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cYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan Haiyan Tan Jing Wu Ha Won Lee andrew D.Huber William c.Wright Ji-Hoon cho Jiyang Yu Junmin Peng Taosheng chen Department of chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

cYP3A5 is a cytochrome P450(cYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether cYP3A5 directly influences cancer *** this report,we demonstrate that cYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that cYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that cYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,cYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of cYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： cell migration cYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

Trends in leadership at orthopaedic surgery sports medicine fellowships

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World Journal of Orthopedics 2021年第6期12卷 412-422页

作者： Nicholas c Schiller andrew J Sama Amanda F Spielman chester J Donnally III Benjamin I Schachner Dhanur M Damodar christopher c Dodson Michael G ciccotti Miller School of Medicine University of MiamiMiamiFL 33136United States Department of Orthopaedic Surgery Rothman Institute at Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Orthopedic Surgery University of Miami HospitalMiamiFL 33316United States

BAcKGROUND Fellowship directors(FDs)in sports medicine influence the future of trainees in the field of *** the characteristics these leaders share must be brought into *** all current sports medicine FDs,our group analyzed their demographic background,institutional training,and academic *** To serve as a framework for those aspiring to achieve this position in orthopaedics and also identify opportunities to improve the *** Fellowship programs were identified using both the American Orthopaedic Society for Sports Medicine and the Arthroscopy Association of North America Sports Medicine Fellowship *** demographic and educational background data for each FD was gathered via author review of current curriculum vitae(cVs).Any information that was unavailable on cV review was gathered from institutional biographies,Scopus Web of Science,and emailed *** ensure the collection of as many data points as possible,fellowship program coordinators,orthopaedic department offices and FDs were directly contacted via phone if there was no response via *** information of interest included:Age,gender,ethnicity,residency/fellowship training,residency/fellowship graduation year,year hired by current institution,time since training completion until FD appointment,length in FD role,status as a team physician and *** Information was gathered for 82 *** these,97.5%(n=80)of the leadership were male;84.15%(n=69)were caucasian,7.32%(n=6)were Asian-American,2.44%(n=2)were Hispanic and 2.44%(n=2)were African American,and 3.66%(n=3)were of another race or *** mean age of current FDs was 56 years old(±9.00 years),and the mean Scopus H-index was 23.49(±16.57).The mean calendar years for completion of residency and fellowship training were 1996(±15 years)and 1997(±9.51 years),*** time since fellowship training completion until FD appointment was 9.77 years.17.07%(n=14)of

关键词： Sports medicine fellowship Medical education Orthopaedic surgery Orthopaedic fellowship Orthopaedic leadership

THE ROLE OF LONG-TERM EXPERIMENTS IN VALIDATING TRAIT-BASED APPROAcHES TO AcHIEVING MULTIFUNcTIONALITY IN GRASSLANDS

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 187-196页

作者： Jonathan STORKEY andrew J.MAcDONALD Rothamsted Research West CommonHarpendenHertfordshireAL52JQUK

Quantifying the relationships between plant functional traits and ecosystem services has been promoted as an approach to achieving multifunctional grassland systems that balance productivity with other regulating,supporting and cultural *** trade-offs and synergies between traits and services has largely relied on meta-analyses of studies from different systems and *** study demonstrated the value of focused studies of long-term experiments in grassland systems that measure traits and services in the same space and time to better understand the ecological constraints underlying these trade-offs and *** analysis is presented that uses data from the Park Grass Experiment at Rothamsted Research on aboveground productivity,species richness and soil organic carbon stocks to quantify the relationships between these three outcomes and the power of variance in plant functional traits in explaining *** was a trade-off between plots with high productivity,nitrogen inputs and soil organic carbon and plots with high species richness that was explained by a functional gradient of traits that are indicative of contrasting strategies of resource acquisition of resource *** were identified of using functional traits to identify opportunities for mitigating these trade-offs and moving toward more multifunctional systems.

关键词： multifunctional grassland systems Park Grass Experiment soil organic carbon ecosystem service

categorical Differentiation of animals vs plants:DLPRF in left hemispheric determinacy

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Categorical Differentiation of animals vs plants:DLPRF in le...

