloy(Ti6Al4V)and aluminium alloy(AA7075)immersed in water is considered for the *** modelled nonlinear ordinary differential equation is numerically solved by the Runge–Kutta–Fehlberg *** impact of geometric parameter on the heat transfer analysis of the fin due to the flow of both nanofluids is plotted and consequences are physically *** is observed that the presence of the water-based titanium alloy better enhances the fin heat transfer rate.

关键词： alloys nanofluid porous fin heat transfer analysis convective condition internal heat generation

FASTER–RcNN for Skin burn Analysis and Tissue Regeneration

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computer Systems Science & Engineering 2022年第9期42卷 949-961页

作者： c.Pabitha b.Vanathi Department of computer Science and Engineering SRM Valliammai Engineering CollegeChennai603203India

Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RcNN (Regional convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RcNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.

关键词： Faster R-cNN skin burn deep learning RPN computer vision