The effect of valence and arousal of emotional pictures on EEG activity

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： andrew c.N.chen center for Higher Brain Functions Capital Medical University

＜正＞Objective categorization is a basic capacity of human,which has been studied between natural objects and artefacts for many ***,the categorization between animal and plant is much less *** behavior experiment outcome has previously indicated that the reaction time in categorizing animals was significantly faster than that in plants by speech *** this study,we continued to carry out related ERP experiment to investigate the different brain activity of animal and plant categorization *** Ten right-handed participants（healthy college male,23±0.5years old） ERP was recorded by a 128-ch ANT-ASA system（band-pass:0.15-100 Hz;sampling rate:512 Hz;impedance＜5kOhm;A1-A2 linked reference） and analyzed by spectral ERP field power mapping and swLORETA source *** participates were required to judge animal or plant pictures（60 items each） with speech *** speech responses were recorded online in a separate EEG trace and the reaction time and accuracy can be analyzed from the onset and morphology of the ***:Left hemispheric determinacy in *** We knew that the reaction time in categorizing animals was significantly faster than that in plants by speech response form a accomplished behavioral experiment（t=4.79,P＜0.001）.The topography between animal and plant pictures categorization displayed that animal and plant pictures incurred different brain activity:in the early stage（111-115ms）,the positive and negative power of animal pictures was larger than that of plants;in the second stage（174-178 ）,the negative power of plant pictures was little larger than that of animal pictures;in the third stage（268-271）,the positive and negative power of animal pictures was larger than that of plants,the trend was same as early *** eminently,the categorization activation was laterized at the dorsolateral prefrontal area（DLPFc） at the late *** From speech response,categorization to judge animals i

关键词： categorization Hemispheric Determinacy animals-plants ERP

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The effect of valence and arousal of emotional pictures on E...

The effect of tonic pain stimulation on attention network test

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： andrew c.N.chen center for Higher Brain Functions Capital Medical University

＜正＞Objective Greenwald and Lang et *** a theory of motivational priming that suggests emotion differentially modulates defensive *** emotion is associated with activation of the appetitive system,and negative emotion is associated with activation of the defensive *** provides an indicator of the motivational system activated,and arousal indicates the level of activation of the ***,valence is associated with the tone and arousal with the intensity of the *** brain regions bear different cognition functions,and so does different EEG *** recent reports,emotional arousal was laid more and more emphasis on,but related study was not *** Fifteen healthy female volunteers（age range 20-30 years） participated in the 2 stages and 8 EEG sessions（separated by 7-8 minutes with continuous EEG recording） *** first stage the subjects were instructed to arte 150 emotional pictures,so these pictures were grouped into arousal higher,arousal normal,arousal lower,valence positive,valence neutral and valence *** second stage was EEG *** first 2 sessions were used as baseline:subject was asked to open and close her eyes for 3mininuts *** other 6 sessions involved different emotion groups:the subjects were told to see the emotional pictures on the middle of the screen at the same time EEG was *** Fourier Transformation analysis was（FFT） performed based on 7 bands spectrum. Results（1） The prefrontal delta EEG exhibiting higher activity in valence than in arousal condition,and lower in both positive and negative valence than the neutral picture.（2） The frontal brain area of theta was higher in low arousal than in high arousal,while both negative and positive valence were lower than the neutral.（3） The posterior beta-1 activity was higher in valence than that in arousal *** Emotional related brain activation can be sensitively differentia

关键词： arousal emotion EEG valence IAPS

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The effect of tonic pain stimulation on attention network te...

作为赋存于花岗岩中钨锡矿化勘探指南的流体包裹体异常——前景展望

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： andrew c.N.chen center for Higher Brain Function Department of NeurobiologyCapital Medical University

Objective To investigate the effect of tonic pain stimulation on the attention network *** Twenty healthy adult male(age:21.60±3.45 y) were enrolled in this study,and laboratory pain was indu

关键词： attention network test(ANT) pain negative affections

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岩石学报 2007年第1期23卷 3-14页

作者： andrew H RANKIN School of Earth Sciences and Geography Kingston UniversityKingston-upon-ThamesSurreyKT1 2EEUK

Studies of the distribution and abundance of fluid inclusions in granitic quartz associated with granite-hosted Sn-W mineralization of the British Isles reveal local and regional scale *** a sampling interval of c.5～50m,inclusion abundances increase towards zones of vein and stockwork mineralization exemplified by case history examples from exploration prospects in the Mourne Mountains of Northern Ireland and the carrock Fell mining district of northwestern *** steam aureoles provide a greater exploration target than the zone of visible alteration and mineralization and the lithogeochemical *** it is important to link them to geochemical data on fluid inclusion compositions,such as the semi-quantitative data from decrepitation-linked,IcP-AES (D-IcP)analysis,to optimize their exploration *** scale fluid inclusion anomalies,based on sampling intervals of c. 2km from the Sn-W mineralized granites of southwest England also broadly correlate with zones of intense mineralization in some areas. Regional-scale D-IcP analyses of quartz from SW England granites did not provide any convincing regional scale anomalies linked to mineralization except for positive boron anomalies around the centrally-mineralized Birch Tor area of the Dartmoor ***-up D-IcP analysis of quartz from stream sediments from this area,however,could be used to discriminate between samples related to mineralization from those draining unmineralized areas,using multivariate statistical *** the present stage of development, the main contribution of fluid inclusion studies to mineral exploration is mostly limited to the conceptual stage where they continue to contribute to ore genetic theory and *** and lack of knowledge transfer between research scientists and mineral explorationists limit their direct use during regional and target selection stages of *** of steam sediment quartz,using the more sensitive IcP-MS technique as

关键词：赋存花岗岩钨锡矿化勘探指南流体包裹体异常前景展望

DNA methylation controlling abscisic acid catabolism responds to light to mediate strawberry fruit ripening

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Journal of Integrative Plant Biology 2024年第8期66卷 1718-1734页

作者： Yunfan Sun Xiaofang Yang Rongrong Wu Shouzheng Lv Yunduan Li Haoran Jia Yuying Yang Baijun Li Wenbo chen andrew c.Allan Guihua Jiang Yan-Na Shi Kunsong chen college of Agriculture&Biotechnology Zhejiang UniversityZijingang CampusHangzhou 310058China Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021China Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou 310058China The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhou 310058China New Zealand Institute for Plant&Food Research Limited Private Bag 92169AucklandNew Zealand School of Biological Sciences University of AucklandPrivate Bag 92019AucklandNew Zealand

Phytohormones,epigenetic regulation and environmental factors regulate fruit ripening but their interplay during strawberry fruit ripening remains to be *** this study,bagged strawberry fruit exhibited delayed ripening compared with fruit grown in normal light,correlating with reduced abscisic acid(ABA) *** of the key ABA catabolism gene,ABA 8′-hydroxylase FacYP707A4,was induced in bagged *** light exclusion whole genome DNA methylation levels were up-regulated,corresponding to a delayed ripening process,while DNA methylation levels in the promoter of FacYP707A4 were suppressed,correlating with increases in transcript and decreased ABA *** indicated FacRY1,a blue light receptor repressed in bagged fruit and FaAGO4,a key protein involved in RNA-directed DNA methylation,could bind to the promoter of *** interaction between FacRY1 and FaAGO4,and an increased enrichment of FaAGO4 directed to the FacYP707A4 promoter in fruit grown under light suggests FacRY1 may influence FaAGO4 to modulate the DNA methylation status of the FacYP707A4 ***,transient overexpression of FacRY1,or an increase in FacRY1 transcription by blue light treatment,increases the methylation level of the FacYP707A4 promoter,while transient RNA interference of FacRY1 displayed opposite *** findings reveal a mechanism by which DNA methylation influences ABA catabolism,and participates in light-mediated strawberry ripening.

关键词： ABA catabolism DNA methylation light ripening strawberry

Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser

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Light(Science & Applications) 2017年第1期6卷 400-407页

作者： Evan P Perillo Jeremy W Jarrett Yen-Liang Liu Ahmed Hassan Daniel c Fernée John R Goldak Andrei Bonteanu David J Spence Hsin-chih Yeh andrew K Dunn Department of Biomedical Engineering The University of Texas at AustinTX 78712USA Department of Physics The University of Texas at AustinTX 78712USA MQ Photonics Department of Physics and AstronomyMacquarie UniversitySydneyNSW 2109Australia

Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength ***,most currently available dual output laser sources rely on the costly and complicated optical parametric generation *** this report,we detail a relatively simple and low cost diamond Raman laser pumped by a ytterbium fiber amplifier emitting at 1055 nm,which generates a first Stokes emission centered at 1240 nm with a pulse width of 100 *** two excitation wavelengths of 1055 and 1240 nm,along with the effective two-color excitation wavelength of 1140 nm,provide an almost complete coverage of fluorophores excitable within the range of 1000–1300 *** compared with 1055 nm excitation,two-color excitation at 1140 nm offers a 90%increase in signal for many far-red emitting fluorescent proteins(for example,tdKatushka2).We demonstrate multicolor imaging of tdKatushka2 and Hoechst 33342 via simultaneous two-color two-photon,and two-color three-photon microscopy in engineered 3D multicellular *** further discuss potential benefits and applications for two-color three-photon *** addition,we show that this laser system is capable of in vivo imaging in mouse cortex to nearly 1 mm in depth with two-color excitation.

关键词： microscopy nonlinear processes three-dimensional imaging ultrafast lasers